Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodi... by Zhiliang Guo, Rula Sa, Daqiang Zhao, Songxia Li, Hui Guo, Lan Zhu, Gang Chen

“…At 24–28 months after treatment, renal biopsy showed partial remission of microvascular inflammation in four of six patients. In addition, capillary C4d deposition became negative in all patients (P = 0.001), and the mean score of i-IFTA was significantly reduced (P = 0.012). …”
Get full text

The PANORAMIC Survey: Pure Parallel Wide Area Legacy Imaging with JWST/NIRCam by Christina C. Williams, Pascal A. Oesch, Andrea Weibel, Gabriel Brammer, Aidan P. Cloonan, Katherine E. Whitaker, Laia Barrufet, Rachel Bezanson, Rebecca A. A. Bowler, Pratika Dayal, Marijn Franx, Jenny E. Greene, Anne Hutter, Zhiyuan Ji, Ivo Labbé, Sinclaire M. Manning, Michael V. Maseda, Mengyuan Xiao

“…The survey includes ∼432 square arcmin of novel sky area not yet observed with JWST using at least six NIRCam broadband filters, increasing the existing area covered by similar Cycle 1 data by ∼60%. Additionally, 70 square arcmin was also covered by a seventh filter (F410M). …”
Get full text

Histology Assessment of Chitosan–Polyvinyl Alcohol Scaffolds Incorporated with CaO Nanoparticles by Carlos David Grande-Tovar, Jorge Ivan Castro Castro, Lemy Vanessa Barba-Rosado, Paula A. Zapata, Daniel Insuasty, Carlos-Humberto Valencia-Llano

“…X-ray diffraction (XRD) analysis showed changes in the crystalline structure, with new diffraction peaks at 2θ values of 7.2° for formulations F2, F3, and F4, likely due to the increased amorphous nature and concentration of CaO NPs. Additionally, higher CaO NPs concentrations led to a reduction in thermal properties and crystallinity. …”
Get full text

The application of hepatopancreatoduodenectomy in advanced gallbladder carcinoma: Patient selection, surgical outcomes and influence on survival compared to radical cholecystectomy by Manar Mikhail Atyah, Yingjixing Luo, Ruyi Liu, Zhiying Yang, Li Xu

“…Similar severity was observed between HPD and no-surgery groups. Additionally, HPD presented higher risks of perioperative bleeding, transfusion and complications (grade III/IV). …”
Get full text

Individual mobility prediction by considering current traveling features and historical activity chain by Xiaotong Zhang, Zhipeng Gui, Yuhang Liu, Dehua Peng, Qianxi Lan, Zhangxiao Shen, Huan Chen, Yuhui Zuo, Yao Yao, Huayi Wu, Kai Li, Kun Qin

“…It outperforms four baselines, Random Forest (RF), Distant Neighboring Dependencies (DND), Location Semantics and Location Importance (LSI)-LSTM, as well as Intersection Transfer Preference and Current Movement Mode (ITP-CMM), by approximately 10%-15% improvement in accuracy. In addition, we further explore the impact of historical activity chain length, and destination visiting frequency on prediction, as well as the relationship between predictability and eight mobility pattern features. …”
Get full text

Derivation and Characterization of Isogenic <i>OPA1</i> Mutant and Control Human Pluripotent Stem Cell Lines by Katherine A. Pohl, Xiangmei Zhang, Johnny Jeonghyun Ji, Linsey Stiles, Alfredo A. Sadun, Xian-Jie Yang

“…CRISPR-Cas9 gene editing yielded both <i>OPA1</i> homozygous and heterozygous mutant ESC lines from a parental control ESC line. In addition, CRISPR-mediated homology-directed repair (HDR) successfully corrected the <i>OPA1</i> mutation in a DOA patient’s iPSCs. …”
Get full text

Partie 1 : Existe-t-il une corrélation entre le diamètre de la plaie de taille et la profondeur du cône de dessèchement ? by Emilie Bruez, Céline Cholet, Massimo Guidici, Marco Simonit, Mathilde Boisseau, Xavier Poitou, Patrice Coll, Laurence Gény-Denis

“…Dans la pratique il est généralement admis que la longueur de ce bois doit être équivalente à son diamètre car la profondeur de la nécrose correspondrait au diamètre de la plaie de taille et qu’il peut être supprimé l’année suivante. …”
Get full text

