Engineered ipilimumab variants that bind human and mouse CTLA-4 by Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee

“…The 9D9-mCTLA4 complex crystal structure was determined and shows that the surrogate antibody binds an epitope distinct from ipilimumab and tremelimumab. In addition, while ipilimumab has pH-independent binding to hCTLA-4, 9D9 loses binding to mCTLA-4 at physiologically relevant acidic pH ranges. …”
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Structural and functional connectivity coupling as an imaging marker for bone metastasis pain in lung cancer patients by Jiahui Zheng, Chengfang Wang, Xiaoyu Zhou, Yu Tang, Lin Tang, Yong Tan, Jing Zhang, Hong Yu, Jiuquan Zhang, Daihong Liu

“…Subsequently, individualized SC-FC coupling networks were constructed based on the Euclidean distance metric. In addition, the convolutional neural network (CNN) model was selected to analyze and classify three groups based on individualized networks. …”
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Acute therapeutic effects and pathophysiology of eosinophilic granulomatosis with polyangiitis neuropathy by Fumitaka Shimizu, Mariko Oishi, Toshihiko Maeda, Yukio Takeshita, Hideaki Nishihara, Ryota Sato, Takashi Kanda, Masayuki Nakamori, Michiaki Koga, Miwako Fujisawa, Yuki Mizumoto, Nanami Yamanaka, Takashi Nawata, Tatsuya Okafuji, Susumu Fujikawa, Kinya Matsuo, Joe Nemoto, Masaya Honda

“…Vasculitis was detected in 67% of ANCA-positive and 29% of ANCA-negative patients in the sural nerve and skin biopsy specimen. In addition, infiltration of eosinophils into peripheral nerve tissues was observed in 40% of ANCA-negative patients, whereas it was absent in ANCA-positive patients. …”
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Identification of nuclear valosin-containing-protein-like as a target of anti-nuclear autoantibodies in systemic sclerosis by Zitao Zeng, Ramona Miske, Madeleine Scharf, Yvonne Denno, Anthonina Ott, Stefanie Brakopp, Bianca Teegen, Winfried Stöcker, Elise Siegert, Elise Siegert, Sandra Saschenbrecker, Christian Probst, Lars Komorowski

“…Preincubation with recombinant NVL abolished the reactivity of the patient serum with HEp-2 cells in IFA. Additionally, the patient serum reacted with recombinant NVL in cell-based IFA and Western blot analysis, whereas sera from 15 healthy controls were nonreactive. …”
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Advancements in Nanotechnology for Enhanced Food Safety and Hygiene: Pathogen Detection, Smart Packaging, and Preservation Applications by Farhang Hameed Awlqadr, Ammar B. Altemimi, Qausar Hamed AlKaisy, Syamand Ahmed Qadir, Aryan Mahmood Faraj, Tablo Azad H.Slih, Rawaa H. Tlay, Tarek Gamal Mohamed Abd El-Maksoud, Franscesco Cacciola

“…Nanoparticles, such as silver and zinc oxide, are increasingly used in packaging to inhibit microbial growth effectively. Additionally, nanoencapsulation techniques protect bioactive compounds, such as antioxidants and antimicrobials, ensuring their stability and controlled release, which enhances food quality and safety. …”
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Cooperative mechanisms of LexA and HtpG in the regulation of virulence gene expression in Pseudomonas plecoglossicida by Rongchao He, Yanfei Zuo, Qiu Li, Qingpi Yan, Lixing Huang

“…Our findings identified 36 downstream virulence genes regulated by LexA, define three critical LexA binding motifs, and provide an in-depth analysis of LexA's recognition and binding to promoters, thereby regulating virulence gene expression. Additionally, we confirm the cooperative regulatory roles of HtpG, RecA, and LexA in virulence gene modulation. …”
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Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences by Gregory C. Antell, Will Dampier, Benjamas Aiamkitsumrit, Michael R. Nonnemacher, Vanessa Pirrone, Wen Zhong, Katherine Kercher, Shendra Passic, Jean Williams, Yucheng Liu, Tony James, Jeffrey M. Jacobson, Zsofia Szep, Brian Wigdahl, Fred C. Krebs

