Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition by Zhi-Hui Zhang, Hai-Xin Yan, Ming-Dong Liu, Feng-Wen Niu, Kai Yao, Shi-Yao Feng, Xi Li, Yuan-Hua Chen, Dong-Dong Xie

“…Wound healing and Transwell assays showed that chronic NaAsO2 exposure promoted migration and invasion of DU145 and PC-3 cells. In addition, chronic NaAsO2 exposure induced epithelial-mesenchymal transition (EMT) of DU145 cells by promoting β-catenin/TCF4 transcriptional activity. …”
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Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma by Junchen Liu, Junchen Liu, Kun Dai, Kun Dai, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan

“…Mechanistically, VPA upregulated NKG2D ligands expression via the PI3K/Akt signaling pathway. Additionally, VPA treatment augmented the antitumor activity of NKG2D CAR-T cells in a glioblastoma xenograft model in vivo. …”
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Effect of regular thicknesses on the microstructural and quantitative analysis for a hypo-eutectic ductile iron alloyed with Ni and V by Colin-García E., Sánchez-Alvarado R.G., Cruz-Ramírez A., Suarez-Rosales M.A., Portuguez-Pardo L., Jiménez-Lugos J.C.

“…The low content of vanadium added to the ductile cast iron had a negligible effect on the solidification pattern, which was mainly due to the graphitizing impact of the nickel and silicon addition. The results of the microstructural characteristics are therefore primarily due to the cooling rate, which is determined by the casting thickness. …”
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A lesson for post-COVID healthcare: assessment of physical and psychosocial risk factors on perceived pain intensity among urban individuals by Hung Chak Ho, Hung Chak Ho, Wentao Bai, Stanley Sau-Ching Wong, Chi Wai Cheung, Chi Wai Cheung

“…Respiratory disease, cardiovascular disease, and low education (secondary school or below) were additional risk factors.ConclusionIt is necessary to develop up-to-date interventions targeting vulnerable populations, particularly individuals with known psychiatric diseases and insomnia, for pain reduction.…”
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Clinical findings of acute necrotizing esophagitis complicated by diabetic ketoacidosis by Yuichiro Iwamoto, Tomohiko Kimura, Takashi Itoh, Shigehito Mori, Taku Sasaki, Mana Ohnishi, Haruka Takenouchi, Hideyuki Iwamoto, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…Notably, ethanol intake was significantly higher in the ANE group (44.4 ± 25.4 g/day) compared to the non-ANE group (6.8 ± 14.0 g/day; p = 0.013). Additionally, sodium-glucose transport protein 2 inhibitor use was significantly more prevalent in the ANE group (p = 0.013). …”
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Description of a new Ornithodoros (Pavlovskyella) (Ixodida: Argasidae) tick species from Pakistan by Abid Ali, Mehran Khan, Muhammad Numan, Abdulaziz Alouffi, Mashal M. Almutairi, Ronel Pienaar, Minique H. de Castro, Lidia Chitimia-Dobler, Sebastián Muñoz-Leal, Ben J. Mans, Ala Tabor

“…., which were collected from animal shelters in Khyber Pakhtunkhwa, Pakistan. Providing additional collections from that same locality and a comprehensive analysis involving detailed morphological and mitogenome-based comparisons with closely related species, this study formally designates a novel species for these specimens. …”
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Tamarind (<i>Tamarindus indica</i> L.) Components as a Sustainable Replacement for Pork Meat in Frankfurter Sausages by Rafael Sepúlveda F. Trevisan Passos, Camila Cristina A. de Sousa, Mauricio C. A. da Silva, Ana M. Herrero, Claudia Ruiz-Capillas, Carlos Pasqualin Cavalheiro

“…In terms of mineral composition, CT5 showed the highest (<i>p</i> < 0.05) calcium content. Additionally, ST5 and CT5 treatments demonstrated the lowest processing loss values. …”
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Development and Evaluation of a Deep Learning–Based Pulmonary Hypertension Screening Algorithm Using a Digital Stethoscope by Ling Guo, Nivedita Khobragade, Spencer Kieu, Suleman Ilyas, Preston N. Nicely, Emmanuel K. Asiedu, Fabio V. Lima, Caroline Currie, Emileigh Lastowski, Gaurav Choudhary

