Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraep... by Fei Chen, Jinghe Lang, Peter Hillemanns, Youzhong Zhang, Zoltán Novák, Long Sui, Ling Han, Christian Dannecker, Ctirad Mokráš, Zhixue You

“…All patients in the Cevira group will be enrolled in an open, long-term extension study for 6 months to collect additional efficacy and safety data (study extension endpoints).Ethics and dissemination The study was approved by the ethics committee of the Peking Union Medical College Hospital and Hannover Medical University, Germany. …”
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Role of plasma metabolome in mediating the effect of plasma lipidome on NAFLD: a Mendelian randomization study by Zhuyuan Zheng, Shaojie Yang, Wanlin Dai, Yang Sun, Jingnan Wang, Xiaolin Zhang, Yiming Zheng, Jing Kong

“…A two-sample MR analysis was conducted to infer causality. Additionally, multiple sensitivity analyses were conducted to assess the heterogeneity, horizontal pleiotropy, and robustness of the MR findings. …”
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Navigating the future of agri-food supply chain: A conceptual framework using bibliometric review by Abdul Kafi, Nizamuddin bin Zainuddin, Mohd Fitri Mansor, Mohamed Najib Bin Salleh, Adam bin Mohd Saifudin, Nurhaizal Azam Arif, Syairah Aimi Shahron, Ravi Ramasamy, Ibrahim Hassan mohamud

“…Co-occurrence analysis was conducted to identify seven core research themes, namely: agri-food supply chain system; agri-food supply chain management; agri-food supply chain industry; agri-food supply chain risk factors; agri-food supply chain information; agri-food supply chain advancement; agri-food supply chain risk management; This study makes a significant contribution by constructing a comprehensive conceptual framework that logically organizes these thematic factors, aligning future research with emerging trends. Additionally, this research highlights the imperative of global collaboration across diverse regions and fields within AFSC to build more resilient supply chains capable of adapting to evolving conditions.…”
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Exploring the Impact of Citric Acid on Mitigating Sweet Potato Soft Rot and Enhancing Postharvest Quality by Yixi Chen, Linjiang Pang, Jiacheng Bai, Wenbao Yu, Yueming Zhu, Melvin Sidikie George, Zunfu Lv, Guoquan Lu

“…Citric acid (CAC) is a ubiquitous, odorless, and non-toxic food additive. Soft rot, caused by the pathogen <i>Rhizopus stolonifer</i>, is a major postharvest disease affecting sweet potato (<i>Ipomoea batatas</i> (L.) …”
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Genetic variability and heritability estimates among nutritional traits of groundnut breeding lines by Richard Adu Amoah, James Yaw Asibuo, Richard Akromah, Kwabena Asare Bediako, Maxwell Lamptey, Collins Yeboah Osei, Samuel Awuah, Richard Boampong

“…Nonetheless, high heritability accompanied by high genetic advance as percent of mean for zinc (Zn) and iron (Fe), indicated that the heritability of these traits is due to additive gene effect and selection for such traits may be effective and rewarding.…”
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The role of ferroptosis and oxidative stress in cognitive deficits among chronic schizophrenia patients: a multicenter investigation by Zhenlei Peng, Qiyu Jia, Junxiong Mao, Shijie Jiang, Qi Ma, Xiao Luo, Zhiguo An, Anqi Huang, Chuang Ma, Qizhong Yi

“…Multiple linear regression analysis revealed that decreased GSH and iron levels, along with elevated SOD levels, were significantly associated with the overall severity of psychiatric symptoms. Additionally, reduced GPX4 levels and increased ACSL4 and FE levels were significantly linked to negative symptoms and cognitive impairments. …”
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Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics by Isy Petit, Quentin Faucher, Jean-Sébastien Bernard, Perrine Giunchi, Antoine Humeau, François-Ludovic Sauvage, Pierre Marquet, Nicolas Védrenne, Florent Di Meo

