Non-invasive 4D transcranial functional ultrasound and ultrasound localization microscopy for multimodal imaging of neurovascular response by Rebecca M. Jones, Ryan M. DeRuiter, Hanjoo R. Lee, Saachi Munot, Hatim Belgharbi, Francisco Santibanez, Oleg V. Favorov, Paul A. Dayton, Gianmarco F. Pinton

“…During stimulation periods, there was a statistically significant (p<0.0001) increase in cerebral blood flow, diameter, and global velocity, but a decrease in velocity in the activated region. Additionally, the global flow increased (p=0.11) and connectivity decreased (24.7%) when compared to baseline. …”
Get full text

HLA-G high-expressor 3’UTR markers are linked to gastric cancer development and survival by Christian Vaquero-Yuste, Ignacio Juarez, Marta Molina-Alejandre, Elisa María Molanes-López, Alberto Gutiérrez-Calvo, Adela López-García, Inmaculada Lasa, Remedios Gómez, Antonio Arnaiz-Villena, Jose Manuel Martín-Villa

“…High-expressor HLA-G 3’UTR haplotypes (UTR-1 and UTR-6) were significantly associated with gastric cancer susceptibility, indicating a potential role in tumor immune evasion. Additionally, the 14 base pair insertion/deletion polymorphism (14 bp I/D) emerged as a prognostic marker, with D/D genotype carriers showing lower survival rates compared to I/D and I/I genotype carriers. …”
Get full text

Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Much of the logistical burden falls on those living with SMI to educate themselves and initiate the completion of a PAD.[11] However, many of those living with SMI already face additional burdens that prevent their successful navigation of a complex healthcare system, including poverty, marginal housing, and food insecurity.[12] In addition, individuals with SMI tend to be more socially isolated, with few others to trust besides their providers.[13] Efforts to promote the uptake of PADs by those living with SMI that neglect these additional burdens risk exacerbating health inequities faced by those with SMI. …”
Get full text

Retrieving the atmospheric concentrations of carbon dioxide and methane from the European Copernicus CO2M satellite mission using artificial neural networks by M. Reuter, M. Hilker, S. Noël, A. Di Noia, M. Weimer, O. Schneising, M. Buchwitz, H. Bovensmann, J. P. Burrows, H. Bösch, R. Lang

“…The necessary accuracy and precision requirements for the measured quantities XCO<span class="inline-formula">₂</span> and XCH<span class="inline-formula">₄</span> (the column-averaged dry-air mole fractions of CO<span class="inline-formula">₂</span> and CH<span class="inline-formula">₄</span>) are demanding. …”
Get full text

Effects of non-pharmacological interventions on depressive and anxiety symptoms in pregnant women: a systematic review and network meta-analysisResearch in context by Guowei Zeng, Jianfeng Niu, Ke Zhu, Fei Li, Liwen Li, Kaiming Gao, Yanlong Zhuang, Boyang Zhang, Xiaoqiang Han, Gang Ye, Zhikun Gao, Haobai Li

“…Subgroup analysis shows that, in addition to mindfulness therapy, mind-body exercises (SUCRA = 67.43%; SMD = −0.97, 95% CrI = −1.61, −0.33; N = 382) and cognitive-behavioral therapy (SUCRA = 52.60%; SMD = −0.74, 95% CrI = −1.38, −0.09; N = 480) may also be effective in alleviating anxiety symptoms among healthy pregnant women. …”
Get full text

Key Drivers Affecting the Future of Power Relations in Tehran Metropolis with a Scenario-Writing Approach by Afshin Mottaghi, Arash Ghorbani Sepehr, Joseph Saloukadz

“…AbstractAs the center of developments on local, regional, national, and global scales, and the site of influential actors, Tehran's metropolitan area has long been a stage for political power dynamics. Additionally, the presence of geopolitical drivers has further elevated its position in power relations. …”
Get full text

Contribution à l’histoire de la boulangerie romaine : étude de « pains/galettes » découverts en Gaule by Andreas G. Heiss, Véronique Matterne, Nicolas Monteix, Margaux Tillier, Camille Noûs

