Intrauterine Malnutrition Reduced Long Leptin Receptor Isoform Expression and Proinflammatory Cytokine Production in Male Rat Pulmonary Endothelial Cells Stimulated by Lipopolysacc... by Aleksandro M. Balbino, Marina M. Silva, Gabriela A. Azevedo, Noemi L. Gil, Renaide R. Ferreira, Leila A. dos Santos, Rebéca M. Gasparin, Liliam Fernandes, Maristella A. Landgraf, Richardt G. Landgraf

“…Leptin increased IL-1β levels in only cells from the NBW group, whereas LPS increased PGE2 and LTB4 levels in cells from both groups; leptin addition potentiated lipid mediator production induced by LPS in the NBW group. …”
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Shrimp White Spot Viral Infections Are Attenuated by Organic Acids by Regulating the Expression of HO-1 Oxygenase and β-1,3-Glucan-Binding Protein by Ioan Pet, Igori Balta, Nicolae Corcionivoschi, Tiberiu Iancu, Ducu Stef, Lavinia Stef, Iuliana Cretescu

“…In vivo, in a shrimp challenge test, 2% Aq significantly downregulated the expression of proteins involved in WSSV virulence, such as the lipopolysaccharide-β-1,3-glucan-binding protein (LGBP) and the TLR signalling pathway (LvECSIT), and increased the expression of HO-1 oxygenase. Additionally, at 2% Aq, the expression of the digestive-related enzyme carboxypeptidase B was upregulated in the gut, alongside a significant decrease in IL-22 expression, a cytokine usually increased during WSSV infection in shrimp. …”
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MicroRNA-26b inhibits cardiac remodeling after myocardial infarction by targeting ring finger protein 6 expression by Chun-Mei Tang, Qiang Su, Hai-Xia Zhao, He-Huan Sui, Jing Liang, Li-Sha Zhu, Si-Yun Yang, Tao Liu

“…Moreover, RNF6 overexpression counteracted the role of miR-26b in cardiac function. Additionally, an in vitro cell model illustrated that miR-26b upregulation could increase cell viability and reduce apoptosis, whereas RNF6 overexpression reversed its effect. …”
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Neurocognitive impact of different irradiation modalities for patients with grade I-II skull base meningioma: a prospective multi-arm cohort study (CANCER COG) by Paul Lesueur, Florence Joly, Benedicte Clarisse, Justine Lequesne, Dinu Stefan, Jacques Balosso, Marie Lange, Sebastien Thureau, Aurelie Capel, Marie Castera, Berenice Legrand, Nicolas Goliot, Jean Michel Grellard, Thomas Tessonier, Helene Castel, Samuel Valable

“…This longitudinal study includes the follow-up of 3 cohorts, including: patients treated with PRT, IMRT, and SRT. An additionally control group will be formed. The primary objective is to report long-term cognitive deterioration in each cohort until 10 years after the end of irradiation. …”
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A study protocol for individualized prognostic counselling in the palliative phase by Boyd Noël van den Besselaar, A. Sewnaik, M. C. Dorr, A. Hoesseini, J. A. Hardillo, R. J. Baatenburg de Jong, M.P.J. Offerman

“…These measurements will be collected after the intervention. Additionally, patients’ perspectives on the decision-making process and proactive care planning, including end-of-life discussions, will be explored through interviews. …”
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Effects of biochar on the chemical properties of soils and the volume of wood in a plantation of Acacia mangium Willd in the Colombian Orinoquía (highlands) by Giovanni Reyes-Moreno, Aquiles Enrique Darghan, Carlos Rivera-Moreno

“…Conclusion: Responses of the different variables analyzed increased with the addition of biochar, either alone or mixed with synthetic fertilizer. …”
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A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus by Wojciech Florczak, Joanna Śnieżna, Jakub Dziewic, Karol Dzwonnik, Wiktoria Domino, Urszula Zelik, Gabriela Trestka, Maria Przygoda, Jagienka Włodyka, Kamila Stępień, Sabina Adamczyk

