Immune imbalance in the pre-ovulatory follicular microenvironment of overweight and obese women during IVF by Yang Liu, Yiran Zhao, Chengliang Zhou, Hong Zhu, Jiexue Pan, Jing Fu, Hefeng Huang, Hui Lin, Li Jin

“…Lipid profiles were screened, revealing no difference between the two groups, however, levels were higher in serum compared to FF. Additionally, the concentration gradient of TG between serum and FF was 22-fold in OW group (2.92 ± 3.66 vs. 0.13 ± 0.03), which was significantly higher than the 12-fold gradient observed in NW group (1.72 ± 0.95 vs. 0.14 ± 0.08). …”
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High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI): an open, randomised controlled trial by Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Angelika Terbuch, Barbara Obermayer-Pietsch, Erika Richtig, Stefan Pilz

“…Nine patients presented with hyponatraemia, two had typical changes on MRI, 12 had isolated adrenal insufficiency, and six had an additional hormone deficiency. None of the patients in neither group experienced a recovery in adrenal function. …”
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A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

“…Here, using BRET2-based biosensors, we demonstrated the ability of ARIP to inhibit agonist-induced β-arrestin recruitment on a series of 7TMRs that includes both stable and transient β-arrestin binders, with efficiencies that depend on receptor type. In addition, we showed that ARIP was unable to recruit β-arrestins to the cell membrane by itself, and that it did not interfere with G protein signalling. …”
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Breeding for Heat Tolerant Aromatic Rice Varieties and Identification of Novel QTL Regions Associated with Heat Tolerance During Reproductive Phase by QTL-Seq by Surangkana Chimthai, Sulaiman Cheabu, Wanchana Aesomnuk, Siriphat Ruengphayak, Siwaret Arikit, Apichart Vanavichit, Chanate Malumpong

“…The results revealed that four promising lines, namely 84-7-1-9, 84-7-1-10, 159-3-3-1, and 159-3-3-10, were classified as heat-tolerant with low amylose content. In addition, lines 84-7-1-9 and 84-7-1-10 were identified as aromatic rice encompassing the aroma gene (badh2). …”
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Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats by Marta Zaforas, Esther Benayas, Raquel Madroñero-Mariscal, Ana Domínguez-Bajo, Elena Fernández-López, Yasmina Hernández-Martín, Ankor González-Mayorga, Elena Alonso-Calviño, Eduardo R. Hernández, Elisa López-Dolado, Juliana M. Rosa, Juan Aguilar, María C. Serrano

“…Together with histological features at the lesion site, such as more abundant and larger blood vessels and more abundant, longer and more homogeneously distributed axons, our results corroborate that rGO scaffolds create a permissive environment that allows the invasion of functional axonic processes from neurons located in brainstem nuclei with motor function in a rat model of complete thoracic transection. Additionally, behavioral tests evidence that these scaffolds play an important role in whole-body mechanical stabilization (postural control) proved by the absence of scoliosis, a higher trunk stability and a larger cervico-thoraco-lumbar movement range in rGO-implanted rats.…”
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Performance Analysis of a Parabolic Trough Collector with Photovoltaic—Thermal Generation: Case Study and Parametric Study by Benjamín Chavarría-Domínguez, Susana Estefany De León-Aldaco, Mario Ponce-Silva, Nicolás Velázquez-Limón, Jesús Armando Aguilar-Jiménez, Fernando Chavarría-Domínguez, Ernesto Raúl Rodríguez-García, Heriberto Adamas-Pérez, Ricardo Eliu Lozoya-Ponce, Eligio Flores-Rodriguez

“…The results demonstrate that the pipe length exerts the most significant influence on the electrical and thermal power output (1.21 kW to 2.22 kW and 3.7 kW to 6.9 kW, respectively). Additionally, the diameter has an impact on the thermal power output (5.23 kW to 7.1 kW) and the electrical and thermal efficiency (0.18 to 0.15 and 0.54 to 0.74, respectively). …”
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Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study by Haiyu Wang, Guangying Cui, Ming Cheng, Tuerganaili Aji, Guotao Li, Xinjun Hu, Guangming Li, Shixi Zhang, Yanyang Zhang, Linqi Diao, Pan Li, Ling Wang, Yiqiang Yuan, Guowu Qian, Ruiqing Zhang, Xiaoli Jin, Juan Wang, Hong Luo, Donghua Zhang, Mingming Wang, Silin Li, Zhan Song, Mengzhao Yang, Guanyue Su, Ranran Sun, Junbiao Chang, Zujiang Yu, Zhigang Ren

