Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats by Gisela Belén Sarrible, María Victoria Bazzano, Caterina Koutsovitis, María Guillermina Bilbao, Rodrigo Hernán Da Cuña, Melanie Neira, Julián Alberto Bartolomé, Evelin Mariel Elia

“…In summary, CoQ10 could be an additional treatment for obesity-related infertility in patients with normal metabolic profiles. …”
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Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway by Qiaoli Chen MS, Quanxiang Hao MBBS, Yanping Yang MBBS, Limei Li PhD, Danping Li MS, Ran Zhao MS, Wanqi Wei MBBS, Lixian Deng MBBS, Jiaming Su MBBS, Ziyuan Liang MBBS, Shiyue Tang MS, Yaomin Lu MBBS, Yushan Liang PhD, Zhe Zhang PhD, Xiaoying Zhou PhD, Xue Xiao PhD, Ping Li PhD, Yi Huang PhD, Weilin Zhao PhD

“…Ectopic expression of CES4A restrains the proliferation, colony formation, migration and invasion of NPC. Additionally, KEGG analysis based on GEO data and high-throughput transcriptome sequencing of cell lines all strongly suggested that CES4A was involved in regulating phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. …”
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Transcriptome Analysis and Phytohormone Profile Reveal Core Phytohormone Regulating Parthenocarpy in Fingered Citron by Qianbin Chen, Jinjian Xu, Xinjian Zou, Yanjun Zhang, Xiaoxian Zhu, Kewei Zhang, Wenrong Chen, Fanglei Liao, Weidong Guo

“…Virus-induced gene silencing (VIGS) experiments demonstrated that silencing <i>CmsABI5</i> led to decreased ABA levels, while auxin levels remained unchanged, resulting in disrupted parthenocarpy and increased ethylene levels, indicating a secondary hormonal response. Additionally, gene expression changes associated with failed parthenocarpy showed down-regulation of SAUR50 and up-regulation of <i>PP2C 56</i>, linking these changes to ABA signaling. …”
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Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort St... by Xue Liu, Jingjing Jiang, Xiaotian Liu, Zhicheng Luo, Yan Wang, Xiaokang Dong, Dandan Wei, Wenqian Huo, Songcheng Yu, Linlin Li, Shuna Jin, Chongjian Wang, Zhenxing Mao

“…Furthermore, the combination of high F/E and 11-dexyocortisol was associated with the lowest odds of prediabetes (OR=0.39, 95% CI: 0.21-0.73) and T2DM (OR=0.25, 95% CI: 0.12-0.52) in females. …”
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Dynamic simulation of landscape ecological risk in Gansu’s farming-pastoral ecotone based on topographic gradients by Le Yang, Jixuan Yan, Guang Li, Weiwei Ma, Tao Li, Pengcheng Gao, Qiang Li, Xiangdong Yao, Jie Li, Wenning Wang

“…Methods such as CA-Markov and the Topographic Position Index (TPI) were employed to assess these risks. Additionally, the study simulates the spatial distribution patterns of ecological risks in future years. …”
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Enhancing Tropical Cyclone Risk Assessments: A Multi-Hazard Approach for Queensland, Australia and Viti Levu, Fiji by Jane Nguyen, Michael Kaspi, Kade Berman, Cameron Do, Andrew B. Watkins, Yuriy Kuleshov

“…For Viti Levu, areas classified with an “extreme” risk to TCs are primarily areas that experienced coastal inundation, with Lautoka and Vuda found to be especially at risk to TCs. Additionally, the Fiji case study was validated using post-disaster damage data, and a statistically significant correlation of 0.40 between TC Winston-attributed damage and each tikina’s overall risk was identified. …”
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Effect of trans-cinnamaldehyde and peracetic acid alone or in combination on multidrug-resistant Salmonella Heidelberg on broiler drumsticks under scalding alone or with chilling a... by C. Peichel, D.V.T. Nair, S. Manjankattil, K.M. Reed, R.B. Cox, A.M. Donoghue, A. Kollanoor Johny