“…Aim of the study:  The aim of the study is to investigate the clinical implications of T1DM and CeD, focusing on the importance of early screening for CeD in patients with T1DM and evaluate the challenges in the management of both diseases simultaneously. Additionally, the study highlights the potential benefits of a personalized approach to treatment. …”
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MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder by Yan Chen, Yun Liu, Ming Xiao, Chun Wang, Panpan Hu, Qiuchen Cao, Hu Feng, Jingfan Xu, Weixi Feng, Huaiqing Sun, Huachen Ding, Junying Gao

“…Background Increasing evidence supports the role of microRNAs (miRNAs) in major depressive disorder (MDD), but the pathophysiological mechanism remains elusive.Aims To explore the mechanism of microRNA-451a (miR-451a) in the pathology and behaviours of depression.Methods Abnormal miRNAs such as miR-451a reported previously in the serum of patients with MDD were screened and then confirmed in a mouse model of depression induced by chronic restraint stress (CRS). …”
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The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study by Lina Ren, Yeqing Dong, Xiaojing Zhou, Chuhao Zhang, Jiajia Gao, Lulu Li, Xiao Zhang, Min Zeng, Guoshuai Luo, Xiangyang Zhang

“…Abstract Background Major depressive disorder (MDD) is a recurrent and persistent mental illness. …”
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The performance status gap in immunotherapy for frail patients with advanced non-small cell lung cancer by Julie Tsu-Yu Wu, June Corrigan, Chloe Su, Clark Dumontier, Jennifer La, Aparjita Khan, Shipra Arya, Alex H. S. Harris, Leah Backhus, Millie Das, Nhan V. Do, Mary T. Brophy, Summer S. Han, Michael Kelley, Nathanael R. Fillmore

“…Among those with poor PS, the additional effect of frailty on treatment selection and mortality is unknown. …”
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Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis by Bin Yang, Leizhen Xia, Rufei Deng, Liping Wu, Zhiqin Zhang, Xingwu Wu, Tao Ding, Yan Zhao, Jialyu Huang, Jialyu Huang, Zhihui Huang

“…Additionally, we assessed whether DFI had a potential impact on long-term maternal and neonatal complications.MethodsA total of 5,271 women who underwent IVF treatment for the first time between October 1, 2020, and July 31, 2023, were included from an academic fertility center. …”
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Comprehensive Hematological and molecular Characterization of hemoglobin Hekinan [α27(B8)Glu→Asp(α1), HBA1:c.84G > T] in a Large Thai cohort by Amornchai Suksusut, Jidapa Jaitheang, Manussavee Prapphal, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Noppacharn Uaprasert

“…Hb Hekinan was confirmed by direct DNA sequencing. Additional genetic determinants, including α-thalassemia, β-thalassemia and other variants, were detected using multiplex GAP-PCR, ARMS-PCR or direct DNA sequencing as appropriate.Results: Among 61,997 Hb typing samples, 149 cases of Hb Hekinan were identified in Thai individuals and classified into 8 genotypic groups. …”
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Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus by Rangi Kandane-Rathnayake, Sang-Cheol Bae, Zhanguo Li, Shereen Oon, Vera Golder, Mandana Nikpour, Masayoshi Harigai, Zhuoli Zhang, Eric Morand, Chak Sing Lau, Worawit Louthrenoo, Alberta Hoi, Sandra Navarra, Sean O’Neill, Shue-Fen Luo, Yanjie Hao, Yasuhiro Katsumata, Dominique Milea, Aisha Lateef, Laniyati Hamijoyo, Sargunan Sockalingam, Madelynn Chan, Jiacai Cho, Leonid Zamora, Fiona Goldblatt, Yeong-Jian Jan Wu, Xiaomeng Xu, Aldo A Navarro Rojas

“…The risk of damage accrual was greater if patients had severe flares (HR (95% CI) 1.58 (1.18 to 2.11)). For each additional flare, the risk of damage accrual increased by 7% (HR (95% CI) 1.07 (1.02 to 1.13)).Conclusions Flares independently increased the risk of damage accrual. …”
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Exploring segmented assimilation theory in health education utilization and its influencing factors among internal migrants in China: insights from the 2017 China migrants dynamic... by Ting Xu, Ting Xu, Zeyu Wang, Tingting Wang, Jiahua Shi, Aiyong Zhu, Enhong Dong, Enhong Dong

