Study of the Interplay Among Melt Morphology, Rheology and 3D Printability of Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Blends by Marco Costantini, Flavio Cognini, Roberta Angelini, Sara Alfano, Marianna Villano, Andrea Martinelli, David Bolzonella, Marco Rossi, Andrea Barbetta

“…Polymeric materials made from renewable sources that can biodegrade in the environment are attracting considerable attention as substitutes for petroleum-based polymers in many fields, including additive manufacturing and, in particular, Fused Deposition Modelling (FDM). …”
Get full text

Total glucosides of paeony ameliorates chemotherapy-induced neuropathic pain by suppressing microglia pyroptosis through the inhibition of KAT2A-mediated p38 pathway activation and... by Rong Chen, Jiantao Hu, Yang Zhang, Yang Liu, Jingsong Zhu, Zheng Pan, Hua Yang, Qin Wang, Ying Chen, Songjiang Tang, Baojun Min

“…KAT2A knockdown inhibited pyroptosis in LPS-induced BV2 cells, an effect that was reversed by the p38 activator metformin. Additionally, the improvements in MWT, CPT, TPT, and inflammatory factor levels observed in CINP rats treated with TGP were negated by KAT2A overexpression. …”
Get full text

Post-marketing safety surveillance for the recombinant zoster vaccine (Shingrix), vaccine adverse event reporting system, United States, October 2017–April 2024 by Yamin Shu, Wenxin Cheng, Xucheng He, Liu Huang, Wei Chen, Qilin Zhang

“…A total of 86 reports documenting deaths were identified following RZV vaccination. In addition to cardiovascular events and falls, Guillain-Barre syndrome was the most common cause of death. …”
Get full text

Melatonin Enhances Maize Germination, Growth, and Salt Tolerance by Regulating Reactive Oxygen Species Accumulation and Antioxidant Systems by Wei-Qing Li, Jia-Yu Li, Shao-Jie Bi, Jia-Yue Jin, Zhong-Ling Fan, Zi-Lin Shang, Yi-Fei Zhang, Yan-Jie Wang

“…Moreover, exogenous melatonin alleviated NaCl-induced membrane damage and oxidative stress, and reduced Na⁺ content and excessively large quantities of reactive oxygen species (ROS). In addition, exogenous melatonin increased antioxidant enzyme activity and the expression of the antioxidant enzyme genes <i>ZmSOD4</i>, <i>ZmCAT2</i>, and <i>ZmAPX2</i>. …”
Get full text

CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite by Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fábio Magalhães-Gama, Jacqueline Almeida Gonçalves Sachett, Iran Mendonça Silva, Kerolaine Fonseca Coelho, Eliane Campos Alves, Andréa Monteiro Tarragô, Luiz Carlos de Lima Ferreira, Adriana Malheiro, Wuelton Marcelo Monteiro, Allyson Guimarães Costa

“…In the AKI(+) group, levels of CXCL-8 and CCL-2 molecules were elevated on admission and progressively decreased during the clinical evolution of patients after antivenom administration. In addition, in the signature analysis, these were produced exclusively by the group AKI(+) at T0. …”
Get full text

Care coordination across healthcare systems: development of a research agenda, implications for practice, and recommendations for policy based on a modified Delphi panel by Aneesa Motala, Susanne Hempel, Michelle Wong, Maria Bolshakova, Ning Fu, David Ganz, Sonali Saluja, Timothy Kim, Carolyn Turvey, Kristina Cordasco, Aashna Basu, Tonya Page, Reshma Mahmood, Jenny Barnard, Isomi M Miake-Lye

“…We introduced common care scenarios and differentiated recommendations for a large (main) healthcare organisation and external healthcare professionals that contribute additional care.Participants The panel composition included health service providers, decision makers, patients and care community, and researchers. …”
Get full text

Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections by Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Tim Tolker-Nielsen, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu

