Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study by Johan Burisch, Lene Terslev, Mikkel Østergaard, Annette Bøjer Jensen, Frank Krieger Jensen, Flemming Bendtsen, Charlotte Wiell, Mohamed Attauabi, Klaus Theede, Viktoria Fana, Hartwig Roman Siebner, Henrik S Thomsen, Jakob M Møller, Simon Francis Thomsen, Gorm Roager Madsen, Anne Vibeke Wewer, Rune Wilkens, Johan Ilvemark, Nora Vladimirova, Sanja Bay Hansen, Yousef Jesper Wirenfeldt Nielsen, Helene Andrea Sinclair Ingels, Trine Boysen, Jacob T Bjerrum, Christian Jakobsen, Maria Dorn-Rasmussen, Sabine Jansson, Yiqiu Yao, Ewa Anna Burian, Frederik Trier Møller, Kristina Bertl, Andreas Stavropoulos, Jakob B Seidelin

“…All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. …”
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Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres by Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

“…VPA impaired the expansion of MB neurospheres enriched in stemness markers and reduced <i>MYC</i> while increasing <i>TP53</i> expression in these neurospheres. In addition, VPA induced morphological changes consistent with neuronal differentiation and the increased expression of differentiation marker genes <i>TUBB3</i> and <i>ENO2</i>. …”
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Milk Composition Is Predictive of Low Milk Supply Using Machine Learning Approaches by Xuehua Jin, Ching Tat Lai, Sharon L. Perrella, Xiaojie Zhou, Ghulam Mubashar Hassan, Jacki L. McEachran, Zoya Gridneva, Nicolas L. Taylor, Mary E. Wlodek, Donna T. Geddes

“…The best-performing model, incorporating 14 milk components and maternal and infant characteristics, achieved an accuracy of 87.9%, an area under the precision-recall curve (AUPRC) of 0.893, and an area under the receiver operating characteristic curve (AUC) of 0.917. Additionally, a simplified model, optimised for clinical applicability, maintained a reasonable accuracy of 78.8%, an AUPRC of 0.776, and an AUC of 0.794. …”
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The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction by Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Irina Zaitseva, Elmira Omirtaeva, Adolat Manakbayeva, Yergali Moldakhanov, Elmira Anarkulova, Anar Imangazy, Kuralay Akanova, Zhumagali Koshemetov, Nurkul Orazymbetova, Bakyt Umuraliyev

“…It was shown that the plant-based complex effectively inhibited the activity of these viral proteins. In addition to its effects on viral proteins, the flavonol and hydroxyorganic acid complex were shown to suppress viral replication in Vero E6 cells. …”
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What all physicians should know about women’s health: a Delphi study by Susanna Price, Eva Gerdts, Julien Mazières, Alexandra Kautzky-Willer, Fedde Scheele, Chiara Benedetto, Kerry Wilbur, Gertraud Stadler, Marieke Wermer, Jeanine Roeters van Lennep, Merel H de Heer-Koster, Vesna Bjegović-Mikanović, Indre Banaitytė-Baleišienė, Mary Perdiou, Alyson McGregor, Connie Newman, Simona Stankevičiūtė, Iris E Sommer, Florence Thibaut, Karine van 't Land

“…The statements were ranked according to a &gt;80% consensus in the first Delphi round and a 4-point Likert scale in the second Delphi round.Results In the first round, 44 participants fully completed the survey. 18 statements progressed to the second round, in which four additional statements were included based on participant suggestions. …”
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Robot-assisted ureteral reconstruction for managing kidney transplant patients with ureteric complications by Dongho Shin, San Kang, Seung Ah Rhew, Chang Eil Yoon, Hyong Woo Moon, Yong Hyun Park, Hyuk Jin Cho

“…The mean follow-up period was 23.9±6.8 months, with no additional interventions required after surgery. No complications above Clavien-Dindo grade I were recorded. …”
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Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis by Omran Davarinejad, Saeid Komasi, Mohammad-Taher Moradi, Farzaneh Golmohammadi, Maryam Bahrami, Hamed Esmaeil Lashgarian, Masumeh Jalalvand, Sara Hookari, Fatemeh Kazemisafa

