Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD by Seong Mi Lee, Yura Choi, Dayeon Kim, Ha Jin Jeong, Young Ho Do, Sohee Jung, Bomee Lee, Hyung Jun Choi, Suhyeon Kim, Jung-Min Oh, Songhee Jeon, Jinju Han, Yeni Kim

“…In Clcn4 KO cortical neurons, the phosphorylation of SYNAPSIN and PSD95 expressions also decreased compared to WT, indicating disrupted synaptic function. Additionally, Sholl analysis revealed a reduction in dendritic branching and neuronal projection length in both mouse and human CLCN4 KD neurons. …”
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Gottron's carcinoid papillomatosis of the skin (сlinical case) by O.M. Biesiedin, V.M. Shkuropat, K.V. Tsygankov, P.O. Hrytsenko, S.V. Biletska

“…The lack of a clear understanding of the diagnostic and treatment algorithm creates additional difficulties in the treatment of Gottron's carcinoid papillomatosis of the skin. …”
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Investigating lightweight recycled brick aggregate concrete incorporating EPS beads: Application to masonry units by Samina Hameed, Syed Asad Ali Gillani, Muhammad Tahir, Rashid Hameed, Safeer Abbas, Moncef L. Nehdi, Muhammad Ahmad

“…The results show that despite that EPS beads addition and exposure to harsh weathering decreased the mechanical and durability properties, LRBAC specimens satisfied the ASTM C129 criteria for lightweight concrete masonry units. …”
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New insights into the effects of Aspergillus oryzae administration during the transition period in Bubalus bubalis by Sameh A. Abdelnour, Walaa M. Essawi, Nasser Ghanem, Ibrahim T. El-Ratel, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Ahmed N. F. Neamat-Allah, Shimaa A. Amer, Simon J. Davies, Ali Ali El-Raghi

“…We examined the potential effect of Aspergillus oryzae (ASG) on blood biochemistry, adaptive immunity, milk yield and composition, dry matter intake, inflammation markers, and oxidative stress in buffalo cows. …”
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Structural characterization and immunomodulatory activity of polysaccharides from the flowers of Imperata cylindrica Beauv.var. major (Nees) C.E.Hubb by Honglin He, Haijun Huang, Yunheng Yang, Yi Liu, Ailing Liang, Yao Lei, Chenghuai Tang, Ling Yao, Zhiwei Chen

“…They were characterized by FT-IR, HPGPC, and SEM, with FIC-1 undergoing additional methylation and NMR analysis. FIC-1 was a neutral polysaccharide with a molecular weight of 5.3 kDa, while FIC-2 was an acidic polysaccharide with a molecular weight of 23.3 kDa. …”
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Application of stem cells alone and in combination with low-level laser therapy for sciatic nerve repair in rats by Mohsen Shalalvand, Hamidreza Mahaseni Aghdam, Ahmad Asghari, Siamak Nehzat, Fatemeh Shahsavari, Rojin Ardalani

“…Notably, the Sciatic Functional Index (SFI) was the most favorable (lowest) in the autograft group, whereas the stem cell-only group exhibited the least favorable (highest) SFI at 5 weeks (P < 0.001). Additionally, distal latency was highest in the stem cell group and lowest in the stem cell combined with LLLT group at 5 weeks (P < 0.001). …”
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A High-Salt Diet Disturbs the Development and Function of Natural Killer Cells in Mice by Xiaokang Zeng, Yan Li, Weibiao Lv, Xinhuai Dong, Chong Zeng, Liming Zeng, Zibo Wei, Xu Lin, Yanning Ma, Qiang Xiao

“…Therefore, the purpose of the present study was to understand the effects of HSD on the development and function of NK cells, in addition to investigating the underlying molecular mechanism. …”
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Understanding the regulatory-procurement interface for medicines in Africa via publicly available information on standards, implementation, and enforcement in five countries by Jillian C. Kohler, Mariangela Castro-Arteaga, Saher Panjwani, David Mukanga, Murray M. Lumpkin, Bonface Fundafunda, Anthony B. Kapeta, Chimwemwe Chamdimba, Anna S. Y. Wong, Kristin N. Harper, Charles Preston

