Epicutaneous immunotherapy for food allergy: a systematic review and meta-analysis by Xiaohong Xiang, Jingwei Hu, Rangui Sachu, Chonghua Gao, Hongyan Niu, Yi Gao, Shiju Chen, Xiaotian Cui, Xiang Li

“…The meta-analysis revealed that EPIT promoted desensitization in patients with food allergy (RR 2.11, 95% CI 1.72–2.58; I 2 = 0%, high certainty), particularly in aged ≤ 11 years (RR 3.84, 95% CI 2.39–6.26; I 2 = 34%). Additionally, treatment duration ≥ 52 weeks was found to increase immune tolerance (RR 3.37, 95% CI 2.39–4.75; I 2 = 13%). …”
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LURAP1L-AS1 long noncoding RNA promotes breast cancer progression and associates with poor prognosis by Radhakrishnan Vishnubalaji, Dania Awata, Nehad M. Alajez

“…Bioinformatics analysis predicted LURAP1L-AS1 to function as a competitive endogenous RNA (ceRNA), sponging key microRNAs, such as miR-7a-5p, miR-101-3p, miR-181a-5p, and miR-27a-3p, thereby modulating oncogenes including EZH2, MCL1, and KRAS, which are linked to increased cancer cell survival, proliferation, and metastasis.In addition to its role in TNBC, correlation analysis using breast cancer patient datasets revealed a significant association between LURAP1L-AS1 and ESR1 expression, suggesting its broader impact across breast cancer subtypes. …”
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Lateral Decubitus 360° Capsular Release for Treatment of Recalcitrant End-Stage Adhesive Capsulitis by Juan Bernardo Villarreal-Espinosa MD, Rodrigo Saad Berreta BA, Richard Danilkowicz MD, Udit Dave BS, Melissa Carpenter BS, Jorge Chahla MD, PhD, Nikhil N. Verma MD

“…Results: It is the senior author’s belief that by performing a capsular release via the lateral decubitus approach, better visualization, and access to the anterior, inferior, and posterior glenoid can be achieved for a complete 360° release. Additionally, risk of cerebral hypoperfusion and iatrogenic injury to the cartilage surfaces while instrumenting the joint is diminished. …”
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Improving care experiences for premenstrual symptoms and disorders in the United Kingdom (UK): a mixed-methods approach by E. L. Funnell, N. A. Martin-Key, S. Bahn

“…Thematic analysis revealed 8 aspects of care improvement: Empathetic care provision; Healthcare professional education, understanding, and research; Comprehensive symptom assessment and investigations; Diagnosis; Professional support and treatment provision; Signposting or referral to additional resources or sources of help; Wider healthcare system improvements; and Patient role/voice and preferences. …”
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Analysis and Validation of Autophagy-Related Gene Biomarkers and Immune Cell Infiltration Characteristic in Bronchopulmonary Dysplasia by Integrating Bioinformatics and Machine Lea... by Xiao S, Ding Y, Du C, Lv Y, Yang S, Zheng Q, Wang Z, Zheng Q, Huang M, Xiao Q, Ren Z, Bi G, Yang J

“…Subsequently, the hub genes were identified by Lasso and Cytoscape with three machine-learning algorithms (MCC, Degree and MCODE). In addition, hub genes were validated with ROC, single-cell sequence and IHC in hyperoxia mice. …”
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Seismic Behavior of Bahareque Walls Under In-Plane Horizontal Loads by Karol Cristancho, Iván Fernando Otálvaro, Daniel M. Ruiz, Natalia Barrera, Jesús D. Villalba-Morales, Yezid A. Alvarado, Orlando Cundumí

“…The scope of this study is limited by the exclusion of dynamic seismic simulations, which could offer additional insights into the behavior of bahareque walls under real earthquake conditions. …”
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Mobilization of plant genetic resources from the territory of India by N. P. Loskutova, T. M. Ozerskaya