“…Positions 36, 37, 41, 89, and 96 of Vpr were characterized by statistically significant divergence across multiple alphabets when X4 and R5 sequence groups were compared. In addition, consensus amino acid switches were found at positions 37 and 41 in comparisons of the R5 and X4 sequence populations. …”
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RETRACTION Dadang Prayoga, H., Tomoliyus, T., Lumintuarso, R., prasetyo, Y., Rini Sukamti, E., Tri Fitrianto, A., Kasanrawali, A., Arifin, R., Maulana, A., & Habibie, M. (2024). Mejorando la Probabilidad de Victorias para los Mejores Jugadores a través del Emparejamiento de Torneos por Eliminación Directa (Enhancing the Probability of Victor for Top Players via Knockout Tournament Fixture). Retos, 57, 462–472. https://doi.org/10.47197/retos.v57.106069 by RETOS RETOS

“…With this fraudulent document the galleys were made and the article was definitively published, assigning it the corresponding DOI. Authors in the Word document of the article submitted for review: 2 Authors in the published PDF with modified authors: 10 Differences between the authors between both moments: +8 (Ria Lumintuarso, Yudik prasetyo,Endang Rini Sukamti, Ari Tri Fitrianto, Andi Kasanrawali, Ramadhan Arifin, Ahmad Maulana, Muhammad Habibie) …”
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Validity and reliability of the Malay language Perception Towards Smoking Questionnaire (BM-PTSQ) among secondary school adolescents: Further validation using Confirmatory Factor A... by Kuang Hock Lim, Yoon Ling Cheong, Hui Li Lim, Kee Chee Cheong, Mohd Hazilas Mat Hashim, Ali Aman Marine, Yong Kang Cheah, Jia Hui Lim, Sumarni Mohd Ghazali

“…We used parallel and exploratory factor analysis (EFA) to determine the domains of the questionnaire. In addition, we also employed EFA, confirmatory factor analyses (CFA), and Cronbach's alpha to evaluate the construct validity and reliability of the BM-PTSQ. …”
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The Use of Le Bail Method to Analyze the Semicrystalline Pattern of a Nanocomposite Based on Polyaniline Emeraldine-Salt Form and α-Al2O3 by Edgar A. Sanches, Adriano de S. Carolino, Amanda L. dos Santos, Edson G. R. Fernandes, Daniela M. Trichês, Yvonne P. Mascarenhas

“…By FTIR analysis characteristic absorption bands of both materials were identified. Additional bands indicating new chemical bonds were not observed, suggesting that nanocomposite was formed by physical deposition. …”
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Effect of Genetic Predisposition on Blood Lipid Traits Using Cumulative Risk Assessment in the Korean Population by Min Jin Go, Joo-Yeon Hwang, Dong-Joon Kim, Hye-Ja Lee, Han Byul Jang, Kyung-Hee Park, Jihyun Song, Jong-Young Lee

“…It has been observed that increasing GRS is significantly associated with decreased HDL-C (effect size, -1.13 ± 0.07) compared to single nucleotide polymorphism combinations without two risk variants. In addition, a positive correlation was observed between allelic dosage score and risk allele (rs10503669 at LPL) on high TG levels (effect size, 10.89 ± 0.84). …”
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Structural basis for the inhibition of coronaviral main proteases by PF-00835231 by Zhou Xuelan, Lu Xiaolu, Lin Cheng, Zou Xiaofang, Li Wenwen, Zeng Xiangyi, Wang Jie, Zeng Pei, Wang Weiwei, Zhang Jin, Jiang Haihai, Li Jian

