Demographics and outcomes of acute type A aortic dissection in young adults in southeastern China: impact of syndromic heritable thoracic aortic disease by Xin-fan Lin, Hang-qi Gao, Qing-song Wu, Yu-ling Xie, Liang-wan Chen, Lin-feng Xie

“…The incidence of reoperation was significantly higher in the HTAD group than that in the non-HTAD group (p = .03). In addition, the late aortic reoperation remained a risk factor for long-term survival after adjusting for clinical factors.Conclusions The prevalence of HTAD is high in the cohort of younger patients with ATAAD. …”
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Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders by Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz

“…Methods and Results: We found that the increase in body weight and adiposity, glucose intolerance, insulin resistance, dyslipidemia, hyperleptinemia, and hepatic disorders which were induced by an obesogenic diet were alleviated by senolytic cocktail treatment in mice. …”
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Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia by Hang Zhang, Sheng Yang, Yi-Lin Lu, Luo-Qi Zhou, Ming-Hao Dong, Yun-Hui Chu, Xiao-Wei Pang, Lian Chen, Lu-Lu Xu, Lu-Yang Zhang, Li-Fang Zhu, Ting Xu, Wei Wang, Ke Shang, Dai-Shi Tian, Chuan Qin

“…Interestingly, we found that the sustained decrease in transiently upregulated expression of Nrf2 following chronic cerebral hypoperfusion resulted in abnormal microglial activation and white matter injury. In addition, high loads of myelin debris promoted lipid peroxidation and ferroptosis in microglia with diminished antioxidant function. …”
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Microstructural lateralization of thalamocortical connections in individuals with a history of reading difficulties by Yueye Zhao, Jianyi Liu, Xue'er Ma, Zi-Gang Huang, Jingjing Zhao

Subjects: “…Neurite orientation dispersion and density imaging (NODDI)…”
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Parishin B blocking TRIB3-AKT1 interaction inhibits breast cancer lung metastasis by Xiongtao Cheng, Xiongtao Cheng, Jianguo Sun, Shouhong Chen, Nan Wang, Weijing Tang, Zijian Xia, Yuhong Shu, Shouhong Gao, Zhipeng Wang, Xinxia Wang, Rongzi Shao, Jianxiong Cao, Jianxiong Cao

“…Finally, the effect of TRIB3 inhibitor on BC lung metastasis in vivo was evaluated.ResultsPB was screened as a possible inhibitor of TRIB3, and CETSA and CO-IP assay indicated that PB could target TRIB3 and block TRIB3-AKT1 interaction. In addition, PB exhibited good anti-BC activity without drug toxicity in normal breast cells by experiments in vitro, and RNA-seq analysis suggested PB could inhibit the proliferation and invasion of BC cells related with cell cycle. …”
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Measuring Medical Waste from Gastrointestinal Endoscopies in South Korea to Estimate Their Carbon Footprint by Da Hyun Jung, Hyun Jung Lee, Tae Joo Jeon, Young Sin Cho, Bo Ra Kang, Nae Sun Youn, Jae Myung Cha

“…Applying the mean waste estimates from this study to annual GIE procedures performed in South Korea in 2022 showed that the total medical waste produced from GIE was 13,704,453 kg. In addition, the total masses of medical waste produced during EGD and colonoscopy procedures were 819,766 kg and 2,889,478 kg, respectively. …”
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Spatiotemporal dynamics of carbon sequestration capacity and its determinants in rubber plantation ecosystems of Hainan Island by Yinghe An, Zhixiang Wu, Runqing Zhang, Xiang Zhang, Zhenghong Tan, Zhongyi Sun

“…Over the past 19 years, NEP shows a slight decreasing trend, with higher carbon sequestration during the rainy season than during the dry season. Rubber plantations in the central region primarily act as weak carbon sources, while those surrounding them predominantly function as carbon sinks (carbon sources/carbon sinks ≈ 6.74 %). …”
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In Vitro Biological Activity of Beauveria bassiana, Beauveria peruviensis, and Metarhizium sp. against Hypothenemus hampei (Coleoptera: Curculionidae) by Beimer Chuquibala-Checan, Magdiel Torres-de la Cruz, Santos Leiva, Elgar Hernandez-Diaz, Karol Rubio, Malluri Goñas, Marielita Arce-Inga, Manuel Oliva-Cruz

