Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…Exposure to mixed NEOs during gestation resulted in elevated glucose levels and impaired insulin sensitivity in normal pregnant and GDM mice models. In addition, we found the metabolic disorders induced by NEOs were linked to the deterioration of BAT thermogenesis in vivo. …”
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Metabolic engineering of Yarrowia lipolytica for the production and secretion of the saffron ingredient crocetin by Tingan Zhou, Young-Kyoung Park, Jing Fu, Piotr Hapeta, Cinzia Klemm, Rodrigo Ledesma-Amaro

“…Conclusions Through metabolic engineering and fermentation optimization, we demonstrated the first de novo biosynthesis of crocetin in the industrial yeast Yarrowia lipolytica. In addition, we achieved a higher crocetin titer in flasks than all our known reports. …”
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Hidden blood loss and risk factors after percutaneous endoscopic transforaminal lumbar interbody fusion by Meng Ge, Meng Ge, Fangbing Zhu, Fangbing Zhu, Weibin Du, Weibin Du, Zhengcong Ye, Zhengcong Ye, Zhenfei Xiong, Zhenfei Xiong, Lukai Zhang, Lukai Zhang, Hua Zhou, Hua Zhou, Jun Yang, Jun Yang

“…PurposeIn this study, we aimed to assess the occurrence of hidden blood loss (HBL) and its associated risk factors in patients with lumbar degenerative diseases who underwent percutaneous endoscopic transforaminal lumbar interbody fusion (Endo-TLIF).MethodsSex, age, height, weight, body mass index, and medical history including hypertension, diabetes, and osteoporosis were recorded. …”
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State Estimation in Power Systems Under False Data Injection Attack Using Total Least Squares by Bamrung Tausiesakul, Krissada Asavaskulkiet, Chuttchaval Jeraputra, Ittiphong Leevongwat, Thamvarit Singhavilai, Supun Tiptipakorn

“…In this work, two non-iterative computation methods based on total least squares are proposed for estimating the state vector from the measurement results contaminated by the additive noise and the malicious attack that can arise in the power transmission systems. …”
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Impact of meropenem exposure on fluoroquinolone and carbapenem resistance in Pseudomonas aeruginosa infection in inpatients in a Japanese university hospital: Insights into oprD mu... by Tadanori Yamochi, Kazuhisa Ugajin, Rintaro On, Sho Inoue, Hiromi Ikeda, Toshiko Yamochi, Masafumi Takimoto, Issei Tokimatsu

“…Of these eight strains, three carrying gyrA mutations had another QRDR mutation in subunits, gyrB or parC, associated with mexY overexpression. Additionally, seven of eight dual fluoroquinolone and carbapenem-resistant isolates carried a premature termination codon within oprD, containing either F170L or L7 shortening. …”
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Prosthetic stomatitis in patients with diabetes mellitus: correction of psycho-emotional stress by V.M. Dvornyk, I.Yu. Lytovchenko, I.Yu. Popovych, I.A. Holovanova, I.L. Dvornyk, O.V. Muravlova, L.B. Yerus, O.I. Teslenko

“…For general therapy, an additional stress-protective drug which corrects psycho-emotional stress in patients with diabetes mellitus was prescribed, thiotriazoline, orally, for 30 days. …”
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Enhancing safety with an AI-empowered assessment and monitoring system for BSL-3 facilities by Yi-Ling Fan, Ching-Han Hsu, Ju-Yu Wu, Ying-Ying Tsai, Wei J. Chen, Min-Shi Lee, Fang-Rong Hsu, Lun-De Liao

“…Methods: An external system captured images of personnel entering a laboratory, which were then analyzed by an AI-based system to verify their compliance with personal protective equipment (PPE) regulations, thereby introducing an additional layer of protection. A deep learning model was trained to detect the presence of essential PPE items, such as clothing, masks, hoods, double-layer gloves, shoe covers, and respirators, ensuring adherence to World Health Organization (WHO) standards. …”
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Genetic Analysis of in Korean Patients Associated with Atrioventricular Conduction Block by Hyoung Seob Park, Yoon Nyun Kim, Young Soo Lee, Byung Chun Jung, Sang Hee Lee, Dong Gu Shin, Yongkeun Cho, Myung Hwan Bae, Sang Mi Han, Myung Hoon Lee

“…The 2 newly discovered variations were not found in the 80 normal controls. In addition, G298S, G514C, P1008S, G1406R, and D1595N, identified in other ethnic populations, were not detected in this study. …”
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Dietary inflammatory index and disability among older adults in Guangzhou: a cross-sectional analysis by Junbin Liao, Junbin Liao, Wenfeng Cai, Danrong Lin, Yuanyun Xiao, Yanxi Liu, Yahui Wang, Yuquan Zhong, Fan Xiao, Heng Fang, Yilu Yao, Yunfeng Lin, Jiewen Su, Siyu Sun, Bo Zhang, Yan Wang, Wei Zhu, Wei Zhu

“…Additionally, a higher DII is associated with a more severe degree of disability.…”
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Development of a multi-laboratory integrated predictive model for silicosis utilizing machine learning: a retrospective case-control study by Guo-kang Sun, Yun-hui Xiang, Lu Wang, Pin-pin Xiang, Zi-xin Wang, Jing Zhang, Ling Wu

“…This model had a satisfactory performance in the training cohort with an area under the ROC curve (AUC) of 0.982, a diagnostic sensitivity of 95.4%, and a specificity of 92.2%. In addition, the model had a prediction accuracy of 0.936 with an AUC of 0.979 in the independent test cohort. …”
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A study of impulsivity and adverse childhood experiences in a population health setting by Robert W. Read, Karen A. Schlauch, Gai Elhanan, Iva Neveux, Stephanie Koning, Takesha Cooper, Takesha Cooper, Joseph J. Grzymski, Joseph J. Grzymski

