Nasal microbial diversity is associated with survival in piglets infected by a highly virulent PRRSV-1 strain by Pau Obregon-Gutierrez, Martí Cortey, Gerard E. Martín-Valls, Hepzibar Clilverd, Florencia Correa-Fiz, Virginia Aragón, Enric Mateu

“…Results Piglets that survived the PRRSV-1 outbreak reported a more diverse and different nasal microbiota at three weeks of age compared to piglets dying, which was highly related with the litter of origin and the sow of the piglets. In addition, a high abundance of classical swine nasal colonizers belonging to genera such as Bergeyella, Glaesserella, Neisseria and Moraxella (among others), was related with good outcome. …”
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Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 – cohort description, test volumes, predictors of viraemia and the road ahead by Tracy Glass, Frédérique Chammartin, Jochen Ehmer, Thomas Klimkait, Alain Amstutz, Josephine Muhairwe, Irene Ayakaka, Blaise Lukau, Jennifer Anne Brown, Lipontso Motaboli, Malebanye Lerotholi, Maurus Kohler, Kathrin Haenggi, Moliehi Mokete, Makobefo Gladys Chakela, Mpho Kao, Mathebe Kopo, Moleboheng Mokebe, Lorena Urda, Bienvenu Lengo Nsakala, Anna Klicpera, Nadine Tschumi, Niklaus Daniel Labhardt

“…Sex, age category/ART regimen core agent (combined variable), time since ART initiation and district were independently associated with viraemia.Future plans VICONEL offers potential for (1) further digitalisation and automation of results sharing at the client, facility and district/national level, (2) integration of additional clinical and diagnostic data, including comorbidities and drug resistance and (3) embedding randomised trials.…”
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Mild ultrasound-assisted alkali de-esterification modified pectins: Characterization and structure–activity relationships in immunomodulatory effects by Huan Guo, Dong Li, Baohe Miao, Kanglin Feng, Guijing Chen, Renyou Gan, Zhiliang Kang, Hong Gao

“…The molecular weights of AP-E1, AP-E2, and AP-E3 were determined to be 30.94 ± 0.83 kDa, 27.61 ± 0.65 kDa, and 22.17 ± 0.57 kDa, respectively. …”
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Nutrient availability in tropical soils fertilized with sewage sludge and natural phosphate by Rodinei Facco Pegoraro, Jefferson Rodrigo Teixeira Silva, Leidivan Almeida Frazão, Regynaldo Arruda Sampaio, Silvana Ferreira Bicalho, Verônica Aparecida Santos Ferreira Soares

“…Results: The application of sludge, natural phosphate, and sulfur increased the contents of SOM, N, P, K, Ca, Mg, Al, H+Al, SB, and CEC and reduced the soil pH, in addition to favoring the rate and time of availability of P, Ca, and Mg, with means higher than 50% in the soils from 30 to 120 days after application. …”
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Optimising Access Surgery in Senior Haemodialysis Patients (OASIS): study protocol for a multicentre randomised controlled trial by Patrick WHE Vriens, Edith M Willigendael, Maarten A Lijkwan, Friedo W Dekker, Chava L Ramspek, Michiel W de Haan, Çaĝdaş Ünlü, Boudewijn DC Heggen, Koen E A van der Bogt, Marc H Hemmelder, Mickaël J C Hiligsmann, Magda M van Loon, Joris I Rotmans, Jan H M Tordoir, Geert Willem H Schurink, Maarten G J Snoeijs, Marijke J Molegraaf, Philippe WM Cuypers, Denise Nio, Cora H Arts, Jacobien C Verhave, Goos D Laverman, Aron S Bode, Marcel C Weijmer, Bas Govaert, Aaltje Y Adema, Gijs MJM Welten, Michel MPJ Reijnen, Marc JH Groeneveld, Hans S Brink, Jeroen B van der Net, Arno Kuijper, Hilde PE Peters, Roos C van Nieuwenhuizen, Rombout R Kruse, Yvonne C Schrama, Karina A de Groot, Karima Farhat

“…For elderly patients, autologous arteriovenous fistulas that are typically created in usual care may not be the best option because a significant proportion of fistulas either fail to mature or remain unused. In addition, long-term complications associated with arteriovenous grafts and central venous catheters may be less relevant when considering the limited life expectancy of these patients. …”
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In-House Fabrication and Validation of 3D-Printed Custom-Made Medical Devices for Planning and Simulation of Peripheral Endovascular Therapies by Arianna Mersanne, Ruben Foresti, Chiara Martini, Cristina Caffarra Malvezzi, Giulia Rossi, Anna Fornasari, Massimo De Filippo, Antonio Freyrie, Paolo Perini

