Case report: Deciphering the clinical significance of a novel partial BRCA1 exon 10 duplication in a patient with triple-negative breast cancer by Alice Faversani, Debora Manuelli, Davide Barteselli, Giulia Melloni, Carlo Santaniello, Luigi Corsaro, Luigi Corsaro, Davide Sacco, Davide Sacco, Davide Clerici, Laura Gargiulo, Fulvio Ferrara, Lucy Costantino

“…The identification and correct classification of these variants is crucial to find individuals with an increased risk of cancer and to support physicians in their clinical and therapeutic decisions. In addition, the status of BRCA1 and BRCA2 variants is important for appropriate management of patients’ family members. …”
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Effects of Macleaya cordata extract supplementation in low-protein, low-fishmeal diets on growth, hematology, intestinal histology, and microbiota in largemouth bass (Micropterus s... by Wenyuan Xu, Ruijun Zhu, Dianyu Huan, Xiaoqin Li, Xiangjun Leng

“…Supplementing MCE in low-fishmeal or low-protein diets significantly increased the abundance of Firmicutes in the intestinal microbiota (P < 0.05). Additionally, the expression levels of the inflammatory factors IL-10 and TGF-β1 were reduced. …”
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Influence of temperature on growth and oxidative status of juvenile Southern black drum (Pogonias courbina) by Felipe Kuroski, Lucas C. Maltez, Olivia Menossi, Thiago P.A.P. Oliveira, Brandon J.Q. Gamboa, Marcelo H. Okamoto, Ricardo V. Rodrigues, Luis A. Sampaio

“…Fish were fed four times a day. Temperature did not affect fish survival, which was above 98 % in all treatments. …”
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A medical insurance fund operation performance evaluation system under the DRG payment mode reform by Zijian Wang, Zijian Wang, Zijian Wang, Weifu Chang, Weifu Chang, Aijing Luo, Aijing Luo, Aijing Luo

“…Notably, the comprehensive indexes of QD and JN cities exhibit significant comparative advantages, resulting in higher performance evaluation scores for their medical insurance funds. Additionally, the performance scores assessed by the proposed evaluation system align closely with actual operational outcomes. …”
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Analysis of 42 Years of Cosmic Ray Measurements by the Neutron Monitor at Lomnický štít Observatory by Imre Kisvárdai, Filip Štempel, Lukáš Randuška, Šimon Mackovjak, Ronald Langer, Igor Strhárský, Ján Kubančák

“…Applying the Pearson method for statistical analysis, we quantified the linear correlation of the data sets. Additionally, a prediction power score was computed to reveal potential non‐linear relationships. …”
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Construction of a miR-15a-based risk prediction model for vascular calcification detection in patients undergoing hemodialysis by Chen Fu, Yingjie Liu, Huayu Yang, Qiaojing Liang, Wenhu Liu, Weikang Guo

“…Logistic regression (LR) models were used to examine the risk factors associated with VC. Additionally, we developed an miR-15a-based nomogram based on the results of the multivariate LR analysis. …”
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Fermented Ophiocordyceps sinensis mycelium products for preventing contrast-associated acute kidney injury: a systematic review of randomized controlled trials by Fenglan Pu, Tianli Li, Chen Shen, Yingqiao Wang, Chunmei Tang, Xiaowen Zhang, Lijiao Yan, Qihe Xu, Jianping Liu

“…However, there was no statistically significant difference between Zhiling with RPP and RPP in the incidence of CA-AKI. Additionally, only when FOSM products were taken before injection of the contrast, it was superior to RPP in reducing the incidence of CA-AKI. …”
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CRISPR/Cas9-editing of PRNP in Alpine goats by Aurélie Allais-Bonnet, Christophe Richard, Marjolaine André, Valérie Gelin, Marie-Christine Deloche, Aurore Lamadon, Gwendoline Morin, Béatrice Mandon-Pépin, Eugénie Canon, Dominique Thépot, Johann Laubier, Katayoun Moazami-Goudarzi, Ludivine Laffont, Olivier Dubois, Thierry Fassier, Patrice Congar, Olivier Lasserre, Tiphaine Aguirre-Lavin, Jean-Luc Vilotte, Eric Pailhoux

“…Among them, one male carrying a one base pair insertion leading to a KO allele is currently used to rapidly extend a PRNP-KO line of Alpine goats for future characterization. In addition to KO alleles, a PRNP del6 genetic variant has been identified in one-third of founder animals. …”
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E-MAC: Enhanced In-SRAM MAC Accuracy via Digital-to-Time Modulation by Saeed Seyedfaraji, Salar Shakibhamedan, Amire Seyedfaraji, Baset Mesgari, Nima Taherinejad, Axel Jantsch, Semeen Rehman

“…This eliminates the need for an additional digital-to-analog converter (DAC) in the design. …”
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S100A8/A9 Molecular Complexes Promote Cancer Migration and Invasion via the p38 MAPK Pathway in Nasopharyngeal Carcinoma by Ning Xu, Bei-Bei Zhang, Xia-Ning Huang, Xiang Yi, Xue-Min Yan, Yan Cai, Qin He, Zi-Jian Han, Yuan-Jiao Huang, Wei Liu, Ai-Jun Jiao

“…Intriguingly, exogenous S100A8/A9 protein stimulation could dramatically enhance NPC migration and invasion abilities. In addition, p38 MAPK pathway blockade could diminish the migration and invasion of NPC cells stimulated by S100A8/A9 proteins. …”
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An Arctic Marine Source of Fluorescent Primary Biological Aerosol Particles During the Transition from Summer to Autumn at the North Pole by Julia Kojoj, Gabriel Pereira Freitas, Morven Muilwijk, Mats A. Granskog, Tuomas Naakka, Annica M. L. Ekman, Benjamin Heutte, Julia Schmale, Anderson Da Silva, Rémy Lapere, Louis Marelle, Jennie L. Thomas, Christian Melsheimer, Benjamin J. Murray, Paul Zieger

