Efficacy and safety of the Russian protease inhibitor narlaprevir at treatment-naive and earlier treated noncirrhotic patients with the 1st genotype chronic hepatitis C (PIONEER st... by M. V. Mayevskaya, V. T. Ivashkin, O. O. Znoyko, Ye. A. Klimova, D. T. Abdurakhmanov, I. G. Bakulin, P. O. Bogomolov, E. Z. Burnevich, M. Yu. Galushko, N. I. Geyvandova, K. V. Zhdanov, Ye. V. Esaulenko, S. N. Kizhlo, D. Yu. Konstantinov, N. I. Mironova, V. G. Morozov, Ye. A. Strebkova, I. G. Nikitin, M. F. Osipenko, V. D. Pasechnikov, O. I. Sagalova, I. M. Khayertynova, V. P. Chulanov, A. A. Yakovlev, I. A. Vasyutin, Ye. P. Tarkhova, E. N. Krasavina, M. Yu. Samsonov

“…In those who were previously treated by peg-IFN/RBV, in the main group SVR-24 was attained in 72.6% at liver fibrosis stage F0-F2 and in 53.3% with F3 liver fibrosis stage. NVR/RTV addition to peg-IFN/RBV treatment did not alter safety profile as compared to peg-IFN/RBV therapy. …”
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Knowledge of COVID-19 and the psychological status of parents: a retrospective survey in Wuhan, Hubei by Lei Wang, Jing Cheng, Lin Lv, Yaqi Xu, Yutong Zhang, Honghui Gan, Change Xiong, Guiping Wang, Can Mei, Linwanyue Chen, Lu He, Shuliu Pan, Jianbo Zhan

“…Overall, 90.4% of the participants were concerned about their children’s mental health and learning during the pandemic. Additionally, 97.0% were aware of the typical symptoms of COVID-19. …”
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Exploring gender dynamics in climate-smart agriculture adoption: a study in semi-arid Dodoma, Tanzania by Mahlet Degefu Awoke, Mahlet Degefu Awoke, Mahlet Degefu Awoke, Katharina Löhr, Katharina Löhr, Anthony A. Kimaro, Marcos Lana, Boris D. Soh Wenda, Kwabena Buabeng, Kwabena Buabeng, Johannes Michael Hafner, Johannes Michael Hafner, Stefan Sieber, Stefan Sieber

“…These include implementing land reforms to ensure equitable land access for women, designing inclusive training programs that accommodate women’s time constraints, and increasing the representation of female extension workers to enhance CSA knowledge dissemination among female farmers. Additionally, improving access to credit facilities for female farmers, strengthening social networks through farmer groups, and improving transport infrastructure to reduce logistical barriers are crucial to further supporting CSA adoption. …”
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Association between fat-soluble vitamin co-exposure patterns and blood pressure in people with hypertension: a cross-sectional study by Suming Dai, Ping Wang, Sijia Wang, Sijia Wang, Hong Chen, Zhixin Cui, Wenhai Lu, Wenhai Lu, Ziyi Zhou, Ziyi Zhou, Nan Zhang, Zhuo Wang, Tengfei Lin, Tengfei Lin, Yun Song, Yun Song, Lishun Liu, Lishun Liu, Xiao Huang, Ping Chen, Genfu Tang, Yong Duan, Yong Duan, Hao Zhang, Binyan Wang, Binyan Wang, Binyan Wang, Yan Yang, Yan Yang, Yan Yang, Zezhong Tian