“…This study provides additional evidence that OoC can help bridge the gaps between systemic and local pharmacokinetics.…”
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The lysosome-related characteristics affects the prognosis and tumor microenvironment of lung adenocarcinoma by Wuguang Chang, Wuyou Gao, Yawei Wu, Bin Luo, Lekai Zhong, Leqi Zhong, Wenqian Lin, Zhesheng Wen, Youfang Chen

“…The lysosome risk signature was constructed after univariate and least absolute shrinkage and selection operator (Lasso) cox regression analysis of the TCGA training set, and its capability was validated by additional validation sets from GEO. Single cell sequencing (scRNA) was obtained from GEO to analyze the differences of lysosome risk signature at the single-cell level and the differences in the function and pathway. …”
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Comparative evaluation of funduscopy, PCR and serology in the diagnosis of ocular toxoplasmosis at ECWA Eye Hospital, Kano by Biodun Bintu Adebakin, Mayor Orezime Atima, Ugbede Idakwo, Jamilu Abubakar Bala, Alhasan Sharif Abdullahi, Auwal Bello Muhammad, Jah Douglas Pam, Emeka John Dingwoke, Florence Olufunke Darda

“…Serological analysis was conducted using ELISA to detect anti-Toxoplasma IgG antibodies. Additionally, PCR was used to confirm the presence of T. gondii DNA in blood samples. …”
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Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice by Qi Li, Chenyi Wu, Zhenlong Liu, Huiqing Zhang, Yuna Du, Yuxiang Liu, Kuangyu Song, Qiaofa Shi, Rong Li

“…Our results showed more aggravated kidney damage in CD38−/− mice than in WT mice, accompanied with an increase of proinflammatory cytokine expression. In addition, compared with CD38−/−TLR4mut mice, we found an increase of TLR4 expression and mRNA expression of these cytokines in the kidney of CD38−/− mice, although only increased IFN-γ level was detected in the serum. …”
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Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1 by Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete

“…We determined that the observed pro-inflammatory effect was ALPK1-dependent in both HEK293 and HT-29 cells and that the released F. nucleatum molecule had characteristics that match those of the pro-inflammatory ALPK1 ligand ADP-heptose or related heptose phosphates. In addition, we determined that not only F. nucleatum promoted an ALPK1-dependent pro-inflammatory environment but also other Fusobacterium species such as F. varium, F. necrophorum and F. gonidiaformans generated similar effects, indicating that ADP-heptose or related heptose phosphate secretion is a conserved feature of the Fusobacterium genus. …”
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Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale as a Novel Tool to Measure Disease Progression by Can Sun, Yong Chen, Lu Xu, Wenjing Wang, Nan Zhang, Christina N. Fournier, Nan Li, Dongsheng Fan

“…<b>Results:</b> Multivariate Cox models confirmed that baseline ROADS positively correlated with ALS survival (HR = 0.95, <i>p</i> < 0.001), while baseline ΔROADS negatively correlated with survival (HR = 1.26, <i>p</i> < 0.001). Additionally, linear mixed effects models suggested that ROADS, similar to ALSFRS-R, declined significantly over time, but there was no significant difference between these two. …”
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Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway by Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

“…In vitro, HG treatment increased the migration of HK-2 cells while reducing their viability and proliferation rate, and treatment with Ori reversed these changes. Additionally, the knockdown of β-catenin arrested cell migration and reduced the expression levels of Wnt/β-catenin signaling-related molecules (Wnt4, p-GSK3β and β-catenin) and fibrosis-related molecules (α-smooth muscle actin, collagen I and fibronectin), and Ori treatment exerted an effect similar to that observed after the knockdown of β-catenin. …”
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Metallothionein 1B attenuates inflammation and hepatic steatosis in MASH by inhibiting the AKT/PI3K pathway by Canghai Guan, Xinlei Zou, Wujiang Shi, Jianjun Gao, Chengru Yang, Yifei Ge, Zhaoqiang Xu, Shaowu Bi, Xiangyu Zhong