Preparation and quality assessment of innovative gluten-free biscuit enriched with galangal (Alpinia galanga Linn.) powder by Eatemad M. El-Sayed, Essam Mohamed Elsebaie, Shaymaa A. Hozifa, Marwa Fawzi Ahmed El-Farsy, Dalia M. El-Mesiry, Soher Abd-Elfattah ElMeslamy, Heba Ali Yousef Shaat, Rehab A. Shehata, Marwa A. Ahmed, Amira Lotfy Abd Allah, Suzan S. Ibraheim

“…The goal of this study was to create functional gluten-free biscuits made from oat flour and fortified with galangal powder at various levels (5, 10, 15, and 20% The study examined how galangal powder addition affects the rheological, physical, thermal, and nutritional qualities after baking, as well as their oxidative stability and sensory assessment after three months of storage at room temperature (25–30 °C The results showed that adding galangal powder caused changes in the rheological properties (dough development and weakening increasing while amylase activity and starch gelling decreased), technological properties (increased weight, thickness, and density while decreasing water activity, width, and spread ratio), textural properties (increased hardness), and color properties (decreased L* while increasing a* and b*) of the biscuits. …”
Get full text

Rooting for Resilience: Arbuscular Mycorrhizal Fungi (AMF) Boost Citrus Tolerance to Water Scarcity in Rangpur Lime and Carrizo Citrange Rootstocks by Sajjad Hussain, Mehwish Jan, Muhammad Fasih Khalid, Sakeena Tul-Ain Haider, Muhammad Arif Ali, Shakeel Ahmad, Samreen Sabir, Mamoudou Sétamou, Raphael Morillon

“…Conversely, stress indicators—such as malondialdehyde (MDA) and hydrogen peroxide (H₂O₂)—increased significantly in the AMF- treatment compared to AMF+. Additionally, the increase in antioxidative enzymes (superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APx) and osmotic adjustment (proline (PRO)) was more pronounced in the AMF+ treatment in the leaves and roots of both citrus rootstocks. …”
Get full text

Large language models for pretreatment education in pediatric radiation oncology: A comparative evaluation study by Dominik Wawrzuta, Aleksandra Napieralska, Katarzyna Ludwikowska, Laimonas Jaruševičius, Anastasija Trofimoviča-Krasnorucka, Gints Rausis, Agata Szulc, Katarzyna Pędziwiatr, Kateřina Poláchová, Justyna Klejdysz, Marzanna Chojnacka

“…Responses were generated using GPT-3.5, GPT-4, and fine-tuned GPT-3.5, with fine-tuning based on pediatric radiotherapy guides from various institutions. Additionally, a radiation oncologist prepared answers to these questions. …”
Get full text

FTO attenuates TNF-α-induced damage of proximal tubular epithelial cells in acute pancreatitis-induced acute kidney injury via targeting AQP3 in an N6-methyladenosine-dependent man... by Xinghui Li, Qi Liang, Lu Liu, Shujun Chen, Yong Li, Yu Pu

“…FTO negatively modulates AQP3 levels in RTECs in an m6A-depednent manner and compromises AQP3 stability. In addition, all FTO overexpression-induced effects in TNF-α-induced PTECs were neutralized following AQP3 upregulation.Conclusion FTO alleviates TNF-α-induced damage to PTECs in vitro by targeting AQP3 in an m6A-dependent manner.…”
Get full text

Hydrothermal conditions dominated sensitivity and lag effect of grassland productivity in Yunnan Province, China: Implications for climate change by Yan Fang, Long Wan, Jing Tong, Guijing Li, Jing Pang, Enfu Chang, Linglan Chen, Zixuan Shi

“…In contrast, warmer temperatures and water stress led to a decline in grassland productivity in the hot and dry vally of the Jinsha River. In addition, grassland productivity showed variable lag effects in different hydrothermal regions. …”
Get full text

Low dose ATG-Fresenius for GVHD prophylaxis: a comparative study with ATG-Thymoglobulin by Itai Falicovich, Boaz Nachmias, Shlomo Elias, Eran Zimran, Adir Shaulov, Polina Stepensky, Batia Avni, Sigal Grisariu

“…Cumulative incidence of overall survival (OS), relapse incidence, non-relapse mortality (NRM) and GVHD free, Relapse free Survival (GRFS) did not significantly differ.ConclusionsThis study highlights the safety and efficacy of low-dose ATG-F compared to a relatively high dose ATG-T. …”
Get full text

Inverse relationship of oxidative balance score with hyperuricemia among Chinese adults: a population-based cross-sectional study by Hewei Peng, Ying Han, Jingru Huang, Wenxin Qiu, Huajing Chang, Jiangwang Fang, Xian-E Peng

