Analysis of Optimal Health-Related Quality of Life Measures in Patients Waitlisted for Lung Transplantation by Junko Tokuno, Toyofumi F Chen-Yoshikawa, Toru Oga, Takahiro Oto, Tomoyo Okawa, Yoshinori Okada, Miki Akiba, Masaki Ikeda, Daisuke Nakajima, Masatsugu Hamaji, Hideki Motoyama, Akihiro Aoyama, Maki Isomi, Kazuo Chin, Hiroshi Date

“…CRF-specific HRQL measures of the Maugeri Respiratory Failure Questionnaire (MRF) and Severe Respiratory Insufficiency Questionnaire (SRI) were assessed in addition to the SGRQ. Results. Compared to the MRF-26 and SRI, the score distribution of the SGRQ was skewed toward the worse ends of the scale. …”
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Identification of the AHP family reveals their critical response to cytokinin regulation during adventitious root formation in apple rootstock by Ke Li, Ke Li, Ke Li, Huan Li, Wei Ling Liang, Jing Ju Liu, Hui Yue Tian, Li Hu Wang, Li Hu Wang, Yan Hong Wei, Yan Hong Wei

“…Excluding MdAHP6, other members’ promoter sequences behaved 2-4 CTK response elements. Additionally, the expression characteristics of MdAHPs family members at key stages of AR formation and in different tissues were also examined with exogenous 6-BA and Lov treatments. …”
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Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia by Luigi Giuliani, Francesco Sanmarchi, Armida Mucci, Paola Rucci, Edoardo Caporusso, Paola Bucci, Giulia M. Giordano, Mario Amore, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Silvana Galderisi, Mario Maj

“…This method may provide additional insights for the identification of potential therapeutic targets to promote recovery in people with chronic schizophrenia. …”
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Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study by Yu Jiang, Yu Jiang, Di Su, Jingwen Xiao, Jingwen Xiao, Wenbo Cheng, Yuemei Hou, Yan Zhang, Yan Zhang

“…The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate maximum (HRmax), heart rate minimum (HRmin), left ventricular ejection fraction (LVEF), left atrial diameter (LAD), Atrial Fibrillation Severity Scale (AFSS) symptom subscale, and Memorial Symptom Assessment Scale-Heart Failure (MSAS-HF) before and after the treatment were observed and compared. In addition, adverse effects of the LL-aVNS procedure and 6-month follow-up were recorded.ResultsSBP, DBP, and HRmin were lower after the treatment than before the treatment (p < 0.05); AFSS symptom subscale scores and MSAS-HF scores after the treatment were lower before the treatment (p < 0.05); itching of the skin was observed in one case during the course of LL-aVNS; and two patients were hospitalized for acute exacerbation of chronic heart failure between 4 months and 6 months after the treatment.ConclusionLL-aVNS in patients with paroxysmal atrial fibrillation can assist in controlling blood pressure and heart rate, effectively relieving symptoms, and the treatment process is safe and feasible.…”
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CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium by Zhixuan Chen, Huayi Qu, Jian Sun, Tao Wang, Yan Yuan, Yan Yuan, Yan Yuan, Jianhong Gu, Jianhong Gu, Jianhong Gu, Jianchun Bian, Jianchun Bian, Jianchun Bian, Zongping Liu, Zongping Liu, Zongping Liu, Hui Zou, Hui Zou, Hui Zou

“…As observed by transmission electron microscopy (TEM), the number of autophagosomes was significantly increased in the PS-MPs and Cd co-treated group. In addition, autophagic flux was assayed by RFP-GFP-LC3, a reporter system expressing dual fluorescent proteins, which showed an overwhelming enhancement of autophagic flux damage by co-exposure to PS-MPs and Cd compared to exposure alone. …”
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Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88 by Hongbo Yi, Li Wang, Yunxia Xiong, Zhilin Wang, Yueqin Qiu, Xiaolu Wen, Zongyong Jiang, Xuefen Yang, Xianyong Ma

“…It was found that L. reuteri LR1, in large part, offset the ETEC K88-induced increase in permeability of IPEC-1 cell monolayers and decreased the adhesion and invasion of the coliform in IPEC-1 cells. In addition, L. reuteri LR1 increased transcript abundance and protein contents of tight junction (TJ) proteins zonula occluden-1 (ZO-1) and occludin in ETEC K88-infected IPEC-1 cells, whereas it had no effects on claudin-1 and F-actin expression. …”
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NF-κB-Inducing Kinase Is Essential for Effective c-Rel Transactivation and Binding to the <i>Il12b</i> Promoter in Macrophages by Natalia Cuesta, Anna D. Staniszewska, Cristóbal Moreno, Carmen Punzón, Manuel Fresno

