Evaluation of the transmission-blocking potential of Plasmodium vivax antigen Pvg37 using transgenic rodent parasites and clinical isolates by Di Zhang, Yan Zhao, Dongyan Liu, Fei Liu, Pengbo Liu, Biying Zhang, Zifang Wu, Wanlapa Roobsoong, Sirasate Bantuchai, Sataporn Thongpoon, Piyarat Sripoorote, Meilian Wang, Liwang Cui, Yaming Cao

“…Initial findings demonstrated that the replacement of Pbg37 with the exogenous Pvg37 did not impact parasite growth or development. Notably, Pvg37 was expressed during the gametocyte to ookinete development and was associated with the plasmic membrane, similar to Pbg37. …”
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Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep by Beaumelle, Camille, Toïgo, Carole, Papet, Rodolphe, Benabed, Slimania, Beurier, Mathieu, Bordes, Léa, Brignone, Anaïs, Curt-Grand-Gaudin, Nadine, Garel, Mathieu, Ginot, Justine, Jacquiet, Philippe, Miquel, Christian, Poirel, Marie-Thérèse, Serafino, Anna, Vannard, Eric, Bourgoin, Gilles, Yannic, Glenn

“…These parasites have free-living stages in the environment that contribute to the ease of transmission among different host species. In addition, gastrointestinal nematodes have developed resistance to anthelmintics which is now considered a major problem for the livestock sector. …”
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Analysis of Risk Factors for Postoperative Progressive Segment Degeneration at the Decompression and Non-decompression Segments after Minimally Invasive Lumbar Decompression Surger... by Hasibullah Habibi, Hiromitsu Toyoda, Hidetomi Terai, Kentaro Yamada, Minori Kato, Akinobu Suzuki, Shinji Takahashi, Koji Tamai, Masayoshi Iwamae, Yuta Sawada, Yuto Kobayashi, Yuki Okamura, Hiroaki Nakamura

“…A logistic regression model identified that Cobb angle 10° (OR 2.53, 95% CI 1.50-4.24), spondylolisthesis 3 mm (OR 4.447, 95% CI 2.06-9.58), and level of segments were more likely to have PSD at the non-decompression level; additionally, lateral listhesis 3 mm (OR 2.91, 95% CI 1.08-7.81) was more likely to have PSD in the decompression segments. …”
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Increasing Health Burdens Driven by Global Trade Induced Air Pollution by Ruifei Li, Yu Luo, Xu Zhu, Jin Zhang, Pei Hua, Zhenyu Wang, Wenyu Yang, Qiuwen Chen, Hui Li

“…Results show that consumption transferred more primary PM2.5 emissions (2.2 Mt, 23.5%) and caused more additional mortality (241,000 deaths) through international trade than primary input (emission: 1.1 Mt, 12.3%, mortality: 167,000 deaths) in 2015. …”
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Evaluation of parent reminder-recall letters to promote human papillomavirus vaccination by Joan M. Griffin, Xuan Zhu, Wei Yi Kong, Robert M. Jacobson, Kathy L. MacLaughlin, Jennifer L. St. Sauver, Jeph Herrin, Gregory D. Jenkins, Nicole L. Larson, Lila J. Finney Rutten

“…Of those who did not remember the letter and did not vaccinate, the primary reason was not knowing the child was due for vaccination (27 %). …”
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Interface enhancement mechanism of rolled Mg/Al clad plate with particle interface control by Xiaobao Ma, Peng Li, Tao Wang, Zhongkai Ren, Peng Chen, Jiang Ji

“…Meanwhile, the dual cold-sprayed Al coatings on both the Mg slab and Al slab underwent dynamic recrystallization during rolling to form a homogeneous unit with no additional coating interfaces. Fine grain strengthening and dislocation strengthening were judged to be important mechanisms for improving the mechanical performance of the interfacial layer.…”
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Mitochondrial DNA oxidation and content in different metabolic phenotypes of women with polycystic ovary syndrome by Mailén Rojo, Mailén Rojo, Hernán Pérez, Hernán Pérez, Andrea Liliana Millán, Andrea Liliana Millán, María Constanza Pautasso, Alejandra Duarte, Alejandra Duarte, Giselle Adriana Abruzzese, Alicia Beatriz Motta, Alicia Beatriz Motta, Gustavo Daniel Frechtel, Gustavo Daniel Frechtel, Gustavo Daniel Frechtel, Gloria Edith Cerrone, Gloria Edith Cerrone

