Cohort profile: Born in Wales—a birth cohort with maternity, parental and child data linkage for life course research in Wales, UK by Amrita Bandyopadhyay, Sarah Davies, Michaela James, Sinead Brophy, Sam Dredge, Hope Jones, Mike J Seaborne, Natasha L Kennedy, Adele Battaglia

“…This comprehensive dataset comprises over 400 000 child electronic records. Additionally, survey responses about health and well-being from a cross-section of the population including 2500 parents and 30 000 primary school children have been collected for enriched personal responses and linkage to the data spine.Findings to date The electronic cohort comprises all children born in Wales since 2011, with follow-up conducted until they finish primary school at age 11. …”
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Mapping Habitat Structures of Endangered Open Grassland Species (<i>E. aurinia</i>) Using a Biotope Classification Based on Very High-Resolution Imagery by Steffen Dietenberger, Marlin M. Mueller, Andreas Henkel, Clémence Dubois, Christian Thiel, Sören Hese

“…By employing various modeling techniques, including Generalized Additive Models (GAM), Generalized Linear Models (GLM), and Random Forest (RF), we assessed the influence of different modeling parameters and pseudo-absence (PA) data generation on model performance. …”
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Establishment and characterization of a new mouse gastric carcinoma cell line, MCC by Yushen Wang, Xianju Li, Yi Wang, Jun Qin

“…Methods Gastric adenocarcinoma in the body region was induced in immunocompetent BALB/c mice using N-Methyl-N-nitrosourea and a 2% NaCl solution. …”
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The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism by Ying Song, Xinyi Zhu, Beibei Wang, Qisong Li, Biwei Song

“…Abstract Skin, as the first line of defence of the human body, is exposed to dangers such as overheating substances, ultraviolet rays, and environmental pollutants, and the incidence of skin diseases is increasing annually. …”
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Resourceful and economical designing of fermentation medium for lab and commercial strains of yeast from alternative feedstock: ‘transgenic oilcane’ by Shraddha Maitra, Bruce Dien, Kristen Eilts, Nurzhan Kuanyshev, Yoel R. Cortes-Pena, Yong-Su Jin, Jeremy S. Guest, Vijay Singh

“…Acclimation of cultures in a blended medium significantly improved the performance of the yeast strains. Conclusions The addition of transgenic oilcane juice, which is inedible and rich in amino acids, to the hydrolysate averted the need for expensive nutrient supplementation and detoxification steps of hydrolysate. …”
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Comparative analysis of gene expression in tea plant (Camellia sinensis (L.) Kuntze) under low-temperature stress by L. S. Samarina, A. O. Matskiv, N. G. Koninskaya, T. A. Simonyan, V. I. Malyarovskaya, L. S. Malyukova

“…Relative electrical conductivity of leaf was measured in response to the stress treatments, and a significant difference in the frost tolerance of the two tea genotypes was confirmed. Cold exposure did not lead to a change in the electrical conductivity of leaf tissue. …”
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Reverse osmosis for the treatment of well water and wastewater for reuse by A. Mélendez- Rivera, J. Musa-Wasil, D. Almestica-Martinez, K. Malave-Llamas

“…Regarding the feasibility of reusing wastewater post-reverse osmosis treatment, the findings showed decreased levels of anions and cations in the treated wastewater. Additionally, all reverse osmosis-treated well water samples tested in 2022 met the quality control laboratory criteria.CONCLUSION: The study confirms that the reverse osmosis system effectively purifies well water for human use and demonstrates the potential for repurposing treated wastewater. …”
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COVID-19 Mortality in Children: A Referral Center Experience from Iran (Mofid Children’s Hospital, Tehran, Iran) by Shahnaz Armin, Seyed Alireza Fahimzad, Sedigheh Rafiei Tabatabaei, Roxana Mansour Ghanaiee, Noushin Marhamati, Seyyedeh Narjes Ahmadizadeh, Azita Behzad, Seyedeh Masumeh Hashemi, Saeed Sadr, Maryam Rajabnejad, Mahnaz Jamee, Abdollah Karimi

“…The median length of stay in the hospital was 10 days (range 1–215). 91.52% had underlying comorbidities of which neurological diseases accounted for the largest share. 54 patients were admitted to the ICU and 83.05% of them had intubation during their hospitalization. In addition, the most common reasons for death in our study were related to respiratory and multiorgan failure. …”
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Inverse association between dietary flavonoid intake and nocturia in middle-aged and older adults from NHANES 2007–2010 by Yu Cai, Ying-Chao Liang, Xin-Yu Hu, Ling Li, De-Liang Liu, Shu-Fang Chu, Hui-Lin Li

“…Restricted cubic spline (RCS) was utilized to explore whether there is a non-linear association between total flavonoid intake and nocturia. In addition, we performed weighted logistic regression and weighted quantile sum (WQS) regression by six flavonoid species (isoflavones, anthocyanins, flavan-3-ols, flavanones, flavonoids and flavonols) to estimate a combined mixture sum effect as well as the contribution of each mixture component. …”
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Diabetic retinopathy further increases risk of cardiovascular disease mortality in a high-risk cohort by Richard Kha, Yasemin Kapucu, Mayuri Indrakumar, George Burlutsky, Aravinda Thiagalingam, Pramesh Kovoor, Paul Mitchell, Gerald Liew