“…Conidia production, Conidia viability, and pathogenicity against H. hampei were evaluated at three concentrations (1 × 105, 1 × 107, and 1 × 109 conidia/mL−1). In addition, lethal times (LT50 and LT90) and lethal concentrations (LC50 and LC90) were calculated. …”
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Dysregulated T Cell Activation and Aberrant Cytokine Expression Profile in Systemic Lupus Erythematosus by Haiyan Zhou, Bojiang Li, Jing Li, Tongqian Wu, Xiaoqian Jin, Rui Yuan, Ping Shi, Yan Zhou, Long Li, Fang Yu

“…Furthermore, levels of serum IL-6, MCP-1, TNFRI, IL-10, IL-12, and CCL20 were higher in SLE patients compared with healthy controls. In addition, patients with hematologic manifestations displayed elevated frequencies of HLA-DR+ T cells and ICOS+ T cells. …”
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Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…The findings arising from the Delphi process provide valuable insights into the unmet needs in the management of moderate-to-severe ulcerative colitis from the clinician’s perspective, while emphasising the benefits of therapeutic individualization and suggesting areas that need additional study with the aim of optimising the treatment of patients with ulcerative colitis.…”
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Localized propranolol delivery from a copper-loaded hydrogel for enhancing infected burn wound healing via adrenergic β-receptor blockade by Wenzhe Sun, Hongwei Lu, Pengqin Zhang, Lian Zeng, Bing Ye, Yi Xu, Jianan Chen, Peiran Xue, Jialin Yu, Kaifang Chen, Bin Wu, Xiao Lv, Xiaodong Guo, Yanzhen Qu

“…During this process, the sympathetic nervous system releases large amounts of catecholamines, which bind to β-adrenergic receptors (β-AR) on cell membranes, negatively affecting skin regeneration. Additionally, recurrent bacterial infections make burn wounds difficult to treat, posing significant and ongoing challenges to burn care. …”
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Effects of a foot-ankle strengthening programme on clinical aspects and gait biomechanics in people with knee osteoarthritis: protocol for a randomised controlled trial by Tania F Salvini, Glauko Dantas, Isabel C N Sacco, Ana F dos Santos, Ricky Watari, Alessandra B Matias, Paula R M S Serrao, Henrique Pott-Junior

“…Data will be analysed on intention-to-treat principles and a per protocol basis.Ethics and dissemination Investigators and sponsors will communicate trial results to participants and healthcare professionals through scientific databases and social media. In addition, findings will be reported in peer-review publications, and at national and international conference presentations. …”
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Sleep as a mediator between chronic diseases and depression: a NHANES study (2005–2018) by Ming Tan, Ming Tan, Haihong Zhao, Haihong Zhao, Ruya Nie, Ruya Nie, Pingping Deng, Pingping Deng, Cuixiao Wang

“…Logistic regression, subgroup analysis, restricted cubic spline (RCS) analysis, and mediation analysis were employed to explore the relationship between common chronic diseases and depression, and the mediating role of sleep.ResultsThe adjusted model indicated that stroke (OR = 1.712, 95% CI: 1.399, 2.103), heart disease (OR = 1.419, 95% CI: 1.262, 1.598), diabetes (OR = 1.243, 95% CI: 1.116, 1.386), and hypertension (OR = 1.249, 95% CI: 1.160, 1.346) were associated with an increased probability of depression. Additionally, trouble sleeping (OR = 2.059, 95% CI: 1.790, 2.375) was associated with an increased probability of depression, while sleep hours (OR = 0.867, 95% CI: 0.846, 0.888) may decrease this probability. …”
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Development and validation of a prognostic nomogram incorporating neutrophil-to-albumin ratio for predicting overall survival in patients with nasopharyngeal carcinoma undergoing c... by Xin Hua, Meng-Di Wang, Wei-Qiong Ni, Zhi-Qing Long, Si-Fen Wang, Fang-Fang Duan, Chao Zhang, Xin Huang, Fei Xu, Wen Xia, Jia-Yi Chen, Yun-Sheng Gao

