Biomarker Investigation Using Multiple Brain Measures from MRI Through Explainable Artificial Intelligence in Alzheimer’s Disease Classification by Davide Coluzzi, Valentina Bordin, Massimo W. Rivolta, Igor Fortel, Liang Zhan, Alex Leow, Giuseppe Baselli

“…Statistical tests (<i>p</i> < 0.05) and ranking of the 15% most relevant parcels revealed the involvement of target areas: the medial temporal lobe for ResNet18 and the default mode network for BC-GCN-SE. Additionally, our findings suggest that different imaging modalities provide complementary information to DL models. …”
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Speed of urban public transport as criterion of the justification of spatial and time-based prioritization by Yurii Yevchuk

“…Given that it is difficult to find additional capacity reserves, space and time have to be taken away from those users of the transport network who use private automobile transport to ensure priority for urban public transport. …”
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Long-Term Dietary Nitrate Supplementation Does Not Prevent Development of the Metabolic Syndrome in Mice Fed a High-Fat Diet by V. B. Matthews, R. Hollingshead, H. Koch, K. D. Croft, N. C. Ward

“…Dietary nitrate, through the nitrate-nitrite-NO pathway, may provide an alternate source of NO when the endogenous eNOS system is compromised. In addition to a role in the vascular system, NO may also play a role in the metabolic syndrome including obesity and glucose tolerance. …”
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Green synthesis and enhanced photocatalytic performance of Co-Doped CuO nanoparticles for efficient degradation of synthetic dyes and water splitting by Daniel Masekela, Lovedonia K. Kganyakgo, Kwena D. Modibane, Tunde L. Yusuf, Sheriff A. Balogun, Wilson M. Seleka, Edwin Makhado

“…The developed Co-doped CuO photocatalyst was highly stable even after 5th cycle. Additionally, the results demonstrated that the Co-doped CuO nanocomposite displayed a significantly higher water-splitting activity. …”
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Comparative Analysis of Tenogenic Gene Expression in Tenocyte-Derived Induced Pluripotent Stem Cells and Bone Marrow-Derived Mesenchymal Stem Cells in Response to Biochemical and B... by Feikun Yang, Dean W. Richardson

“…Moreover, mechanical stretch increased SCX, EGR1, DCN, ELN, and TNC in BMSCs and SCX, MKX, EGR1, COL1A2, DCN, FMOD, and TNC in teno-iPSCs; TGF-β3 tended to further elevate SCX, ELN, and TNC in BMSCs and SCX, MKX, COL1A2, DCN, and TNC in teno-iPSCs, while BMP12 further uptrended the expression of SCX and DCN in BMSCs and DCN in teno-iPSCs. Additionally, the aforementioned tenogenic inducers also affected the expression of signaling regulators SMAD7, ETV4, and SIRT1 in BMSCs and teno-iPSCs. …”
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Greener and rapid magnetic solid phase microextraction method using Fe3O4@Al2O3/AC for chromatographic determination of neonicotinoid pesticides in vegetable oils by Musiiwa V. Sengane, Masixole Sihlahla, Philiswa N. Nomngongo, Nomvano Mketo

“…The proposed Fe3O4@Al2O3/AC method showed high accuracy (80–119.21%) and precision (≤10 %) for all the investigated NEOs. Additionally, the obtained limit of detection (LOD) ranged from 0.5–1.76 ng µL-1, the limit of quantification (LOQ) ranged from 1.87–6.62 ng µL-1 and satisfactory high preconcentration factors (73.02- 407.0) were comparable with literature reported studies. …”
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Measurement properties of the Traumatic Brain Injury Quality of Life (TBI-QoL) and Spinal Cord Injury Quality of Life (SCI-QoL) measurement systems: a systematic review by Rebecca Ataman, Rehab Alhasani, Line Auneau-Enjalbert, Adria Quigley, Henry Ukachukwu Michael, Sara Ahmed

“…Besides the cognition domains of TBI-QoL, which have indeterminate evidence for measurement error and sufficient evidence for responsiveness (GRADE: high), there is no additional evidence available for these measurement properties. …”
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Chemical Characterization of Marine Aerosols in a South Mediterranean Coastal Area Located in Bou Ismaïl, Algeria by Sidali Khedidji, Konrad Müller, Lyes Rabhi, Gerald Spindler, Khanneh Wadinga Fomba, Dominik van Pinxteren, Noureddine Yassaa, Hartmut Herrmann

“…A source analysis of total contents organic compounds (PAHs, alkanes, hopanes, and alkanones) and individual inorganic compounds by spearman rank correlation illustrated that the principal sources consisted of sea salt, secondary aerosol, and biomass burning. Additionally, PM10 constituent diagnostic ratios and the carbon preference index (CPI) for n-alkanes indicated the importance of anthropogenic emissions.…”
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Treating chronic kidney disease in Danish primary care: results from the observational ATLAS study by Morten Lindhardt, Søren Tang Knudsen, Thomas Saxild, Morten Charles, Rikke Borg

“…Abstract Objectives To describe the clinical characteristics, comorbidity, and medical treatment in a primary care population with chronic kidney disease (CKD). Additionally, to investigate how primary care physicians (PCPs) diagnose, manage and treat impaired kidney function, including uptake of cardio-renoprotective renin–angiotensin–aldosterone system inhibitors (RAASis) and sodium glucose co-transporter 2 inhibitors (SGLT2is). …”
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Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs by Alana C. Costa, Arquimedes Gasparotto, Jr., Alana A.K. Garcia, Cícero A.C. Pereira, Emerson L.B. Lourenço, Helena P.G. Joaquim