“…Non-medicated SCZ patients (d = –1.08, p ≤ 0.001) exhibited lower GDNF levels than those on medication (d = – 0.70, p = 0.004). Additionally, patients with a disease duration of ≥ 10 years showed lower levels of GDNF (d = –0.93, p = 0.058 versus d = –0.82, p = 0.002). …”
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Prediction of clinical efficacy of acupuncture intervention on upper limb dysfunction after ischemic stroke based on machine learning: a study driven by DSA diagnostic reports data by Yaning Liu, Yuqi Tang, Zechen Li, Pei Yu, Jing Yuan, Lichuan Zeng, Can Wang, Su Li, Ling Zhao, Ling Zhao, Ling Zhao

“…Notably, the MBI emerged as the most sensitive outcome measure for evaluating patient response to acupuncture treatment. Additionally, secondary analysis revealed that the number of sites with cerebral vascular stenosis (specifically 1 and 3 sites) had a significant impact on the final model’s predictions.ConclusionThis study highlights the M1 segment, the origin of the ICA, and the C1 segment as key stenotic sites affecting acupuncture treatment efficacy in stroke patients with upper limb dysfunction. …”
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A comprehensive analysis of the effect of quorum-sensing molecule 3-oxo-C12-homoserine lactone on Candida auris and Candida albicans by Fruzsina Kovács, Ágnes Jakab, Noémi Balla, Zoltán Tóth, Dávid Balázsi, Lajos Forgács, Andrea Harmath, Aliz Bozó, Ágota Ragyák, László Majoros, Renátó Kovács

“…Our findings indicate that HSL-induced effects are not specific to C. albicans; additionally, several characteristics are present in C. auris but not in C. albicans following HSL exposure. …”
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Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury by Xiaozhen Chen, Yinglin Wang, Xiang Xie, Hongfei Chen, Qiqi Zhu, Zhidong Ge, Hua Wei, Jingshong Deng, Zhengyuan Xia, Qingquan Lian

“…The lung injury score and the lung wet to dry (W/D) ratio in lungs were significantly reduced in septic rats after ER stress inhibition. …”
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Contemporaneous Emotion Regulation Theoretical Models: A Systematic Review by Camila Florencia Cremades, Cristian Javier Garay, Martín Juan Etchevers, Roberto Muiños, Graciela Mónica Peker, Juan Martín Gómez Penedo

“…We identify that people's learning history is an important factor in the development of emotional regulation skills. In addition, context and personality traits are proposed as moderators of the therapeutic efficacy of interventions focused on emotional regulation. …”
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Nicotine promotes M2 macrophage polarization through α5-nAChR/SOX2/CSF-1 axis in lung adenocarcinoma by Guiyu Kang, Hui Song, Lei Bo, Qi Liu, Qiang Li, Jingtan Li, Pan Pan, Jingting Wang, Yanfei Jia, Haiji Sun, Xiaoli Ma

“…Nicotine-induced SOX2 expression was mediated by α5-nAChR via STAT3. Additionally, SOX2-mediated macrophage colony-stimulating factor (CSF-1) expression contributed to LUAD progression in vitro. …”
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Systematic identification and quantification of factors and their interactions with age, sex, and panel wave influencing cognitive function in Korean older adults by Eunmi Kim, Eunmi Kim, Jinkyung Oh, Jinkyung Oh, Jungsoo Gim, Jungsoo Gim, Jungsoo Gim, Iksoo Huh, Iksoo Huh

