Oxypeucedanin hydrate alleviates rheumatoid arthritis by inhibiting the TLR4-MD2/NF-κB/MAPK signaling axis by Liu Mengdan, Huo Xueyan, Li Congcong, Hu Yunjie, Lei Haoran, Wang Dong, Zhu Lin, Gu Yucheng, Guo Dale, Huang Lijun, Deng Yun

“…OXH effectively ameliorates the symptoms of CIA, including improving body weight, reducing swelling and redness, increasing talus volume, and decreasing bone erosion. …”
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Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4/JNK/ERK/NF-κB Pathway by Yu Long, Yan Xiang, Songyu Liu, Yulu Zhang, Jinyan Wan, Qiyue Yang, Mingquan Cui, Zhimin Ci, Nan Li, Wei Peng

“…Pharmacodynamics studies showed that BA-LP had a better effect than the BA group at the same dosage on reducing the W/D ratio, alleviating the lung injury score, and decreasing the proinflammatory factors (TNF-α, IL-1β) and total proteins in bronchoalveolar lavage fluids (BALF). In addition, the therapeutic effects of BA-LP showed a dose-dependent manner. …”
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A survey of team culture and learning organization in the resuscitation of neonates with congenital anomalies: A single center experience by Anna Bostwick, Anne Ades, Carolina Rodriguez-Paras, Madeline Dombroski, Charis Lim, Maria Ordoñez Paredes, Lauren Heimall, Leane Soorikian, Sara C. Handley, Heidi M. Herrick

“…Methods: We administered the Short-Form Learning Organization Survey with the addition of an open-ended question to all delivery room resuscitation team members from 5/2023 to 7/2023. …”
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Characteristics of Chemical Composition and Particle Size Distribution from Real Coal-fired Circulating Fluidised Bed (CFB) Boiler by Xin Du, Jianhui Wu, Yingze Tian, Yufen Zhang, Baoshuang Liu, Yinchang Feng

“…Furthermore, the size distribution of chemical species was influenced by the pollution control device employed, and the same chemical species showed a marked difference among coal-fired boiler equipped with different pollution control devices. In addition, it was observed that the ratio of OC to EC was related to dust-cleaning method.…”
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Mitral Valve Repair in Pediatric Patients with Dilated Cardiomyopathy and Mitral Insufficiency: Single-Center Experience and Results by Mustafa Yılmaz, Başak Soran Türkcan, Ata Niyazi Ecevit, İbrahim Ece, Hazım Alper Gürsu, Atakan Atalay

“…Wooler annuloplasty and posterior valve pericardial patch augmentation were applied as the primary approach in all patients. The patients did not develop additional morbidities, and no mortality was observed during hospitalization. …”
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Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen by Mark Hutchinson, Jeffrey A. Ruffolo, Nantaporn Haskins, Michael Iannotti, Giuliana Vozza, Tony Pham, Nurjahan Mehzabeen, Harini Shandilya, Keith Rickert, Rebecca Croasdale-Wood, Melissa Damschroder, Ying Fu, Andrew Dippel, Jeffrey J. Gray, Gilad Kaplan

“…The 200 variants were produced through a robust high-throughput method and tested for thermal and colloidal stability (Tonset, Tm, Tagg), affinity (KD) relative to the parental antibody, and for developability parameters (nonspecific binding, aggregation propensity, self-association). …”
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Comparative genomics analyses of Actinobacteriota identify Golgi phosphoprotein 3 (GPP34) as a widespread ancient protein family associated with sponge symbiosis by Cláudia Ferreira, Ilia Burgsdorf, Tzipora Perez, Gustavo Ramírez, Maya Lalzar, Dorothée Huchon, Laura Steindler

“…Analyses of a broader set of microbes showed that members of the GPP34 family are also found in sponge symbionts across 16 additional bacterial phyla. While GPP34 proteins were thought to be restricted to eukaryotes, our phylogenetic analysis shows that the GPP34 domain is found in all three domains of life, suggesting its ancient origin. …”
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Bacteriocin-Producing Staphylococci and Mammaliicocci Strains for Agro-Food and Public Health Applications with Relevance of Micrococcin P1 by Rosa Fernández-Fernández, Carmen Lozano, Allelen Campaña-Burguet, Carmen González-Azcona, Tamara Álvarez-Gómez, Rocío Fernández-Pérez, Raquel Peña, Myriam Zarazaga, Jaime Carrasco, Carmen Torres

“…These indicators (excluding Gram-negative strains) were grouped into seven categories based on their potential application areas: dairy livestock mastitis, avian pathogen zoonoses, swine zoonoses, food safety, aquaculture, wine making, and mushroom cultivation. In addition, cross-immunity assays between the BP-S/M strains were carried out to identify potential strain combinations to enhance their activity against pathogens. …”
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Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

“…BackgroundDiabetic kidney disease (DKD) is the leading risk factor for end-stage renal disease (ESRD). …”
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Successful Multimodal Management of an Aggressive Functional Gonadotropic Pituitary Macroadenoma by Jeffrey J. Feng, MS, Sophie M. Cannon, MD, Stephanie K. Cheok, MD, Mark S. Shiroishi, MD, Kyle M. Hurth, MD, PhD, Anna J. Mathew, MD, Gabriel Zada, MD, John D. Carmichael, MD