“…However, the plasma 25-hydroxyvitamin D3 (VD3) levels were negatively associated with SBP (logarithmic 10 transformed) (β = −0.002, 95% CI: −0.004, 0); participants in the fourth α-tocopherol quartile had mean SBP levels that were 1.02% (95% CI: 0.43, 1.61%) greater than those in the lowest quartile (p for trend <0.01). In addition, no significant relationships were found between plasma VA/VK concentrations and blood pressure.DiscussionAlthough no significant association between fat-soluble vitamin co-exposure patterns and blood pressure was found, further analyses could imply that plasma α-tocopherol levels may offset the potential protective effect of plasma VD3 on blood pressure among hypertensive adults. …”
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Global research landscape and emerging trends of non-coding RNAs in prostate cancer: a bibliometric analysis by Yu-Liang Zhou, Yu-Liang Zhou, Wen-Liang Yao, Wen-Liang Yao, Sheng-Hui Chen, Sheng-Hui Chen, Peng Wang, Peng Wang, Jing-Wen Fu, Jing-Wen Fu, Jia-Qin Zhao, Jia-Qin Zhao, Jia-Yi Zhang, Jia-Yi Zhang

“…The co-operation network of countries, institutions, and authors on this topic was analyzed using CiteSpace (version 6.2. R6). In addition, co-occurrence analysis of keywords and co-citation analysis of references were performed using CiteSpace, and emergent detection was also performed.ResultsA total of 2,951 articles on PC-related ncRNAs were finally included in this study for analysis. …”
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Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study by Umberto Simeoni, Antje Horsch, Arnaud Chiolero, Yvan Vial, Nicole Sekarski, Jardena J Puder, Pascal Bovet, Stefano Di Bernardo, Yvan Mivelaz, Adina Mihaela Epure, Sandrine Estoppey Younes, Bobby Stuijfzand, Leah Gilbert, Stefano Lanzi, Justine Gross, Stefano Di Bernardo, Dan Quansah, Jean-Benoît Rossel, Amar Arhab, Sandrine Estoppey Younes, Seyda Mayerat

“…The difference in CIMT between offspring of women with and without GDM was of 0.00 mm (95% CI −0.01 to 0.01; p=0.96) and remained similar on adjustment for potential confounding factors, such as maternal prepregnancy body mass index, maternal education, smoking during pregnancy, family history of diabetes, as well as offspring’s sex, age, and body surface area (0.00 mm (95% CI −0.02 to 0.01; p=0.45)).Conclusions We found no evidence of increased CIMT in neonates exposed to GDM. …”
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Analysis of Radio Science Data from the KaT Instrument of the 3GM Experiment During JUICE’s Early Cruise Phase by Paolo Cappuccio, Andrea Sesta, Mauro Di Benedetto, Daniele Durante, Umberto De Filippis, Ivan di Stefano, Luciano Iess, Ruaraidh Mackenzie, Bernard Godard

“…The comparison of the orbital solutions showed an excellent agreement. In addition, the Doppler and range residuals allowed a preliminary assessment of the quality of the radiometric measurements. …”
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Current methods for detecting and assessing HIV-1 antibody resistance by Stanley Odidika, Stanley Odidika, Stanley Odidika, Martin Pirkl, Martin Pirkl, Thomas Lengauer, Thomas Lengauer, Thomas Lengauer, Philipp Schommers, Philipp Schommers, Philipp Schommers

“…Structural analysis of antibody-HIV-1 Env complexes has provided insight into viral residues critical for neutralization, while testing of viruses for antibody susceptibility has verified the impact of some of these residues. In addition, in vitro viral neutralization and adaption assays have shaped our understanding of bNAb susceptibility based on the envelope sequence. …”
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Distinctive dust weather intensities in North China resulted from two types of atmospheric circulation anomalies by Q. Huo, Q. Huo, Z. Yin, Z. Yin, Z. Yin, X. Ma, X. Ma, H. Wang, H. Wang, H. Wang

“…Previous research has primarily focused on the role of the Mongolian cyclone in influencing dust weather in NC, with less attention given to other synoptic systems. Additionally, the differences in PM<span class="inline-formula">₁₀</span> concentrations in NC caused by different synoptic systems have not yet been quantified. …”
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Comparative analysis of the performance, egg quality and ovarian immune function of fast and slow feather strains in tianfu green shell laying hens at various stages of egg product... by Zhi Hu, Hengyong Xu, Zhipeng Zhang, Yuxiang Lu, Yuxin Zhou, Jiajun Zhu, Qingqing Deng, Xi Wang, Yiping Liu, Yao Zhang, Yan Wang