“…This likely reflects additional contribution of microvascular disease to CVD mortality. …”
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Experimental research on mechanical and impact properties of ceramsite prepared from secondary aluminum dross and municipal solid waste incineration ash by Wangze He, Yufei Yang, Xinghan Zhu, Jinzhong Yang, Yingjie Sun, Qifei Huang

“…Single-factor experiments demonstrate that the compressive strength of ceramsite initially follows a non-linear ascending trend with increasing sintering temperatures. Additionally, the strength is enhanced with reductions in particle size of the raw material balls, prolongation of the sintering time, and a reduction in the silica-to-alumina ratio of the raw materials. …”
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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

“…Acquired data were processed using the license version of the SPSS programme. In addition, the selective secondary (comparative) analysis of social science research, conducted by Russian and foreign scientists, was applied.Results and scientific novelty. …”
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Impact of gas composition, pressure, and temperature on interfacial Tension dynamics in CO₂-Enhanced oil recovery by Rahul Gajbhiye

“…The research stands out for its innovative experimentation and detailed analysis, which focus on evaluating the impact of individual parameters crucial for modeling. Additionally, it sheds light on the combined effects of these parameters, which are essential for practical field applications. …”
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User-Oriented Requirements for Artificial Intelligence–Based Clinical Decision Support Systems in Sepsis: Protocol for a Multimethod Research Project by Pascal Raszke, Godwin Denk Giebel, Carina Abels, Jürgen Wasem, Michael Adamzik, Hartmuth Nowak, Lars Palmowski, Philipp Heinz, Silke Mreyen, Nina Timmesfeld, Marianne Tokic, Frank Martin Brunkhorst, Nikola Blase

“…ConclusionsThe results of the research project represent the first attempt to create a comprehensive user-oriented requirement profile for the development of sepsis-specific AI-based CDSS. In addition, general recommendations are derived, in order to reduce barriers in the development and implementation of AI-based CDSS. …”
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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…In this investigation, the tools SIFT, PROVEAN, PolyPhen-2, PANTHER, SNAP 2.0, PhD-SNP, and SNPs&GO were used to predict potentially harmful and disease-causing nsSNPs in CXCR4. Additionally, their impact on protein stability was examined by I-mutant 3.0, MUpro, Consurf, and Netsurf 2.0, combined with conservation and solvent accessibility analyses. …”
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Automated Generation of Multiple-Choice Questions for Computer Science Education Using Conditional Generative Adversarial Networks by Muhammad Shoaib, Ghassan Husnain, Nasir Sayed, Yazeed Yasin Ghadi, Masoud Alajmi, Ayman Qahmash

“…Through rigorous evaluation using comprehensive performance metrics, including Question Relevance Score (QRS), Diversity Index (DI), and Difficulty Alignment Accuracy (DAA), we demonstrate the efficacy and robustness of our framework in generating high-quality MCQs. …”
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Seasonal activity patterns of Ixodes scapularis and Ixodes pacificus in the United States by Lars Eisen

“…Scarcity of data for seasonal activity patterns of I. pacificus outside of California and for I. scapularis from parts of the Southeast, Northeast, and Upper Midwest is a key knowledge gap. In addition to informing the public of when during the year the risk for tick bites is greatest, high-quality studies describing current seasonal activity patterns also will generate the data needed for robust model-based projections of future climate-driven change in the seasonal activity patterns and provide the baseline needed to empirically determine in the future if the projections were accurate.…”
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Clinical Holistic Medicine: Metastatic Cancer by Søren Ventegodt, Elin Solheim, Mads E. Saunte, Mohammed Morad, Isack Kandel, Joav Merrick

“…We believe that the consciousness-based/holistic medical toolbox has a serious additional offer to cancer patients and, as a consequence, designed a treatment for the patient with metastasized cancer. …”
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CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…Then, we generated and characterized an APP/PS1 mouse model with neuron-specific Cd2ap deletion, using immunoblotting, immunofluorescence, enzyme-linked immunosorbent assay, electrophysiology and behavioral tests. Additionally, we established a stable CD2AP-knockdown SH-SY5Y cell line to further elucidate the specific molecular mechanisms by which CD2AP contributes to AD pathogenesis. …”
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CST2 promotes cell proliferation and regulates cell cycle by activating Wnt-β-catenin signalling pathway in serous ovarian cancer by Xiaohua Wang, Sufen Zhao, Yanwei Guo, Chunhui Wang, Shuyu Han, Xingcha Wang

“…Functionally, CST2 played vital roles in promoting cell proliferation, orchestrating the G1-to-S phase transition, and driving malignant SOC progression through activating the Wnt-β-catenin signalling pathway.Conclusions The elevated expression of CST2 may be related to the occurrence and progression of SOC by activating the Wnt-β-catenin pathway. Additionally, our findings suggest that CST2 is a promising novel biomarker with potential applications in therapeutic, prognostic, and diagnostic strategies for SOC.…”
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