“…Conclusion: FGAs are rare, and those of similar size and extent of invasion as in our case are even more so. In addition to surgical resection, consideration of adjunct therapies including radiation and multidisciplinary physician involvement are vital in achieving clinical improvement and remission while preventing possible progression and recurrence.…”
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Transcriptome analysis of 3D4/21 cells expressing CSFV NS4B by Wang Dong, Huifang Lv, Yuzhen Song, Yujin Lv, Xiapeng Xu, Huiyuan Jing, Zhifeng Peng, Xinghui Song, Yongbin Guo

“…The expression of endocytosis-related genes, including CAV1/2, CAVIN2, Rab1B, CHMP2B/4C, VPS35, SNX2, Rab11B, CHMP6, MVB12B and VPS28, were found to be regulated. In addition, some genes associated with host immune defense, such as USP15, DHX29, DDX3, RIG-I and MDA5, were downregulated and the genes associated with host autophagy, such as WIPI2, ATG16L2, SMCR8, RPTOR and MLST8, were upregulated. …”
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Qualitative study of antibiotic prescription patterns and associated drivers in Sudan, Guinea-Bissau, Central African Republic and Democratic Republic of Congo by Mohit Nair, Carolina Jimenez, Tonka Eibs, Alena Koscalova, Paul Grohma, Gisa Kohler, Rawa Gafar Bakhit, Mzia Thurashvili, Estrella Lasry, Sandra Wagner Bauer

“…Patient demands influenced prescription decisions, and self-medication was commonly reported in the context of failing health systems. Additionally, there was a strong demand for quick cures and communities preferred injections over pills. …”
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An initial exploration of core collection construction and DNA fingerprinting in Elymus sibiricus L. using SNP markers by Xinrui Li, Xinrui Li, Xinrui Li, Daping Song, Mingfeng Li, Daxu Li, Minghong You, Yan Peng, Jiajun Yan, Shiqie Bai

“…Genetic diversity assessments, allele evaluations, and principal component analyses of the 36 core germplasm samples all indicate that these 36 samples accurately and comprehensively represent the genetic diversity of all 90 E. sibiricus germplasm accessions. Additionally, we identified 290 SNP loci from among the high-quality SNP loci generated by whole-genome sequencing of the 90 E. sibiricus samples as candidate markers. …”
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Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion by Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue

“…Malignant pleural effusion (MPE) from humans and mouse was used to investigate the potential mechanisms by which lactate regulates TNFR2 expression.Results Treg cells with high TNFR2 expression exhibited elevated levels of immune checkpoint molecules. Additionally, the high expression of TNFR2 on Treg cells was positively correlated with a poor prognosis in MPE patients. …”
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Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis in vitro and in vivo by Xuezhen Li, Han Huang, Yanan Li, Yi Feng, Jinxuan Wang, Shuping Luo, Yaping Chen, Yuqin Zhang, Guohong Yan, Lihong Nan

“…Microglial cells were activated with LPS, and primary neuronal cells were exposed to LPS-activated microglia to simulate neuroinflammation. Additionally, we investigated the effects of GLGZG in combination with N-[N-[3,5-difluorophenacetyl]-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) or siRNA-Notch1 to further elucidate the involvement of the Notch signaling pathway.ResultsGLGZG significantly inhibited microglia activation and reduced neuroinflammation by de-creasing the levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in both in vitro and in vivo models. …”
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Association of self-reported dental caries with sex, lifestyle, and problematic Internet use among elementary school children in Japan by Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse, Yukiko Yanai

“…Conclusion Being a girl, having an undesirable lifestyle, and PIU were significantly associated with multiple self-reported caries. In addition to a having a healthy lifestyle, restricting PIU is recommended to prevent caries in children.…”
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Ethical issues in the development and implementation of nutrition-related public health policies and interventions: A scoping review. by Thierry Hurlimann, Juan Pablo Peña-Rosas, Abha Saxena, Gerardo Zamora, Béatrice Godard

“…The results illustrate the various natures, types, and scopes of existing public health nutrition-related interventions, and the various ethical issues that may be raised by these interventions, in addition to the numerous and different contexts in which they may be implemented.…”
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Toxicity of standing milkvetch infected with Alternaria gansuense in white mice by Bo Yang, Zhi Biao Nan, Yan Zhong Li

“…There was a significantly higher percentage of liver weight to body weight of the mice fed DPF (p < 0.05) than those fed HPF for 3 weeks and those fed CMF for 3 and 6 weeks. …”
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Computational Modeling and Experimental Investigation of CO₂-Hydrocarbon System Within Cross-Scale Porous Media by Feiyu Chen, Linghui Sun, Bowen Li, Xiuxiu Pan, Boyu Jiang, Xu Huo, Zhirong Zhang, Chun Feng

“…Unlike conventional Gibbs free energy-based models, this approach effectively accounts for confinement-induced deviations in phase equilibrium, ensuring improved predictive accuracy for nanoscale reservoirs. Additionally, adsorption effects in micro- and nano-scale pores are explicitly integrated to enhance model reliability. …”
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Internal validation of self-reported case numbers in hospital quality reports: preparing secondary data for health services research by Limei Ji, Max Geraedts, Werner de Cruppé

“…For future practice, we recommend a validation process when using GHQR as a data source for MCR-related research. Additionally, an adapted plausibility control could help to improve the quality of MCR documentation.…”
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