“…Further experiments indicate that AKT inhibition can reverse the lipid metabolism disorders and inflammatory responses caused by MT1B downregulation. Additionally, Zinc can promote the nuclear translocation of MTF1, leading to its binding to the MT1B promoter, thereby upregulating MT1B expression and ultimately mitigating MASH progression. …”
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USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation by Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang

“…The underlying mechanism may involve the downregulation of RORγt. Additionally, during increased inflammatory responses or Th17 cell differentiation, USP25 expression is activated, forming a negative feedback regulatory loop that attenuates immune activation.…”
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Modality Specific CBAM-VGGNet Model for the Classification of Breast Histopathology Images via Transfer Learning by Areesha Ijaz, Basit Raza, Iqra Kiran, Abdul Waheed, Aadil Raza, Habib Shah, Sulaiman Aftan

“…We have implemented the VGG16 and VGG19 in a novel way following the configuration of state-of-the-art models with our own concatenated layers. The addition of the GAP layer in VGGNet has reduced the number of parameters, requiring less computational power. …”
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Host genetics and gut microbiota influence lipid metabolism and inflammation: potential implications for ALS pathophysiology in SOD1G93A mice by Elena Niccolai, Leandro Di Gloria, Maria Chiara Trolese, Paola Fabbrizio, Simone Baldi, Giulia Nannini, Cassandra Margotta, Claudia Nastasi, Matteo Ramazzotti, Gianluca Bartolucci, Caterina Bendotti, Giovanni Nardo, Amedeo Amedei

“…ALS symptom progression does not significantly alter microbiota composition, suggesting stability. Additionally, we assessed systemic immunity and inflammatory responses revealing strain-specific differences in immune cell populations and cytokine levels. …”
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Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis by José Alberto Choreño-Parra, Luis Armando Jiménez-Álvarez, Ellis Daniela Maldonado-Díaz, Graciela Cárdenas, Luis Alejandro Fernández-Lopez, José Luis Soto-Hernandez, Marcela Muñoz-Torrico, Gustavo Ramírez-Martínez, Alfredo Cruz-Lagunas, Armando Vega-López, María Lilia Domínguez-López, Carlos Sánchez-Garibay, Parménides Guadarrama-Ortíz, Silvia Giono, Luis Antonio Jiménez-Zamudio, Shabaana A. Khader, Ethel A. García-Latorre, Citlaltepetl Salinas-Lara, Joaquín Zúñiga

“…We found that NK cells from TBM patients showed lower absolute frequencies, higher CD69 expression, and poor expansion of the CD45RO+ memory-like subpopulation upon Mtb exposure in vitro compared to LTBI individuals. In addition, a reduction in the frequency of CD56brightCD16- NK cells characterized TBM patients but not LTBI or PTB subjects. …”
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Prediction of microvascular obstruction from angio-based microvascular resistance and available clinical data in percutaneous coronary intervention: an explainable machine learning... by Zhe Zhang, Yang Dai, Peng Xue, Xue Bao, Xinbo Bai, Shiyang Qiao, Yuan Gao, Xuemei Guo, Yanan Xue, Qing Dai, Biao Xu, Lina Kang

“…The ML workflow comprised feature selection using the Boruta algorithm, model construction with seven classifiers, hyperparameter optimization via ten-fold cross-validation, model comparison based on the area under the curve (AUC), and a Shapley additive explanations (SHAP) analysis to analyze the significance of different features. 32.29% of patients showed inconsistency between AMR and MVO, but we successfully constructed a predictive model for MVO. …”
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Prognostic factors of thalamic and thalamopeduncular low-grade gliomas in children: A systematic review and recommendations for surgical management by Jana Táborská, Adéla Bubeníková, Petr Skalický, Jakub Táborský, David Horváth, Michal Zápotocký, Ondřej Bradáč, Vladimír Beneš, 3rd

“…Given the excellent long-term outlook of these patients, the extent of resection should not be pursued at the risk of neurological function since additional therapeutic possibilities are available today, such as molecular-targeted agents.…”
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