mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice by Xiaoming Liang, Yuxia Yuan, Junbin Wang, Cong Tang, Yun Yang, Yanan Zhou, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Yuhuan Yan, Dongdong Lin, Yanwen Li, Xuena Du, Longhai Yuan, Wenqi Quan, Daoju Wu, Shuaiyao Lu

“…In this study, we designed new mRNA vaccines, BSCoV05 and BSCoV06, and generated point mutations in the receptor-binding domain (RBD) of the original Wuhan strain to increase their broad-spectrum antiviral activity. Additionally, we used the BA.1 RBD as a control. Both vaccines elicited a robust immune response in BALB/c and K18-hACE2 mice, generating high levels of specific binding antibodies against the BA.2 RBD. …”
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Evolutionary analysis of genes associated with the sense of balance in semi-aquatic mammals by Yuehuan Dong, Qinguo Wei, Guolei Sun, Xiaodong Gao, Tianshu Lyu, Lidong Wang, Shengyang Zhou, Xibao Wang, Yongquan Shang, Lupeng Shi, Honghai Zhang

“…Particularly, genes such as SLC26A2, SOX10, MYCN, and OTX1 are implicated in collectively orchestrating morphological adaptations in the semicircular canals to suit semi-aquatic environments. Additionally, genes associated with otolith development, including SLC26A2, OC90, and OTOP1, likely regulate otolith sensitivity across various locomotor modes. …”
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Enhanced multistress tolerance of Saccharomyces cerevisiae with the sugar transporter-like protein Stl1F427L mutation in the presence of glycerol by Zixiong Liu, Lingling Shangguan, Linglong Xu, Huiyan Zhang, Wenxin Wang, Qiao Yang, Xiaoling Zhang, Lan Yao, Shihui Yang, Xiong Chen, Jun Dai

“…Molecular dynamics simulations indicated that Stl1F427L may enhance glycerol molecular binding, resulting in a significant increase in the intracellular glycerol content of the mutant strain STL. Additionally, under multistress conditions, pyruvate and ergosterol levels and catalase (CAT) and superoxide dismutase (SOD) activities were significantly increased in the mutant strain STL compared with the control strain 5D. …”
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Improving capacity for advanced training in obstetric surgery: evaluation of a blended learning approach by Helen Allott, Alan Smith, Sarah White, Irene Nyaoke, Ogoti Evans, Michael Oriwo Oduor, Steven Karangau, Sheila Sawe, Nassir Shaaban, Ochola Ephraim, Charles Anawo Ameh

“…We assessed the completion rate of part-1 (21 assignments), participation rate in parts 2 and 3, participant satisfaction and change in knowledge and skills. Additionally, we compared the cost of the blended delivery to the 5-day face-to-face delivery, in GB pounds. …”
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RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner by Chuling Li, Yijin Chen, Qiqi Chen, Haoxiang Huang, Michael Hesse, Yilin Zhou, Ming Jin, Yu Liu, Yifei Ruan, Xiang He, Guoquan Wei, Hao Zheng, Senlin Huang, Guojun Chen, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin

“…Abstract Stimulating cardiomyocyte (CM) dedifferentiation and cell cycle activity (DACCA) is essential for triggering daughter CM formation. In addition to transcriptional processes, RNA‐binding proteins (RBPs) are emerging as crucial post‐transcriptional players in regulating CM DACCA. …”
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Wenxin Granules Influence the TGFβ-P38/JNK MAPK Signaling Pathway and Attenuate the Collagen Deposition in the Left Ventricle of Myocardial Infarction Rats by Ya Huang, Aiming Wu, Lixia Lou, Dongmei Zhang, Bo Nie, Yizhou Zhao, Keke Liu, Mingjing Zhao, Hongcai Shang

“…Then, animals were randomly assigned to the model group, the Carvedilol group, and the Wenxin Granules group. In addition, sham operation rats were used as the control group. 10 rats were allocated in each group. …”
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The Changes in Biochemical Compositions of Five Different Macroalgae and Seagrass (Halophila stipulacea (Forsskal) Ascherson 1867) Collected from Iskenderun Bay by Eyüp İlker Saygılı, Zafer Çetin, Mehmet Naz, Oktay Söyler, Ergün Taşkın, Selin Sayın

