Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways by Mohamed El-Sherbiny, Hany A. Elkattawy, Shimaa Hadhoud, Ahmed N. Nasr, Ateya M. Ibrahim, Ateya M. Ibrahim, Omar Z. Ameer, Noorhan Alsaleebi, Joud Asfari, Madaniah O. Zakari, Moaz A. Mojaddidi, Ehab K. Ali, Hailah M. Almohaimeed, Ahmed Abdeen, Sahar K. Ali, Mamdouh Eldesoqui, Mamdouh Eldesoqui

“…Besides, LPS increased the malondialdehyde (MDA) and decreased the glutathione (GSH) levels, inducing an oxidative stress cascade. In addition, there are dramatic increases in the TLR4, MyD88, NF-κB, and PK2/PKR1 protein expression levels. …”
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Challenges and Prospects of Digital Core-Reconstruction Research by Linqi Zhu, Chong Zhang, Chaomo Zhang, Xueqing Zhou, Zhansong Zhang, Xin Nie, Weinan Liu, Boyuan Zhu

“…In this paper, existing 3D digital core-reconstruction methods are divided into two categories: 3D digital cores based on physical experiments and 3D digital core stochastic reconstructions based on two-dimensional (2D) slices. Additionally, 2D slice-based digital core stochastic reconstruction techniques are classified into four types: a stochastic reconstruction method based on 2D slice mathematical-feature statistical constraints, a stochastic reconstruction method based on statistical constraints that are related to 2D slice morphological characteristics, a physics process-based stochastic reconstruction method, and a hybrid stochastic reconstruction method. …”
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Safe-and-sustainable-by-design redox active molecules for energy storage applications by Clemens Wolf, Janine Maier, Julia Wenger, Georg Rudelstorfer, Christian Leypold, Julia Voglhuber-Höller, Matiss Reinfelds, Andrea Weiner, Arantza Muriana, Susanne Lux, Claudia Mair-Bauernfeind, Andreas Falk, Stefan Spirk

“…(Social) life cycle assessment focused on the workflow from sourcing, processing and generation of intermediate products to the quinone used in the redox flow batteries and revealed important insights, highlighting critical steps in the process chain. Additionally, we identified two specific points of intervention regarding solvent and quinone choice, based on sustainability parameters. …”
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Incidence of seroma and postoperative complications after breast surgery before and during the Covid-19 pandemic: results from a retrospective multicenter analysis by Maximilian Heinz Beck, Izabela A. Brachaczek, Pimrapat Gebert, Jens-Uwe Blohmer, Askin C. Kaya, Julia S. M. Zimmermann, Julia C. Radosa, Maria M. Karsten

“…Additional real-world evidence is needed for understanding both early and late complications following breast surgery in the context of the ongoing SARS-CoV-2 endemic.…”
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Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study by Peter Koch, Inke König, Johann Roider, Jan Tode, Konstantine Purtskhvanidze, Claus von der Burchard, Helge Sudkamp, Cristoph Ehlken, Moritz Moltmann, Britta Heimes, Michael Münst, Malte vom Endt, Timo Kepp, Dirk Theisen-Kunde, Gereon Hüttmann

“…This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT).Design Prospective single-arm diagnostic accuracy study.Setting Tertiary care centre (University Eye Clinic).Participants 46 patients with age-related macular degeneration.Interventions Patients received short training in device handling and then performed multiple self-scans with the SELFF-OCT according to a predefined protocol. Additionally, all eyes were examined with standard SD-OCT, performed by medical personnel. …”
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Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases by Sára Mravinacová, Sofia Bergström, Jennie Olofsson, Nerea Gómez de San José, Sarah Anderl-Straub, Janine Diehl-Schmid, Klaus Fassbender, Klaus Fliessbach, Holger Jahn, Johannes Kornhuber, G. Bernhard Landwehrmeyer, Martin Lauer, Johannes Levin, Albert C. Ludolph, Johannes Prudlo, Anja Schneider, Matthias L. Schroeter, Jens Wiltfang, Petra Steinacker, FTLD Consortium, Markus Otto, Peter Nilsson, Anna Månberg