“…Clinical outcomes were compared between the two drugs via Kaplan–Meier analysis and Cox regression models. Additionally, in vitro and in vivo experiments were used to evaluate the antitumor effects and safety of both drugs. …”
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PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil by Albert L. Juhasz, Farzana Kastury, Ruby Jones, Mahima Seeborun, Tanya Caceres, Carina Herde, Michelle Cavallaro, Sarah Dilmetz, Joshua Hutchings, Yevgeniya Grebneva, Chris Desire, Peter Hoffmann

“…Oral and intravenous dose (∼20 µg kg−1 body weight) comparisons highlighted the high absolute bioavailability of PFOA (AUC: 100.3 ± 23.4 %; UE: 94.7 ± 26.6 %), PFOS (LA: 102.9 ± 15.6 %) and PFHxS (AUC: 88.3 ± 15.1 %; UE: 90.9 ± 7.3 %). …”
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Development of Speech and Communication in Polish Children with 22q11.2 Deletion Syndrome: A Cross-Sectional Study by Natalia Moćko, Marcin Rudzki, Zuzanna Miodońska, Julia Olesiak, Katarzyna Jochymczyk-Woźniak, Michał Kręcichwost

“…Conclusions: Our findings suggest that this may represent a phenomenon associated with 22q11DS that warrants further investigation using standardized tests for assessing disfluencies. Additionally, we observed that speech therapists and caregivers were perceived as not fully aware of the speech development impairments caused by 22q11DS. …”
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Effects of Resveratrol on the Kidney in Rats with Streptozotocin Induced Diabetic Nephropathy by Duygu Tozcu, Çiğdem Özer, Aydan Babül, Sevim Ercan, Ergin Dileköz, Gülnur Take Kaplanoğlu, Güleser Göktaş

“…At the study’s end, transmission electron microscopy and immunohistochemical analyses were performed. Additionally, the left kidney was isolated and suspended in an organ bath to study the functional changes without damaging the renal artery. …”
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Direct Photocoagulation Guided by Merged Retinal Images for the Treatment of Focal Diabetic Macular Edema by Yoshihiro Takamura, Takehiro Matsumura, Shogo Arimura, Makoto Gozawa, Masakazu Morioka, YutakaYamada, Masaru Inatani

“…The numbers of laser spots (p=0.0001), additional laser treatments (p=0.0121), and intravitreal injection of ranibizumab (p=0.0012) in the MIG-PC group were significantly lower than those in the FG-PC group (Mann–Whitney test). …”
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Association of dust exposure with anxiety and depression in the occupational population: The important role of sleep duration by Zhuoheng Shen, Yue Sun, Yang Li, Qi Zhang, Yifei Liu, Jiyan Han, Jiafei Yang, Jiangping Li, Zhiyun Ha, Yaowen Yang, Zhihong Liu, Suzhen Guan, Jian Sun

“…Binary logistic regression was used to explore the association of dust exposure with anxiety and depression. Generalized additive models (GAM) were constructed to explore the nonlinear relationships between dust exposure duration, sleep duration, and mental health outcomes. …”
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Comprehensive analysis of H3K27me3 LOCKs under different DNA methylation contexts reveal epigenetic redistribution in tumorigenesis by Yuan Liang, Mengni Liu, Bingyuan Liu, Benjamin Ziman, Guanjie Peng, Qiong Mao, Xingzhe Wang, Lizhen Jiang, De-Chen Lin, Yueyuan Zheng

“…Notably, a significant subset of tumor-associated long LOCKs in intermediate- and long-PMDs exhibit reduced H3K9me3 levels, suggesting that H3K27me3 compensates for the loss of H3K9me3 in tumors. Additionally, we find that genes upregulated in tumors following the loss of short LOCKs are typically poised promoter genes in normal cells, and their transcription is regulated by the ETS1 transcription factor. …”
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Prediction of Cisplatin‐Induced Acute Kidney Injury Using an Interpretable Machine Learning Model and Electronic Medical Record Information by Kaori Ambe, Yuka Aoki, Miho Murashima, Chiharu Wachino, Yuto Deki, Masaya Ieda, Masahiro Kondo, Yoko Furukawa‐Hibi, Kazunori Kimura, Takayuki Hamano, Masahiro Tohkin