“…In total, the Institute’s collecting and exploration activities in India mobilized and added to its collections over 13,146 accessions, representing 620 plant species. In addition to direct collecting in India, VIR has always been replenishing its holdings by seed requests. …”
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Targeting necroptosis in MCF-7 breast cancer cells: In Silico insights into 8,12-dimethoxysanguinarine from Eomecon Chionantha through molecular docking, dynamics, DFT, and MEP stu... by Maram B Alhawarri, Mohammad G Al-Thiabat, Amit Dubey, Aisha Tufail, Katreen Banisalman, Ghazi A Al Jabal, Eman Alkasasbeh, Esra'a Ibrahim Al-Trad, Bilal Harieth Alrimawi

“…MM-PBSA revealed the enhanced binding efficacy of SG-A, with a significant binding free energy of -31.03 ± 0.16 kcal/mol against MLKL, surpassing that of the control (23.96 ± 0.11 kcal/mol). In addition, the individual residue contribution analysis highlighted key interactions, with ARG149 showing a significant contribution (-176.24 kcal/mol) in the MLKL-SG-A complex. …”
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Effects of dietary chlorogenic acid supplementation on laying performance, egg quality, antioxidant capacity, and liver lipid metabolism in late-peak laying hens by Haitong Zhao, Lianxiang Guo, Ming Yan, Yue Sun, Yan Hong, Mingkun Zhu

“…Meanwhile, CGA treatment significantly upregulated hepatic Nrf2 and SOD2 gene expression while downregulating Keap1 gene expression. Additionally, 600 and 800 mg/kg CGA treatment significantly decreased serum TG, T-CHO, and LDL-C levels, as well as liver TG and T-CHO levels, while increasing serum lipoprotein lipase activity. …”
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MOBILIZATION OF PLANT GENETIC RESOURCES FROM THE TERRITORIES OF INDONESIA, SRI LANKA (CEYLON) AND NEPAL by N. P. Loskutova, T. M. Ozerskaya

“…In total, the Institute’s collecting and exploration activities in Indonesia, Sri Lanka (Ceylon) and Nepal added 3496 accessions to its collections. In addition to direct collecting in Indonesia, Sri Lanka (Ceylon) and Nepal, VIR has always been replenishing its holdings by seed requests. …”
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Characterizing microcycles’ workload when combining two days structure within single training sessions during congested fixtures in an elite male soccer team by Antonio Gómez-Díaz, Fábio Yuzo Nakamura, Pedro Menezes, João Barreira, Pedro Figueiredo, Diogo Coutinho

“…Coaches may use the MD+1 MD−2 to emphasize total distance covered, while both MD+1 MD−2 and MD-2 MD+2 to promote HSR and HML distance compared to MD-1 sessions. In addition, combining training sessions allows to normalize external load across playing positions with the exception of fullbacks that are exposed to higher stimulus.…”
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Effects and function of citric acid on fermentation quality and microbial community in sugarcane tops silage with high and low water-soluble carbohydrate content by Qichao Gu, Jie Zhang, Bo Lin, Hao Ding, Qi Yan, Caixiang Wei, Yipei Yao, Ruizhanghui Wang, Caixia Zou

“…Fresh sugarcane tops with low-WSC [143.05 g/kg dry matter (DM)] and high-WSC (249.99 g/kg DM) contents were treated with and without CA and then ensiled for 125 days, followed by aerobic exposure for 4, 8, and 16 days. …”
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The Relationship Between LRP-5 and LRP-6 Gene Mutations and Postmenopausal Type 2 Diabetes and Obesity by Jun Li, Ya Li, Yunqiu Lu, Siyuan Li, Yecheng Zhu, Chuanbing Sun, Partab Rai, Xuehai Jia

“…There was a statistical difference in the distribution of genotypes (CC/CT) at locus rs4988331 (χ2 = 67.940, P  = .000) and in the distribution of alleles (C/T) between the T2DM and non-T2DM groups (χ2 = 50.506, P  = .000). Additionally, there were significant differences in the allele (G/A) at locus rs11054704, and both allele (G/T) and genotype (GG/GT) distributions at locus rs1181334 between the OB group and the normal weight group ( P  < .05). 2. …”
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Patients’ Perspectives on the Preference for the Gender of Medical Professionals in Perioperative Care and Attitudes Toward Anaesthesiologists: A Cross-sectional Study by Usha Devi, Minnu Panditrao, Shilpa Bansal