“…Wave number interacted with depressive symptoms and social activity. In addition, the group-wise delta R2 values were found to be 10.9, 6.3, and 5.9% in the difficult-to-modify, modifiable, and non-modifiable factor groups, respectively. …”
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Genetic status assessment and future development forecast for an isolated giant panda population by Jiabin Liu, Jiaojiao Yu, Wenlei Bi, Mingxia Fu, Xiang Yu, Rong Hou, Xinqiang Song, Rui Ma, Yanshan Zhou, Zusheng Li, Hong Yang, Wei Wu, Jiang Gu, Chong Huang, Long Zhang, Xiaodong Gu, Haijun Gu, Daode Yang, Dunwu Qi

“…The interval of releases (every 5, 2, or 1 year) has little impact on long-term dynamics of population size, whereas the sex of released individuals does have a significant impact. Additionally, the duration of releases (spanning 20, 30, 50 or 100 years) also has notable effects on future population prospects. …”
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Role of Renal Nerves in the Treatment of Renovascular Hypertensive Rats with L-Arginine by Sonia Alves Gouvea, Renata V. Tiradentes, Cintia H. Santuzzi, Vinícius Mengal, Henrique de A. Futuro Neto, Nyam F. Silva, Gláucia R. Abreu

“…Our results suggest that renal sympathetic activity participates in the genesis and the maintenance of the hypertension and also demonstrate that treatment with L-arg alone is incapable of normalizing the MAP and that the effect of such treatment is not additive with the effect of kidney denervation.…”
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Comparison of MRI and CT in the Evaluation of Unilateral Maxillary Sinus Opacification by Elise Chua, Annakan V. Navaratnam, Dominic St Leger, Vincent Lam, Samit Unadkat, Alexander Weller

“…MRI is more specific than CT in characterising UMSO, with greater diagnostic certainty and reproducibility. The additive diagnostic value of MRI complements CT, potentially reducing diagnostic delays in some cases and the need for diagnostic endoscopic sinus surgery in others. …”
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Temporal and habitat-specific variations in drivers of aboveground biomass dynamics in a Chinese subtropical forest by Yuxuan Bian, Qi Wu, Rong Zheng, Jiaqin Fu, Jianhua Chen, Xiangcheng Mi, Mingjian Yu, Yunquan Wang, Yunquan Wang, Yunquan Wang

“…In the subsequent 2012-2017 period, phylogenetic and structural diversity emerged as key factors, explaining 48.46% and 36.43% of relative importance, respectively. Additionally, we observed that the drivers and effects impacting ΔAGB exhibited significant variability across different habitat types. …”
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Tumor Size Is a Critical Factor in Adjuvant Chemotherapy for T3-4aN0M0 Gastric Cancer Patients after D2 Gastrectomy by Shi Chen, Li-Ying Ou-Yang, Run-Cong Nie, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, Ying-Bo Chen, Jun-Sheng Peng

“…Our results imply that tumor size should be a critical factor in the decision to utilize adjuvant chemotherapy for T3-4aN0M0 gastric cancer patients after D2 gastrectomy. Additional randomized controlled trials are required before this conclusion can be considered definitive.…”
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Construction of complex three-dimensional vascularized liver tissue model in vitro based on a biphasic cell-laden embedding medium by Weikang Lv, Haoran Yu, Abdellah Aazmi, Tuya Naren, Wanli Cheng, Mengfei Yu, Zhen Wang, Xiaobin Xu, Huayong Yang, Liang Ma

“…In summary, this method is adaptable to various materials, allowing the rheological properties of the supporting bath and the tissue’s porosity to be modified using microgels, thus enabling precise regulation of the liver tissue microenvironment. Additionally, it facilitates the rapid construction of three-dimensional vascular structures within liver tissue. …”
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Effect of Ti content on spinodal decomposed microstructure and properties of AlCoCrFeNiTix high-entropy alloy coatings prepared by laser cladding by Kun Yue, Xiaoqin Yang, Lin Wang, Liji Su, Quan Xu, Zhe Xu, Chunlong Cheng, Yeqing Wang, Zhijun Wang, Zheng Chen

“…The results showed that Ti promoted the formation of a body-centered cubic (B2) phase, transforming the coating structure into a typical dendritic (DR)–inter-dendritic (ID) structure. …”
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