“…An inverse association between OBS and hyperuricemia was observed and remained after adjusting for potential confounders. Each additional unit of OBS was associated with a 4% and 7% reduction in the risk of hyperuricemia in men [OR: 0.96(0.94,0.99)] and women [OR: 0.93(0.90,0.96)], respectively. …”
Get full text

Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults by Yaoyao Wu, Zesheng Chen, Zongxue Cheng, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu

“…After correcting for demographic and life characteristics, the mediation analysis results indicated that sleep difficulty mediated the relationship between chronic diseases and HRQoL (β=-0.0022, 95% Bca CI: -0.0034 -0.0014). Additionally, sleep difficulty influenced the association between chronic diseases and daily activities as well as pain (or discomfort) (β = 0.0083, 95% Bca CI: 0.0042–0.0111; β = 0.0162, 95% Bca CI: 0.0107–0.0225) in the analysis of the dimensions. …”
Get full text

HfC–HfO2 modified high/superhigh temperature thermal protection coating for superior hot corrosion resistance and antioxidation performance by Zhiyun Ye, Shuqi Wang, Shuang Yu, Xinrui Zhao, Yongchun Zou, Guoliang Chen, Lei Wen, Lina Zhao, Guangxi Zhang, Yaming Wang, Jiahu Ouyang, Dechang Jia, Yu Zhou

“…This improvement is attributed to the formation of a robust Hf-rich skeleton provided by the deposited HfC–HfO2 layer, which can accelerate the formation of a highly stable corroded layer/oxide scale. In addition, multiple stress release mechanisms of the composite coating at high temperatures also provide substantial contributions to long-term service. …”
Get full text

Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis by Kai Tang, Kai Tang, Kai Tang, Wei Deng, Wei Deng, Wei Deng, Wei Deng, Zhiying Huang, Zhiying Huang, Zhiying Huang, Simin Chen, Simin Chen, Simin Chen, Zilin Zhu, Zilin Zhu, Shukun Lin, Shukun Lin, Lubin Zhong, Lubin Zhong, Quanxin Zheng, Quanxin Zheng, Wenhua Zhao, Wenhua Zhao, Zhida Zhang, Zhida Zhang, Ling Mo, Ling Mo, Ling Mo

“…Western blot findings also indicate that NEO inhibits the phosphorylation of ERK, P38, JNK, and P65 but does not reverse the degradation of IκB-α. Additionally, NEO affects the phosphorylation of proteins in the PI3K/AKT, GSK3β, and PPARγ signaling pathways, demonstrating that NEO can inhibit OC formation through multiple pathways and targets. …”
Get full text

Clinical features of cystic neutrophil granulomatous mastitis in 62 cases by Mengjie Wang, Dongxiao Zhang, Na Fu, Min Liu, Hongkai Zhang, Shuo Feng, Yifei Zeng, Wenjie Zhao, Jianchun Cui, Khattak Mazher Mansoor

“…The primary clinical manifestations were characterized by pain and palpable masses, accompanied by redness, ulceration, nipple discharge, and nipple retraction. Additionally, systemic symptoms, such as fever, headache, erythema nodosum, and cough, were observed. …”
Get full text

Computerized QT and QTc Measurements From Bedside ICU Monitors Are Similar to Those Derived From a Standard 12‐Lead ECG by Arthur Murray, Karolina Ho, Thomas J. Hoffmann, Gopika K. Ganesh, Shelvin Prasad, Sarah Berger, Cass Sandoval, Amy Larsen, Hildy Schell‐Chaple, Michele M. Pelter

“…These pilot data are promising and suggest QT/QTc measurements from bedside monitors (four leads) may be an acceptable alternative to obtaining additional standard 12‐lead ECGs. Given that half of the ICU patients screened did not have a 12‐lead ECG recorded, bedside monitor QT/QTc's could identify at‐risk patients. …”
Get full text

Experimental study of thaw settlement and internal structural changes in frozen soil during the thawing process by Chunguang Xu, Ze Zhang, Yaojun Zhao, Doudou Jin, Qihao Yu, Xiangxi Meng

“…The results indicated that there were variations in the packing density of the soil–ice mixtures according to the soil type. Additionally, the packing density exhibited a favourable correlation with the water content, and the following size relationship for the packing density of the different soil types at the same water content could be established: ST (sand) > HB (silty loam) > SL (sandy loam) > YC (silty clay). …”
Get full text