“…In conclusion, the information of the biochemical compositions of five different macroalgae and Angiosperms/Seagrass (Halophila stipulacea) are important for the evaluation of potential sources for commercial and human consumption. In addition, biochemical compositions of tested macroalgae and seagrass could make important contributions to feed formulations and functional foods in future.…”
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Application of human-in-the-loop hybrid augmented intelligence approach in security inspection system by Ying Huang, Ying Huang, XiaoKan Wang, XiaoKan Wang, Yong Zhang, Yong Zhang, Li Chen, Li Chen, HongJi Zhang

“…This “Hybrid decision-making” method not only enhances risk perception, thereby widening the safety margin of the security inspection system, but also reduces the need for human labor, leading to increased efficiency and reduced labor costs. Additionally, it is less time-consuming, further improving the system’s overall efficiency. …”
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Global, regional, and national survey on burden and quality of care index (QCI) of nasopharyngeal cancer: A systematic analysis of the Global Burden of disease study 1990–2019 by Saba Ilkhani, Sahar Saeedi Moghaddam, Delaram Sakhaei, Mohammad-Mahdi Rashidi, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Naser Ahmadi, Ozra Tabatabaei-Malazy, Mohammadreza Naderian, Erfan Ghasemi, Parnian Shobeiri, Sahar Mohammadi Fateh, Farzad Kompani, Bagher Larijani, Farshad Farzadfar

“…Young people (<40) receive the best care at almost all SDI levels, and the gender gap is shrinking in lower SDI quantiles with time. …”
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An Early Experience of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in the Republic of Korea: A Retrospective Multicenter Study by Joonhyeon Park, Sung Woo Jang, Byungchul Yu, Gil Jae Lee, Sung Wook Chang, Dong Hun Kim, Ye Rim Chang, Pil Young Jung

“…By LRA for complications, total occlusion has significantly lesser risk than intermittent or partial occlusion in both univariate (odds ratio [OR] 0.06, 95% confidence interval [CI] 0.00-0.36, p=0.01) and multivariate (OR 0.05, 95% CI 0.00-0.38, p=0.01) analyses. …”
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A brief alcohol intervention during smoking cessation treatment in daily cigarette smokers: A pilot randomized controlled trial by Yee Tak Derek Cheung, Tin Shun Titan Mak, Tzu Tsun Luk, Kam-wing Joe Ching, Nga-ting Grace Wong, Ching Han Helen Chan, Man Ping Wang, Tai Hing Lam

“…Both intervention (n = 51) and control (n = 49) groups received conventional smoking cessation treatment, the intervention group additionally received a brief alcohol intervention. Primary outcome was biochemically validated tobacco abstinence at 2 months. …”
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Effect of cold plasma and ultrasonic pretreatment on drying characteristics and nutritional quality of vacuum freeze-dried kiwifruit crisps by Danhua Yue, Lin Lin, Rongxing Li, Zhongjun Zhang, Jianfeng Lu, Shaotong Jiang

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Auricular acupressure for minimizing adverse reactions to colonoscopic bowel preparation in hospitalized patients: A randomized controlled trial by Jiahui Zhang, Chang Liu, Guodong Ruan, Haiyan Zhang, Beiping Zhang, Xuejun Hu, Cailing Zhong

“…The intervention group received auricular acupressure during bowel preparation, whereas the control group received no additional treatment. Analyses were conducted using the intention-to-treat method. …”
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Artesunate Restrains Maturation of Dendritic Cells and Ameliorates Heart Transplantation-Induced Acute Rejection in Mice through the PERK/ATF4/CHOP Signaling Pathway by Yuanyang Chen, Sihao Zheng, Zhiwei Wang, Xin Cai, Yanjia Che, Qi Wu, Shun Yuan, Xiaohan Zhong

“…The proportion of multiple lymphocytes in spleen and lymph nodes was then determined using flow cytometry. In addition, cell experiments were conducted to determine the changes in expression of surface maturation markers of BMDC and changes in intracellular reactive oxygen species after LPS stimulation. …”
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Access to Healthy Built and Natural Environments and Physical Activity and Screen Time in New Zealand Adolescents: A Geospatial Cross‐Sectional Study by L. Marek, J. Wiki, S. Mandic, J. C. Spence, M. Smith, E. García Bengoechea, K. J. Coppell, S. Kingham, M. Hobbs