“…The dimensional accuracy of the models was evaluated by comparing their CT scan images with the corresponding patient data, using OsiriX MD. Additionally, both flexible and rigid models were evaluated by eight vascular surgeons during simulations in an in-house-designed setup, assessing both the technical aspects and operator perceptions of the simulation. …”
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3D echocardiography derived reference values and determinants of left ventricular twist and torsion from the population-based STAAB cohort study by Julia Napp, Götz Gelbrich, Floran Sahiti, Vladimir Cejka, Dora Pelin, Lena Schmidbauer, Mengmeng Chen, Niklas Hitschrich, Marcus Schreckenberg, Stefan Frantz, Peter U. Heuschmann, Stefan Störk, Caroline Morbach

“…We found a differential association with respective determinants as LV rotational parameters increased with age and with higher blood pressure but decreased with higher body weight. Further research is needed to elucidate these associations in more detail and to determine the additional information contributed by twist and torsion. …”
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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence by Fatma Al-zahraa A. Yehia, Hisham A Abbas, Tarek M. Ibrahim, Basem Mansour, Zuhier A. Awan, Mohammed W. Al-Rabia, Wesam H. Abdulaal, Mustafa Adnan Zeyadi, Solomon Z. Okbazghi, Tarek S. Ibrahim, Wael A. H. Hegazy, Salwa E. Gomaa

“…The rapid emergence of azole resistance in C. albicans, in addition to the limited available antifungal agents, complicates the treatment and emphasizes the urgent need for novel therapeutic options. …”
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Risk factors for moderate disturbance of consciousness in patients with unilateral chronic subdural hematoma by Adrian Liebert, Thomas Eibl, Thomas Bertsch, Hans-Herbert Steiner, Karl-Michael Schebesch, Leonard Ritter

“…In bivariate analysis, radiographic parameters, like greater mean midline shift (p < 0.001), homogenous hypodense type (p = 0.017), additional temporal (p < 0.001) and occipital (p < 0.001) location, “acute-to-chronic” (p = 0.002) and “acute-on-chronic” (p = 0.049) forms were more frequent in group 1. …”
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Overcoming breast cancer cell treatment resistance by optimizing sonodynamic therapy and radiation sensitizers on lncRNA PVT1 and miR-1204 expression by Ali Neshastehriz, Zeinab Hormozi-Moghaddam, Zahra Abedi Kichi, Seyedeh Mona Taheri, Seyed Mohammad Amini, Amir Aghaei

“…Several parameters were evaluated, including reactive oxygen species (ROS) generation and colonization. Additionally, the investigation included assessing the long non-coding RNA (lncRNA) PTV1 with miRNA1204 and related genes using Real-Time PCR. …”
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Design of multifunctional interfaces on ceramic solid electrolytes for high-performance lithium-air batteries by Yunxin Shi, Ziyang Guo, Changhong Wang, Mingze Gao, Xiaoting Lin, Hui Duan, Yonggang Wang, Xueliang Sun

“…The cathode-friendly LiI/PMMA layer displays excellent stability towards superoxide intermediates and also greatly reduces the decomposition voltage of discharge products in Li–air system. Additionally, the anode-friendly PVDF-HFP coating shows low-resistance properties towards anodes. …”
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Thermal Response and Degressive Reaction Study of Oxo-Biodegradable Plastic Products Exposed to Various Degradation Media by S. M. Al-Salem, A. Y. Al-Nasser, M. H. Behbehani, H. H. Sultan, H. J. Karam, M. H. Al-Wadi, A. T. Al-Dhafeeri, Z. Rasheed, M. Al-Foudaree

“…The weight loss measured exceeded 58% after soil burial indicating deterioration under natural environmental stressors. In addition, the thermal characterization campaign executed with the aim of determining the product’s thermal response followed internationally recognised experimental protocols for the determination of thermal stability. …”
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Protective or limited? Maternal antibodies and RSV-associated lower respiratory tract infection in hospitalized infants aged 28-90 days by Shuanglian Li, Shuanglian Li, Chenghao Mei, Chenghao Mei, Sainan Chen, Chenglin Wang, Chenglin Wang, Yelei Gao, Yelei Gao, Jinhua Ma, Jinhua Ma, Li Zhong, Li Zhong, Tingting Luo, Tingting Luo, Xin Zhao, Xin Zhao, Huaqin Bu, Huaqin Bu, Ying Lyu, Ying Lyu, Xiaohu Kuang, Zhenxing Jia, Xiaoli Wang, Yuqing Wang, Daiyin Tian, Daiyin Tian, Daiyin Tian

