The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…In in vitro models, we further demonstrated that ABA treatment elevates lipid droplet formation by enhancing the phagocytic capacity of macrophages. Additionally, in a mouse model of microglial activation, we showed that ABA-treated mice maintain a less inflammatory microglial phenotype.ConclusionOur findings highlight a crucial role for macrophages and microglia in enabling ABA to enhance the remyelination process. …”
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EMC2 suppresses ferroptosis via regulating TFRC in nasopharyngeal carcinoma by Xianghui Chen, Xiaoyan Wang, Yuxia Zou, Yan Wang, Tingting Duan, Zijie Zhou, Yi Huang, Qing Ye

“…Conversely, EMC2 overexpression contributed to ferroptosis repression, malignant progression, and reduced the efficacy of cisplatin. In addition, EMC2 knockdown suppressed xenograft tumor growth and enhanced ferroptosis in nude mice. …”
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Seaweed (Porphyra) cultivation enhances production of autochthonous refractory dissolved organic matter in coastal ecosystems by Ting Wang, Ting Wang, Jiajun Xu, Jiajun Xu, Randy A. Dahlgren, Qiang Liu, Yang Jia, Yang Jia, Binbin Chen, Binbin Chen, Hanqin Xu, Hanqin Xu, Zengling Ma, Zengling Ma, Liyin Qu, Liyin Qu

“…Redundancy analysis revealed that more microbial modules mediated organic matter transformations during the cultivation period, leading to a 169% higher estuarine addition of microbially-sourced humic-like C3 compared to the non-cultivation period. …”
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EARice10: a 10 m resolution annual rice distribution map of East Asia for 2023 by M. Song, M. Song, M. Song, L. Xu, L. Xu, J. Ge, J. Ge, J. Ge, H. Zhang, H. Zhang, H. Zhang, L. Zuo, L. Zuo, J. Jiang, J. Jiang, J. Jiang, Y. Ding, Y. Ding, Y. Ding, Y. Xie, Y. Xie, Y. Xie, F. Wu, F. Wu

“…EARice10 is accessible at <a href="https://doi.org/10.5281/zenodo.13118409">https://doi.org/10.5281/zenodo.13118409</a> (Song et al., 2024).…”
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Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens by Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Cristian Melgarejo, Cristian Melgarejo, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Gareth J. Jones, Bernat Pérez de Val, Bernat Pérez de Val

“…In this study, we investigated the interferences caused by the tuberculin (PPD)-based TB diagnostic tests in goats immunized by different mucosal and parenteral vaccination strategies: three single-dose strategies based on intranasal administration of BCG and two heat-inactivated M. bovis (HIMB) vaccines, and two prime-boost strategies based on parenteral BCG or HIMB priming and intranasal HIMB boosting. In addition, the defined antigens ESAT-6, CPF10, and EspC were evaluated as alternative diagnostic reagents to PPDs. …”
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Prevalence and factors associated with burnout syndrome in resident physicians: A cross-sectional study in Italy by Luca DI GIAMPAOLO, Andrea ROSSETTI, Teresa GALANTI, Simone DE SIO, Luca COPPETA, Hector NIETO, Hiroo WADA, Niu QUIAO, Younes RAMI, Hicham KHABBACHE, Driss AIT ALI, Amelia RIZZO, Kavita BATRA, Murat YILDIRIM, Mahmood BAHRAMIZADEH, Francesco CHIRICO

“…To evaluate levels of emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA), we utilized the Maslach Burnout Inventory. Additionally, we assessed work-life balance using questions related to Free-time satisfaction (FTS), Free-Time Satisfaction Reduction (FTRS), and Work-problems pervasiveness (WPP). …”
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Understanding the Impact of Salt Stress on Plant Pathogens Through Phenotypic and Transcriptomic Analysis by Hyejung Jung, Gil Han, Duyoung Lee, Hyun-Kyoung Jung, Young-Sam Kim, Hee Jeong Kong, Young-Ok Kim, Young-Su Seo, Jungwook Park

“…Uniquely upregulated patterns in <i>Pcc</i> were associated with enhanced survival under high salinity, such as protein quality control, osmotic equilibrium, and iron acquisition. Additionally, the application of salt stress combined with the beneficial bacterium <i>Chryseobacterium salivictor</i> significantly reduced tomato wilt caused by <i>R. solanacearum</i>, suggesting a potential management strategy. …”
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The low-cost technical system of rural sustainable wood construction and its suitability based on the small-diameter round timber of fast-growing Northeast Larch by Ying Wu, Hongpeng Xu, Jianmei Wu, Yuncheng Ji