“…Immunologically, EF hens demonstrated elevated peak serum levels of IgA, IgG, and IgM compared to LF hens. Additionally, the expression levels of IFN-γ and interleukin 6 (IL-6) genes in the ovaries were markedly higher in EF hens. …”
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Addressing challenges in pediatric thrombosis: a comprehensive guideline development by Yin Wang, Qinan Yin, Jiangting Liao, Na Wang, Li Li, Siyan Li, Qingxia Zhang, Feifei Yu, Jianchun Luo, Hongmei Wang, Die Hu, Wenyi Li, Biao Li, Jingjing Chen, Limei Dong, Min Luo, Yu Yan, Lie Dong, Zheng Ding, Xi Wei, Jiadan Yang, Shenglan Tan, Lian Li, Xi Zheng, Liuyun Wu, Yong Yang, Linan Zeng, Jinqi Li, Lizhu Han, Yuan Bian

“…Recent studies have indicated a rising incidence of this disease in children over the years. Additionally, the pharmacological treatment of thrombotic diseases in children faces numerous challenges. …”
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Predicting 30-day mortality in severely injured elderly patients with trauma in Korea using machine learning algorithms: a retrospective study by Jonghee Han, Su Young Yoon, Junepill Seok, Jin Young Lee, Jin Suk Lee, Jin Bong Ye, Younghoon Sul, Se Heon Kim, Hong Rye Kim

“…The models’ performance was compared using metrics such as area under the receiver operating characteristic curve (AUC), accuracy, precision, recall, specificity, F1 score, as well as Shapley Additive Explanations (SHAP) values and learning curves. …”
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Mannan-Binding Lectin Suppresses Peptidoglycan-Induced TLR2 Activation and Inflammatory Responses by Fanping Wang, Yanhua Li, Can Yang, Yonghui Mu, Yan Wang, Wei Zhang, Yonghui Yang, Chen Chen, Shijun Song, Zhifa Shen, Wenjun Wang, Junpeng Li, Jingjing Zhai, Kang Guo, Ruili Sun, Lili Yu, Mingyong Wang

“…Administration of MBL alone did not have an effect on the expression of TLR2. …”
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Applied machine learning for predicting the properties and carbon and phosphorus fate of pristine and engineered hydrochar by Shiyu Xie, Tao Zhang, Siming You, Santanu Mukherjee, Mingjun Pu, Qing Chen, Yaosheng Wang, Esmat F. Ali, Hamada Abdelrahman, Jörg Rinklebe, Sang Soo Lee, Sabry M. Shaheen

“…FeCl3 impregnation increased Fe-phosphate content, while it reduced H/C and O/C ratios and hydroxyapatite P content, and therefore improved C stability and P availability in the HC-Fe as compared to HC, particularly under lower pH (4), temperature of 220 ℃, and at 120 min. The generalized additive ML model outperformed the other models for predicting the HC properties with a correlation coefficient of 0.86. …”
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Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways by Md. Niaj Morshed, Reshmi Akter, Imran Mahmud, Ah-Yeong Gwon, Jin Woo Jeang, Yeong-Geun Lee, Dae Won Park, Deok Chun Yang, Yeon Ju Kim, Se-Chan Kang

“…Using 3T3-L1 adipocytes in vitro assessments, CK could effectively decrease intracellular lipid accumulation, inhibit α-glucosidase enzyme, increase 2-NBDG glucose uptake, reduce inflammation-associated cytokines (<i>TNFα</i>, and <i>IL-6</i>), adipogenic regulatory genes (<i>PPARγ</i>, <i>FAS</i>, <i>C/EBPα</i>), lipogenic gene <i>LPL</i>, and increase the expression of thermogenic gene <i>UCP1</i>. Additionally, CK treatment induced osteoblast development in MC3T3-E1 cells as shown by increased mineralization and calcium distribution, collagen content, alkaline phosphatase activity, and decreased inflammatory cytokines <i>TNFα</i>, and <i>IL-6</i> and increased the regulated expressions of osteogenic genes including <i>Runx2</i>, <i>ALP</i>, <i>BGLAP</i>, <i>OCN</i>, and <i>Col1a1</i>. …”
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Pilot implementation of two specific problem lists before and after solid organ transplantation into routine care by Sanna Higgen, Evamaria Müller, Markus J. Barten, Markus J. Barten, Doreen Eickhoff, Doreen Eickhoff, Florian Grahammer, Martin Härter, Sabine Bart, Martina R. Sterneck, Martina R. Sterneck, Angela Buchholz, Angela Buchholz