“…Conclusion: The findings of the current study conclude that gender bias exists in the medical profession, as female surgeons are not acknowledged in the same way as their male professional colleagues. Additionally, the level of knowledge about anesthesia and anaesthesiologists among surgical patients is quite low, despite their recognition of the importance of anesthesia during surgery.…”
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Dietary ferulic acid improves growth performance of broilers via enhanced intestinal antioxidant capacity and barrier function by Yaodong Hu, Shi Tang, Wei Zhao, Silu Wang, Caiyun Sun, Binlong Chen, Yuxing Zhu

“…Conclusion Dietary FA addition could improve the growth performance, antioxidant capacity, and gut integrity of broilers. …”
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A comparative study on the efficacy of kirschner wire tension band combined with anchor cross-suture internal fixation versus partial patellectomy in the treatment of comminuted in... by Siyu Duan, Rongda Xu, Hanfei Liu, Ming Sun, Hairui Liang, Zhencun Cai

“…Methods A retrospective analysis was conducted on 14 patients who underwent Kirschner wire tension band combined with anchor cross-suture fixation (Group A) in our department of orthopedics from September 2020 to April 2022. Additionally, we matched 14 patients with similar baseline characteristics who received inferior pole patellectomy combined with patellar tendon repair (Group B). …”
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Effect of Qingjie Fuzheng Granules on Proliferation, Apoptosis and Migration of Colorectal Cancer SW620 Cells by Xiaoqin ZHU, Hong YANG, Bin HUANG, Lihui WEI, Jiumao LIN

“…Compared with the control group, the difference of 12 h and 24 h was statistically significant (<italic>P</italic>&lt;0.01). (6) In addition, compared with the control group, QFG in the 0.5,1,2 mg/mL concentration significantly reduced the protein expression of Ki-67 and MMP-2, increased the protein expression of Cleaved-Caspase-3, and showed a dose-dependent, the difference was statistically significant (<italic>P</italic>&lt;0.01).Conclusion:QFG can inhibit the proliferation, induce apoptosis and inhibit migration of colorectal cancer SW620 cells, and its mechanism may be related to down-regulation of Ki-67 and MMP-2 protein expression and up-regulation of Cleaved-Caspase-3 protein expression.…”
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Antagonistic Effects of Sublethal Concentrations of Certain Mixtures of Metal Oxide Nanoparticles and the Bulk (Al2O3, CuO, and SiO2) on Gill Histology in Clarias gariepinus by Amaeze Henry Nnamdi, Tam-Miette Dawarri Briggs, Oluwaseun Olusola Togunde, Henry Ebele Obanya

“…Similarly, all bulk combinations were also antagonistic except for the equal ratio of bulk CuO (HAI, 20) and bulk Al2O3 (HAI, 10) that gave additive effect with HAI of 32. Conclusion. The joint actions of nano Al2O3 and CuO with SiO produced a low toxic effect, unlike the high toxicity of their single trials; this also indicates that nano Al2O3 and CuO are antagonists. …”
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Vincristine Regulates C/EBP-&beta;/TGF-&beta;1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…Pain threshold of rats was measured by thermal withdrawal latency (TWL) and mechanical withdrawal threshold (MWT), Elisa was used to detect the expression level of inflammatory factors, qRT PCR and Western blotting were used to detect astrocyte polarization markers, C/EBP-β, TGF-β 1, p-smad2 and p-smad3.Results: Following Vincristine administration, the TWL and MWT of rats exhibited a decrease. Additionally, there was an increase in A1 polarization of astrocytes, while A2 polarization remained relatively unchanged. …”
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Early experience of Sacubitril–Valsartan in heart failure with reduced ejection fraction in real‐world clinical setting by Charlotte Nordberg Backelin, Michael Fu, Charlotta Ljungman

“…Sac/Val was well tolerated, but 41% of the patients did not reach target dose. How this affects outcome is not known and needs further investigation.…”
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