2′-O-Methylperlatolic Acid Enhances Insulin-Regulated Blood Glucose-Lowering Effect through Insulin Receptor Signaling Pathway by Wang Yinghao, Guan Qiaoli, Liu Guanfu, Wu Xiaoyun, Wang Xuanjun, Sheng Jun

“…In mice with streptozotocin-induced diabetes, 2-O-M significantly prolonged the blood glucose-lowering effect of insulin, significantly reduced the secretion of exogenous insulin, and reduced the blood glucose concentration in vivo. In addition, treatment with 2-O-M alone significantly enhanced the phosphorylation of AKT in muscle tissue, which enhanced glucose uptake in C2C12 myotubes. …”
Get full text

The effect of conservation in various cryoprotectants on the properties and morphological structure of the umbilical cord arteries by V. A. Brumberg, T. A. Astrelina, T. F. Malivanova, I. V. Kobzeva, Yu. B. Suchkova, V. A. Nikitina, D. Yu. Usupzhanova, V. A. Brunchukov, S. V. Lishchuk, P. S. Kyzlasov, A. A. Kazhera, V. M. Troyakov, A. S. Samoilov

“…Freezing with 5 % dextran, 10 % DMSO and 7.5 % human albumin did not lead to significant changes in the morphology of vascular tissue compared to control. …”
Get full text

Retrospective cohort study based on the MIMIC-IV database: analysis of factors influencing all-cause mortality at 30 days, 90 days, 1 year, and 3 years in patients with different t... by Xuehui Fan, Jing Xu, Ruixue Ye, Qiu Zhang, Yulong Wang

“…ObjectiveThis study aims to evaluate key factors influencing the short-term and long-term prognosis of stroke patients, with a particular focus on variables such as body weight, hemoglobin, electrolytes, kidney function, organ function scores, and comorbidities. …”
Get full text

Short- to Medium-Term Weather Forecast Skill of the AI-Based Pangu-Weather Model Using Automatic Weather Stations in China by Siyi Xu, Yize Zhang, Junping Chen, Yunlong Zhang

“…The results indicate that Pangu surpasses traditional NWP systems in temperature forecasting, while its performance in predicting wind direction, wind speed and pressure is comparable to them. Additionally, the forecast skill of Pangu diminishes as the lead time extends, but it tends to surpass traditional NWP systems with longer lead times. …”
Get full text

Pretreatment with AM1241 Enhances the Analgesic Effect of Intrathecally Administrated Mesenchymal Stem Cells by Junran Xie, Jinxuan Ren, Na Liu, Chengwei Wu, Dongju Xiao, Huanyu Luo, Jingxian Du

“…In untreated CCI mice, expression of TGF-β1 was increased, whereas pretreatment with AM1241-treated mesenchymal stem cells regulated the expression of TGF-β1 on 10 days and 19 days after surgery. In addition, i.t. injection of exogenous TGF-β1 slightly alleviated neuropathic pain whilst neutralization of TGF-β1 potently blocked the effect of AM1241-treated mesenchymal stem cells on thermal hyperalgesia and mechanical allodynia of CCI mice. …”
Get full text

Jackknife versus Lithotomy Position for Hemorrhoidectomy Surgery: A Randomized Controlled Trial by Sina Ghasemi, Behzad Imani, Alireza Jafarkhani, Ashkan Karimi, Ali Yamini

“…Conclusions: Performing hemorrhoidectomy surgery with the Jackknife position compared to the Lithotomy position can reduce the amount of bleeding in patients, shorten the duration of surgery, and provide a better field of view and exposure for the surgeon. Additionally, based on the findings, using either position does not significantly impact the level of local discomfort or postoperative pain.…”
Get full text

Comparative genomics of Botryosphaeria dothidea and B. kuwatsukai, causal agents of apple ring rot, reveals both species expansion of pathogenicity-related genes and variations in... by Bo Wang, Xiaofei Liang, Mark L. Gleason, Rong Zhang, Guangyu Sun

“…Both species encode a significant number of pathogenicity-related genes, e.g.carbohydrateactive enzymes (CAZYs), plant cell wall degrading enzymes (PCWDEs), secondary metabolites (SMs) biosynthetic enzymes, cytochrome P450 enzymes (CYPs), and secreted peptidases, in comparison to all additional sequenced fungal species involved in various life-styles. …”
Get full text

Severe subcutaneous infection with Clostridium septicum in a herd of native Icelandic horses by Charlotta Oddsdóttir, Ólöf G. Sigurðardóttir, Vala Friðriksdóttir, Vilhjálmur Svansson, Birkir Þór Bragason, Sigríður Björnsdóttir

“…The clinical signs included pyrexia, depression, swollen limbs, chest and neck, reluctance to move and dyspnoea, leading to the death or euthanasia of five horses. In addition, one horse was found dead with no previously noted clinical signs. …”
Get full text

Left ventricular hypertrophy in young hypertensives: the possible crosstalk of mTOR and angiotensin-II -a case-control study by Busayo Onafowoke Oguntola, Stephen Olawale Oguntola, Opeyemi Ezekiel Ojo, Pauleen Ayomide Ukpabio, Adams Olalekan Omoaghe, Kehinde Samuel Olaniyi

“…Conclusions The results suggest an interaction between mTOR and Ang II in the development of LVH. In addition, it shows that LVH is associated with dyslipidemia, inflammation, and fibrosis.…”
Get full text

Research on path planning for coal mine rescue robots by ZHU Hongbo, YIN Hongliang