“…However, mtDNA oxidation levels did not differ significantly among these groups. …”
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Latitudinal patterns of tree β-diversity and relevant ecological processes vary across spatial extents in forests of southeastern China by Maochou Liu, Wenxiang Wu, Ke Wang, Xinshuai Ren, Xueqin Zhang, Lei Wang, Jing Geng, Bo Yang

“…We found that β-diversity decreased along a latitudinal gradient and that this pattern was clearer at larger spatial extents. In addition, latitudinal patterns of β-deviation were explained by the degree of species spatial aggregation. …”
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A new leaf pubescence gene, Hl1^th, introgressed into bread wheat from <i>Thinopyrum ponticum</i> and its phenotypic manifestation under homoeologous chromosomal substitu... by A. V. Simonov, E. I. Gordeeva, M. A. Genaev, W. Li, I. O. Bulatov, T. A. Pshenichnikova

“…Replacement of both copies of chromosome 4B with two copies of wheatgrass chromosome 4Th modifies leaf pubescence in line S29_4Th(4B) so that the leaf pubescence characteristic of S29 becomes more sparse, and trichomes of up to 600–700  µm in length are formed. Additionally, we described modification of pubescence in the substitution line S29_4Th(4D) where chromosome 4D that does not carry any pubescence gene was replaced. …”
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Fetal Cartilage Progenitor Cells in the Repair of Osteochondral Defects by Bruno C. Menarim, DVM, PhD, Chan Hee Mok, PhD, Kirsten E. Scoggin, PhD, Alexis Gornik, DVM, Emma N. Adam, DVM, PhD, Shavahn C. Loux, PhD, James N. MacLeod, VMD, PhD

“…Studies grafting IZN or ANL tissues in larger animal models with regular immune functions may provide additional insights into improving osteochondral regeneration.…”
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Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models by Ya-Chu Tang, Jing-Jim Ou, Shu-Ching Hsu, Chih-Hsiang Huang, Li-Mei Lin, Hsin-Huei Chang, Yi-Hsin Wang, Zih-Ting Huang, Manwu Sun, Ko-Jiunn Liu, Yi-Mei Hung, Chi-Yun Lai, Chuan Shih, Chiung-Tong Chen, Jang-Yang Chang, Hsing-Pang Hsieh, Weir-Torn Jiaang, Ching-Chuan Kuo

“…Furthermore, the decrease in viable cells after SRC knockout and the poorer prognosis observed in patients with higher SRC expression, emphasizes the critical significance and clinical relevance of SRC in CRC. Additionally, BPR1J481 exhibits robust anti-angiogenic effects by suppressing VEGF- and PDGF-induced endothelial cell proliferation, migration, and capillary-like tube formation through inhibition of VEGFR2 and PDGFRβ phosphorylation. …”
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Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…Using network proximity analysis, we screened for FDA-approved drugs that interact with SCM-associated pathways. Additionally, we tested the cardioprotective effects of two drug candidates in the SCM mouse model and explored their mechanism-of-action in H9c2 cells. …”
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Immunohistochemistry‐based molecular subtypes of urothelial carcinoma derive different survival benefit from platinum chemotherapy by Csilla Olah, Oleksandr Shmorhun, Gilbert Georg Klamminger, Josefine Rawitzer, Lara Sichward, Boris Hadaschik, Mulham Al‐Nader, Ulrich Krafft, Christian Niedworok, Melinda Váradi, Peter Nyirady, Andras Kiss, Eszter Szekely, Henning Reis, Tibor Szarvas

“…We aimed to determine the platinum sensitivity of molecular subtypes by using the protein expression‐based Lund Taxonomy. In addition, we assessed the tumor heterogeneity within the primary tumor and between the primary and lymph node (LN) metastatic sites. …”
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Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis by Mengling Wang, Feng Zeng, Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana Reilly, Hong Xin, Xudong Xu, Xuemei Zhang

