Highly Aggressive CD4-Positive Mast Cell Leukaemia (Leukaemic Variant) Associated with Isolated Trisomy 19 and Hemophagocytosis by Neoplastic Mast Cells: A Case Report with Challen... by Dina Sameh Soliman, Ahmad Al-Sabbagh, Feryal Ibrahim, Amna Gameil, Mohamed Yassin, Halima El-Omri

“…Mast cell leukaemia is a unique disease among hematopoietic neoplasms, being one of the rarest leukaemia subtypes. In addition, its prompt diagnosis is usually challenging. …”
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Timing of risk factors, prodromal features, and comorbidities of dementia from a large health claims case–control study by Stefan Teipel, Manas Akmatov, Bernhard Michalowsky, Steffi Riedel-Heller, Jens Bohlken, Jakob Holstiege

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miR-199a-5p Exacerbated Intestinal Barrier Dysfunction through Inhibiting Surfactant Protein D and Activating NF-κB Pathway in Sepsis by Xianjin Du, Dan Tian, Jie Wei, Chen Yan, Peng Hu, Xu Wu, Wenbin Yang, Zhanyong Zhu

“…Moreover, miR-199a-5p increased D-lactic acid, DAO, and FD-40 while inhibition of miR-199a-5p exhibited a reversed process. Additionally, we observed that miR-199a-5p affected the oxidative damage and inflammation in the intestine tissues from sepsis mice. …”
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Transcutaneous vagus nerve stimulation as a pain modulator in knee osteoarthritis: a randomized controlled clinical trial by Gehad Gamal Elsehrawy, Maha Emad Ibrahim, Nermeen Hassan A.moneim, Mohamed Ahmed Hefny, Nashwa Kamel El Shaarawy

“…Abstract Background Our understanding of osteoarthritis (OA) has evolved from a degenerative disease to one in which low-grade, chronic inflammation plays a central role. In addition, evidence suggests that OA is accompanied by both peripheral and central nervous system sensitization that can cause pain. …”
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Approaches to implementing and financing primary health care in Kenya: a case of seven counties by Janette Karimi, Salim Hussien, Elizabeth Wangia, Mercy-Irene Kimani, Mohamud Mohamed, Melissa Wanda, Rosemarie Muganda, Rachel Ndirangu, Daniel Mwai, Mercy Wanjala, Fadhila Richter

“…Key informant interviews were conducted with county health officials and partners. Additionally, counties were supplied with templates for qualitative data. …”
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Navigating diabetes care inequities: an observational study linking chronic care model’s structural elements to process and outcomes of type 2 diabetes care in Belgium by Philippe Bos, Katrien Danhieux, Edwin Wouters, Josefien van Olmen, Veerle Buffel

“…By estimating a series of hierarchical mixed-effects models, we assessed the association between primary care practices’ CCM implementation and two process and two outcome indicators of T2D care. In addition, we explored cross-level interactions with patients’ socioeconomic vulnerability. …”
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Diagnostic Decision-Making Variability Between Novice and Expert Optometrists for Glaucoma: Comparative Analysis to Inform AI System Design by Faisal Ghaffar, Nadine M. Furtado, Imad Ali, Catherine Burns

“…Furthermore, approaches to the exam assessment and decision differed significantly: experts emphasized comprehensive risk assessments and progression analysis, demonstrating cognitive efficiency and intuitive decision-making, while novices relied more on structured, analytical methods and external references. Additionally, significant variations in patient follow-up times were observed, with a P value of <.001 on the chi-square test, showing a stronger influence of experience on follow-up time decisions. …”
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Relationships between muscle strength, lung function, and cognitive function in Chinese middle-aged and older adults: A study based on the China health and retirement longitudinal... by Yixuan Ma, Xinze Wu, Yinjiao Zhao, Weihao Hong, Yisheng Luan, Peiyu Song, Bing Zhang

“…Specifically, PEF played a substantial mediating role in linking grip strength to cognitive function scores (estimated indirect effect = 0.0132, boot-strapped standard error = 0.0015, boot-strapped standard 95% confidence interval = 0.0104, 0.0162). Additionally, PEF served as a significant mediator in the association between chair-standing time and cognitive function scores (estimated indirect effect = −0.0204, boot-strapped standard error = 0.0023, boot-strapped standard 95% confidence interval = −0.0251, −0.0159). …”
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Cross-Sectional Survey to Assess Tobacco and Nicotine Product Use since the Introduction of Heated Tobacco Products in Japan: Wave 2 by Prasad Krishna, Shetty Mandara, Edward Lauren, Kanitscheider Claudia, Marczykowski Felix

“…In Wave 2, the concern of this publication, additional population-level data was obtained on use patterns and behaviour relating to tobacco and nicotine products in Japan. …”
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Cost-effectiveness analysis for implementation of smoking cessation strategies at primary health care settings in Tamil Nadu. by Vasantha Mahalingam, Ramesh Kumar Santhanakrishnan, Muniyandi Malaisamy, Karthick Chelvanayagam, Kavi Mathiyazhagan, Adhin Bhaskar, Karikalan Nagarajan, Jerard Maria Selvam, Surendran Veeraiah, Kavitha Rajsekar, Kirti Tyagi, Ponnuraja Chinnaiyan

