Should We Adopt Increased Dilutions for Indirect Immunofluorescence in Pediatric Anti-Centromere Antibody Testing? Insights from a Three-Year Retrospective Study by Mehmet Soylu, Raziye Burcu Taşkın, Gülçin Aytaç, Güzide Aksu, Seyfi Durmaz, Miray Karakoyun, Şaziye Rüçhan Sertöz

“…This study aimed to evaluate the diagnostic concordance between indirect immunofluorescence (IIF) at different dilution levels (1/80 and 1/640) and immunoblot findings for anti-centromere antibody (ACA) positivity. Additionally, the clinical significance of ACA positivity and its association with SARDs in pediatric patients was assessed. …”
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Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye by Sezen Karakus, Alan N. Baer, Esen K. Akpek

“…Medical records of 136 patients with a primary diagnosis of dry eye who underwent laboratory testing between April 2014 and July 2017 were reviewed retrospectively. …”
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Protocol for a multicentre randomised controlled trial examining the effects of temporarily pausing Bruton tyrosine kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination... by Abhishek Abhishek, Jonathan A Cook, Helen M Parry, Anne Francis, Lelia Duley, Vicki S Barber, Paul Moss, Nicholas Peckham

“…Secondary outcomes are RBD antibody levels at 12 weeks postbooster vaccination, participant global assessments of disease activity, blood films, full blood count and lactate dehydrogenase levels, impact on quality of life, self-reported adherence with request to temporarily pause or continue BTKi, T cell response against spike protein and relative neutralising antibody titre against SARS-CoV-2 viral variants. Additionally, there will be an investigation of any effects in those given influenza vaccination contemporaneously versus COVID-19 alone.The primary analysis will be performed on the as randomised groups (‘intention to treat’). …”
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Assessment of factors predicting the nutritional status of geriatric people in Tabuk, Saudi Arabia by Samar Lafi Aljohani

“…Background: On a global level, geriatric malnutrition is a substantial problem as it has many adverse health outcomes including increased morbidity and death rates, in addition to poor health-related quality of life. This study aims to assess the nutritional status of patients attending geriatric clinics at hospitals. …”
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Methodical approaches to identification of effective wheat genes providing broad-spectrum resistance against fungal diseases by E. S. Skolotneva, I. N. Leonova, E. Yu. Bukatich, E. A.  Salina

“…When evaluating the contribution of the genes (including genes located on the alien translocations) to the formation of common wheat resistance to fungal diseases, it is necessary to use an extended sample, including genotypes carrying the same group of genes in a different genetic background. In addition, recommendations are given on the terms and frequency of monitoring of fungal diseases in Western Siberia, depending on the pathogen. …”
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Explainable Predictive Model for Suicidal Ideation During COVID-19: Social Media Discourse Study by Salah Bouktif, Akib Mohi Ud Din Khanday, Ali Ouni

“…According to Local Interpretable Model-Agnostic Explanations (LIME) and Shapley Additive Explanations (SHAP) XAI algorithms, there was a drift in the features during and before COVID-19. …”
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Peripheral corneal ulcers in association with rheumatic diseases by E.A. Drozdova

“…Russian Journal of Clinical Ophthalmology. 2024;24(2):88–93 (in Russ.). DOI: 10.32364/2311-7729-2024-24-2-8. </p>…”
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Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 by Xinran He, Tingyi Xie, Li Shi, Xuyi Kuang, Lei Li, Xingyu Shang, Bo Fu

“…Elkord, Eyad is the most prolific author, and Frontiers in Immunology is the journal that published the most papers on the TME of CRC. In addition, keyword and cluster analysis showed that immune checkpoint inhibitors, cancer-associated fibroblasts, macrophage polarization, intestinal microbiota, colorectal cancer liver metastasis, drug resistance, scRNA-seq, etc. may be the research hotspots and trends in this field.ConclusionsColorectal cancer and tumor microenvironment research is in the developmental stage, and strengthening international cooperation can help to drive this field forward. …”
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Effect Of Exercise Therapy on Lipid Profile and Oxidative Stress Indicators in Patients with Type 2 Diabetes by Madeeha Jadoon, Shazia Zeb, Sajid Razaq, Munazza Khan, Muhammad Shoaib, Sara Mariyum

“…LDL-C adiposity levels were reduced (p = 0. 378), but desirable cholesterol levels, HDL-C, improved (p = 0. 032). Additionally, oxidative stress indicators improved: Apropos to this, serum MDA, a marker of oxidative stress, significantly reduced (p = 0. 012). …”
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Prominence of Microbiota to Predict Fibrous Stenosis in Crohn&rsquo;s Disease by Yang X, Pan Y, Gao CP, Li H, Zhang YH, Huang CL, Cao L, Xiao SY, Zhou Z

“…We identified specific microbiota and assessed their predictive accuracy for intestinal fibrous stenosis. Additionally, we explored functional differences in intestinal microbiota between the two groups.Results: : Our investigation of fecal samples revealed no significant differences in the gut microbiota structure between patients with fibrous stenosis and those without stenosis in CD. …”
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Fruit quality retention and shelf-life extension of papaya through organic coating by Sazia Jahan, Joydeb Gomasta, Jahidul Hassan, Md Habibur Rahman, Md Abdul Kader, Emrul Kayesh

