A comparison of new and existing rootstocks to reduce canker of apple trees caused by Neonectria ditissima (Nectriaceae, Hypocreales) by Lucas A. Shuttleworth, Sonia Newman, Ioannis Korkos

“…The current study investigated the effect of rootstock selection on canker and tree death using eight common rootstocks M9 337, M9 337 with Golden Delicious (GD) interstock, M9 EMLA, MM106, M116, M26, Geneva® G11 and G41, in addition to six advanced selections from the NIAB East Malling apple breeding programme EMR-001—EMR-006, all grafted with Gala scions. …”
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Assessing and optimizing the potential for climate change mitigation and carbon sequestration in urban residential green spaces: energizing sustainable cities by Hancheng Liu, Jialong Zhang, Zijun Wang

“…Seasonal variations were also observed, with autumn and summer exhibiting higher carbon sequestration rates compared to spring and winter. Additionally, CO2 concentrations were monitored across the four residential areas, providing insights into the spatial and temporal dynamics of carbon sequestration.DiscussionBased on the findings, optimization strategies were proposed, such as prioritizing the selection and integration of high-performing evergreen tree species in urban green space design and incorporating diverse plant types to enhance year-round carbon sequestration. …”
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OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer by Qihui Sun, Xiaoqi Zhu, Qi Zou, Yang Chen, Tingting Wen, Tingting Jiang, Xiaojia Li, Fang Wei, Keping Xie, Jia Liu

“…Single-cell analyses further confirmed OSBPL3’s role in shaping the immunosuppressive landscape by modulating Treg cells and M2 macrophages. Additionally, OSBPL3 expression was linked to resistance to immunotherapy, with high OSBPL3 expression associated with lower Immunophenoscore (IPS) scores, indicating poor responsiveness to immunotherapy. …”
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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

“…Our research further shows that both gene families experienced significant diversification through various duplication events. Additionally, their evolutionary paths have been shaped by frequent gene losses and lineage-specific transposition. …”
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Comparative study of the effects of different lipid oxidation simulation systems on the physicochemical properties of proteins isolated from four cultivated walnut (Juglans sigilla... by Wenyun Xiong, Lixin Ding, Wendie Cui, Lei Zhao, Shengbao Cai

“…The 11S globulin-like and cupin type-1 domain-containing protein (A0A833YDI2) have stronger affinities with the key lipid oxides. …”
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Effects of photobiomodulation combined with rehabilitation exercise on pain, physical function, and radiographic changes in mild to moderate knee osteoarthritis: A randomized contr... by Yan Ling Tay, Mohd Azzuan Ahmad, Nor Hamdan Mohamad Yahaya, Devinder Kaur Ajit Singh

“…Participants will be blinded to their group allocation through the use of a placebo device that mimics the active treatment without emitting therapeutic energy. Additionally, the outcome assessors will be blinded to the group allocations to ensure unbiased evaluation of the trial outcomes. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…A series of machine learning algorithms was used to screen two feature genes (ETS1 and IL7R) to establish the diagnostic model, which exhibited satisfactory diagnostic efficiency. In addition, these hub genes were closely associated with the infiltration of specific immune cells (such as neutrophils, memory B cells, and M2 macrophages) as well as with the JAK/STAT pathway. …”
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Desain Faktorial untuk Pembuktian Teori Masters dalam Penentuan Jumlah Lapisan dan Neuron Tersembunyi pada Peramalan Multivariat dengan Jaringan Syaraf Tiruan by Dwi Ayu Lusia, Awalludiyah Ambarwati

“…Masters Theory formulates the number of neurons based on geometric pyramid rules. In addition, the Masters Theory also reveals that there is no reason to use more than two hidden layers. …”
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A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases by Eva Lukas, Rada R. Veeneman, Dirk J. A. Smit, Tarunveer S. Ahluwalia, Jentien M. Vermeulen, Gita A. Pathak, Renato Polimanti, Karin J. H. Verweij, Jorien L. Treur

“…While insomnia, smoking, alcohol, and inflammation were important mediators, independent causal effects also remained. In addition to shared genetic liability between PTSD and CVD, we present strong evidence for causal effects of PTSD on CVD. …”
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Effects of exogenous SLs on growth and physiological characteristics of flue-cured tobacco seedlings under different degrees of drought stress by Xiao-dong Wang, Yi-nan Zhang, Xiao-guo Wang, Ye Zhuang, Shao-hua Ge

“…Strigolactones reduced the accumulation of reactive oxygen species and malondialdehyde content, enhancing the antioxidant capacity of both varieties. Additionally, strigolactones increased the levels of osmoregulatory substances and activated the production of antioxidant enzymes, thereby enhancing drought tolerance. …”
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Ethical attitudes of the future Russian officials and businessmen: Comparative analysis by A. A. Maksimenko, O. S. Deyneka, D. V. Krylova, E. V. Zabelina, E. A. Bulgakova

“…Future officials turned out to have higher indicators on the scales of cynicism, aggressiveness and hostility than students in the field of business education. In addition, future civil servants have more uncertainty about whether they will be able to take place in life, fears about possible collisions with life crises and difficulties, as well as anxiety for their future. …”
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TAK-242 improves sepsis-associated acute kidney injury in rats by inhibiting the TLR4/NF-κB signaling pathway by Yan-mei Xia, Yu-qian Guan, Ji-fang Liang, Wei-dong Wu