“…Thirdly, compared to the LVL (laminated veneer lumber) frame structure system, the SDRT structure system can achieve a reduction in wood consumption per unit area ranging from 53.63 % to 75.87 % across various structural spans. Additionally, the cost of the building structure per unit area can be decreased by at least 45 %.…”
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Accurate identification of snoRNA targets using variational graph autoencoder to advance the redevelopment of traditional medicines by Zhina Wang, Zhina Wang, Yangyuan Chen, Hongming Ma, Hongming Ma, Hong Gao, Hong Gao, Yangbin Zhu, Hongwu Wang, Nan Zhang, Nan Zhang

“…Accurate prediction of potential snoRNA therapeutic targets is essential for early disease intervention and the redevelopment of traditional medicines. Additionally, researchers have developed artificial intelligence (AI)-based methods to screen and predict potential snoRNA therapeutic targets, thereby advancing traditional drug redevelopment. …”
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Characterizing the deformation, failure, and water-conducting fractures evolution of shallow weakly cemented overburden under coal mining by Zhenhua Li, Yandong Zhang, Xuefeng Gao, Xuefeng Gao, Dan Ma, Dan Ma, Limin Fan, Guodong Li, Xiaolei Li, Min He, Zheng Cheng

“…Hence, we conducted a meter-scale similar physical model experiment using high-resolution digital speckle technology to replicate the deformation and failure patterns of shallowly buried, weakly cemented overburden under mining activities, and to determine the initiation, development, and stability of water-conducting fractures. Additionally, a site-scale numerical model was developed to allow for the examination of the stress-displacement evolution within the weakly cemented overburden. …”
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Enhanced Influence of Late‐Winter Arctic Oscillation on Early Spring Temperature in North and Northeast Asia by Xin Zhou, Tingting Han, Huijun Wang, Botao Zhou, Shengping He

“…Accordingly, the AO exerts a strengthened impact on Mongolian anticyclone and Asian westerly anomalies through modulation of a Rossby wave train that propagates from the Arctic to the NNA in early spring, leading to significant SAT anomalies at NNA. Additionally, the AO‐related temperature anomalies intensified in the stratosphere after the 1990s, linking AO and stratospheric polar vortex (SPV). …”
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Isoforsythiaside confers neuroprotection against Alzheimer’s disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro by Chunyue Wang, Hongbo Jiang, Honghan Liu, Shanshan Chen, Hangyu Guo, Shuoshuo Ma, Weiwei Han, Yu Li, Di Wang

“…Isoforsythiaside (IFY) is a phenylethanoid glycoside isolated from the dried fruit of Forsythia suspensa (Thunb.) Vahl that has been confirmed to improve the memory and cognitive abilities of APP/PS1 mice in our previous study. …”
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Refining δ15N isotopic fingerprints of local NOx for accurate source identification of nitrate in PM2.5 by Hao Xiao, Qinkai Li, Shiyuan Ding, Wenjing Dai, Gaoyang Cui, Xiaodong Li

“…However, failure to consider the isotopic signatures of local NOx sources could result in an overestimation of the contribution from natural gas combustion. Additionally, the absence of industrial sources, an uncharacterized source in previous studies, may directly result in the contribution fraction of other sources being overestimated by the model more than 10 %. …”
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Characteristic and Antimicrobial Resistance of Bacillus cereus Group Isolated from Food in Poland by Joanna Kowalska, Elżbieta Maćkiw, Dorota Korsak, Jacek Postupolski

“…Ampicillin and penicillin resistance was the most common resistance phenotype and was identified in 100% of the B. cereus isolates. In addition, the tested isolates exhibited resistance to: amoxicillin-clavulanic acid (96.25%), cephalothin (67.79%), ceftriaxone (64.42%), rifampicin (46.82%), trimethoprim-sulfamethoxazole (5.62%), quinupristin/dalfopristin (4.87%), chloramphenicol (3.75%), clindamycin (2.62%), teicoplanin (1.87%), erythromycin (1.87%), ciprofloxacin (0.75%), imipenem (0.75%), tetracycline (0.37%), and gentamicin (0.37%). …”
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Effect and factors associated with reactivation after intravitreal conbercept or aflibercept in retinopathy of prematurity by Chunling Huang, Weikang Zou, Wenbei Ma, Jiali Li, Yichen Bai, Rong Wu, Qiqi Li, Qi Fang, Wenna Chen, Xiaohe Lu, Songfu Feng