“…Each 15‐second PCG, recorded using a digital stethoscope, was processed to generate 5‐second mel‐spectrograms. An additional labeled data set of 196 patients was used for testing. …”
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Optimization of Flaxseed Meal Protein Extraction Process and Study of Protein Structure and Functional Properties by Tingting LUO, Jingjing LI, Haiyue HU, Yajun HE, Yuzhuo LI, Lingxuan ZHAO, Lina WANG, Chen YANG, Jianming WANG

“…In addition, the functional properties of FPI were highly dependent on pH, when the pH away from the isoelectric point of FPI (pH4), there was a significant improvement in its functional properties. …”
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Incidence and Factors Associated with Postoperative Delayed Hyponatremia after Transsphenoidal Pituitary Surgery: A Meta-Analysis and Systematic Review by Cheng-Chi Lee, Yu-Chi Wang, Yu-Tse Liu, Yin-Cheng Huang, Peng-Wei Hsu, Kuo-Chen Wei, Ko-Ting Chen, Ya-Jui Lin, Chi-Cheng Chuang

“…Among the predictors evaluated, older age was the only significant factor associated with increased delayed hyponatremia (odds ratio = 1.16, 95% CI = 1.04–1.29, P = 0.006). …”
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Conception of a mobile health application targeting early postoperative physiotherapeutic care after total knee replacement, a qualitative study by Hassan Tarek Hakam, Hassan Tarek Hakam, Hassan Tarek Hakam, Nikolai Ramadanov, Nikolai Ramadanov, Awda Garzuzi, Mikhail Salzmann, Mikhail Salzmann, Hannes Hofmann, Hannes Hofmann, Felix Muehlensiepen, Felix Muehlensiepen, Roland Becker, Roland Becker, Robert Prill, Robert Prill, Robert Prill

“…Primarily, mobile applications targeting rehabilitative care after TKR need to be tailored to the needs of the elderly population. Additionally, no unified rehabilitative physiotherapeutic (PT) program was found reflecting a discrepancy regarding what exercises are most useful. …”
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The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics by Szonja Polett Pósa, Éva Saskői, Lili Bársony, Lőrinc Pongor, Fanni Fekete, János Papp, Anikó Bozsik, Attila Patócs, Henriett Butz

“…Based on data from 1085 human breast cancer specimens, GR pathway expression correlated with migratory, extracellular matrix, and angiogenesis gene signatures. Additionally, higher expression of GR and increased GR signature were observed in fast-migrating cells compared to slow-migrating ones. …”
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Effects of non-contact electric fields on the kidneys and livers of tumour-bearing rats [version 6; peer review: 1 approved, 2 approved with reservations, 1 not approved] by Luthfi Nurhidayat, Ahmad Ghitha Fadhlurrahman, Firman Alamsyah, Warsito Purwo Taruno, Nisrina Firdausi, Subekti Evi Dwi Nugraheni, Rarastoeti Pratiwi

“…Animals were treated with 7,12-dimethylbenz[a]anthracene at a dose of 20 mg/kg body weight for mammary tumour induction. Animals were then exposed to electric fields (100 kHz, 50-60 V/m) for 10 hours a day for three weeks. …”
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Ampelopsin induces MDA-MB-231 cell cycle arrest through cyclin B1-mediated PI3K/AKT/mTOR pathway in vitro and in vivo by Meng Minjun, Yang Qiaolu, Ouyang Zhong, Yang Qingmo, Wu Xinyi, Huang Yufan, Su Yonghui, Chen Shuanglong, Chen Wenlin