“…The PS3, with an incremental cost of ₹462,497 ($5,510) for 131 additional quitters, resulted in an ICER of ₹3,531 ($42) per quitter, making it a cost-effective option compared to PS1.…”
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Longitudinal analysis of academic stress and its effects on salivary cortisol, alpha-amylase, and academic outcomes: Study protocol. by Juan Luis Castillo-Navarrete, Alejandra Guzmán-Castillo, Claudio Bustos

“…<h4>Biological and psycho-behavioural data collection</h4>Participants will answer electronic questionnaires on academic stress and psycho-behavioural variables three times a week via the REDCap platform. In addition, smart devices will be used to continuously collect biological data such as heart rate, oxygen saturation, and sleep patterns. …”
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Optimized extraction and kinetic study of cholesterol oxidase from a newly isolated Escherichia fergusonii strain from local whey samples: insights through a combined experimental... by Simin Khataee, Gholamreza Dehghan, Samaneh Rashtbari, Arezu Marefat, Sina Jamei, Hamed Farzi-Khajeh

“…The crude product was purified by ammonium sulfate precipitation and followed by ion exchange chromatography utilizing Q-Sepharose, resulting in 5.35-fold and 13.86-fold purification, respectively, with a final specific activity of 15.8 U/mg. Additionally, molecular weight was determined by SDS-PAGE to be 49.0 kDa. …”
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Gardé·es à vue. Domination(s) et reconfigurations des rapports entre manifestant·es et policier·es pendant le hirak (2019-2021) by Lina Benchekor

“…This study begins by showing the specific features of repression of women’s bodies and the vulnerability of minority groups. We show that law enforcement agencies use information relating to private life to put pressure on marginalized categories such as single women or sexual minorities. …”
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Non-invasive methods for diagnosing portal hypertension and variceal bleeding due to liver cirrhosis secondary to NAFLD/MASLD: systematic review by Nebyu Yonas Shanka, Nebyu Yonas Shanka, Chavdar S. Pavlov, Nigatu Leul Mekonnen

“…Future research should aim to standardize protocols and explore additional biomarkers to further enhance diagnostic accuracy.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?…”
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Effect of Swimming on Gut Microbiota and Inflammation in Colorectal Cancer Cells Transplanted Mice by LI Jiapeng, XIE Qiurong, WEN Ying, CHEN Haichun, PENG Jun, SHEN Aling

“…SPSS 26.0 and GraphPad Prism 7 software were used for statistical analysis.ResultsCompared with the model group, swimming significantly reduced the weight of CRC transplanted tumor in mice (<italic>P</italic>&lt;0.05). 16S rRNA sequencing and OTU cluster analysis identified 487 overlapping bacterial populations in the model and swimming groups. In addition, 73 unique bacterial populations were found in the model group, while 40 in the swimming group. …”
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Oakland score to identify low-risk patients with lower gastrointestinal bleeding performs well among emergency department patients by Daniel D. DiLena, Sean C. Bouvet, Madeline J. Somers, Maqdooda A. Merchant, Theodore R. Levin, Adina S. Rauchwerger, Dana R. Sax

“…The Oakland Score composite outcome includes re-bleeding, defined as additional blood transfusion requirements and/or a further decrease in hematocrit (Hct) >/= 20% after 24 h in clinical stability; red blood cell transfusion; therapeutic intervention to control bleeding, including surgery, mesenteric embolization, or endoscopic hemostasis; in-hospital death, all cause; and re-admission with further LGIB within 28 days. …”
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Isolation, Identification, and Susceptibility Profile of E. coli, Salmonella, and S. aureus in Dairy Farm and Their Public Health Implication in Central Ethiopia by Umer Seid Geletu, Munera Ahmednur Usmael, Abdulmuen Mohammed Ibrahim

“…The objectives of the present study were to isolate and identify S. aureus, E. coli, and Salmonella from dairy cattle, personnel, and equipment at farms. In addition to this, antimicrobial resistance profiles of the isolates were determined. …”
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The association between frailty and falls among individuals aged 60 years and older residing in community settings and experiencing hip fractures in China: a cross-sectional study by Lan Jiang, Shulong Ding, Juxia Wang

“…Analysis revealed a strong association between each additional point in the frailty score and an increased risk of fall in patients aged 60 and older (CHARLS, OR: 1.53, 95% CI: 1.41–1.66; A single center, OR: 1.57, 95% CI: 0.92–2.71). …”
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Assessing costs and constraints of forest residue disposal by pile burning by Jake Barker, Jake Barker, Jimmy Voorhis, Sinéad M. Crotty

“…Simulations of direct emissions from pile burning on National Forests included in this study indicated annual emissions of 11,322 metric tons (MT) of particulate matter (PM), 8,029 MT of PM10, and 6,993 MT of PM2.5 across the study area. In addition, pile burning on these National Forests annually emits &gt;1.7 million MT CO2, 61,515 MT of carbon monoxide, 3,823 MT of methane, and 3,211 MT of non-methane hydrocarbons. …”
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Relationship Between Vertical Facial Patterns and Palatal Morphology in Class I and Class II Malocclusion by Ilaria Tucci, Simone Sferra, Luca Giuliante, Andrea Scribante, Alice Mannocci, Cristina Grippaudo

“…The more a Class II subject tended towards high-angle divergence, the narrower the palate was. (4) A greater posterior palatal height was found in Class II malocclusion, while greater surface area was noted in Class I malocclusion. In addition to this result, another statistical significance was detected in Class II malocclusion: the intermolar distance was greater in hypodivergent than in hyperdivergent patients. …”
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