“…CRAE was associated with not only the severity of ROP but also its reactivation. Additionally, it may be an objective indicator in the early indication and follow-up of ROP.…”
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Targeting immune cellular populations and transcription factors: unraveling the therapeutic potential of JQF for NAFLD by Lijuan Zhou, Jingyi Zhao, Kaile Ma, Rui Hao, Chensi Yao, Xiaowen Gou, Chuanxi Tian, Li Wan, Min Li, Xiaolin Tong

“…Further SCENIC analysis additionally uncovered the essential transcription factors that regulate these cell subclusters, such as Stat2, Mta3, Eomes, and Etv5.ConclusionOverall, our research suggests a promising potential therapeutic agent and identifies critical cell populations and transcription factors that contribute to its therapeutic effects, thereby revealing potential therapeutic targets for NAFLD.…”
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Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility by Sophie Debaenst, Tamara Jarayseh, Hanna De Saffel, Jan Willem Bek, Matthieu Boone, Ivan Josipovic, Pierre Kibleur, Ronald Y Kwon, Paul J Coucke, Andy Willaert

“…Larval crispants showed variable osteoblast and mineralization phenotypes, while adult crispants displayed consistent skeletal defects, including malformed neural and haemal arches, vertebral fractures and fusions, and altered bone volume and density. In addition, aldh7a1 and mbtps2 crispants experienced increased mortality due to severe skeletal deformities. …”
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After Treatment Decrease of Bone Marrow Tregs and Outcome in Younger Patients with Newly Diagnosed Acute Myeloid Leukemia by Mario Delia, Paola Carluccio, Anna Mestice, Roberta Frappampina, Francesco Albano, Giorgina Specchia, Pellegrino Musto

“…An emerging body of evidence demonstrates that defects in antileukemic effector cells in patients with acute myeloid leukemia (AML) can contribute to the development and/or persistence of the disease. …”
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SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations by Meng-Yuan Yang, Jia-Dong Zhong, Xin Li, Geng Tian, Wei-Yang Bai, Yi-Hu Fang, Mo-Chang Qiu, Cheng-Da Yuan, Chun-Fu Yu, Nan Li, Ji-Jian Yang, Yu-Heng Liu, Shi-Hui Yu, Wei-Wei Zhao, Jun-Quan Liu, Yi Sun, Pei-Kuan Cong, Saber Khederzadeh, Pian-Pian Zhao, Yu Qian, Peng-Lin Guan, Jia-Xuan Gu, Si-Rui Gai, Xiang-Jiao Yi, Jian-Guo Tao, Xiang Chen, Mao-Mao Miao, Lan-Xin Lei, Lin Xu, Shu-Yang Xie, Jin-Chen Li, Ji-Feng Guo, David Karasik, Liu Yang, Bei-Sha Tang, Fei Huang, Hou-Feng Zheng

“…For East Asian populations, SEAD shows concordance comparable to ChinaMAP, but outperforming TOPMed. Additionally, we apply the SEAD panel to conduct a genome-wide association study for total hip (Hip) and femoral neck (FN) bone mineral density (BMD) traits in 5369 genotyped Chinese samples. …”
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Impact of Comprehensive Health Insurance affiliation on mortality in children under one year: an analysis of the Demographic and Health Survey 2010–2022 in Peru by Marcos Espinola-Sánchez, Marcos Espinola-Sánchez, Andres Campaña-Acuña, Diego Urrunaga-Pastor, Diego Urrunaga-Pastor, Jorge L. Maguiña, Manuel Jumpa, Oscar Ugarte-Ubillus

“…ObjectiveTo assess the impact of Comprehensive Health Insurance (CHI) coverage on mortality in children under 1 year of age in the Peruvian population from 2010 to 2022. Additionally, the study evaluated how CHI affects infant mortality according to wealth quintiles in the Peruvian population.MethodsA causal inference analysis with observational data was applied, employing propensity score matching. …”
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