“…Heidelberg populations enumerated by surface plating and enrichment methods. Additionally, the efficacy of the scalding treatments (PC, 1 % TC, 0.05 % PAA, and 1 % TC + 0.05% PAA) against S. …”
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Opening up Corpus FinSL: enriching corpus analysis with linguistic ethnography in a study of constructed action by Puupponen Anna, Hodge Gabrielle, Anible Benjamin, Salonen Juhana, Wainio Tuija, Keränen Jarkko, Hernández Doris, Jantunen Tommi

“…This article outlines a novel interview method developed to enrich the original Corpus of Finnish Sign Language (Corpus FinSL) with additional ethnographic information eight years after it was first documented and archived with standard IMDI corpus metadata. …”
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Assembly and comparative analysis of the complete mitochondrial genome of red raspberry (Rubus idaeus L.) revealing repeat-mediated recombination and gene transfer by Huajie Zhang, Minghui Yan, Lijuan Li, Zhuo Jiang, Ye Xiong, Yusheng Wang, Caleb Onoja Akogwu, Olutayo Mary Tolulope, Hao Zhou, Yanxia Sun, Hengchang Wang

“…Key characteristics of the mitogenome were examined, including its gene composition, repetitive elements, and homologous DNA fragments. Additionally, we identified multiple recombination events in the mitogenome mediated by repetitive sequences The high-quality and well-annotated mitogenome for the known fruit red raspberry will provide essential genetic information for species classification, evolution analysis, and even genetic improvement in Rubus in the future.…”
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Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Wom... by Marica Franzago, Federica Fraticelli, Antonio Nicolucci, Claudio Celentano, Marco Liberati, Liborio Stuppia, Ester Vitacolonna

“…Moreover, a significant correlation was observed between lipid parameters and genetic variations in additional genes, namely, PPARG2 [p = 0,02], APOA5 [p = 0,02], MC4R [p = 0,03], LDLR [p = 0,01], and FTO [p = 0,02]. …”
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Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling by Raquel Arantes Megid, Guilherme Gomes Ribeiro, Izabela Natalia Faria Gomes, Ana Carolina Laus, Letícia Ferro Leal, Letícia Ferro Leal, Luciane Sussuchi da Silva, Abu-Bakr Adetayo Ariwoola, Josiane Mourão Dias, Rui Manuel Reis, Rui Manuel Reis, Renato Jose da Silva-Oliveira, Renato Jose da Silva-Oliveira

“…The synergistic effect of combining AKT, p38, and EGFR inhibitors was assessed using the SynergyFinder platform. Additionally, AKT and p38 genes were silenced using esiRNA.ResultsSotorasib-resistant H358-R cell line displayed markers of the mesenchymal-epithelial transition and loss of cell adhesion. …”
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Transcriptomic and behavioral studies reveal that glutamate receptors are involved in depressive-like behavior in adult olive flounder Paralichthys olivaceus by Liangfang Liu, Tangsong Feng, Mengmeng Shi, Huafeng Zou, Weiqun Lu

“…Meanwhile glial fibrillary acidic protein, the biomarkers of astroglial pathology, and glutamatergic synaptic genes were significantly up-regulated in AG flounder. In addition, Gene Ontology (GO) enrichment analysis revealed that DEGs enriched in peptide biosynthetic process, translation procession were down-regulated in the AG flounder. …”
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Hypercholesterolemia triggers innate immune imbalance and transforms brain infarcts after ischemic stroke by Ali Ata Tuz, Nils Hoerenbaum, Özgür Ulusoy, Adel Ahmadi, Alana Gerlach, Alexander Beer, Andreas Kraus, Anja Hasenberg, Nina Hagemann, Dirk M. Hermann, Matthias Gunzer, Matthias Gunzer, Vikramjeet Singh

“…After stroke neutrophils in HFD mice expressed higher levels of activation markers Ly6G and PSGL-1 (CD162) compared to ND mice. In addition, stroke led to an increased expression of the activation markers Ly6C and CD68 on monocyte/macrophages (MΦ) in HFD mice but not in ND mice. …”
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Five-year carry-over effects in dune slack vegetation response to hydrology by Lisanne van Willegen, Hilary Wallace, Angela Curreli, Ciara Dwyer, John Ratcliffe, Davey L. Jones, Graham Williams, Martin Hollingham, Laurence Jones