“…Results In the present study, CeNP-PEG treatment significantly ameliorated renal fibrosis by increased E-cadherin protein expression, and decreased α-SMA, Vimentin and Fibronectin expression both in vitro and in vivo. Additionally, CeNP-PEG significantly reduced the ROS formation and improved the levels of mitochondrial ATP. …”
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Stability, performance and participatory evaluation of potato varieties under rain-fed and irrigation conditions at Southeast, Ethiopia by Gizaw Wegayehu Tilahun, Nimona Fufa, Dasta Tsagaye, Demis Fikre, Awoke Ali, Fekadu Gebretensay, Kedir Jaleto

“…The study provides baseline data for potato breeding, and the varieties must be evaluated in the nation's mega-environments for additional recommendations. …”
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Identification and quantification of transposable element transcripts using Long-Read RNA-seq in Drosophila germline tissues by Rebollo, Rita, Gerenton, Pierre, Cumunel, Eric, Mary, Arnaud, Sabot, François, Burlet, Nelly, Gillet, Benjamin, Hughes, Sandrine, S. Oliveira, Daniel, Goubert, Clément, Fablet, Marie, Vieira, Cristina, Lacroix, Vincent

“…Transposable elements (TEs) are repeated DNA sequences potentially able to move throughout the genome. In addition to their inherent mutagenic effects, TEs can disrupt nearby genes by donating their intrinsic regulatory sequences, for instance, promoting the ectopic expression of a cellular gene. …”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…Rapamycin also enhanced AD-MSC differentiation into chondrocytes and reduced their differentiation into adipocytes. In addition, rapamycin improved AD-MSC immunoregulatory functions by promoting the expression of immunosuppressive factors, such as IDO1, PTGS2 and also CD274 (encoding PD-L1). …”
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Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats by Vanessa Mba Matah Marte, Gilbert Ateufack, Marius Mbiantcha, Albert Donatien Atsamo, Carine Flore Adjouzem, Stéphanie Flore Djuichou Nguemnang, Eric Gonzal Tsafack, William Yousseu Nana, Yacine Karelle Madjo Kouam, Elvira Ngoufack Azanze

“…At all doses (125, 250, and 500 mg/kg), the extract significantly reduces the ulceration index and the area of ulceration and significantly increases the mass of gastric mucus. In addition, the extract significantly decreases the level of MDA, significantly increases the activities of catalase and glutathione, and then improves the hematological parameters in sick animals. …”
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Hubble Space Telescope Observations within the Sphere of Influence of the Powerful Supermassive Black Hole in PKS 0745-191 by Julie Hlavacek-Larrondo, Hyunseop Choi, Minghao Guo, Annabelle Richard-Laferrière, Carter Rhea, Marine Prunier, Helen Russell, Andy Fabian, Jonelle L. Walsh, Marie-Joëlle Gingras, Brian McNamara, Steve Allen, André-Nicolas Chené, Alastair Edge, Marie-Lou Gendron-Marsolais, Michael McDonald, Priyamvada Natarajan, Jeremy Sanders, James F. Steiner, Benjamin Vigneron, Anja von der Linden

“…Compared to other BCGs with weaker radio-mode feedback, where rotation is more stable, intense feedback may lead to more chaotic flows, indicating a stronger coupling between jet activity and gas dynamics. Additionally, we observe a sharp increase in velocity dispersion near the nucleus, consistent with a very massive M _BH  ~ 1.5 × 10 ^10 M _⊙ SMBH. …”
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Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma by Masahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Saya Ozaki, Hideaki Watanabe, Hajime Yano, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda

“…Here, we investigated the existence and functions of GSCs in the tumor periphery, which is considered to constitute the invasion niche for GSCs in GBM, by analyzing expression of stem cell markers and stem cell-related molecules and measuring particular activities of cultured GSCs. In addition, the relationship between GSCs expressing particular stem cell markers and pathological features on MRI and prognosis in GBM patients was analyzed. …”
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