“…With this approach, the proteins adjust for each other and further increase the biomarker performance through additive effect. When comparing the diseases, two proteins—neurofilament medium and myelin basic protein—showed increased levels in ALS compared to other diseases, and neurogranin showed a specific increase in AD. …”
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Functional Analysis of DNMT1 SNPs (rs2228611 and rs2114724) Associated with Schizophrenia by Sonal Saxena, Pranay Amruth Maroju, Sumana Choudhury, Vidhya Chitta Voina, Poonam Naik, Kavitha Gowdhaman, Poornima Kkani, Kiranmai Chennoju, S. Ganesh Kumar, C. Ramasubramanian, G. Prasad Rao, Trinath Jamma, Kumar Pranav Narayan, K. Naga Mohan

“…This significant association persisted after Bonferroni correction when the previously published data of 301 controls and 325 patients were also considered (P ≤ 0.0002). In addition, we found that the proportion of male patients with homozygous minor alleles at rs2114724 was significantly higher than that of females (P = 0.002). …”
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Research progress on the treatment and nursing of ingrown toenails paronychia (嵌甲型甲沟炎的临床治疗及护理进展) by DENG Yiou (邓翼鸥), CHEN Yuguo (陈玉果)

“…Appropriate treatment methods should be selected according to the demands of patients and the clinical manifestations of nail inlay. In addition, enhancement of prevention, removing potential causes and treating according to the nail inlay are helpful to reduce the recurrence rate and achieve relatively sound clinical efficacy. …”
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Peripheral Expression of IL-6, TNF-α and TGF-β1 in Alzheimer's Disease Patients by Gamze Güven, Pınar Köseoğlu, Ebba Lohmann, Bedia Samancı, Erdi Şahin, Başar Bilgiç, Haşmet Ayhan Hanağası, Hakan Gürvit, Nihan Erginel-Ünaltuna

“…Materials and Methods: We quantitatively assessed serum IL-6 and TGF-β1 levels in 25 AD patients and 33 age-matched controls using enzymelinked immunosorbent assay. In addition, we evaluated the mRNA expressions of IL-6 and TNF-α in peripheral blood mononuclear cells from 31 AD patients and their respective controls (n=30) via quantitative real-time polymerase chain reaction. …”
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RAGE and its ligands in breast cancer progression and metastasis by Madalina Coser, Bogdan Mihai Neamtu, Bogdan Mihai Neamtu, Bogdan Pop, Bogdan Pop, Calin Remus Cipaian, Calin Remus Cipaian, Maria Crisan, Maria Crisan

“…In addition, studies have shown that RAGE and its ligands influence the way breast cancer cells interact with immune cells present in the tumor microenvironment (macrophages, fibroblasts), thus regulating it to promote tumor growth and metastasis.ConclusionBreast cancers with a high expression of RAGE are associated with poor prognosis. …”
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A novel agricultural drought index based on multi-source remote sensing data and interpretable machine learning by Hao Chen, Ni Yang, Xuanhua Song, Chunhua Lu, Menglan Lu, Tan Chen, Shulin Deng

“…The drought monitoring performance of IMLDI was validated in the eastern parts of China, and three integrated drought indies composited by PCA, multiple linear regression, and gradient boosting method were also included for comparison. …”
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Research on the movement process of erosion-denudation type debris flow in middle-low mountains based on particle algorithm model by Xiaofeng He, Yongfeng Gong, Jinkai Yan, Shichang Gao, Zheng He, Gang Zhang, Guorui Wang, Zhiyong Hu, Hui Wang

“…Regarding movement speed, the debris flow initially accelerated and then decelerated, with the extreme condition resulting in a greater travel distance compared to the normal condition. Additionally, the debris flow exhibited greater erosion depth and volume under normal conditions. …”
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Familial Hypercholesterolemia: Genetics, Symptoms, Diagnosis and Treatment - A Literature Overview by Maciej Rutkiewicz, Sabina Przygodzka, Katarzyna Gadżała, Karolina Garbino, Katarzyna Brudniak, Antoni Szuścik, Magdalena Czyczerska

“…Weight reduction is recommended. In addition, pharmacological treatment must be performed. …”
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Countertransference, alliance, and outcome in the treatment of patients with personality disorder: a longitudinal naturalistic study by Randi Breivik Øvstebø, Randi Breivik Øvstebø, Geir Pedersen, Theresa Wilberg, Theresa Wilberg, Jan Ivar Røssberg, Jan Ivar Røssberg, Hanne-Sofie Johnsen Dahl, Elfrida Hartveit Kvarstein, Elfrida Hartveit Kvarstein