“…Additionally, lifetime predicted probability of MDD was approximately 40% higher for high ACEs and high impulsivity compared to no ACEs and low impulsivity. …”
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Comparative analysis of the intestinal flora of Siniperca chuatsi at different growth stages under three feeding practices by Yunyun Yan, Fubao Wang, Xiao Chen, Junjian Dong, Fengying Gao, Hetong Zhang, Xing Ye, Chengbin Wu, Chengfei Sun

“…With growth, the α-diversity of the intestinal flora in the live bait group and mixed diet group significantly decreased (p < 0.05), while the α-diversity in the compound feed group did not change significantly (p > 0.05). There were no significant differences in α-diversity among the feeding practices at either one month or two months of age (p > 0.05). …”
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Study protocol for a randomised controlled trial of a care partner assisted intervention to improve oral health of individuals with mild dementia by Bei Wu, Gary Yu, Brenda L Plassman, Patricia Poole, Shahrzad Siamdoust, Melanie Bunn, Bobbi Burwell, Yaolin Pei, Christine Downey, Danni Gomes, Angela Kamer, A Leak Bryant, Ruth A Anderson

“…The duration of the active intervention is 3 months, with an additional 3-month maintenance phase. Data collection will involve three home visits: baseline, 3 months and 6 months. …”
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The Impact of Ageing on Diaphragm Function and Maximal Inspiratory Pressure: A Cross-Sectional Ultrasound Study by Toru Yamada, Taro Minami, Takahiro Shinohara, Shuji Ouchi, Suguru Mabuchi, Shunpei Yoshino, Ken Emoto, Kazuharu Nakagawa, Kanako Yoshimi, Mitsuko Saito, Ayane Horike, Kenji Toyoshima, Yoshiaki Tamura, Atsushi Araki, Ryoichi Hanazawa, Akihiro Hirakawa, Takeshi Ishida, Takuma Kimura, Haruka Tohara, Masayoshi Hashimoto

“…Multivariate linear regression analysis adjusted for sex, height, body mass index, and underlying diseases showed positive associations between age and diaphragm thickness (<i>p</i> = 0.001), but not with TF or DE. …”
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Salivary alpha-amylase activity and its association with early childhood caries and rampant caries experience: a cross-sectional study by Vivek Padmanabhan, Md Sofiqul Islam, Muhammed Mustahsen Rahman, Manjunatha B. K. Goud, Latifa Majed Sulaiman Allay Alshehhi, Hebah Mushref Ahmad Hamed, Sheela Haridas, Dileep Sharma

“…Pearson’s correlation coefficients indicated a strong positive correlation between salivary alpha-amylase levels and severity of dental caries in both ECC (r = 0.9891, p &lt; 0.0001) and RC (r = 0.9142, p &lt; 0.0001) groups.ConclusionThe study concludes that elevated salivary alpha-amylase levels, which are statistically significant, are observed in children with ECC and RC. Additionally, it was found that salivary alpha-amylase levels increased with the number of carious lesions. …”
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A Study on the Induction of Multi-Type Immune Responses in Mice via an mRNA Vaccine Based on Hemagglutinin and Neuraminidase Antigen by Mengyuan Liu, Yixuan Liu, Shaohui Song, Qiurong Qiao, Jing Liu, Yun Xie, Jian Zhou, Guoyang Liao

“…Hemagglutination-inhibiting antibody titer and neutralizing antibody titer in the sera of immunized mice were evaluated, and a viral challenge experiment was conducted. Additionally, the immune responses elicited by the two immunization strategies were characterized using flow cytometry and ELISA. …”
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Prednisolone versus antihistamine for allergic rhinitis: No significant difference found in randomized trial by Carl Skröder, Laila Hellkvist, Ulla Westin, Pernilla Sahlstrand‐Johnsson, Kerstin Hansson, Agneta Karlsson, Åslög Dahl, Leif Bjermer, Lars Olaf Cardell

“…Conclusions Prednisolone tablets did not show superior efficacy over antihistamine tablets in reducing symptoms or medication usage in tree pollen‐induced AR. …”
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The neural correlates of guilt highlight preclinical manifestations between bipolar and major depressive disorders by Yu-Chi Lo, Chenyi Chen, Yawei Cheng

“…Background: Over 25 % of bipolar disorder (BD) patients are misdiagnosed with major depressive disorder (MDD). An urgent need exists for a biomarker to differentiate BD from MDD. …”
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Deep-Learning-Based Land Cover Mapping in Franciacorta Wine Growing Area by Girma Tariku, Isabella Ghiglieno, Andres Sanchez Morchio, Luca Facciano, Celine Birolleau, Anna Simonetto, Ivan Serina, Gianni Gilioli

“…Integrating pre-trained feature extraction networks significantly improves performance across various metrics. Additionally, addressing challenges such as data availability, computational resources, and model interpretability is essential for advancing the field of remote sensing, in support of biodiversity conservation and the provision of ecosystem services and sustainable agriculture.…”
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Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation by Yu Ga, Yuanyuan Wei, Qingyu Zhao, Yimeng Fan, Yannan Zhang, Zhifang Zhang, Sijia Hao, Lixia Wang, Zhifen Wang, Jinlong Han, Shuang Wu, Zhihui Hao

“…PR treatment suppressed upregulation of NOD-like receptor protein 3 (NLRP3), cysteinyl aspartate-specific proteases-1 (caspase-1), apoptosis-associated speck-like (ASC) and gasdermin D (GSDMD) at both the protein and mRNA expression levels. The addition of a small molecule dual-specifi city phosphatase inhibitor NSC 95397 inhibited the positive effects of PR. …”
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