SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

“…The principal investigator (CY) used internal staff resources, together with additional resources from external partners, to conduct this study. …”
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Synergistic photothermal conversion and visible-light photodegradation of antibiotic in S-type TiO2 derived Ti3C2-MXene loaded on NaYF4: Tm3+, Er3+, Yb3+ @BiOI by Seyyedeh Fatemeh Hosseini, Mir Saeed Seyed Dorraji, Shiva Mohajer, Seyedeh Narges Saeedi, Masoumeh Kianfar, Alexandr V. Koshelev, Nataliya A. Arkharova, Denis N. Karimov

“…It can be attributed to the synergistic photocatalytic and photothermal effects triggered by NIR light. In addition, the broad photoresponse range of TiO2 and the Schottky junction formed by Ti3C2 MXenes between TiO2 and BiOI facilitate charge separation while reducing photo-generated electron-hole pair recombination. …”
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Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma by Kai Zhang, Kai Zhang, Luyao Wang, Huili Chen, Lili Deng, Mengling Hu, Ziqiang Wang, Yiluo Xie, Chaoqun Lian, Xiaojing Wang, Xiaojing Wang, Jing Zhang

“…There were significant differences in prognosis between patients of different subtypes, and the NMBRS showed high accuracy in predicting the prognosis of LUAD patients. In addition, patients of different subtypes showed significant differences in genomic mutation and functional enrichment and exhibited different anti-tumor immune profiles. …”
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Knowledge, attitudes and practices of intensive care unit physicians towards the management of acute respiratory distress syndrome in China: a cross-sectional survey by Jing Qian, Yinglin Wu, Xiaoqin Zhao, Zhidan Qin, Yongyi Meng, Mingjing Yin, Hanchun Wen, Juntao Hu, Zhanhong Tang

“…Pearson correlation analysis showed positive correlations between knowledge and attitude (0.367), knowledge and practice (0.582) and attitude and practice (0.314) (all p<0.001).Results Mediation analysis indicated that attitude (β=0.07, p<0.001) and hospital type (β=−0.84, p=0.005) had direct effects on practice, while knowledge had significant direct (β=0.68, p<0.001) and indirect (β=0.03, p=0.019) effects. Additionally, education (β=0.47, p<0.001), work experience (β=0.25, p<0.001), hospital classification (β=−0.91, p<0.001), ICU type (β=−0.61, p=0.001) and ARDS experience (β=−1.57, p<0.001) showed various indirect effects on practice.Conclusions ICU physicians in China exhibited inadequate knowledge, moderate attitudes and suboptimal practices regarding ARDS management. …”
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Effect of Eight-Week Transcranial Direct-Current Stimulation Combined with Lat Pull-Down Resistance Training on Improving Pull-Up Performance for Male College Students by Qian Li, Jiaqi Yan, Hanya Dai, Minjie Qiao, Mingxin Gong, Wenxin Niu, Ye Yang, Lejun Wang

“…Both groups demonstrated significant improvements in pull-up endurance and lat pull-down MVIC peak force after training, but no significant difference between the two groups was observed in the post-training test. Additionally, muscle activation of BR, PD, and PM decreased significantly in both groups, while the RT + tDCS group also demonstrated a significant reduction in TB coactivation after training. …”
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En första kriminologisk inblick i lagen (2007:1150) om tillsyn över hundar och katter by Sirkku Sarenbo, Helena Striwing

“…Not to criminalize Section 1 of the Supervision Act and transfer of responsibility for the law from the Swedish Police Authority to the County Admi- ESSAY nistrative boards have reduced the burden on the Police Authority and the district courts at the expense of an increased burden on the County Administrative boards and the administrative courts. …”
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Fusion protein-based COVID-19 vaccines exemplified by a chimeric vaccine based on a single fusion protein (W-PreS-O) by Pia Gattinger, Luibov I. Kozlovskaya, Alexander S. Lunin, Olga S. Gancharova, Dina I. Sirazova, Dina I. Sirazova, Vasiliy D. Apolokhov, Egor S. Chekina, Ilya V. Gordeychuk, Ilya V. Gordeychuk, Alexander V. Karaulov, Alexander V. Karaulov, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Rudolf Valenta, Aydar A. Ishmukhametov, Aydar A. Ishmukhametov