“…Model interpretation using SHapley Additive exPlanations showed that concomitant use of intravenous magnesium preparations was negatively correlated with Cis‐AKI, whereas loop diuretics were positively correlated. …”
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Unveiling the Texture Secrets of <i>Morchella</i> Germplasm: Advanced Grading and Quality Assessment Through Texture Profile Analysis (TPA) by Jialiang Li, Ying Chen, Xuelian Cao, Jie Tang, Liyuan Xie, Lixu Liu, Yan Wan, Rongping Hu

“…According to the correlation analysis, there was a significant correlation between the texture characteristics of the pileus, and a significant positive correlation between the hardness and the gumminess of the stipe (correlation coefficient of 0.96). Additionally, the hardness was negatively correlated with cohesiveness and resilience, with correlation coefficients of −0.51 and −0.38. …”
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Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study by Hongxia Xin, Ping He, Bin Xi, Zhaojun Wang, Han Wang, Faxuan Wang, Zhanbing Ma, Jing Xue, Yuanyuan Jia, Hourong Cai, Bi Chen, Juan Chen

“…Furthermore, a generalized additive mixed model (GAMM) was applied to compare the NLR variations over time between 30-day survival group and non-survival group. …”
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Ecological risk assessment and response prediction caused by LUCC in the central Yunnan Province by Yongdong Zhang, Zisheng Yang, Renyi Yang, Fuhua Liu, Yimei He, Linlin Cao, Jinrong Yang, Jiayi Zhang

“…Therefore, this study takes the central Yunnan Province (CYP) as an example, and uses the Patch-Generating Land Use Simulation (PLUS) model and the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) model to simulate the land use/land cover (LULC) in different scenarios in the future, calculate the ecosystem services (ESs) from 2000 to 2020 and the next 20 years, as well as ERs of various types of ESs caused by LUCC. In addition, the Pearson correlation coefficient and geographically weighted regression (GWR) are used to analyze the trade-off and synergy relationships between various ecological risks, and the geographic detector method (GDM) is used to analyze their driving factors. …”
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Guadua angustifolia biochar/TiO2 composite and biochar as bio-based materials with environmental and agricultural application by Luis A. Cañon-Tafur, Juan F. Mateus-Maldonado, Hair Santiago Lozano-Puentes, Carlos D. Herrera-Acosta, Juan J. Sánchez-Matiz, Lucía A. Díaz-Ariza, Geison Modesti Costa, Luis C. Jiménez-Borrego, Ana K. Carrascal-Camacho, Aura M. Pedroza-Rodríguez

“…This study provides new information on the conversion and use of G. angustifolia sawdust as an alternative for new bio-based materials with environmental and agricultural applications. In addition, obtaining biochar and composite could positively impact the bamboo production chain in Colombia because of renewable and globally accepted alternatives that help capture gaseous emissions causing the greenhouse effect.…”
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Hybrid Prophet-NAR Model for Short-Term Electricity Load Forecasting by Winita Sulandari, Yudho Yudhanto, Etik Zukhronah, Isnandar Slamet, Hilman Ferdinandus Pardede, Paulo Canas Rodrigues, Muhammad Hisyam Lee

“…The proposed PropNAR integrated the strengths of the Prophet model in capturing deterministic structures, such as trends, seasonality, and holiday effects with the NAR model&#x2019;s ability to handle nonlinear stochastic relationships. Additionally, SSA-based bagging is employed to manage data uncertainties, and ensemble techniques are applied to further refine the forecasting accuracy. …”
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Biomass allocation between reproductive and vegetative organs of Artemisia along a large environmental gradient by Tumenjargal Tsogtsaikhan, Xuejun Yang, Ruiru Gao, Jiangrui Liu, Wenqiang Tang, Guofang Liu, Xuehua Ye, Zhenying Huang

“…Overall, there were significant isometric relationships between reproductive and vegetative mass. In addition, the ratio of reproductive to vegetative mass increased with the second principal component of climate (representing climate variability), but decreased with the second principal component of soil (representing bulk density and available water capacity). …”
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