“…While RSV Pre-F IgG antibody was inversely correlated with disease severity, RSV Post-F IgG, and RSV A and B neutralizing antibodies did not show a similar correlation across the three illness severity categories. …”
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Explore the evolution of winter wheat production and its response to climate change under varying precipitation years in the Loess Plateau of China by Donglin Wang, Yanbin Li, Binbin Zhang, Tengcong Jiang, Siyu Wu, Wenjie Wu, Yi Li, Jianqiang He, Deli Liu, Qinge Dong, Hao Feng

“…The predicted potential yield across three precipitation types showed that wet years exhibited the least fluctuation, while the highest fluctuation were observed in dry years. In particular, the potential winter wheat yield without irrigation in wet years and dry years was 19.84 % higher under SSP245 scenario and 25.22 % higher under SSP585 scenario compared with current conditions. …”
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Mechanical properties and cracking behavior of rebar reinforced UHPC (R-UHPC) under uniaxial tension: Evaluation and design by Xianzhi Luo, Sumei Zhang, Yuchen Zhang, Yuexin Jiang

“…The research findings reveal that the tensile deformability of R-UHPC depends on the combination of reinforcement ratio and fiber dosage, rather than a single parameter. The additional load-bearing capacity provided by strain-hardening of rebar cannot cover the load transfer from UHPC to rebar during the tensile cracking process, causing deformability degradation of R-UHPC. …”
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Probiotic properties of Bacillus licheniformis HN318 and comparison of the effects of its bacterial cells and cultures on growth, immunity and disease resistance of hybrid grouper... by Zhenjie Cao, Qiaoli Yang, Aie Kang, Guotao Wang, Pengshuo Li, Guiping Qiu, Jinge Wang, Chunsheng Liu, Yun Sun, Yun Sun, Yun Sun

“…Hybrid grouper were fed with HN318 cultures and bacterial cells for 8 weeks, and their growth, feed utilization, immune responses, and survival rates upon challenge with Vibrio harveyi were evaluated. Additionally, the expression of immune-related genes was analyzed.ResultsHN318 exhibited high auto-aggregation and gastrointestinal stress resistance, and was found to be safe for use in aquaculture. …”
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The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors by Renhao Li, Jing-Chu Hu, Li Rong, Yige He, Xiaolei Wang, Xuansheng Lin, Wenjun Li, Yangfan Wu, Chaiyaporn Kuwentrai, Canhui Su, Thomas Yau, Ivan Fan-Ngai Hung, Xiang Gao, Jian-Dong Huang

“…Given that the majority of the global population has acquired memory immunity against various pathogens through infection or vaccination, we believe that, in addition to utilizing the widely held immune memory against SARS-CoV-2 via COVID-19 vaccine, mRNA vaccines against other pathogens, such as Hepatitis B Virus (HBV), Common Human Coronaviruses (HCoVs), and the influenza virus, could be rapidly transitioned into clinical use and holds great promise in treating different types of cancer. …”
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Extraction of tree branch skeletons from terrestrial LiDAR point clouds by Jimiao Gao, Liyu Tang, Honglin Su, Jiwei Chen, Yuehui Yuan

“…The results show that the proposed method performs effectively, with overall wood–leaf separation accuracies ranging from 86% to 93%. Additionally, the extracted branch skeleton accurately reflects the natural geometric structure of the trees. …”
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Bending performance of SFCBs reinforced UHPC beams prestressed with FRP bars by Wenjie Ge, Feng Zhang, Subedi Sushant, Ashraf Ashour, Kangbao Chen, Shihu Fu, Linfeng Qiu, Laiyong Luo, Dafu Cao

“…Moreover, increasing the reinforcement ratio of both prestressed FRP and non-prestressed SFCBs results in an increase in ultimate load, but a decrease in ultimate deflection, ductility, deformation, and energy absorption capacity. Additionally, by analyzing the comprehensive performance of various beams, the economic benefits of UHPC beams reinforced with non-prestressed SFCBs and prestressed FRP bars are less prominent, but they are still suitable for structures that require high strength, durability, and ductility. …”
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The Sunburst Arc with JWST. III. An Abundance of Direct Chemical Abundances by Brian Welch, T. Emil Rivera-Thorsen, Jane R. Rigby, Taylor A. Hutchison, Grace M. Olivier, Danielle A. Berg, Keren Sharon, Håkon Dahle, M. Riley Owens, Matthew B. Bayliss, Gourav Khullar, John Chisholm, Matthew Hayes, Keunho J. Kim

“…This nitrogen abundance is consistent with enrichment from a population of Wolf–Rayet stars, additional signatures of which are reported in a companion paper. …”
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