“…Neutralizing antibody (nAB) titers, weight, lung symptoms, and viral loads, as measured using RT-PCR in the upper and lower respiratory tracts, were determined. In addition, infectious virus titers from the lungs were measured using a plaque-forming assay. …”
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Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging by Yuan Song, Yihui Wang, Wenyuan Wang, Yuji Xie, Junmin Zhang, Jing Liu, Qiaofeng Jin, Wenqian Wu, He Li, Jing Wang, Li Zhang, Yali Yang, Tang Gao, Mingxing Xie

“…Additionally, microRNA (miRNA) profiling enhances the diagnostic specificity for precise AR detection. …”
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Combining Unity with machine vision to create low latency, flexible and simple virtual realities by Yuri Ogawa, Raymond Aoukar, Richard Leibbrandt, Jake S. Manger, Zahra M. Bagheri, Luke Turnbull, Chris Johnston, Pavan K. Kaushik, Jaxon Mitchell, Jan M. Hemmi, Karin Nordström

“…This can be implemented programmatically in Unity, or by using our new tool CAVE, which allows users to design new experiments without additional programming. We provide resources for replicating experiments and our interface CAVE via GitHub, together with user manuals and instruction videos, for sharing with the wider scientific community.…”
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Accelerating discoveries at DIII-D with the Integrated Research Infrastructure by T. Bechtel Amara, S. P. Smith, Z. A. Xing, S. S. Denk, A. Deshpande, A. O. Nelson, C. Simpson, E. W. DeShazer, T. F. Neiser, O. Antepara, C. M. Clark, J. Lestz, J. Colmenares, N. Tyler, P. Ding, M. Kostuk, E. D. Dart, R. Nazikian, T. Osborne, S. Williams, T. Uram, D. Schissel

“…So far this has been achieved by ensuring the data is available with existing tools, but as more novel results are produced new visualization tools must be developed. In addition, all of the high-quality data we have generated has been collected into databases that can unlock even deeper insights. …”
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Advancing presurgical non-invasive spread through air spaces prediction in clinical stage IA lung adenocarcinoma using artificial intelligence and CT signatures by Guanchao Ye, Guangyao Wu, Yiying Li, Chi Zhang, Lili Qin, Lili Qin, Jianlin Wu, Jun Fan, Yu Qi, Fan Yang, Yongde Liao

“…Quantifying the contribution of radiomics features of CT to prediction model using Shapley additive explanations (SHAP) method. The models' performance was evaluated using metrics such as the area under the receiver operating characteristic curve (AUC), negative predictive value (NPV), positive predictive value (PPV), sensitivity, specificity, calibration curve, and decision curve analysis (DCA).ResultsIn the training cohort, the clinical model achieved an AUC value of 0.775, the radiomics model achieved an AUC value of 0.836, and the combined model achieved an AUC value of 0.837. …”
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Sustainable geopolymer adsorbents utilizing silica fume as a partial replacement for metakaolin in the removal of copper ion from synthesized copper solution by Pilomeena Arokiasamy, Mohd Mustafa Al Bakri Abdullah, Eva Arifi, Noorina Hidayu Jamil, Md Azree Othuman Mydin, Shayfull Zamree Abd Rahim, Andrei Victor Sandu, Shafiq Ishak

“…The generation of N-A-S-H gel with the 75 % replacement level of S1 producing more reactive Si and Al binding sites for Cu2+ adsorption. In addition, S1 contains exchangeable cations such as Ca2+, Mg2+ and Na+ which further promote the adsorption of Cu2+ by ion exchange. …”
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Little Red Dots: Rapidly Growing Black Holes Reddened by Extended Dusty Flows by Zhengrong Li, Kohei Inayoshi, Kejian Chen, Kohei Ichikawa, Luis C. Ho

“…There is no need for additional stellar emission or AGN scattered light. …”
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Study of interfacial bonding properties and shrinkage deformation of cement-alkali activated gradient-structured composite in complex environments with temperature-humidity changes by Xinzhe Li, Ganyou Jiang, Naishuang Wang, Yisong Wei, Zheng Chen, Zheng Chen, Jing Li, Jing Li, Ben Chen, Ben Chen, Jiamin Yu, Jiamin Yu