“…HK-SL Ms eradicated 71.73% of biofilms by targeting extracellular polysaccharides, extracellular proteins, and viable cells within the biofilm. Additionally, 1.66 log10CFU/mL units of S. aureus within biofilms were killed. …”
Get full text

Vegetation height estimation based on machine learning model driven by multi-source data in Eurasian temperate grassland by Wuhua Wang, Jiakui Tang, Na Zhang, Xuefeng Xu, Anan Zhang, Yanjiao Wang, Kaihui Li, Yidan Wang

“…This study utilized machine learning models such as Random Forest (RF), AdaBoost, BP-Neural Network (BPNN), and Stacking Ensemble, combining them with topographic and meteorological data, MODIS reflectance data, and grassland height measurement data. …”
Get full text

OA-MEN: a fusion deep learning approach for enhanced accuracy in knee osteoarthritis detection and classification using X-Ray imaging by Xiaolu Ren, Xiaolu Ren, Lingxuan Hou, Shan Liu, Peng Wu, Siming Liang, Haitian Fu, Chengquan Li, Ting Li, Yongjing Cheng

“…This effectively expands the model’s receptive field and strengthens its understanding capability. Additionally, we conducted unseen-data tests and compared our model with widely used baseline models to highlight its superiority over conventional approaches.ResultsThe OA-MEN model demonstrated exceptional performance in tests. …”
Get full text

Diagnostic accuracy of human papillomavirus testing on self-collected samples among women referred for colposcopy by ChunX Yan, Jiong Ma, Xia Zheng, Jing Shu, XiaoJ Wang, XiaoY Chen, Feng Gao, XiaoQ Li, ShanQ M, LongM Huang, XiaoT Yu, XueJ Chen

“…It may be an alternative option for cervical cancer screening. Additional studies are still required to substantiate this issue.…”
Get full text

Assessment of awareness of keratoconus and its relation to eye rubbing among Saudi Arabia population by Nuwayyir Abdullah Alqasimi, Lujain Hatim Aljohani, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Renato Ambrósio, Bader Saad AlQahtani, Bader Saad AlQahtani, Nasser Saleh Al Haydar, Bdour Raja Alanazi, Danah Tariq Alfurayhan, Lina Sami Hussain Saber, Fatemah Saleh Alsalem, Nawaf Abdullah Alqahtani, Jose Manuel Vargas

“…The group with acceptable awareness of KC was predominantly aged between 18 and 30 years and female, with a percentage of 30.4%.ConclusionThe study revealed that Saudi citizens are not knowledgeable about KC and the risks associated with eye rubbing. Additionally, the study identified several KC risk factors, including but not limited to eye rubbing, allergies, and family history. …”
Get full text

Mode of action of silver-based perovskite against Gram-negative bacteria by Fereshteh Fani, Cyrus Talebpour, Philippe Leprohon, Hossein Salimnia, Houshang Alamdari, Marc Ouellette

“…Drastic morphological changes in E. coli were observed after their exposure to AgNbO3 NPs. In addition to cellular damage, AgNbO3 NPs induced the production of reactive oxygen species and lipid peroxidation, likely following the release of small amounts of Ag+. …”
Get full text

Evaluation of Medical School Students in Terms of Attention Deficit Hyperactivity Disorder and Emotional Regulation Difficulties by Ayşe Akan, Engin Burak Selçuk, Burcu Kayhan Tetik, Mustafa Akan, Ahmet Kadir Arslan

“…The ASRS total scores were positively correlated with the DERS total scores (r=0.643, p<0.001). In addition, suicide attempts, forensic event history, and class failure were significantly more frequent in the HP-ADHD group than in the WO-ADHD group (p<0.001, p=0.043, p=0.024 respectively). …”
Get full text

Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák, Marián Hajdúch

“…Similar to 2D cultures, senescent fibroblasts increased DNA demethylation of CRC cells in coculture spheroids, in addition to increasing the stemness of CRC cells. This study presents the first evidence of the effect of normal and senescent stromal cells and their conditioned medium on DNA demethylation by DAC. …”
Get full text