“…Finally, the expression of proteins related to the TLR4/NF-κB signaling pathway was observed by western blot.Results Compared with the CLP + vehicle and CLP + TAK-242 groups, the CLP + TAK-242 group reduced blood urea nitrogen (BUN), creatinine (Cr), cystatin-C (Cys-C), reactive oxygen species (ROS), malondialdehyde (MDA), and inflammatory factors levels (p < 0.01), as well as increased superoxide dismutase (SOD) activity of CLP rats (p < 0.01). Additionally, TAK-242 treatment improved the condition of CLP rats that had glomerular and tubular injuries and mitochondrial disorders (p < 0.01). …”
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Exploring the mediating role of blood metabolites in the relationship between gut microbiota and gastric cancer risk: a Mendelian randomization study by Xiaocheng Li, Xiaocheng Li, Huapeng Lin, Huapeng Lin, Huapeng Lin, Jing Peng, Jianping Gong

“…However, the causal nature of these associations remains uncertain.MethodsWe utilized summary data from genome-wide association studies (GWAS) on GM (European, n=8,956), blood metabolites (European, n=120,241; East Asian, n=4,435), and GC (European, n=476,116; East Asian, n=167,122) to perform a bidirectional Mendelian randomization (MR) analysis, investigating the causal effects of GM and metabolites on GC risk. Additionally, we conducted mediation analysis (two-step MR) to identify potential metabolite mediators in the GM-GC relationship.ResultsWe identified twelve negative and seven positive associations between specific GM taxa and GC risk. …”
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Effect on Balance Function in Patients with Parkinson's Disease Treated by Transcranial Direct Current Stimulation by Na QIAO, Jianjun LU, Yongliang GUO, Wenhua ZHENG, Tiebin YAN

“…Objective:To observe the improvement of balance function in patients with Parkinson's disease treated by transcranial direct current stimulation(tDCS).Methods:With double-blind, random and control studies, using the random number generator in SPSS 20.0 statistical software, a total of 49 patients with Parkinson's disease who met the inclusion criteria were divided into intervention group(<italic>n</italic>=25)and control group(<italic>n</italic>=24).In addition to the routine treatment, both of groups were given the treatment of tDCS respectively. …”
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Urban vegetation and well‐being: A cross‐sectional study in Montreal, Canada by Rita Sousa‐Silva, Yan Kestens, Zoé Poirier Stephens, Benoit Thierry, Daniel Schoenig, Daniel Fuller, Meghan Winters, Audrey Smargiassi

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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…Moreover, the adipose Dicer-knockout mouse model was constructed to identify adipose tissue as the main source of microRNA-450a-5p. microRNA-450a-5p could inactivate the insulin signal pathway by targeting the inhibited Dual Specificity Phosphatase 10 (DUSP10) and inducing IR and glucose metabolism disorders in vitro cultured hepatocytes and adipocytes. Additionally, microRNA-450a-5p was found to regulate DUSP10 expression and insulin signaling activity, influencing glucose tolerance and insulin sensitivity across various models, including normal diet, HFD-induced obese, adipose tissue-specific microRNA-450a-5p-knockout, and db/db mice. …”
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Evaluation of Elemental and Chemical Compositions of Some Fuelwood Species for Energy Value by A. M. Dadile, O. A. Sotannde, B. D. Zira, M. Garba, I. Yakubu

“…The results of carbon content ranges from 49.54% in A. sieberiana to 50.98% in A. leiocarpus. Meanwhile, the addition of 5% and 10% bark reduces carbon content of wood by 1.25% and 2.74%, respectively. …”
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Developing a Transparent Anaemia Prediction Model Empowered With Explainable Artificial Intelligence by Muhammad Sajid Farooq, Muhammad Hassan Ghulam Muhammad, Oualid Ali, Zahid Zeeshan, Muhammad Saleem, Munir Ahmad, Sagheer Abbas, Muhammad Adnan Khan, Taher M. Ghazal

“…With the integration of explainable AI techniques like SHapley Additive exPlanations (SHAP), and Local Interpretable Model-agnostic Explanations (LIME), the proposed model offers insights into the underlying factors influencing anaemia predictions. …”
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Trimethylamine N-Oxide (TMAO) Plasma Levels in Patients with Different Stages of Chronic Kidney Disease by Marcia Ribeiro, Julie Ann Kemp, Ludmila Cardozo, Drielly Vargas, Marcelo Ribeiro-Alves, Peter Stenvinkel, Denise Mafra

“…There was a negative correlation between TMAO and HDL plasma levels [rho = −0.380 (<i>p</i> < 0.004)], calcium [rho = −0.321 (<i>p</i> < 0.016)], and albumin [rho = −0.416 (<i>p</i> < 0.001)]. In addition, a positive correlation between TMAO and urea levels was observed [rho = 0.717 (<i>p</i> < 0.001)]. …”
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The relationship between gallstone disease and the genetic variants of the sterol transporter adenosine triphosphate–binding cassette G8 and G5 in Egyptians by Menna A. Hassan, Salwa M. Abo El-Khair, Noha M. Mesbah, Dina M. Abo-Elmatty, Asmaa R. Abdel-Hamed

“…This alteration can lead to cholesterol supersaturation in the bile, a key factor in the development of cholesterol gallstones. Additionally, the study aimed to examine the impact of these genetic variations on serum lipid profile to understand their role in modulating biochemical markers associated with GSD. …”
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