“…Before decay of all the coated papaya at 9 DAS, chitosan (1 %) performed superior in retaining maximum reducing sugar (0.77 %, 1.41 % and 3.85 % more than aloevera, seaweed and clybio application, respectively), β-carotene (10.94 %, 12.5 % and 9.89 % greater than aloevera, seaweed and clybio coatings, respectively), total flavonoids content (18.36 %, 29.81 % and 25.29 % better than aloevera, seaweed and clybio treatments, respectively), total antioxidant activity (21.85 %, 68.2 % and 47.91 % than noted in aloevera, seaweed and clybio formulations, respectively) and potassium content (3.14 % and 9.32 % than aloevera and clybio treatments, respectively). In addition, clybio gave better results over chitosan up to completion of shelf life (12 DAS) such as retention of ascorbic acid (6.21 %), non-reducing sugar (13.48 %), magnesium content (8.31 %) and disease incidence (20 %). …”
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An analysis of knowledge, attitudes, practice and influencing factors for tuberculosis prevention and control among Hainan University students by Huifang Xie, Huifang Xie, Wencai Wang, Xuan Chen, Dan Huang, Qiuyue Yu, Liumei Luo

“…Moreover, students who had received tuberculosis education had higher correct scores compared to those who had not (5.92 vs. 5.31, 3.08 vs. 2.65, 3.31 vs. 2.93, respectively). Additionally, students in higher grades demonstrated higher scores in attitude. …”
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Filamented hydrogels as tunable conduits for guiding neurite outgrowth by Hao Liu, Anna Puiggalí-Jou, Parth Chansoria, Jakub Janiak, Marcy Zenobi-Wong

“…The incorporation of protein microcrystals containing nerve growth factor (NGF) into the photoresin enabled sustained neurite outgrowth without the need for additional NGF in the media. Finally, laminin was added to the resin to enhance the bioactivity of the biomaterial, resulting in a further increase in maximum neurite outgrowth to 3.5 mm after 4 days of culture in softer matrices. …”
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Effects of Quetiapine on Novelty‐Related Object Recognition Memory and Hippocampal BDNF Level in Sleep‐Deprived Rats by Öznur Özge Özcan, Burcu Çevreli, Emel Serdaroğlu Kaşıkçı, Mesut Karahan, Muhsin Konuk

“…Results Long‐term QET administration in healthy rats decreased NOR and BDNF protein expression in the hippocampus, as did 72 h SD. Long‐ and short‐term QET administration reversed SD effects, but only short‐term QET administration increased hippo BDNF. …”
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Raw Cured Poultry Meat Fortified with Bee Pollen: Biomedical Research on Laboratory Animals by Maksim A. Sukhov, Tatiana M. Giro, Sergey V. Kozlov, Irina V. Ziruk

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Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices by Chao Ping Wu, Rachel Benish Shirley, Alex Milinovich, Kaiyin Liu, Eduardo Mireles-Cabodevila, Hassan Khouli, Abhijit Duggal, Anirban Bhattacharyya

“…These outcomes underwent subsequent validation within a distinct cohort from the year 2020. Additionally, the models’ performance was assessed in comparison to physician judgments, with any discrepancies between the two carefully analyzed. …”
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ITS amplicon sequencing revealed that rare taxa of tea rhizosphere fungi are closely related to the environment and provide feedback on tea tree diseases by Yuanqi Zhao, Weiwei Ran, Wenming Xu, Yuehua Song

“…For various taxa, we found that numerous taxa consistently maintained core positions within the community, whereas rare taxa were able to stabilize due to a high proportion of positive effects. Additionally, abundant taxa presented a wider range of environmental feedback, whereas the rare taxon diversity presented a stronger positive association with the soil Z score. …”
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Cardiometabolic index as a predictor of gallstone incidence in U.S. adults: insights from NHANES 2017–2020 by Ji Li, Shou-jun Bai

“…Receiver Operating Characteristic (ROC) curves evaluated and compared the predictive performance of CMI, Body Mass Index (BMI), and Waist Circumference (WC), establishing optimal cutoff values along with their sensitivity and specificity. …”
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African animal trypanocide resistance: A systematic review and meta-analysis by Keneth Iceland, Kasozi, Ewan, Thomas MacLeod, Susan, Christina Welburn

“…Major markers of resistance explored include TbAT1, P1/P2 transporters, folate transporters, such as F-I, F-II, F-III, and polyamine biosynthesis inhibitors. In addition, immunosuppressed hosts favor the development of AATr. …”
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Bank Credit and Loan Repayment During Covid-19 In Kabale District: A Case of Lyamujungu SACCO. by Byamukama, Dicky

“…With the help of a questionnaire and interviews, data was collected from 108 clients of Lyamujungu SACCO. In addition, interviews were conducted with the general manager, branch managers and loans officers. …”
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