“…This study’s aim was to characterise the regulatory-procurement interface – the intersection of decision-making in these two spheres – using publicly available data from five African countries.Methods For the five target countries, we adapted criteria from WHO’s 2018 Pharmaceutical System Transparency and Accountability Assessment Tool to identify key national policies and practices around the nexus of medicines regulation and procurement.Results Though legal and policy frameworks enabling best practices in procurement were often in place, implementation and enforcement of these practices appear to be key areas for strengthening. In addition, we documented a lack of publicly available information related to the role that quality plays in selecting medical products. …”
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The role of SPINK5 mutation distribution in phenotypes of Netherton syndrome by Min Xu, Yujie Shi, Li Lin, Liang Wang, Xianzhong Zhu, Jinglin Xiong, Jiawen Yin, Qing Qi, Wenlin Yang

“…Logistic regression was employed to analyze the correlation between the location of these variants and phenotypes. Additionally, the association between the homozygous condition of variants and death during infancy was analyzed using the Chi-square test.ResultsAmong 162 patients, we identified 324 allele variants, comprising 75 different mutations. …”
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Cytomegalovirus infection in an immunocompetent host presenting as haemophagocytic lymphohistiocytosis by Inês Matias-Lopes, Henrique Atalaia Barbacena, Margarida Guiomar, Raquel Soares, Catarina Barão, Ana Rita Ferreira, Federica Parlato, Patrícia Howell-Monteiro

“…Primary CMV infection is unusual in older patients. Additionally, in IMCh infection is usually mild, and severe infections are rare. …”
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A non-randomised open-label exploratory ‘window of opportunity’ study of TG02 treatment in patients with locally advanced primary and recurrent RAS mutant colorectal cancer by Sara Roth, Kasmira Claire Wilson, Robert George Ramsay, Catherine Mitchell, Shienny Sampurno, Toan Duc Pham, Joseph Cherng Huei Kong, Stephen Q. Wong, Alexander Graham Heriot, Sanjeev Deva, Matthew Burge, Cecilie Sverdrup, Anne-Sophie Moller, Lukasz Kuryk, Jon Amund Eriksen, Magnus Jaderberg, John Raymond Zalcberg, Michael Michael

“…High PD-1 expression on post-treatment TILs encourages the addition of an immune checkpoint inhibitor to TG02 and potentially other studies of peptide vaccines in future studies.…”
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Increased rate of multidrug-resistant gram-negative bacterial infections in hospitalized immunocompromised pediatric patients by Sarah Khafaja, Sarah Khafaja, Yara Salameh, Celina F. Boutros, Cherine Awad, Kawthar Faour, Nadim Tfaily, Sarah Merhi, Zeinab El Zein, Zeinab El Zein, Samer Bou Karroum, Dana Oweini, Danielle Fayad, George F. Araj, George F. Araj, George F. Araj, Ramia Zakhour, Ghassan S. Dbaibo, Ghassan S. Dbaibo

“…The aim of this study was to describe the frequency of infections with multidrug resistant (MDR) Gram-negative bacteria (GNB) in immunocompromised pediatric patients and to determine the risk factors. In addition, we aimed to identify the antimicrobial resistance patterns of these isolates.Materials and methodsThis was a retrospective observational study conducted at the American University of Beirut Medical Center (AUBMC) from 2009 to 2017. …”
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Hydroxocobalamin for the treatment of vasoplegia after lung transplantation: A case series by Anh Nguyen, MD, PhD, Rima Bouajram, PharmD, Marek Brzezinski, MD, Sahand Hassanipour, David Gordon, Binh Trinh, MD, Tobias Deuse, MD, Aida Venado, MD, Steve Hays, MD, Jonathan Singer, MD, Jasleen Kukreja, MD, MPH