“…Four psychologists assessed the appropriateness and feasibility by answering to open-ended and close-ended questions. Additionally, patients before (n = 8) and after (n = 100) transplantation filled out the screening and rated its acceptance. …”
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Thulium laser enucleation of the prostate plus thulium fiber laser therapy for benign prostatic hyperplasia combined with bladder stones by Chen Wang, Yuanwei Li, Yongjun Yang, Junjie Chen, Zhuo Li, Guangqing Song, Jia Chen, Liu Zhe, Yili Teng, Qiang Lu

“…Results: The patients in the observation group exhibited lower surgery duration, smaller postoperative decrease in Hb levels, shorter duration of postoperative indwelling catheterization, and proportion of American Society of Anesthesiologists (ASA) II patients, with a higher proportion of ASA I patients than the individuals in the control group (P <⁠0.05). Additionally, in comparison with the control group, the patients in the observation group had lower postoperative IPSS scores and higher levels of Hb, Qmax, and QoL score (P <⁠0.05). …”
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Optimal timing of pharmacoinvasive strategy and its impact on clinical and economic outcomes in patients with ST-elevation myocardial infarction: a real-world perspective by Andrea Dias Stephanus, Alice Pacheco Santos, Ana Carolina Machado Rodrigues da Cunha, Ana Carolina Augusto Rocha, Amanda de Amorim Meireles, Mariana Guimarães Souza de Oliveira, Pietra Arissa Coelho Matsunaga, Alexandre Anderson de Sousa Munhoz Soares, Alexandre Anderson de Sousa Munhoz Soares, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Ana Claudia Cavalcante Nogueira, Adriana de J. B. de Almeida Guimarães, Adriana de J. B. de Almeida Guimarães, Gustavo de Almeida Alexim, Alessandra M. Campos-Staffico, Luiz Sergio Fernandes de Carvalho, Luiz Sergio Fernandes de Carvalho, Luiz Sergio Fernandes de Carvalho

“…Cost analyses were conducted from the perspective of Brazilian public healthcare system, with values converted to international dollars (Int$) for broader applicability.ResultsEvery 4-h delay in lysis-PCI was associated with a 44% reduction in in-hospital mortality [OR = 0.560 (95% CI: 0.381–0.775); p = 0.001] and a 13% decrease in 4p-MACE [OR = 0.877 (95% CI: 0.811–0.948); p = 0.001]. Additionally, 4-h delay in lysis-PCI was also associated with a significant reduction in in-hospital costs (Int$916.20 ± 99) and disease-induced years of productivity lost (β = −41.79 ± 151 years; p = 0.001). …”
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Antibodies against neuronal surface antigens in acute stroke: a systematic review and meta-analysis by Matteo Paolucci, Andrea Zini, Luana Morelli, Luana Morelli, Rocco Liguori, Rocco Liguori, Maria Pia Giannoccaro, Maria Pia Giannoccaro

“…Due to several methodological issues, these findings should be interpreted cautiously. Additional, methodologically robust studies are needed to clarify the prevalence and significance of NMDAR-Abs in patients with stroke.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
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Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018) by Zhongshan Li, Zhongshan Li, Qi Qu, Qi Qu, Zhiyu Wang, Zhiyu Wang, Shuanglin Mou, Rui Jiang, Rui Jiang, Wensheng Zhu, Wensheng Zhu

“…In multivariate logistic regression, high EO level exposure was significantly associated with increased OA risk. Additionally, a nonlinear U-shaped and J-shaped association was observed in the unadjusted and adjusted RCS models, respectively. …”
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