“…Prolonged administration of 6 months in rats and 9 months in rabbits did not lead to significant changes in organ histopathology, body weight, or behavior. …”
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Analysis of medical services provided to patients with ankle sprains in Korea between 2015 and 2017: a cross-sectional study of the health insurance review and assessment service n... by In-Hyuk Ha, Boyoung Jung, Jiyoon Yeo, Dongwoo Nam, Ho-sun Ryu, Jae-Hong Kim

“…Most patients used one institution, rather than alternating between WM and KM.Conclusions By identifying the trends and costs of treatment methods used for ankle sprains and comparing WM and KM, our data provide basic information for future health policy-making. In addition, the duality of the Korean medical system is highlighted as a possible cause of increased costs.…”
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A network meta-analysis comparing treatment modalities of short and long implants in the posterior maxilla with insufficient bone height by Yixuan Zhang, Xiaoyue Tang, Yue Zhang, Can Cao

“…Long implants have lower failure rates (OR = 1.26; 95% CI = 0.53, 3.00) and short dental implants showed a trend towards lower biological (OR = 0.47; 95% CI = 0.19, 1.18) and mechanical (OR = 0.94; 95% CI = 0.45, 1.94) complications rates, although this trend was not statistically significant. Additionally, compared to longer implants, short implants resulted in a significant reduction in marginal bone loss, regardless of whether long implants were immediately (MD=-0.17; 95%CI: -0.29, -0.05) or delayed (MD = 0.35; 95%CI: 0.05, 0.64) placed following sinus floor elevation. …”
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Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet by Qinqin Yang, Yanyun Xu, Liye Shen, Yongming Pan, Junjie Huang, Quanxin Ma, Chen Yu, Jiaojiao Chen, Yu Chen, Minli Chen

“…The results have suggested that GXNT could regulate dyslipidemia, improve heart function, and inhibit the levels of ox-LDL, CRP, TNF-α, IL-1β, SOD, MDA, vWF, and ET-1, as well as platelet aggregation. Additionally, histopathological findings revealed that GXNT could reduce lipid deposition, alleviate AS lesions, and restrain the expressions of NF-κB, TNF-α, and MMP-9. …”
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Tyrosine hydroxylase of the brain and it’s regulation by glucocorticoids by E. V. Sukhareva, T. S. Kalinina, V. V. Bulygina, N. N. Dygalo

“…Protein – protein interactions between hormone-activated GR and other transcription factors, for example, AP-1, provide an additional mechanism for the effects of glucocorticoids on gene expression. …”
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The association of activity patterns on female reproductive diseases: a prospective cohort study of UK biobank by Huanyu Guo, Yingzi Sun, Wei Gao, Yuqing Liu, Tianshu Han, Dandan Zhang

“…Conclusions Compared with midday-afternoon group, morning and mixed MVPA timing groups, but not evening group, were associated with decreased risks for female reproductive diseases and PCOS. In addition, we found that women with mixed MVPA timing exercise had a lower risk of HMB, compared with the reference group.…”
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The preoperative neutrophil‐to‐lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving r... by Zhi Cao, Jin Ji, Chao Zhang, Fubo Wang, Huan Xu, Yongwei Yu, Yinghao Sun

“…When we dichotomized the NLR value into the high‐NLR group (NLR ≥ 2) and low‐NLR group (NLR < 2), we found that the patients in the high‐NLR group had more prostate capsule invasion (P = 0.047). Additionally, no significant correlation was found between the NLR and infiltrating CD3+ cells, the CD4/CD8 ratio, AR, ERG, PTEN, p‐AKT, Bcl‐2, Beclin‐1, Ki‐67, IFN‐γ or TNF‐α (P > 0.05). …”
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Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…Otherwise, we utilized the inverse variance weighted (IVW) method as the main analytical approach. Additionally, we conducted various sensitivity analyses and statistical tests to further illustrate the robustness of the observed associations. …”
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High-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer in vitro and in vivo models by Hak Su Kim, Seung-hyun Kwon, Ok Kyung Choi, Taekyu Lim, Taekyu Lim

“…To investigate the molecular mechanism, tumor tissues from mice were analyzed by comprehensive proteomic profiling using nano-LC-ESI-MS/MS.ResultsPretreatment with a high dose of AA led to enhanced the sensitivity to the cytotoxicity of CD8+ T cells derived from healthy donor for H460 cells. Additionally, the combination of anti-PD1 and high-dose AA significantly increased CD8+ T cell cytotoxicity in H460 cells. …”
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DNA barcoding of terrestrial invasive plant species in Southwest Michigan by Sneha Nath, Joshua T. VanSlambrouck, Janelle W. Yao, Ashika Gullapalli, Fayyaz Razi, Yan Lu

“…Further increases in the number of DNA barcode regions show little or no additional increases in the species discrimination rate, suggesting that dual‐barcode approaches (e.g., ITS + trnH‐psbA) might be the efficient and cost‐effective method in DNA‐based TIPS identification. …”
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The book graphics of Vilnius printing houses in XVI-XVII centuries by Jolita Liškevičienė

“…The first books published in Vilnius had no uniform style because the printer was responsible for the appearance of a book in addition to other duties. Besides two inherited traditions of book illustration (the Eastern one that used two-colored printing inherited from Russian manuscripts; the Western one coming from German book decoration), a third, new and modern decoration with emblems emerged during the first period. …”
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