Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety by Víctor Mayoral, Rafael Galvez, Marta Ferrándiz, Xoán Miguéns Vázquez, Carlos Cordero-García, Antonio Alcántara Montero, Concepción Pérez, María Pérez-Páramo

“…Sensitivity analysis supported the efficacy of pregabalin.ConclusionIn conclusion, pregabalin demonstrated superior and faster efficacy in alleviating neuropathic pain than gabapentin did. Additionally, it improved patient-reported outcomes, resulted in lower opioid consumption, and led to fewer adverse events.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
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Icariin modulates osteogenic and adipogenic differentiation in ADSCs via the Hippo-YAP/TAZ pathway: a novel therapeutic strategy for osteoporosis by Shaozi Lin, Zuyu Meng, Mei Wang, Zixuan Ye, Mengsha Long, Yiyao Zhang, Fang Liu, Hongling Chen, Menghan Li, Jiajia Qin, Haiquan Liu

“…Western blotting was performed to analyze the expression of factors associated with the Hippo-YAP/TAZ signaling pathway and the adipogenic marker PPARγ. Additionally, ADSCs were labeled with lentiviruses carrying enhanced green fluorescent protein (EGFP) and 5-bromo-2-deoxyuridine (BrdU) to assess their in vivo distribution, survival, proliferation, and differentiation of ADSCs post-ICA intervention.ResultsIn vitro, ICA significantly inhibited the Hippo pathway, reducing YAP and TAZ phosphorylation and enhancing their transcriptional activity, while simultaneously suppressing PPARγ. …”
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Metabolic Effects of Testosterone Hormone Therapy in Normal and Orchiectomized Male Rats: From Indirect Calorimetry to Lipolytic Enzymes by Mahmoud Mustafa Ali Abulmeaty, Ali Madi Almajwal, Mohamed Farouk ElSadek, Mohamed Y Berika, Suhail Razak

“…This study measured respiratory quotient (RQ), TEE, ghrelin, insulin, and key lipolysis enzyme concentrations in relation to body weight (wt) and food intake (FI) in both normal and bilaterally orchiectomized rats with/without T treatment. …”
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Randomized, Open-Label Phase 2 Study of Apalutamide plus Androgen Deprivation Therapy versus Apalutamide Monotherapy versus Androgen Deprivation Monotherapy in Patients with Bioche... by Rahul Aggarwal, Joshi J. Alumkal, Russell Z. Szmulewitz, Celestia S. Higano, Alan H. Bryce, Angela Lopez-Gitlitz, Sharon A. McCarthy, Branko Miladinovic, Kelly McQuarrie, Shibu Thomas, Ke Zhang, Eric J. Small

“…In 90 enrolled patients (apalutamide plus ADT (n = 31), apalutamide (n = 29), ADT (n = 30)), FACT-P at 12 months was not significantly different between apalutamide, ADT and apalutamide, and ADT groups. Addition of apalutamide to ADT prolonged time to PSA progression but this change did not reach statistical significance (hazard ratio (HR): 0.56, 95% confidence interval (CI): 0.23–1.36, P=0.196); time to testosterone recovery was similar in the ADT-containing groups. …”
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TAp63γ is the primary isoform of TP63 for tumor suppression but not development by Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang

“…Like TAp63-deficient mice, p63γ-deficient mice have a short lifespan and are prone to spontanenous tumors. Additionally, loss of p63γ shortens the lifespan of tumor-free mice potentially via increased cellular senescence. …”
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Associations between health, productive performance and oral fluid biomarkers in commercial pig farms by Mario Andre S. Ornelas, Edgar Garcia Manzanilla, José J. Cerón, Alba Ortín-Bustillo, María José López-Martínez, Carla Correia-Gomes, Finola C. Leonard, Lorena Franco-Martínez

“…Abstract Background Oral fluid contains analytes that may be reflective of health and welfare in pig herds. Additionally, oral fluid collection is a more convenient and cost-effective option when compared to blood sampling, increasing the potential of oral fluid as a non-invasive alternative tool. …”
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Novel Fusion Technique for High-Performance Automated Crop Edge Detection in Smart Agriculture by F. Martinez, James B. Romaine, P. Johnson, A. Cardona Ruiz, Pablo Millan Gata

“…This combination enables lettuce area identification using bounding box labels instead of contour labels during training, improving efficiency compared to other methods like YOLOv8 and Detectron2. Additionally, the combination of the YKMS method with YOLOv8 (YKMSV8) is evaluated, where YKMS serves as a label assistant. …”
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Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia by Shasha Wu, Tailian Xue, Yilin Li, Weikang Chen, Yan Ren

“…Subsequently, a PPI network was constructed to select the top 10 potential hub genes, and functional analysis was performed by GeneMANIA, resulting in the identification of four immune-related genes. In addition, significant differences were observed among the four immune cell types in the two groups of samples. …”
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Time and cost of linking administrative datasets for outcomes assessment in a follow-up study of participants from two randomised trials by Mohammad Shahbaz, Jane E. Harding, Barry Milne, Anthony Walters, Lisa Underwood, Martin von Randow, Lena Jacob, Greg D. Gamble, for the ANCHOR Study Group

“…Team members estimated the average time they spent on each action, and invoices from agencies were recorded. Additionally, we compared the estimated costs and time required for data linkage with those for obtaining self-reported questionnaires and conducting in-person assessments. …”
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Assessing and projecting the global impacts of Alzheimer’s disease by Nanlong Zhang, Shuren Chai, Jixing Wang