“…Adjusting for socioeconomic factors, first-generation integrated assimilation groups showed lower HEU (IRR = 0.922, p < 0.01), while second-generation underclass groups demonstrated higher HEU (IRR = 1.110, p < 0.001) than the second-generation segmented assimilation groups. Additionally, factors such as ethnicity, marital status, employment status, educational attainment, hukou type, health insurance type, time of access to healthcare, social integration, social participation, establishment of health records, and issues encountered in host and origin places significantly influenced HEU.DiscussionThis study highlights diverse assimilation patterns among Chinese internal migrants regarding HEU, consistent with the theory of segmented assimilation. …”
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Changes in Phenylacetylglutamine Levels Provide Add-On Value in Risk Stratification of Hypertensive Patients: A Longitudinal Cohort Study by Xuan Xu, Lixin Jia, Bokang Qiao, Yanyan Gong, Shan Gao, Yuan Wang, Jie Du

“…We examined the predictive performance of PAGln in different subgroups and evaluated the incremental predictive value of PAGln as an addition to the ASCVD risk assessment model. Results: Among all high-risk hypertensive patients, 148 patients experienced MACEs after a mean follow-up of 3.02 years. …”
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Integrated systems improve soil microclimate, soybean photosynthesis and growth by Luciana Maria da Silva, Eduardo Habermann, Kátia Aparecida de Pinho Costa, Adriano Carvalho Costa, João Antônio Gonçalves e Silva, Eduardo da Costa Severiano, Lourival Vilela, Fabiano Guimarães Silva, Alessandro Guerra da Silva, Bruno de Souza Marques, Fabrício Rodrigues, Carlos Alberto Martinez

“…A comparative analysis of microclimate and soil respiration, plant physiology, and growth was conducted between a conventional soybean monoculture (soybean grown without plant residues on the soil from the previous crop) and soybean grown in soil containing maize residues. Additionally, experiments were conducted to evaluate the effect of monocultures and previous integration between maize, three cultivars of Panicum maximum (Zuri, Tamani, and Quênia guinea grass) and Pigeon pea (Cajanus cajan cv. …”
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Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways by Jing Huang, Lei Li, Liyan Xu, Lixin Feng, Yuxin Wang, Attila Gabor SIK, Meng Jin, Rongchun Wang, Kechun Liu, Xiaobin Li

“…Furthermore, MBD notably inhibited the intestinal migration of immune cells, enhanced the integrity of the gut mucosal barrier and improved intestinal peristalsis function in a zebrafish IBD model induced by trinitro-benzene-sulfonic acid (TNBS). In addition, MBD could inhibit ROS elevation induced by TNBS. …”
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A Resource-Efficient Multi-Entropy Fusion Method and Its Application for EEG-Based Emotion Recognition by Jiawen Li, Guanyuan Feng, Chen Ling, Ximing Ren, Xin Liu, Shuang Zhang, Leijun Wang, Yanmei Chen, Xianxian Zeng, Rongjun Chen

“…The results reveal that DTW yields the best performance in similarity measures with a 5 s window. In addition, the single-channel input mode outperforms the single-region mode. …”
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Effects of Limosilactobacillus reuteri on gastrointestinal microbiota, muscle fiber formation and meat quality of Sunit sheep by Ting Liu, Chenlei Wang, Mirco Corazzin, Taiwu Zhang, Maoqin Zhai, Yue Zhang, Qiaoge Zhang, Xin Zhao, Ye Jin, Lina Sun

“…This study offers novel insights into the use of feed additives for improving meat quality.…”
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Systemic Diseases in Patients with Congenital Aniridia: A Report from the Homburg Registry for Congenital Aniridia by Jessica Obst, Fabian N. Fries, Maryam Amini, Annamária Náray, Cristian Munteanu, Tanja Stachon, Shweta Suiwal, Neil Lagali, Berthold Seitz, Barbara Käsmann-Kellner, Nóra Szentmáry

“…Age, gender, genetic test results, and information on systemic anomalies were recorded. In addition, parents and affected patients were interviewed about developmental and other disease-related conditions. …”
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