Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial by Judith Bellapart, Vinesh Appadurai, Melissa Lassig-Smith, Janine Stuart, Christopher Zappala, Rob Boots

“…High levels of plasma melatonin during the overnight period of intensive care cohort patients did not improve sleep nor decreased the prevalence of delirium. …”
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Effects of Dietary Protein-to-Energy Ratios on Growth, Immune Response, Antioxidative Capacity, Liver and Intestinal Histology, and Growth-Related Gene Expression in Hybrid Yellow... by Sehrish Taj, Quan Han, Xiaoyi Wu, Haoran Yin, Lixia Tian, Huijun Yang, Yongjian Liu, Junwa Huang

“…Additionally, an optimum P/E ratio improved intestinal morphology. …”
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The association of BMI and subclinical myocardial dysfunction in breast cancer patients after single or dual anti-HER2 targeted therapy by Feng Zhang, Siyuan Wang, Chao Yu, Wenying Jin, Dan He, Xiaoxiao Hu, Shu Wang, Tiangang Zhu

“…Increased BMI (OR 2.683; 95% CI 1.225–5.879) was a risk factor of subclinical cardiotoxicity in dual anti-HER2 targeted therapy group. In addition, the patients with BMI ≥ 25 were more prone to have subclinical myocardial dysfunction in dual anti-HER2 therapy group compared with those with BMI ≥ 25 in single anti-HER2 therapy group. …”
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Conventional endotracheal tubes versus polymer-coated tubes in ventilator-associated pneumonia development: A systematic review and meta-analysis by Oscar Inácio de Mendonça Bisneto, Luanna Paula Garcez de Carvalho Feitoza, Larissa Calixto Hespanhol, Sávio Benvindo Ferreira, Caroline Serafim Dagostin, Roberto Augusto Mazetto Silva Vieira, Lucas Alencar Queiroz, Lucas Chen, Taniela Marli Bes, Ho Yeh Li

“…The statistical data indicated that coated endotracheal tubes perform better in preventing pneumonia than conventional tubes (RR 0.57 Cl 95 % 0.45–0.90; p < 0.001; I2 0 %). Additionally, conventional tubes were also associated with higher bacterial colonization (47.02 CI 95 % 26.88–68.18; p < 0.01; I2 81 %) compared to coated tubes. …”
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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model by Patricia Ramos-Ramírez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petrén, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner

“…Hematoxylin and eosin, Picro-Sirius Red, and Periodic Acid-Schiff staining were performed to evaluate airway inflammation, collagen deposition, and mucus-producing cells. In addition, Astra blue and immunostaining against tryptase and chymase were used to visualize mast cells. …”
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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson&rsquo;s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

“…Subsequently, the expression of hub genes was validated using additional TBI- and PD-related GEO datasets and the Comparative Toxicogenomics Database (CTD). …”
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Assessment of Traffic-Related Ambient Air Particulate Matter (PM) Levels in Douala, Cameroon by Yannick Cédric Ngangmo, Cyrille Adiang Mezoue, Cyrille Meukaleuni, Brice B. S. Wandjie, David Monkam

“…The concentration measured values of the pollutants are three times for PM2.5 and four times for PM10 above the recent WHO limits for daily exposure. In addition, it provides essential information on the pollution in Douala, which can be a major source of illness in the city and must be addressed.…”
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Fluid volume status detection model for patients with heart failure based on machine learning methods by Haozhe Huang, Jing Guan, Chao Feng, Jinping Feng, Ying Ao, Chen Lu

“…Data from 186 heart failure patients collected between January 2022 and July 2022 were employed as an external validation set to investigate the effects of model training. SHapley Additive exPlanations (SHAP) were used to interpret the ML models Results: Thirty features were selected for model development, and the area under the ROC curve AUC (95 % CI) for the four machine learning models in the testing set was 0.75 (0.73–0.77), 0.77 (0.74–0.79), 0.70 (0.67–0.73), and 0.76 (0.73–0.78), and the AUC (95 % CI) in the external validation set was 0.74 (0.71–0.76), 0.70 (0.67–0.73), 0.64 (0.59–0.68), and 0.67 (0.63–0.71). …”
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Development and validation of an explainable machine learning prediction model of hemorrhagic transformation after intravenous thrombolysis in stroke by Yanan Lin, Yan Li, Yayin Luo, Jie Han

“…The models' explainability was assessed using SHapley Additive exPlanations (SHAP) global feature plot, SHAP Summary Plot, and Partial Dependence Plot.ResultsA total of 1,007 patients were included in the original modeling cohort, with an HT incidence of 8.94%. …”
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Informing climate-smart agriculture in low resource settings for practitioners: A review and analysis of interactive tools [version 1; peer review: 1 approved, 2 approved with rese... by Kirsten Franzen, Daniel Lapidus, Tyler Ovington, Caleb Milliken, Jenny Frankel-Reed