“…Next, a correction factor is incorporated into the cost function of the Bidirectional A* algorithm to ensure that the forward and backward search paths intersect, preventing them from diverging. Additionally, a dynamic weighting factor is added to the estimated cost function to eliminate irrelevant expanded nodes during pathfinding, thus improving search efficiency. …”
Get full text

Dietary Histidine Supplementation Maintained Amino Acid Homeostasis and Reduced Hepatic Lipid Accumulation of Juvenile Largemouth Bass, Micropterus Salmoides by Hualiang Liang, Gangchun Xu, Pao Xu, Jian Zhu, Songlin Li, Mingchun Ren

“…In addition, increased dietary histidine levels decreased the lipid content of the whole body and the liver by upregulating the mRNA levels of core genes of the PPARα signaling pathways, including PPARα, CPT1, L-FABP, and PGC1α. …”
Get full text

Developing an Evidence- and Theory-Informed Mother-Daughter mHealth Intervention Prototype Targeting Physical Activity in Preteen Girls of Low Socioeconomic Position: Multiphase Co... by Carol Brennan, Grainne ODonoghue, Alison Keogh, Ryan E Rhodes, James Matthews

“…Throughout these phases, workshops were conducted with preteen girls (n=10), mothers of preteen girls (n=9), and primary school teachers (n=6), with additional input from an academic advisory panel. …”
Get full text

Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroi... by Derk J. Slotman, Lambertus W. Bartels, Ingrid M. Nijholt, Martijn Froeling, Judith A. F. Huirne, Chrit T.W Moonen, Martijn F. Boomsma

“…Contrast in perfusion fraction maps between areas with low perfusion fraction and surrounding tissue in the target uterine fibroid immediately following MR-HIFU treatment was evaluated. Additionally, the Dice similarity coefficient (DSC) was calculated between delineated areas with low IVIM-derived perfusion fraction and hypoperfusion based on CE-T1w.Results Average perfusion fraction ranged between 0.068 and 0.083 in areas with low perfusion fraction based on visual assessment, and between 0.256 and 0.335 in surrounding tissues (all p < 0.001). …”
Get full text

FLT3 is associated with dendritic cell infiltration, tertiary lymphoid structure construction, and predict response to checkpoint inhibitors immunotherapy in solid cancers by Yongchang Tang, Hong Wang, Jiankun Zhang, Chunhui Yang, Fei Xu, Yan Song, Tianen Li, Qiangbo Zhang

“…We analyzed the frequency of FLT3 alterations, its mRNA expression levels, and its prognostic implications across multiple cancer types. Additionally, we explored genes co-expressed with FLT3 and performed gene ontology analysis to identify associated biological processes. …”
Get full text

Urban and Rural Differences in Cancer Treatment Disruption Among Patients With COVID‐19: An Analysis of the US ASCO COVID‐19 in Oncology Registry by Yu Chen Lin, Kea Turner, Oliver T. Nguyen, Emma Hume, Marlene Camacho‐Rivera, Jessica Y. Islam

“…Controlling for other factors, receiving care in a rural oncology practice was associated with cancer TDD (aPR: 1.25, 95% CI: 1.01–1.55). Differences in cancer TDD were not found across rurality of patient residence. …”
Get full text

Integrated Analysis and Validation of Ferroptosis-Related Genes Associated with Ischemia/Reperfusion Injury in Lung Transplantation by Li Q, Yin J, Lin Q, He J, Shi X, Nie H

“…MR analysis suggested that SESN2 might play a protective role against PGD. Additionally, consensus clustering revealed distinct immune infiltration patterns across subtypes, providing insights for personalized therapeutic approaches to lung ischemia/reperfusion injury (LIRI).Conclusion: This study highlights TNFAIP3, CXCL2, NEDD4L, and SESN2 as candidate genes associated with ferroptosis during LIRI, with SESN2 potentially protecting against PGD. …”
Get full text

Temporal and Spatial Characteristics and Influencing Factors of Carbon Storage in Black Soil Area Under Topographic Gradient by Zhaoxue Gai, Wenlu Zheng, Bonoua Faye, Hongyan Wang, Guoming Du

“…Carbon storage was dominant at elevation I (range is 0–200 m), slope I (range is 0–2°), and relief amplitude I (range is 0–30 m). Additionally, the carbon storage losses were severe at elevation II (range is 200–500 m), slope II (2–6°), and relief amplitude II (30–70 m). …”
Get full text

A descriptive analysis of a medical humanitarian aid initiative for quality perinatal management in war-torn Ukraine by Iryna Mogilevkina, Dmytro Dobryanskyy, Rhona MacDonald, Diane Watson, David Southall

“…After informed consent, mothers (n = 13735) who agreed to use in labour fetal self-monitoring in addition to standard intrapartum fetal health surveillance, monitored and recorded fetal heart rate changes on a “contraction-by-contraction” basis into a special form. …”
Get full text

Accommodative Exercises to Lower Intraocular Pressure by Thomas J. Stokkermans, Jeremy C. Reitinger, George Tye, Chiu-Yen Kao, Sangeetha Ragupathy, Huachun A. Wang, Carol B. Toris

“…Three different tests were performed in random order: (1) 10 minutes of nonaccommodation (gazing at the target through lenses that allowed clear vision without accommodating), (2) 10 minutes of accommodation (addition of a minus 3 diopter lens), and (3) 10 minutes of alternating between accommodation and nonaccommodation (1-minute intervals). …”
Get full text

Study on hsa_circ_101209 in Plasma of Pregnant Women with Deep Venous Thrombosis by Zhang Y, Li J

Get full text