“…An analysis based on the Socio-Demographic Index (SDI) reveals that regions with higher SDI values have greater burdens of AD, with countries having SDI ≥ 0.8 showing significantly higher age-standardized Incidence Rates (ASIR), age-standardized Death Rates (ASDR), and age-standardized DALY rates compared to those with SDI < 0.8.ConclusionFrom 1990 to 2030, global burden of AD is projected to decrease, with significant gender and regional disparities. …”
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Annual change in the distribution and landscape health of mangrove ecosystems in China from 2016 to 2023 with Sentinel imagery by Yuchao Sun, Mingzhen Ye, Bin Ai, Zhenlin Lai, Jun Zhao, Zhuokai Jian, Xinyan Qi

“…The research shows that compared to the combination model of PSPNet and DeepLabV3 with Resnet, the U-net+ResNet34 model gave the most optimal results in identifying mangroves. In addition, the F1-score of the model reached 0.843 when validated with the samples collected from the national mangrove dataset. …”
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Comparison of HCG Trigger versus Dual Trigger in Improving Pregnancy Outcomes in Patients with Different Ovarian Responses: A Retrospective Study by Ke Xu, Jinrong Wang, Shuangshuang Yang, Zhenjing Wang, Ning Hou, Mei Sun

“…The results of this study highlight the necessity of adopting a customized and individualized treatment approach that should be based on the patient’s ovarian response. Additionally, recognizing the pivotal role of the endocrine environment in influencing pregnancy outcomes and the occurrence of OHSS, further exploration of the effects of different triggering regimens on endocrine parameters is warranted. …”
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How Authoritative Media and Personal Social Media Influence Policy Compliance Through Trust in Government and Risk Perception: Quantitative Cross-Sectional Survey Study by Hua Zhang, Cheng Yang, Xiuxian Deng, Chunyan Luo

“…ConclusionsBy combining the motivation theory of compliance behavior with the social amplification of risk framework in risk communication, we found that trust in government, as a normative motivation, operates through authoritative media, while risk perception, as a calculative motivation, promotes compliance behavior through we-media. In addition, in major crises, the public’s use of authoritative media can lead to the paradox of trust: on the one hand, trust in the government increases policy compliance; on the other hand, this trust reduces risk perception, thereby decreasing compliance behavior. …”
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A comprehensive review of probiotics and human health-current prospective and applications by Bhutada Sarita, Dahikar Samadhan, Md Zakir Hassan, Md Zakir Hassan, Elena G. Kovaleva

“…However, several methods including, spray drying where liquid is atomized within a heated air chamber to evaporate moisture and produce dry particles that improves the efficacy and stability of probiotics. …”
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Spacer-type tibial osteotomy versus open wedge high tibial osteotomy and unicompartmental knee arthroplasty for Kellgren-Lawrence grade 3–4 medial unicompartmental knee osteoarthri... by Yi Zhang, Xiangzhi Yin, Jinli Chen, Yingze Zhang, Tengbo Yu

“…Although spacer-type tibial osteotomy offers shorter operation time and comparable clinical outcomes, it also has extended recovery phase, additional fibular incision and the risk of spacer dislocation, which did not appear to be superior to OWHTO and UKA under the indications outlined in this study. …”
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Enablers of and barriers to ART adherence among female sex workers in mid-western Uganda: a qualitative study by David Friday Apuulison, Brenda Nabawanuka, Michael Muhoozi, Julian Aryampa, Pauline Irumba, Edson Katsomyo, Moses Asiimwe, Joshua Epuitai, Pardon Akugizibwe, Wasswa George, John Rubaihayo

“…., food scarcity), and occupation-related factors (substance use, incarceration, busy and predictable schedules, and abrupt migrations) were the additional barriers to ART adherence. Conclusion ART adherence among FSWs was influenced by attitudes, subjective norms, and perceived behavioral control. …”
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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy by Gao Y, Li L, Zhao F, Cheng Y, Jin M, Xue FS

“…Furthermore, the effects of esketamine were enhanced by addition of autophagy inducer rapamycin.Conclusion: Esketamine at a clinical dose attenuates cerebral I/R injury by inhibiting AKT signaling pathway to facilitate microglial M2 polarization and autophagy. …”
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Diagnosis of Schizophrenia and Its Subtypes Using MRI and Machine Learning by Hosna Tavakoli, Reza Rostami, Reza Shalbaf, Mohammad‐Reza Nazem‐Zadeh

“…We extracted volumetrics of 66 subcortical and thickness of 72 cortical regions. Additionally, we obtained four graph‐based measures for 116 intracranial regions from rsfMRI data, including degree, betweenness centrality, participation coefficient, and local efficiency. …”
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INNOVATIVE LOGISTICS STRATEGY AS AN EFFECTIVE MEANS FOR OPTIMIZING THE BUSINESS PROCESSES OF INDUSTRIAL ENTERPRISES by Malahat Soltan Huseynova, Zulfiya Elman Hajiyeva, Zulfiya Mirza Gasimova, Saida Rahim Mammadova

“…It was established that developing such a strategy by the higher management bodies of industrial enterprises, aligned with their goals, can optimize the use of all resources in managing logistics flows. …”
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Obstacle recognition and elimination method for humanoid robots based on point cloud processing by Naigong YU, Qiusheng XIE, Hongzheng LI

“…The data and experimental results were recorded and analyzed. Additionally, experiments were conducted to estimate staircase parameters with and without obstacle rejection. …”
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