The symbiont Wolbachia increases resistance to bifenthrin in Ectropis grisescens by regulating the host detoxification function by Tian Gao, Yong Zhang, Wanpeng Sun, Qiangkun Li, Xueyu Huang, Dian Zhi, Huabin Zi, Ruijie Ji, Yanhua Long, Chunmei Gong, Yunqiu Yang

“…Moreover, the population treated with 2.5 mg ml−1 tetracycline exhibited even greater reductions in these parameters than the 300 μg ml−1 tetracycline-treated group. Additionally, 16S rRNA sequencing results showed a significant decrease in xenobiotics metabolism by cytochrome P450 in the E. grisescens population treated with 2.5 mg ml−1 tetracycline. …”
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Effect of ocean acidification on the oxygen consumption of the sea urchins Paracentrotus lividus (Lamarck, 1816) and Arbacia lixula (Linnaeus, 1758) living in CO2 natural gradients by Robert Fernández-Vilert, Robert Fernández-Vilert, Vanessa Arranz, Vanessa Arranz, Marta Martín-Huete, Marta Martín-Huete, José Carlos Hernández, Sara González-Delgado, Sara González-Delgado, Rocío Pérez-Portela, Rocío Pérez-Portela

“…Notably, P. lividus and A. lixula displayed unsynchronized acidosis/alkalosis cycles, suggesting different physiological mechanisms. Additionally, environmental history seemed to influence adaptive capacity, as specimens from fluctuating pH environments exhibited respiration rates similar to those from stable environments with heightened phenotypic plasticity. …”
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Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…The enrichment of TCR and BCR by LNP-M/pSpike suggested an increase in immune response specificity and diversity. Additionally, LNP-M effectively delivered DNA-encoded antigens, such as mouse PD-L1 and p53R172H, or monoclonal antibodies targeting mouse PD1 and human p53R282W. …”
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TAS2R38 genotype and CRS severity in children with cystic fibrosis by Elena Cantone, Antonella Tosco, Angela Sepe, Valeria Raia, Rossella Negri, Alice Castaldo, Chiara Cimbalo, Paolo Pezzella, Mario Brandon Russo, Giusi Grimaldi, Claudio Di Nola, Luigi Greco

“…The clinical implications include the potential development of T2R38-targeted topical therapies and the use of taste testing or genotyping to predict susceptibility to infection. In addition, these results may pave the way for novel, tailored therapeutic approaches in the era of precision medicine.…”
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Enhanced Performance of New Scaling-Free CORDIC for Memory-Based Fast Fourier Transform Architecture by C. Paramasivam, Sandeep Singh Chauhan, Veerpratap Meena, A. Sreejagathi, B. A. V. N. Hasini, K. L. K. Kishore, T. V. N. G. Vamsikrishna, M. Durga Ananta Sai, Abdessamad Didi

“…The angle of convergence (AOC) of the algorithm is 57.1°, and it is extended to 180° using the pre-rotation operation and optimized shift value prediction technique. In addition to that, the new CORDIC cell architecture is designed to perform Taylor series-based iterations. …”
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The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women by Xinjun Hu, Shasha Li, Renliang Huang, Ziwei Fu, Chenyu Ma, Zheng Cheng, Hongjun Hu, Qiaomiao Zhou, Frank Petersen, Xinhua Yu, Xinhua Yu, Junfeng Zheng

“…Our study included 490 healthy controls and 492 TB patients who were genotyped for the NCF1 rs201802880 polymorphism.ResultsOur results showed that the NCF1 rs201802880 AA genotype was associated with a reduced risk of TB in women (OR= 0.25, 95% CI: 0.09-0.68, p=0.0023). Additionally, healthy individuals with the NCF1 rs201802880 AA genotype had significantly lower circulating white blood cell (5.56 ± 1.78 vs 6.43 ± 1.59, p=0.003) and neutrophil (3.23 ± 1.20 vs 3.74 ± 1.23, p = 0.02) counts compared to those with the GG or GA genotypes, with this difference being more pronounced in women than in men.ConclusionThis study demonstrates that the autoimmune disease-causal NCF1 variant is associated with a protective effect against TB infection.…”
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Impaired arbitration between reward-related decision-making strategies in Alcohol Users compared to Alcohol Non-Users: a computational modeling study by Srinivasan A. Ramakrishnan, Riaz B. Shaik, Tamizharasan Kanagamani, Gopi Neppala, Jeffrey Chen, Vincenzo G. Fiore, Christopher J. Hammond, Shankar Srinivasan, Iliyan Ivanov, V. Srinivasa Chakravarthy, Wouter Kool, Muhammad A. Parvaz