“…Conclusions: The NAR, an emergent biomarker combining nutritional and inflammatory status, offers a practical, low-cost, and non-invasive prognostic measure for NPC patients treated with CCRT. Additionally, the prognostic nomogram derived from NAR surpasses traditional staging systems in predictive accuracy.…”
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Preservation of cellular structure via immersion fixation in brain banking by Macy Garrood, Emma L. Thorn, Adam Goldstein, Allison Sowa, William Janssen, Alyssa Wilson, Claudia S. López, Raakhee Shankar, Erin S. Stempinski, Kurt Farrell, John F. Crary, Andrew T. McKenzie

“…Using light microscopy, we found that there was no significant change in the size of pericellular or perivascular rarefaction areas based on the postmortem interval (PMI) or on the progression from the outer (frontal cortex) to the inner (striatum) brain regions. Additionally, we did not identify any significant number of ghost cells – a state of late-stage cellular necrosis – in the light micrographs analyzed. …”
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Predicting prognosis using stroke-heart indicator: brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage by Jionghao Xue, Jionghao Xue, Fa Lin, Fa Lin, Minghao Liu, Minghao Liu, Wenxiong Song, Wenxiong Song, Runting Li, Runting Li, Yu Chen, Yu Chen, Jun Yang, Jun Yang, Heze Han, Heze Han, Yitong Jia, Yitong Jia, Xiaolin Chen, Xiaolin Chen, Rong Wang, Rong Wang, Yuanli Zhao

“…Univariable and multivariable logistic regression analyses were conducted to examine the association between BNP levels and prognosis. Additionally, we assessed the potential impact of incorporating BNP into a predictive model for poor prognosis.ResultsThe statistical analysis encompassed a total of 932 patients. …”
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Color Stability and Surface Properties of PMMA/ZrO2 Nanocomposite Denture Base Material after Using Denture Cleanser by Mohammed M. Gad, Reem Abualsaud, Shaimaa M. Fouda, Ahmed Rahoma, Ahmad M. Al-Thobity, Soban Q. Khan, Sultan Akhtar, Khalid S. Al-Abidi, Mohamed S. Ali, Fahad A. Al-Harbi

“…Denture cleansers can significantly result in color change and alter the surface roughness and hardness of denture base resin even with ZrO2 nanoparticles addition. Therefore, they should be carefully used.…”
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Preservation of cfRNA in cytological supernatants for cfDNA & cfRNA double detection in non‐small cell lung cancer patients by Yidan Ma, Yifei Wang, Lei He, Jun Du, Lin Li, Zhixin Bie, Yuanming Li, Xiaomao Xu, Wei Zhou, Xiaonan Wu, Li Yang, Jing Di, Chenyang Li, Xiaoguang Li, Dongge Liu, Zheng Wang

“…Abstract Backgroud Supernatants from various cytological samples, including body cavity effusion, sputum, bronchoalveolar lavage fluid (BALF), and needle aspiration, have been validated for detecting genetic alterations using cell‐free DNA (cfDNA) in patients with non‐small cell lung cancer (NSCLC). …”
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Integrated transcriptomic analysis reveals evolutionary and developmental characteristics of tendon ossification in teleost by Xu-Dong Wang, Fei-Long Shi, Jia-Jia Zhou, Zheng-Yu Xiao, Tan Tu, Xue-Mei Xiong, Chun-Hong Nie, Shi-Ming Wan, Ze-Xia Gao

“…However, in runx2b −/− zebrafish, the differentiation of myoseptal stem cell into osteoblast was inhibited, while differentiation into clec3bb + tenocyte and fibroblast was enhanced. Additionally, runx2b deficiency led to the upregulation of clec3bb expression in the clec3bb + tenocyte cluster. …”
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Acute Severe Anaphylaxis in Nepali Patients with Neurotoxic Snakebite Envenoming Treated with the VINS Polyvalent Antivenom by Sanjib Kumar Sharma, Emilie Alirol, Anup Ghimire, Suman Shrestha, Rupesh Jha, Surya B. Parajuli, Deekshya Shrestha, Surya Jyoti Shrestha, Amir Bista, David Warrell, Ulrich Kuch, Francois Chappuis, Walter Robert John Taylor

“…Later, IV adrenaline infusion (IVAI) was introduced for patients with antecedent ARA requiring additional antivenom infusions. Preantivenom subcutaneous adrenaline (SCAd) was introduced in the second study year (2012). …”
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