Anterior skull base reconstruction using nasoseptal flap: cadaveric feasibility study and clinical implication [SevEN-001] by Kyoung Su Sung, Jaejoon Lim, Minkyun Na, Sanghun Lee, Ju-Seong Kim, Je Beom Hong, Chang-Ki Hong, Ju Hyung Moon

“…When possible, by leaving some portion of the anterior sphenoid wall for supporting the PNSF, successful ASB reconstruction could be achieved in endoscopic resection of ASB tumors. Additional methods might be needed in some cases of large ASB lesions wherein the anterior sphenoid wall should be removed totally and the ASB defect is too large.…”
Get full text

Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children by Yudy Fonseca, MD, Alise Davies, PA, Stephanie Jarrin, MD, Liliana Simon, MD, Cortney Foster, DO, Sun Kai, Adnan Bhutta, MD

“…Our study indicates that COVID-positive patients are 4.8 times more likely to develop PE than COVID-negative patients. Additionally, the study highlights substantial racial disparities in the prevalence of PE, with Black or African American patients being disproportionately affected.…”
Get full text

Microbial dynamics of acute pancreatitis: integrating culture, sequencing, and bile impact on bacterial populations and gaseous metabolites by Agnieszka Chmielarczyk, Edyta Golińska, Anna Tomusiak-Plebanek, Natalia Żeber-Lubecka, Natalia Żeber-Lubecka, Maria Kulecka, Maria Kulecka, Antoni Szczepanik, Katarzyna Jedlińska, Krzysztof Mech, Konrad Szaciłowski, Agata Kuziak, Agata Pietrzyk, Magdalena Strus

“…The therapeutic intervention necessitated Hartmann's procedure, culminating in colostomy creation.AimsEmploying a thorough microbiological analysis we attempted to demonstrate whether the microflora isolated from the peripancreatic fluid exhibited a stronger correlation with the contents of the stoma or with the rectal swab. Additionally, we sought to determine the association between later onset of AP and diverticulitis.MethodsFollowing clinical materials from the patient in the initial phase of AP were collected: rectal swab, colostomy bag contents (in the publication referred to as stoma content/stool) and peripancreatic fluid. …”
Get full text

Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis by Kaiwen Sheng, Jun Chen, Ruitang Xu, Haoqiang Sun, Ran Liu, Yongjie Wang, Wenwen Xu, Jiao Guo, Miao Zhang, Shuai Liu, Juan Lei, Yawen Sun, Yang Jia, Dianhao Guo

“…Results Our study identified enhancer-specific activation within epithelial cells orchestrated by the three-dimensional structure of chromatin that regulates SERPINH1 transcription, and promotes the epithelial-mesenchymal transition (EMT) and metastasis of ESCC. Additionally, chromatin element activation facilitated the expression of TNFSF4 in CD8 + exhausted T cells, thereby activating Tregs. …”
Get full text

Investigating the psychology of eating after exercise — a scoping review by Alice Porter, Russell Jago, Luke A Robles, Elin Cawley, Peter J. Rogers, Danielle Ferriday, Jeffrey M. Brunstrom

“…Individuals may consume additional food to refuel their energy stores after exercise (psychological compensatory eating), or consume unhealthy or energy dense foods to reward themselves after exercise, especially if exercise is experienced negatively (post-exercise licensing), however the population-level prevalence of these behaviours is unknown.…”
Get full text

Assessment of ecological environment quality and their drivers in urban agglomeration based on a novel remote sensing ecological index by Fangyuan Lu, Chen Zhang, Haoyu Cao, Xibin Wang, Tong Zheng, Zhenfang Huang

“…This study utilizes the Google Earth Engine (GEE) platform, integrates MODIS imagery and NPP-VIIRS data to develop a Novel Remote Sensing Ecological Index (NRSEI). …”
Get full text