“…We evaluated 80 hydrological metrics (weighted and un-weighted median, mean, minimum, maximum, mean spring level, averaged over 1–8 year duration, and 5 additional 1-year metrics) against plant community responses (variants of Ellenberg EbF moisture indicator). …”
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Negative frequency-dependent selection through variations in seedling fitness due to genetic differentiation of parents’ pair in a tropical rainforest tree, Rubroshorea curtisii (D... by Naoki Tani, Naoki Tani, Chin Hong Ng, Soon Leong Lee, Chai Ting Lee, Norwati Muhammad, Toshiaki Kondo, Yoshihiko Tsumura, Saori Sugiyama, Kaoru Niiyama, Azizi Ripin, Abdul Rahman Kassim, Samsudin Musa

“…IntroductionThe role of syngameons in adaption to microgeographical environmental heterogeneity is important and could be one of the sources of rich species diversity in tropical forests. In addition, negative frequency- or density-dependent selection is one of the major processes contributing to the maintenance of genetic diversity.MethodsTo assess genetic factors that affect the fitness of seedlings of Rubroshorea curtisii, a dominant canopy tree species in hill dipterocarp forests, the inter- and intra-population genetic structure of individuals from natural populations and individuals at two permanent plots in a hill dipterocarp forest with reproductive stage was studied. …”
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Oral behaviors in Chinese temporomandibular disorder patients: insights from exploratory and confirmatory factor analyses by Tiqian Liu, Tiqian Liu, Adrian Ujin Yap, Adrian Ujin Yap, Adrian Ujin Yap, Yanyu Sun, Yanyu Sun, Yunhao Zheng, Yunhao Zheng, Tianqi Wang, Tianqi Wang, Shiya Zeng, Shiya Zeng, Zhen Liu, Xin Xiong, Xin Xiong

“…AimThis study aimed to evaluate the factor structure of the Oral Behaviors Checklist (OBC) in Chinese temporomandibular disorder (TMDs) patients and compare the outcomes with those of Western patients. Additionally, it examined the correlations between different OBC subscale scoring methods.MethodsA total of 869 patients completed a survey that included demographic information, the Symptom Questionnaire, and OBC. …”
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Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

“…TXNIP inhibits the disulfide reductase enzymatic activity of thioredoxin (Trx), impairing its antioxidant function and, ultimately, leading to the disruption of cellular redox homeostasis. In addition, TXNIP restricts cell growth and survival by blocking glucose uptake and metabolism. …”
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Employing a low-code machine learning approach to predict in-hospital mortality and length of stay in patients with community-acquired pneumonia by Hao Chen, Shurui Zhang, Hiromi Matsumoto, Nanami Tsuchiya, Chihiro Yamada, Shunsuke Okasaki, Atsushi Miyasaka, Kentaro Yumoto, Daiki Kanou, Fumihiro Kashizaki, Harumi Koizumi, Kenichi Takahashi, Masato Shimizu, Nobuyuki Horita, Takeshi Kaneko

“…Model performance was assessed using the area under the receiver operating characteristic curve (AUC) for mortality prediction and the R2 score for LOS prediction, with benchmarks set at AUC > 0.9 and R2 > 0.5. The Shapley Additive Explanations (SHAP) method was used for interpreting individual predictions. …”
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Scalable Fabrication of Light-Responsive Superhydrophobic Composite Phase Change Materials via Bionic-Engineered Wood for Solar–Thermal Energy Management by Yang Meng, Jiangyu Zhang, Yuchan Li, Hui Jiang, Delong Xie

“…Encapsulating stearic acid (SA) as the PCM, the CPCM exhibits exceptional stability, achieving a high latent heat of 175.5 J g⁻¹ and an energy storage efficiency of 87.7%. In addition, the thermal conductivity of the CPCM is significantly enhanced along the longitudinal direction, a 2.1-fold increase compared to pure SA, due to the integration of Ag NPs and the unidirectional wood architecture. …”
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Proteomics analysis reveals age-related proteins in the urine of chronic kidney disease patients by Lin Xiong, Changwei Wu, Sipei Chen, Yong Zhang, Li Wang, Yi Li, Guisen Li

“…In the validation cohort, we demonstrated that patients with CKD exhibited lower urinary levels of L-selectin (SELL), uromodulin (UMOD), and epidermal growth factor (EGF). Additionally, a significant negative correlation was found between age and EGF levels. …”
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