“…In the present work, the results showed that AMP could significantly inhibit the growth of breast cancer MDA-MB-231 cells in vitro and in vivo. In addition, treatment with AMP decreased the levels of PI3K, AKT and mTOR, as well as cyclin B1 expression, followed by p53/p21 pathway activation to arrest the cell cycle at G2/M. …”
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Psychosocial wellbeing and risk perception of older adults during COVID-19 pandemic in Nigeria: perspectives on the role of social workers by Farah Naz Rahman, Farah Naz Rahman, Anthony Obinna Iwuagwu, Christopher Ndubuisi Ngwu, Michael Ebe Kalu, Amani Kasherwa, Anika Tasnim, Mohamman Rocky Khan Chowdhury, Mamunur Rashid, Manzur Kader

“…Data were analyzed through reflexive thematic analysis.ResultsThe findings revealed that the COVID-19 restrictive measures negatively impacted the psychosocial well-being of older adults, where social isolation, lack of support, the inability to engage in wellbeing activities, and emotional trauma collectively contributed to a significant decline in their mental and emotional health. Additionally, widespread misconceptions about the origin of COVID-19 led to reluctance in adopting preventive measures. …”
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Effects of initial soil moisture on rill erodibility and critical shear stress factors in the WEPP model across diverse soil types by Fikret Ari, Selen Deviren Saygin, Cagla Temiz, Sefika Arslan, Mehmet Altay Unal, Gunay Erpul, Dennis C. Flanagan

“…Additionally, we examined the efficiency of soil cohesion obtained from an Automated Soil Cohesion Measurement Apparatus in predicting Kr and τcr across various soil textures. …”
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IFN-γ/TNF-α Synergism Induces Pro-Inflammatory Cytokine and Chemokine Production by In Vitro Canine Keratinocytes by Kyungsook Jung, Ji-Yeong Ku, Je-Seong Kwon, Gayeon Won, Hakyoung Yoon, Sang-Ik Oh, Mi Hye Kim, Chongchan Kim, Ji-Seon Yoon

“…CPEKs incubated with the IFN-γ/TNF-α mixture showed significantly increased IL-6 concentration. In addition, significantly increased concentrations of CXCL8 were detected in CPEKs incubated with TNF-α and with the IFN-γ/TNF-α mixture. …”
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How to Reduce Delayed Gastric Emptying After Pancreatoduodenectomy: A Systematic Literature Review and Meta-Analysis by Artur Rebelo, MD, Randi Kresse, Yoshiaki Sunami, PhD, Ulrich Ronellenfitsch, MD, Jörg Kleeff, MD, Johannes Klose, MD

“…Patients undergoing ppPD exhibited a higher incidence of DGE compared with those undergoing prPD (logOR, −0.95; 95% CI = −1.57 to −0.34; P = 0.002). Additionally, patients in the ERAS group showed reduced rates of DGE (logOR, −0.712; 95% CI = −1.242 to −0.183; P = 0.008). …”
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Expression of MMP-2, MMP-9 and TIMP-2 in pituitary tumors and their relationship with cavernous sinus invasion by Ane Caroline Thé B Freire, Raquel S Jallad, Rafael L Batista, Andrea Glezer, Marcio C Machado, Gilberto Ochman, Valter A Cescato, Malebranche Berardo Carneiro Cunha Neto, Fernando P Frassetto, Raphael S S de Medeiros, Ericka B Trarbach

“…Objective: To evaluate the expression of matrix metalloproteinase-2 (MMP-2), MMP-9 and tissue inhibitor of metalloproteinase-2 (TIMP-2) in pituitary tumors and investigate their correlation with circulating plasma proteins and cavernous sinus invasion. In addition, the Ki-67 index was also assessed. Methods: Seventy-four patients (37 females) with pituitary adenomas were included, with preoperative peripheral blood collected in 29 cases. …”
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Screening of Lactic Acid Bacteria Isolated from Fermented Cowpea and Optimization of Biomass Production Conditions by Hong Xu, Danyang Li, Xue Jiang, Qi Pei, Zhengqin Li, Philippe Madjirebaye, Mingyong Xie, Tao Xiong, Zhanggen Liu

“…Using these response surface plots and point predictions, the optimal factors were soy peptone (38.75 g/L), FeSO₄ (0.10 g/L), and VB₇ (20 g/L). In addition, the optimized incubation conditions were a temperature of 39 °C, an initial pH value of 7, and an inoculation volume of 3%. …”
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