“…Without damaging the archaeological specimen, X-ray microtomography allows for an observation of the internal structure of the dough and the gas bubbles (pores) produced by fermentation, as well as inclusions and additions of ingredients other than flour. Results from initial analysis reveal that the products studied were prepared from extremely pure flours and were very carefully ground and sieved. …”
Get full text

Research of efficiency of ferrous metallurgy slag use in pavement base layers by S. A. Chernov, E. V. Lekontsev, V. S. Schreiner, A. V. Fuchs, A. I. Piskunov

“…Steelmaking slags of ferrous metallurgy can contribute to the production of organomineral mixtures with increased physical, mechanical and operational properties due to the increased content of calcium compounds, microporous additions of the crystal structure and active hydration processes, which can have a beneficial effect on the durability of the structural layer of the pavement when used.Materials and methods. …”
Get full text

Microbial metabolites and immune modulation by Hassan Ghasemi

“…Further research is needed to dissect the precise molecular pathways linking specific metabolites to immune responses, as much remains unknown about their multifaceted roles. Additionally, translational hurdles -such as ensuring the stability, bioavailability, and targeted delivery of microbial metabolites- must be overcome to realize their full clinical potential.14 Microbial metabolites are central to immune modulation, bridging the intricate relationship between host and microbiota. …”
Get full text

The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 2; peer review: 1 approved, 2 approved wit... by Paul Leighton, Wei Chern Gavin Fong, Ingrid Muller, Laura Howells, Arabella Baker, Eleanor J Mitchell, Eleanor Harrison, Leila Thuma, Yimin Jiang, Lucy Bradshaw, Alan Montgomery, Fiona Cowdel, Matthew J Ridd, Jane Ravenscroft, Reiko J Tanaka, Miriam Santer, Richard Swinden, Nicholas Hilken, Carron Layfield, Richard Dooley, Sophia Collins, Clare Upton, Tracy Owen, Firoza Davies, Devin Patel, Mars Eddis-Finbow, Hywel C Williams, Goldie Putrym, Kim S Thomas, Amanda Roberts

“…Trial registration ISRCTN12016473, 22/11/2023, https://doi.org/10.1186/ISRCTN12016473…”
Get full text

The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 1; peer review: 1 approved, 2 approved wit... by Paul Leighton, Wei Chern Gavin Fong, Ingrid Muller, Laura Howells, Arabella Baker, Eleanor J Mitchell, Eleanor Harrison, Leila Thuma, Yimin Jiang, Lucy Bradshaw, Alan Montgomery, Fiona Cowdel, Matthew J Ridd, Jane Ravenscroft, Reiko J Tanaka, Miriam Santer, Richard Swinden, Nicholas Hilken, Carron Layfield, Richard Dooley, Sophia Collins, Clare Upton, Tracy Owen, Firoza Davies, Devin Patel, Mars Eddis-Finbow, Hywel C Williams, Goldie Putrym, Kim S Thomas, Amanda Roberts

“…Trial registration ISRCTN12016473, 22/11/2023, https://doi.org/10.1186/ISRCTN12016473…”
Get full text

Combining a WT1 Vaccine (Galinpepimut-S) With Checkpoint Inhibition (Nivolumab) in Patients With WT1–Expressing Diffuse Pleural Mesothelioma: A Phase 1 Study by Prashasti Agrawal, MD, Michael Offin, MD, Victoria Lai, MD, Michelle S. Ginsberg, MD, Prasad S. Adusumilli, MD, FACS, Valerie W. Rusch, MD, Jennifer L. Sauter, MD, Teresa Ho, BS, Phillip Wong, PhD, Marjorie G. Zauderer, MD

“…Patients received two doses of GPS followed by six doses of GPS with intravenous nivolumab every 2 weeks, and up to six additional cycles until disease progression or unacceptable toxicity. …”
Get full text

Developing an Ethical Regulatory Framework for Artificial Intelligence: Integrating Systematic Review, Thematic Analysis, and Multidisciplinary Theories by Jian Wang, Yujia Huo, Jinli Mahe, Zongyuan Ge, Zhangdaihong Liu, Wenxin Wang, Lin Zhang

“…To this end, we developed the Ethical Regulatory Framework for AI (ERF-AI) to guide regulatory bodies in constructing mechanisms, including role setups, procedural configurations, and strategy design. …”
Get full text

Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study by Zhengwei Chen, Liangqun Rong, Lijie Xiao, Jie Rao, Haiyan Liu, Tengfei Liu, Fei Chen, Jun Zhang, Lu Wang, Xi Li, Xiue Wei

“…Methods of voxel-based amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were adopted to compare the difference in brain function between the two groups. In addition, we evaluated the associations between abnormal neuroimaging results and clinical data in AUVP patients.ResultsCompared with HC, patients with AUVP showed lower ALFF in brain regions of bilateral insular, right precentral gyrus, left inferior frontal gyrus and right middle frontal gyrus, as well as higher ALFF in left cerebellar anterior lobe. …”
Get full text

Treatment of inoperable pancreatic adenocarcinoma with focused ultrasound and microbubbles in patients receiving chemotherapy by Margrete Haram, Rune Hansen, Ola Finneng Myhre, Stian Solberg, Naseh Amini, Bjørn Atle Angelsen, Catharina de Lange Davies, Eva Hofsli

“…Results: Treatment with FUS and MB is safe with the used settings. No additional effects of FUS and MBs regarding tumor volume or resectability were observed. …”
Get full text

Relativistic Electron Model in the Outer Radiation Belt Using a Neural Network Approach by Xiangning Chu, Donglai Ma, Jacob Bortnik, W. Kent Tobiska, Alfredo Cruz, S. Dave Bouwer, Hong Zhao, Qianli Ma, Kun Zhang, Daniel N. Baker, Xinlin Li, Harlan Spence, Geoff Reeves

“…ORIENT‐R reproduces radiation belt dynamics during an out‐of‐sample geomagnetic storm with good agreement to the observations. In addition, ORIENT‐R was run for a completely out‐of‐sample period between March 2018 and October 2019 when the AL index ended and was replaced with the predicted AL index (lasp.colorado.edu/home/personnel/xinlin.li). …”
Get full text

Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for <i>Trypanosoma cruzi</i> Infection by Citlali Vázquez, Rusely Encalada, Isabel Jiménez-Galicia, Rogelio Gómez-Escobedo, Gildardo Rivera, Benjamín Nogueda-Torres, Emma Saavedra

“…Remarkably, the antidiabetic drugs in monotherapy decreased the infection in mice by 40–60% in a similar extent to BNZ (80%). In addition, the combination of BNZ plus antidiabetics perturbed the antioxidant metabolites in epimastigotes. …”
Get full text

Observations and Quantitative Compositional Analysis of Ceres, Pallas, and Hygiea Using JWST/NIRSpec by Andrew S. Rivkin, Cristina A. Thomas, Ian Wong, Bryan Holler, Helena C. Bates, Ellen S. Howell, Bethany L. Ehlmann, Stefanie N. Milam, Heidi B. Hammel

“…This similarity in spectral properties, and thus in interpretations of surface composition, implies that the two bodies may have had similar processes occur and similar histories. …”
Get full text

Multi-environmental traits selection and farmer's participatory assessment of mean performance and stability of orange-fleshed sweet potato genotypes in Benin by Idrissou Ahoudou, Nicodeme V. Fassinou Hotegni, Dêêdi E.O. Sogbohossou, Tania L.I. Akponikpè, Charlotte O.A. Adjé, Françoise Assogba Komlan, Ismail Moumouni-Moussa, Enoch G. Achigan-Dako

“…The PVS revealed that farmers assigned high importance to yield performance for field evaluation and root dry matter content. In addition, they prioritized many different traits, such as the attractiveness of orange flesh colour and the lower fibrousness of boiled roots. …”
Get full text

Strengthening HIV Education and Health Promotion in Schools: A Case Study of ‘Aisyiyah Junior High School Bantul, Indonesia by Dhesi Ari Astuti, Muhamad Saleh, Nurul Kurniati, Siti Fatimah, Cindy Putri Febrianti, Khoirunnisah Hasibuan

“…Therefore, providing access facilitates infrastructure and makes teenagers the agents of prevention of HIV. In addition, advocacy in the form of promotion and prevention can be conducted. …”
Get full text