“…As expected, Alcohol Non-Users showed significantly higher model-based control in higher compared to lower reward conditions, whereas no such difference between the two conditions was observed for the Alcohol Users. Additionally, both groups were significantly less risk-averse in higher compared to lower reward conditions. …”
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Expression and localization of two β-carbonic anhydrases in Bienertia, a single-cell C4 plant by Tho Nguyen, Nakyoung Lee, Fabian J. Frömling, Toni L. Meister, Toni L. Meister, Toni L. Meister, Jung Sun Kim, Sascha Offermann, Inhwan Hwang

“…Higher plants contain many different isoforms of CAs that can be classified into α-, β- and γ-type subfamilies. β-type CAs play a key role in the CO2-concentrating mechanism, thereby contributing to efficient photosynthesis in the C4 plants in addition to many other biochemical reactions in plant metabolism. …”
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The Aryl Hydrocarbon Receptor (AhR) Is a Novel Gene Involved in Proper Physiological Functions of Pancreatic β-Cells by Shuhd Bin Eshaq, Jalal Taneera, Shabana Anjum, Abdul Khader Mohammed, Mohammad H. Semreen, Karem H. Alzoubi, Mohamed Eladl, Yasser Bustanji, Eman Abu-Gharbieh, Waseem El-Huneidi

“…This study aimed to investigate the expression of AhR in human pancreatic islets using publicly available RNA-sequencing (RNA-seq) databases and to explore its correlations with various metabolic parameters and key β-cell markers. Additionally, functional experiments were conducted in INS-1 cells, a rat β-cell line, to elucidate the role of Ahr in β-cell biology. …”
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CTX-M, SHV, TEM and VEB β-lactamases, and MCR-1 among multidrug-resistant Escherichia coli and Klebsiella isolates from environment near animal farms in Thailand by Arpasiri Srisrattakarn, Bhanubong Saiboonjan, Patcharaporn Tippayawat, Sunpetch Angkititrakul, Aroonwadee Chanawong, Chanakan Pornchoo, Chokdee Smithkittipol, Aroonlug Lulitanond

“…Results: A total of 123 E. coli (n = 59) and Klebsiella species (n = 64) were identified and 25 isolates of them were MDR; 21 and 4 isolates from the downstream and upstream areas respectively. In addition, 13 isolates were ESBL producers, of which 12 isolates were from the downstream area. …”
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Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats by Baocang Yin, Baocang Yin, Mingzhen Yang, Mingzhen Yang, Bowen Wang, Bowen Wang, Yun Zhang, Yun Zhang, Ningli Li, Ningli Li, Qin Li, Yingying Li, Cory J. Xian, Tiejun Li, Tiejun Li, Yuankun Zhai, Yuankun Zhai

“…After 13 weeks of treatment, the rats were sacrificed to measure bone turnover markers, related tissue biochemical indices, microstructure parameters, and osteoclastogenesis promotor RANKL and inhibitor OPG expression levels. Additionally, fecal samples were obtained for high-throughput sequencing to analyze the intestinal flora.ResultsOral administration of TFEL for 13 weeks increased the serum level of bone formation marker PINP and decreased the level of bone resorption marker NTX-I. …”
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Design of a novel Cu-Cr-X alloy with high strength and high electrical conductivity based on mechanical learning by Yunqing Zhu, Yicheng Cao, Lijun Peng, Qian Yu, Zhen Yang, Zengde Li, Junsheng Wu, Haofeng Xie