“…Analysis of chemical composition and particle size suggested a marine origin for these fPBAPs, a hypothesis further supported by additional evidence. Air parcel trajectory analysis coupled with ocean productivity reanalysis data, as well as analysis of large-scale meteorological conditions, all linked the high concentrations of fPBAPs to biologically active, ice-free areas of the Arctic Ocean.…”
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Improving the charge transport of perovskite nanocrystal light-emitting-diodes through Benzylammonium ligand exchange by Minsik Gong, Dong Gyu Lee, Gwang Yong Shin, Yun Seop Shin, Donghwan Yun, Yunhye Jeong, Sang Wook Park, Chan Beom Park, Yung Jin Yoon, Sung Yong Bae, Yun-Hi Kim, Jin Young Kim, Tae Kyung Lee, Gi-Hwan Kim

“…The alkyl chain in the surface ligands significantly affect external stimuli depending on their length. Additionally, aromatic ring-containing ligands improve conductivity of the film due to their conjugated structure. …”
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A global Corynebacterium diphtheriae genomic framework sheds light on current diphtheria reemergence by Hennart, Mélanie, Crestani, Chiara, Bridel, Sébastien, Armatys, Nathalie, Brémont, Sylvie, Carmi-Leroy, Annick, Landier, Annie, Passet, Virginie, Fonteneau, Laure, Vaux, Sophie, Toubiana, Julie, Badell, Edgar, Brisse, Sylvain

“…To define the population background of this emergence, we sequenced 379 additional isolates (mainly from France, 2018-2021) and collated 870 publicly-available genomes. …”
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Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants by Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad, Ingrid Meulenbelt

“…Upon treatment of ex vivo OA articular cartilage with hrIL11, we overall observed unbeneficial effects on chondrocyte phenotype, as illustrated by upregulation of MMP13, EPAS1, RUNX2, and POSTN. We did not observe significant differences in Mankin scores upon addition of hrIL11. …”
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Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy by Baijin Xia, Huolun Feng, Xinmiao Jiang, Jialing Guo, Keming Lin, Wenxing Zhang, Fan Xing, Lixue Cao, Yong Li, Hui Zhang, Xu Zhang, Wenyu Li, Fei Yu

“…The Nb-GrB conjugation enhances tumor targeting, while a Gv/Sd linker coupled to h-HFn further improves cellular transport and targeting. Additionally, the multimerization of GrB enhances its effectiveness. …”
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Biocontrol yeast Kurtzmaniella quercitrusa BS-AY-S1 controls postharvest green mold of citrus fruit by producing metabolites with antifungal activity by Bi Liao, Ou Chen, Hongyan Zhang, Wenjun Wang, Lanhua Yi, Honghai Li, Kaifang Zeng

“…Subsequently, 8 yeast strains tested in vivo effectively inhibited green mold in citrus fruit, with Kurtzmaniella quercitrusa BS-AY-S1 achieving the best biocontrol efficacy by reducing the disease incidence (DI) by 58.33 % and lesion diameter (LD) by 73.36 % compared to the control on the 6th day. …”
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Epidemiology of bacterial biofilms on polyps and normal tissues in a screening colonoscopy cohort by Julia L. Drewes, Samara B. Rifkin, Madison McMann, Sara Glass, Emma Spence, Caroline R. Wensel, Abby L. Geis, Courtney Stevens, Joell J. Gills, Hao Wang, Linda M. Hylind, Gerard Mullin, David Kafonek, David Cromwell, Louis La Luna, Francis M. Giardiello, Cynthia L. Sears

“…Procedural, demographic, and lifestyle predictors of bacterial scores were evaluated using multivariable proportional odds regression models.Results Procedural variables that negatively impacted bacterial scores and biofilm detection included smaller biopsy forcep size, physician, bowel preparation type, and shorter times from bowel preparation completion to colonoscopy. …”
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Public support for smoke-free private indoor and public outdoor areas in the Netherlands: A trend analysis from 2018– 2022 by Nienke W. Boderie, Sabri Ennissay, Wilhelmina IJzelenberg, Frank J. van Lenthe, Jessica Baars, Jasper V. Been

“…Introduction In addition to smoke-free policies in indoor public and workplaces, governments increasingly implement smoke-free policies at beaches, in parks, playgrounds and private cars (‘novel smoke-free policies’). …”
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Analysis of environmental health risks from exposure to polyethylene terephthalate microplastics in refilled drinking water by S. Kasim, A. Daud, A.B. Birawida, A. Mallongi, A.I. Arundana, A. Rasul, M. Hatta

“…A total of 100 respondents were involved. Additionally, 20 samples of refilled drinking water were examined in the laboratory using the Fourier Transform Infrared test. …”
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Irisin Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis in Bile Duct Ligation Mice Model and Improves Mitochondrial Dysfunction by Thuy Linh Lai, So Young Park, Giang Nguyen, Phuc Thi Minh Pham, Seon Mee Kang, Jeana Hong, Jae-Ho Lee, Seung-Soon Im, Dae-Hee Choi, Eun-Hee Cho

“…In vivo, irisin ameliorated the elevated liver-to-body weight ratio induced by BDL and alleviated liver fibrosis, as evidenced by Masson’s trichrome staining. …”
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