“…Immunoprecipitation studies showed that the binding of NIK to c-Rel was not efficient in RAW 264.7 cells over-expressing the <i>aly</i>/<i>aly</i> mutation. In addition, the shuttling of c-Rel to the nucleus was shown to be impaired in <i>aly</i>/<i>aly</i> macrophages in response to LPS. …”
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Fixing cobalt metal onto mordenite through spray impregnation and its evaluation as a catalyst in transforming used coconut cooking oil into bio-jet fuel by Aldino Javier Saviola, Karna Wijaya, Akhmad Syoufian, Marini Fairuz Vebryana, Widuri Anggraeni, Kharistya Rozana, Nono Darsono, Dita Adi Saputra, Wahyu Dita Saputri

“…gas at a flow rate of 20 mL/min and a catalyst-to-feed ratio of 1:200 (w/w) for a duration of 2 h. The addition of cobalt significantly enhanced the efficiency of the hydrotreatment by improving the catalytic performance of mordenite as a support material. …”
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SSVEP Enhancement in Mixed Reality Environment for Brain&#x2013;Computer Interfaces by Jieyu Wu, Feng He, Xiaolin Xiao, Runyuan Gao, Lin Meng, Xiuyun Liu, Minpeng Xu, Dong Ming

“…Color contrast ratios (CCRs) between stimulus and background colors were introduced to assess the performance difference among all conditions. Additionally, we proposed a cross-correlation task-related component analysis based on simulated annealing (SA-xTRCA), which can increase the signal-to-noise ratio (SNR) and detection accuracy by aligning SSVEP trials. …”
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Differential coping capacities underlie the overall resistance of temperate seagrasses to herbivory by J. Boada, T. M. Smith, A. M. Ricart, T. Alcoverro, M. Pérez, J. Romero, N. Sanmartí, Y. Ontoria, M. Pierrejen, R. Arthur, D. Alonso, M. P. Adams, F. Rossi

“…., canopy height and shoot density) to reflect the ecosystem state. Additionally, we used mechanistic models to assess induced and constitutive responses in the different seagrass species. …”
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Effects of tropical cyclone Freddy on the social determinants of health: the narrative review of the experience in Malawi by Joseph Okeibunor, Otim Patrick Cossy Ramadan, Ishata Nannie Conteh, Abdou Salam Gueye, Jayne Byakika-Tusiime, Annie Chauma-Mwale, Ebenezer Obi Daniel, Dick Chamla, Fiona Braka, Neema Kimambo Rusibamayila, Chol Thabo Yur, Emmanuel Maurice Ochien, Mathew Kagoli

“…This narrative study aimed at unravelling the consequences of the TCF and its possible relationship with the already existing cholera epidemic in the fourteen affected districts. Additionally, it aimed to document the immediate humanitarian responses in the acute phase of the disaster. …”
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Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19 by Aurelie Guironnet-Paquet, Aurelie Guironnet-Paquet, Hind Hamzeh-Cognasse, Frederic Berard, Fabrice Cognasse, Fabrice Cognasse, Jean Christophe Richard, Hodane Yonis, Mehdi Mezidi, Olivier Desebbe, Bertrand Delannoy, Sophie Demeret, Clemence Marois, Clemence Marois, Clemence Marois, Samir Saheb, Quoc Viet Le, Mathieu Schoeffler, Paul Simon Pugliesi, Sophie Debord, Paul Bastard, Paul Bastard, Paul Bastard, Paul Bastard, Aurélie Cobat, Aurélie Cobat, Aurélie Cobat, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Rémi Pescarmona, Sébastien Viel, Jean François Nicolas, Jean François Nicolas, Audrey Nosbaum, Audrey Nosbaum, Marc Vocanson, Olivier Hequet, Olivier Hequet

“…Interestingly, while TPE did not influence changes in ARDS parameters throughout the protocol, it proved more effective than ST in reversing lymphopenia, preventing T-cell hyperactivation and reducing T-cell exhaustion, notably in a fraction of TPE patients who had an early favourable respiratory outcome. …”
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Dietary inclusion of Moringa oleifera leaf extracts as alternatives to antibiotic growth promoter on live performance, carcass traits, physical meat quality, and health status of b... by Al Ibne Rifat, Chondhon Chandro Bormon, Md Golam Akib, Mohammad Shamsul Ataher, Md Kamruzzaman, Amitush Dutta, Amio Kante Das, Kanan Talukder, Mahmoud Azzam, Mohammed Hamdy Farouk, Razib Das, Shad Mahfuz