“…This review can help users understand how these tools can be useful and the types of additional context-specific and local information that should be sought.…”
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Assessment of Antimicrobial Use for Companion Animals in South Korea: Developing Defined Daily Doses and Investigating Veterinarians’ Perception of AMR by Sun-Min Kim, Heyong-Seok Kim, Jong-Won Kim, Kyung-Duk Min

“…To our best knowledge, this study provided DDDA for companion animals for the first time in South Korea. …”
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Enhancement of Cytomegalovirus-Specific Cytokine Production after Modulation of the Costimulation in Kidney Transplant Patients by Theresa Dornieden, Benjamin Wilde, Johannes Korth, Kai Werner, Peter A. Horn, Oliver Witzke, Monika Lindemann

“…Besides immunosuppressive treatment, additional mechanisms may reduce CMV-specific immunocompetence such as enhanced negative costimulation. …”
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Liraglutide Regulates the Kidney and Liver in Diabetic Nephropathy Rats through the miR-34a/SIRT1 Pathway by Shan Xiao, Ye Yang, Yue-Tong Liu, Jun Zhu

“…HE staining revealed that the kidney of the liraglutide-treated rats had a more regular morphology of the glomerulus and Bowman sac cavity and lighter tubular edema. Additionally, the liraglutide-treated DN rats had a clear hepatic structure, a lower degree of steatosis, and mild inflammatory cell infiltration. …”
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Factors influencing osteoradionecrosis progression during hyperbaric oxygen therapy: A case study [version 2; peer review: 1 approved, 2 approved with reservations] by Khadija Bahrini, Chaima Zitouni, Sameh Mezri, Hedi Gharsallah, Wiem Boughzala, Mounir Haggui

“…Analysis of factors influencing ORN progression on the univariate study revealed significant associations with high blood pressure (p=0.046), larger tumor size (p=0.004), advanced tumor stages (p=0.048), mean radiation dose (p=0.002), delays between dental care and radiotherapy (p=0.045), and the location of ORN within the mandible (p=0.049). Additionally, the number of HBOT sessions significantly affected ORN evolution, with more sessions correlating with better outcomes (p=0.001). …”
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Intestinal microbiota as biomarkers for different colorectal lesions based on colorectal cancer screening participants in community by Gairui Li, Gairui Li, Dan Zhao, Binfa Ouyang, Yinggang Chen, Yashuang Zhao

“…Specifically, the 55 bacterial genera combination model exhibited superior performance in differentiating CRC from Nor (AUC 0.98; 95% CI, 0.96-1), the 25 bacterial genera combination showed superior performance in distinguishing Aade from Nor (AUC 0.95). Additionally, the 27 bacterial genera combination demonstrated superior efficacy in differentiating Nade from Nor (AUC 0.82). …”
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Gender Disparities in Medical and Dental Admissions: Students' Perspectives on Barriers by Nabiha Farasat Khan, Muhammad Ilyas, Usama Saeed Usama, Muhammad Saeed, Muhammad Saim, Raz Muhammad

“…The themes that emerged were safety concerns, transportation issues, cultural norms and social pressures, lack of female role models, and family support. In addition, the study examined the availability and accessibility of MDCAT preparation resources, specifically for students from rural backgrounds, who reported more challenges in accessing coaching and educational materials. …”
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Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial by Francesca Colombo, Stefano Alfano, Massimo Milani

“…Clinical evaluations included lipidomic analysis, skin moisturization, and wrinkle depth analysis at baseline and after 84 days. The addition of oral melatonin supplementation to the topical regimen led to improvements in the skin’s lipid profile and moisturization levels. …”
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Detection of Invasive Species (Siam Weed) Using Drone-Based Imaging and YOLO Deep Learning Model by Deepak Gautam, Zulfadli Mawardi, Louis Elliott, David Loewensteiner, Timothy Whiteside, Simon Brooks

“…A reliable detection model was found to be sufficiently trained with approximately 1000 image tiles, with additional images offering marginal improvement. Increased model complexity did not notably enhance model performance, indicating that a smaller model was adequate. …”
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Causal relationships between air pollution and common autoimmune diseases: a two-sample Mendelian randomization study by Ming Zhang, Yidian Wang, Shouye Hu, Yue Wu

“…Random-effects inverse variance weighted (IVW) is used as the primary method to assess causal relationships, with results reported in terms of odds ratios (OR). In addition, we used a two-step MR to assess the mediating role of common risk factors for ADs in the effects of air pollution on ADs. …”
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Pre- and Post-Operative Pain Intensity and Physical Activity Levels in Individuals with Acetabular Dysplasia Undergoing Periacetabular Osteotomy: A Prospective Cohort Study by Naif Alrashdi, Robert Motl, Elroy Aguiar, Donald Lein Jr, Suzanne Perumean-Chaney, Michael Ryan, Matthew Ithurburn

“…However, PA levels at six months following PAO did not differ from pre-PAO PA levels (*p*\>0.05). …”
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