“…Each patient received hydroxocobalamin 5,000 mg infused over 15 minutes, with patient #3 receiving an additional 6 doses over the subsequent 4 days. At the 2-hour time-point, mean arterial pressure increased in all patients (+11%, +17%, and +13%, respectively), although cumulative vasopressor indexes were inconsistent. …”
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Dendriform pulmonary ossification in military combat veterans: A case series by Jeremy T. Hua, Carlyne D. Cool, Tami J. Bang, Silpa D. Krefft, Richard C. Kraus, Cecile S. Rose

“…A high index of clinical suspicion combined with a detailed occupational history may reveal additional exposure-related associations with DPO. Access to large medical databases of military veterans with linkage to exposure histories may further elucidate risk factors for lung injury with ossification, paving the way for targeted prevention.…”
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High-dose dual therapy for Helicobacter pylori eradication inducing less impact on the gut microbiota by Jia-Lun Guan, Ting-Ting Xu, Ya Lin, Yan-Shuai Mo, Bi-Yu He, Ying-Ying Han, Ji-Yan Li, Su-Hong Xia, Ya-Ni Zhou, Jia-Zhi Liao, Pei-Yuan Li

“…Additionally, a greater number of species had alterations in their abundances in the BQT group compared to the HDDT group at week 2. …”
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Modulated Light Elicitation and Associated Physiological and Molecular Processes in Phenolic Compounds Production in <i>Ocimum basilicum</i> L. Microgreens by Gabriel-Ciprian Teliban, Naomi-Eunicia Pavăl, Gabriela Mihalache, Marian Burducea, Vasile Stoleru, Andrei Lobiuc

“…Within the current research, basil plantlets were grown for 10 days under either full spectrum light (white light) or modulated blue/red/far-red/UV spectrum elicitation with an additional factorization, by applying fertilization. …”
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Role of postoperative radiotherapy in pT3N0 rectal cancer: A risk‐stratification system based on population analyses by Yun‐xia Huang, Yan‐zong Lin, Jin‐luan Li, Xue‐qing Zhang, Li‐rui Tang, Qing‐yang Zhuang, Fei‐fei Lin, Xi‐jin Lin, Jun‐xin Wu

“…Low‐risk patients had better CSS than high‐risk patients (92.13% vs 72.55%, P < 0.001). The addition of radiotherapy to surgery doubled the CSS among the high‐risk patients (42.06% vs 91.26%, P = 0.001) but produced no survival benefit among the low‐risk patients (93.36% vs 96.38%, P = 0.182). …”
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Study of the corrosion behavior of cast Ti2AlNb alloy in HF–HNO3 solution by Yunyun Liu, Xianfei Ding, Lihong Wu, Xin Feng, Jiabin Zuo, Yunan Zhang, Lei Wen

“…Scanning Kelvin probe atomic force microscopy (SKPFM) combined with microstructural analysis revealed that the electrochemical system consisting of matrix B2 phase and secondary phase governs the high localized dissolution rate of Ti2AlNb alloy. Additionally, the segregation of elements at grain boundaries accelerates corrosion, leading to more severe degradation in those regions. …”
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Adult hypophosphatasia presenting with recurrent acute joint pain by Hayao Yoshida, Takaaki Murakami, Atsubumi Ogawa, Takashi Sunouchi, Naoko Hidaka, Nobuaki Ito, Hiromi Murakami, Hidenori Kawasaki, Tomoyuki Akiyama, Katsumi Nakajima, Daisuke Yabe, Taizo Yamamoto

“…., c.979T>C (p.Phe327Leu) and c.1559del (p.Leu520Argfs), confirming HPP. Additional genetic testing of his parents showed a heterozygous c.1559del variant in his father and a heterozygous c.979T>C variant in his mother. …”
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Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2 by Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang

“…Mechanistically, SUMOylation of microglial TRPC1 exacerbated neutrophil infiltration into the peri-infarct area. Additionally, SUMOylated TRPC1 activates the Nod-like receptor protein (NLRP) 3 signaling pathway in microglia and stimulates multiple CC-chemokine ligands and C-X-C motif ligand chemokines after MCAO/R. …”
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