“…The MLE group had the highest average daily gain, final body weight, and lower feed conversion ratio than both control and antibiotic groups. …”
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The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates by Qingbo Fang, Tianlai Qiu, Fenglan Chen, Xuqi Tian, Zijun Feng, Yanan Cao, Jinbing Bai, Jing Huang, Yanqun Liu

“…We found that in the neonatal gut microbiome, Sediminibacterium and Thermovirga were positively associated with SPEI after controlling for PM2.5 in linear regression models. Additionally, SPEI was significantly associated with phenylpropanoid biosynthesis and cyanoamino acid metabolism in neonates. …”
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In silico comparative genomic analysis unravels a new candidate protein arsenal specifically associated with Fusarium oxysporum f. sp. albedinis pathogenesis by Hafida Ayada, Boutayna Dhioui, Hamid Mazouz, Abdelhay El harrak, Fatima Jaiti, Bouchra Ouhmidou, Mohammed Diouri, Mohieddine Moumni

“…Transcription factors and membrane transporters (MFS) involved in fungicide efflux have been predicted in Foa, in addition to a variety of secondary metabolites. These comprise mycotoxins as well as chrysogin, the latter provides Foa with resistance against adverse environmental conditions. …”
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Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled tri... by Karen J. Bosma, Myriam Lafreniere-Roula, Arlene Jiang, Anna Heath, Yongdong Ouyang, Kaitlyn Wade, Pingzhao Hu, Karen E. A. Burns, Claudio M. Martin, Yoanna Skrobik, Sorcha Mulligan, Kevin E. Thorpe, Laurent Brochard, members of the Canadian Critical Care Trials Group and the REVA Network

“…This update summarizes the changes made and their rationale and provides a refined SAP for the PROMIZING trial with additional background information, in adherence with guidelines for the prospective reporting of SAPs for randomized controlled trials. …”
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Explainable AutoML models for predicting the strength of high-performance concrete using Optuna, SHAP and ensemble learning by Muhammad Salman Khan, Tianbo Peng, Tianbo Peng, Muhammad Adeel Khan, Asad Khan, Mahmood Ahmad, Mahmood Ahmad, Kamran Aziz, Mohanad Muayad Sabri Sabri, N. S. Abd EL-Gawaad

“…This study introduces four explainable Automated Machine Learning (AutoML) models that integrate Optuna for hyperparameter optimization, SHapley Additive exPlanations (SHAP) for interpretability, and ensemble learning algorithms such as Random Forest (RF), Extreme Gradient Boosting (XGB), Light Gradient Boosting Machine (LGB), and Categorical Gradient Boosting (CB). …”
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EIF4A3-induced circ_0022382 promotes breast cancer cell progression through the let-7a-5p/PI3K/AKT/mTOR signaling pathway and SLC7A11 axis by Wei Liu, Wei Liu, Jun Zhang, Jiawen Zhang, Yu Ye, Jianqin Zhu, Qiwen Yu, Tao Li, Tao Li, Xiaochun Sun, Huabiao Chen, Huabiao Chen

“…In terms of regulatory mechanisms, circ_0022382 activated PI3K/AKT/mTOR signaling pathway and SLC7A11 by sponging let-7a-5p, while knockdown of circ_0022382 contributed to the occurrence of disulfidptosis. In addition, EIF4A3 promoted the expression of circ_0022382 in MDA-MB-231 and MCF-7. …”
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The search for microRNAs potentially involved in the selfrenewal maintaining of laboratory rat pluripotent stem cells by V. V. Sherstyuk, S. P. Medvedev, M. T. Ri, Y. V. Vyatkin, O. V. Saik, D. N. Shtokalo, S. M. Zakian

“…The analysis of differential expression between groups of rat pluripotent cells and fibroblasts, and the analysis of experimentally confirmed target genes of differentially expressed known rat miRNAs revealed novel potential players of pluripotency maintaining and reprogramming processes. In addition, novel members of these processes were revealed among novel rat miRNAs. …”
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Clinical assessment and transcriptome analysis of host immune responses in a vaccination-challenge study using a glycoprotein G deletion mutant vaccine strain of infectious laryngo... by Gayathri Gopakumar, Mauricio J. C. Coppo, Mauricio J. C. Coppo, Andrés Diaz-Méndez, Carol A. Hartley, Joanne M. Devlin

“…The results from this study demonstrated that vaccination with ΔgG-ILTV prevented the changes in tracheal transcriptome induced during ILTV challenge, resulting in clinical protection. Additionally, these results also provide insights into the molecular mechanisms underlying the tracheal pathology induced by ILTV infection.…”
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