“…Further moderator analysis did not yield additional information.ConclusionThe study demonstrates significant associations between negative CTs and lower patient-rated WAI in the early phase of therapy, and a development of increasingly more negative CTs during therapy in treatments which were not completed according to schedule. …”
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First Detection of <i>Wolbachia</i> in Namibian Bird Ectoparasites (Acariformes: Syringophilidae) with a Description of New Quill Mite Species by Eliza Glowska-Patyniak, Katarzyna Kaszewska-Gilas, Izabella Laniecka, Julia Olechnowicz, Kamila Ostrowska, Wiktoria Dmuchowska, Brian K. Schmidt, Jan Hubert, Artur Trzebny

“…We detected <i>Wolbachia</i> in two mite populations collected from two species of larks. However, we did not find any other endosymbiotic bacteria or any that could be of epidemiological importance. …”
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Cell Wall Protein 2 as a Vaccine Candidate Protects Mice Against <i>Clostridioides difficile</i> Infection by Shaohui Wang, Joshua Heuler, Jessica Bullock, Junling Qin, Soumyadeep Chakraborty, Agbendeh Lubem Nathaniel, Shifeng Wang, Xingmin Sun

Subjects: “…<i>Clostridioides difficile</i> infection (CDI)…”
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Hypertensive disorders of pregnancy affected thyroid hormone synthesis via endoplasmic reticulum stress in preterm infant rats by Maomao Sun, Congrong Wu, Jie Jiang, Yue He, Sha Zhu, Yonghui Yu

“…While electron microscopy revealed that the endoplasmic reticulum of thyroid follicular epithelial cells was marked swollen within L-NAME group. Additionally, the mRNA expression of Ttf1, Pax8 and Tshr was down-regulated in thyroid tissues of L-NAME group. …”
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Diagnostic ability of myxovirus resistance-A in pediatric cases of viral-acute respiratory tract infections with vitamin A and zinc deficiencies by Dian Kesumapramudya Nurputra, Amalia Setyati, Nur Arfian, Endy Paryanto Prawirohartono, Zulvikar Syambani Ulhaq

“…To determine the etiology, we conducted blood cultures and employed RT-PCR analysis on nasopharyngeal swabs. Additionally, we assessed plasma levels of vitamin A, zinc, and MxA protein expression. …”
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Geohazard features of the Gulf of Naples and Pontine Islands (Eastern Tyrrhenian Sea) by Francesca Budillon, Eleonora Martorelli, Alessandro Conforti, Giovanni De Falco, Alessandro Bosman, Gabriella Di Martino, Marco Firetto Carlino, Martina Misuraca, Sara Innangi, Martina Pierdomenico, Andrea Sposato, Renato Tonielli, Daniele Casalbore, Roberto Capperucci, Aida Maria Conte, Francesco G. Falese, Michela Ingrassia, Ennio Marsella, Cristian Montanaro, Eleonora Morelli, Roberto Sisinni, Francesco L. Chiocci

“…These include canyon systems, erosive scarps, landslide complexes, fault – and volcanic-related features, such as the products of the volcanic edifices instability, which claim to varying degrees of geo-hazard. Additionally, bedforms, fluid seepages and creeping phenomena in the prodelta slopes suggest high morpho-tectonic and environmental dynamics.HighlightsThis article reports on the thematic maps developed along the Lazio – Campania offshore (Central-eastern Tyrrhenian Sea, Italy) within the framework of the Magic Project, based on geomorphological analysis of the HR Digital Elevation Model of the seafloor.Several classes of hazard-related elements have been identified offshore, mainly associated with high-gradient slopes, volcanic activity and intense morphodynamic processes.The entire suite of maps created in the context of the Magic Project serves as a valuable base of knowledge, extending to the national scale and benchmarks for future monitoring of critical sites and geo-hazard-related features, as well as for maritime spatial planning actions.…”
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Seedling Stage Corn Line Detection Method Based on Improved YOLOv8 by LI Hongbo, TIAN Xin, RUAN Zhiwen, LIU Shaowen, REN Weiqi, SU Zhongbin, GAO Rui, KONG Qingming

“…The YOLOv8-G algorithm achieved average precision (AP) values of 98.22%, 98.15%, and 97.32% for corn detection at 7, 14, and 21 days after emergence, respectively. Additionally, the crop line extraction accuracy across all stages was 96.52%. …”
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