“…It was found that the addition of Zr tends to nucleation at the interface of the K-S orientation relationship (OR) bcc-Cr phases. …”
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Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Thus, we detail recommendations for best practice and strategies for identifying cryptic taxa and hybridisation. In addition, cryptic coral taxa present an untapped resource for studying speciation which could provide rich opportunities for collaboration among coral and speciation biologists and fill key knowledge gaps relevant to conservation and restoration.…”
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Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance by Tianming Qiu, Yu Zhi, Jingyuan Zhang, Ningning Wang, Xiaofeng Yao, Guang Yang, Liping Jiang, Li Lv, Xiance Sun

“…Notably, overexpression of SET or inhibition of Rac1 substantially mitigated the apoptosis of islet β-cells and ameliorated the impaired insulin secretion (increased from 0.1 ng/ml to 0.2 ng/ml) caused by NaAsO2 exposure. In addition, we detected cytoskeletal disorganization following NaAsO2 treatment, characterized by elevated Cofilin-1 protein expression (approximately 2.5-fold) and disrupted cytoskeleton arrangement. …”
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Improving Autonomous Vehicle Cognitive Robustness in Extreme Weather With Deep Learning and Thermal Camera Fusion by Mehmood Nawaz, Sheheryar Khan, Muhammad Daud, Muhammad Asim, Ghazanfar Ali Anwar, Ali Raza Shahid, Ho Pui Aaron HO, Tom Chan, Daniel Pak Kong, Wu Yuan

“…In the YoloV8 model, we adjusted the network architecture to incorporate additional convolutional layers and altered the loss function to enhance detection accuracy in foggy and rainy conditions. …”
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The Influences of Key Strata Compound Breakage on the Overlying Strata Movement and Strata Pressure Behavior in Fully Mechanized Caving Mining of Shallow and Extremely Thick Seams:... by Junmeng Li, Yanli Huang, Jixiong Zhang, Meng Li, Ming Qiao, Fengwan Wang

“…The research results showed that during the fully mechanized caving mining in shallow and extremely thick seams, the inferior key strata affected by mining movement behaved in the mode of sliding instability and could not form the stable structure of the voussoir beam after breaking and caving. In addition, the main key strata behaved in the mode of rotary instability, and the caving rocks behind the goaf were gradually compacted because of the periodic instability of the main key strata. …”
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Rhegmatogenous retinal detachment: current treatment approaches by A.V. Doga, D.O. Shkvorchenko, L.A. Kryl, M.R. Taevere, D.A. Buryakov

“…Russian Journal of Clinical&nbsp;Ophthalmology. 2020;20(2):72–78. DOI: 10.32364/2311-7729-2020-20-2-72-78.</i> </p> <i><br> </i><br>…”
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3D highly isolated 6-port tri-band MIMO antenna system with 360° coverage for 5G IoT applications based machine learning verification by Md Afzalur Rahman, Samir Salem Al-Bawri, Sultan S. Alharbi, Wazie M. Abdulkawi, Noorlindawaty Md Jizat, Mohammad Tariqul Islam, Abdel-Fattah A. Sheta

“…Maximum realized gain of 4.3 dBi in the sub-6 GHz band, 5.5 dBi in the Ku-band, and 9.9 dBi in the millimeter wave (mm-wave) band for 3D MIMO setup is ensured. …”
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Surgery and Medical Treatment in Microprolactinoma: A Systematic Review and Meta-Analysis by Jianglong Lu, Lin Cai, Zerui Wu, Weiwei Lin, Jiadong Xu, Zhangzhang Zhu, Chengde Wang, Qun Li, Zhipeng Su

“…Surgery showed a high remission rate in treatment-naive microprolactinoma patients after treatment withdrawal and may be an alternative first-line treatment strategy in addition to DAs, particularly in patients with a preoperative prolactin level of ≤200 ng/mL.…”
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Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition by Anastasiia Lozovska, Ana Casaca, Ana Novoa, Ying-Yi Kuo, Arnon D Jurberg, Gabriel G Martins, Anna-Katerina Hadjantonakis, Moises Mallo

“…Similar alterations in the LPM and vascular system were also observed in Isl1 null mutants, indicating that this factor acts in the regulatory cascade downstream of Tgfbr1 in LPM-derived tissues. In addition, in the absence of Tgfbr1 the embryonic endoderm fails to expand to form the endodermal cloaca and to extend posteriorly to generate the tail gut. …”
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