“…A positive association existed between meeting physical activity guidelines and access to health‐promoting environments (OR = 1.23 [95% CI 1.03; 1.47]), particularly blue space. In addition, the mixture of health‐promoting and health‐constraining environments was also important (ψ = 1.18 [1.01; 1.37]). …”
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Thymosin alpha 1 in the prevention of infected pancreatic necrosis following acute necrotising pancreatitis (TRACE trial): protocol of a multicentre, randomised, double-blind, plac... by Tao Chen, Jing Zhou, Jianfeng Tu, Weiqin Li, XinTing Pan, Wenjian Mao, Lu Ke, Wenhua He, Miao Chen, Chengjian He, Weili Gu, Jingyi Wu, Jingchun Song, Haibin Ni, Junli Sun, Guoxiu Zhang, Weiwei Chen, Bing Xue, Xiangyang Zhao, Min Shao, Yuxiu Liu, Zhihui Tong

“…Considering the possibility of readmission, an additional follow-up will be arranged 90 days after enrolment, and IPN and death at day 90 will also be served as secondary outcomes.Ethics and dissemination This study was approved by the ethics committee of Jinling Hospital, Nanjing University (Number 2015NZKY-004-02). …”
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Restoration of Properties of Heat-Resistant Steel After Long-Term Operation in Steam Pipeline Bends of TPP by Heat Treatment by Halyna Krechkovska, Ivan Tsybailo, Ihor Dzioba, Oleksandra Student, Robert Pała

“…However, such nanosized particles were not found on the samples’ fracture surfaces in the steel after restorative heat treatment. In addition, the ductile dimples on the fractures of the restored steel were more prominent, which indicated high energy costs for their formation. …”
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Potential Probiotic Yeasts of the Pichia Genus Isolated from ‘Dadih’, a Traditional Fermented Food of West Sumatra, Indonesia by Tatenda Calvin Chihombori, Apon Zaenal Mustopa, Rika Indri Astuti, Ilma Mutiara, Redoyan Refli, Rifqiyah Nur Umami, Fatimah, Herman Irawan, Nurlaili Ekawati, Joko P Trinugroho, Rizna Akmaliyah, Sheila Chairunnisa, Febriyanti Nur Amani, Baso Manguntungi, Ai Hertati, Jendri Mamangkey

“…Notably, secondary metabolite biosynthesis genes were located on contig 7. In addition, 26 probiotic-related genes, including GSY1, HSC82, HSP104, TPS1, ARN1, FLO1, ALA1, SIR2, and others, were identified in P. kudriavzevii GBT37, indicating its potential as a probiotic yeast. …”
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The immune landscape and viral shedding of Omicron SARS-CoV-2 variants implicate immune escape by Weilong Zhang, Xiaoyan Gai, Zhonghui Duan, Changjian Yan, Chunyuan Huang, Chaoling Wu, Siping Zheng, Zixiang Lin, Qingtao Zhou, Lili Dai, Ping Yang, Fang Bao, Hongmei Jing, Chao Cai, Yingmin Ma, Yongchang Sun

“…Based on the viral strain, patients were divided into BA.4/5 group and BF.7 group. Additionally, we categorized patients into rapid viral shedding and slow viral shedding groups according to their viral shedding rates. …”
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Biodiversity of Non-<i>Apis</i> Bees (Hymenoptera: Apoidea) in the Potohar Region of Pakistan by Sumera Aslam, Muhammad Naeem, Sabir Hussain, Maryam Riasat, Muhammad Ather Rafi, Ahmed Zia, Muhammad Khalid Rafique, Nawaz Haider Bashir, Huanhuan Chen

“…Simpson’s Index and Simpson’s Reciprocal Index exhibited dominance and high diversity across sites, with values ranging from 0.094 to 0.880 and 4.446 to 11.315, respectively. Additionally, the Shannon–Wiener and Shannon Equitability indices indicated fairly even species distributions across localities. …”
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