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Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: pro... by Suzana Shahar, Kalavathy Ramasamy, Norhayati Ibrahim, Nur Nadia Mohamad Habibullah, Munirah Ismail, Mohd Zul Amin Kamaruddin, Shirley Gee Hoon Tang, Mohd Faisal Abdul Hamid

“…The outcomes measures include respiratory infection symptoms, fatigue, mood state and quality of life assessed using Wisconsin Upper Respiratory Symptoms Scale, Multidimensional Fatigue Inventory, Profile of Mood State and Short Form 36 Health Survey Questionnaire, respectively. In addition, full blood analysis and assessment of immune, inflammatory and oxidative stress biomarkers will be taken. …”
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Pan-cancer and experimental analyses reveal the immunotherapeutic significance of CST2 and its association with stomach adenocarcinoma proliferation and metastasis by Dan Huang, Jing Li, Zhijun He, Wenjing Liang, Likun Zhong, Jun Huang, Yinteng Wu, Shijian Zhao

“…These factors include prognosis, immune cell infiltration, immune-related genes, mutations, methylation, tumor mutation burden (TMB), and microsatellite instability (MSI). In addition, we analyzed the sensitivity of drugs dependent on CST2 expression. …”
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Lactiplantibacillus plantarum (CECT7484 and CECT7485) and Pedioccoccus acidilactici (CECT7483) enhance actin cytoskeleton and CYP1A1 expression restoring epithelial permeability al... by Maria Raffaella Barbaro, Francesca Bianco, Cesare Cremon, Giovanni Marasco, Francesca Bonomini, Marta Palombo, Cecilia Delprete, Marta Perez, Jordi Espadaler-Mazo, Vincenzo Stanghellini, Simone Guglielmetti, Giovanni Barbara

“…The PB recovers the permeability increase induced by IBS mediators inducing the up-regulation of β-actin. In addition, the PB up-regulates the expression of CYP1A1, known to be involved in the metabolism of xenobiotics, possibly through the production of the indole-3-lactic acid.…”
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Alpha and Theta Oscillations Associated With Behavioral Phenotypes of Pain–Attention Interaction by Nikou Kelardashti, Benjamin T. Dunkley, Rima El‐Sayed, Vaidhehi Veena Sanmugananthan, Junseok Andrew Kim, Natalie Rae Osborne, Joshua C. Cheng, Anton Rogachov, Rachael L. Bosma, Ariana E. Besik, Karen Deborah Davis

“…ABSTRACT Purpose Pain is inherently salient and so draws our attention in addition to impacting performance on attention‐demanding tasks. …”
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Treating common mental disorder including psychotic experiences in the primary care improving access to psychological therapies programme (the TYPPEX study): protocol for a stepped... by David Fowler, Jesus Perez, Peter B Jones, Debra Russo, Clare Knight, Mary Dixon-Woods, Allan B Clark, Margaret Heslin, Sarah Byford, Paul French, Thomas Kabir, Jan Stochl, Mona Kanaan, James Clarke, Nick Grey, Ann Marie Swart, Polly-Anna Ashford, Ushma Patel, Freya Stuart, Hannah Murray, J Hodgekins, Nesta Reeve, Nicola Marshall, Michelle Painter, Maria Leathersich, Martin Pond

“…Introduction At least one in four people treated by the primary care improving access to psychological therapies (IAPT) programme in England experiences distressing psychotic experiences (PE) in addition to common mental disorder (CMD). These individuals are less likely to achieve recovery. …”
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Prenatal exposure to a mixture of organophosphate ester and organophosphorus pesticides in relation to child neurodevelopment in the Shanghai Birth Cohort by Hui Wang, Dezheng Fu, Xiaoning Liu, Xiaochen Chang, Siyu Guo, Xiaomeng Cheng, Ying Tian, Jinjun Ran, Jun Zhang, Shengju Yin

“…Additional research is required to validate our findings and elucidate the underlying mechanisms.…”
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