“…In addition, the crystal structures of SARS-CoV-2 M^pro, SARS-CoV M^pro, MERS-CoV M^pro, and seven SARS-CoV-2 M^pro mutants (G15S, M49I, Y54C, K90R, P132H, S46F, and V186F) in complex with PF-00835231 are solved. …”
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Validity and Reliability of Kinovea^® for Pelvic Kinematic Measurement in Standing Position and in Sitting Position with 45° of Hip Flexion by Lucía Vicente-Pina, Rocío Sánchez-Rodríguez, Loreto Ferrández-Laliena, Jose Heredia-Jimenez, Julián Müller-Thyssen-Uriarte, Sofía Monti-Ballano, César Hidalgo-García, José Miguel Tricás-Moreno, María Orosia Lucha-López

“…The Intraclass Correlation Coefficient (ICC) was used to evaluate reliability and validity. Additionally, the technical error of measurement (TEM), relative TEM, standard error of measurement, and minimal detectable change (MDC) were calculated to establish Kinovea^®’s accuracy. …”
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Tannic acid-loaded inorganic-organic coating on magnesium bone nails for enhanced antibacterial, anti-inflammatory and corrosion resistance by Sirui Xu, Chuanyao Dong, Xiaolin Yu, Tianshu Lv, Dapeng Zeng, Ruiyan Li, Xingfu Bao, Kan Zhang

“…The micro-arc oxidation layer improves adhesion to the magnesium alloy, while the addition of chitosan increases coating density through interlaced pores. …”
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Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Fac... by Qie Guo, Xiao Li, Meng-Na Cui, Yu Liang, Xiang-Peng Li, Jun Zhao, Li-Na Wei, Xiao-Lei Zhang, Xiang Hua Quan

“…MMC also reduced the expression of inflammatory factors TGF-β1, VEGF, and IL-6. In addition to influencing these factors, MMC suppressed neovascularization and the proliferation of corneal fibroblasts to effectively reduce the recurrence rate of pterygium. …”
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A Novel Wild-Type <i>Lacticaseibacillus paracasei</i> Strain Suitable for the Production of Functional Yoghurt and Ayran Products by Ioanna Prapa, Chrysoula Pavlatou, Vasiliki Kompoura, Anastasios Nikolaou, Electra Stylianopoulou, George Skavdis, Maria E. Grigoriou, Yiannis Kourkoutas

“…As a next step, freeze-dried immobilized <i>Lc. paracasei</i> FBM_1327 cells on oat flakes were used for the preparation of functional yoghurt and ayran products. …”
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Cancer Cachexia: Innovations in Pharmacotherapy for Terminal-Stage Patients - Review of the latest reports by Kinga Witowska, Karolina Sacher, Negar Hosseinnejad, Mikolaj Biskupski, Mariola Turemka, Aneta Mandziuk, Urszula Korotko, Krystyna Zabojska, Aneta Klaudia Wojtas, Aleksandra Cygnarowicz

“…The issue is characterized by anorexia, skeletal muscle loss, adipose tissue wasting, involuntary weight loss, malnutrition, and poor appetite due to dysfunction of metabolism and chronic, systemic inflammation. Additionally, it impacts oncological treatment and a decline in Quality of Life. …”
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Association of combined pulmonary fibrosis and emphysema in rheumatoid arthritis with high titer of rheumatoid factor and autoimmunity to the lung by Aiping Ma, Renliang Huang, Jiaxi Guo, Guangdong Wang, Heqing Huang, Xinze Li, Shan Zhong, Yan Huang, Shaowei Lin, Yikai Lin, Qiaomiao Zhou, Susanne Krauss-Etschmann, Frank Petersen, Zhanxiang Wang, Xinhua Yu, Xinhua Yu

“…Multiple logistic regression analysis revealed that male gender, cigarette smoking, occupational exposure to dust, high ILD score, high rheumatoid factor (RF) titers, and the presence of anti-SSA were associated with an increased risk for RA-CPFE. Additionally, levels of IgG and IgM autoantibodies to HBEC were elevated in RA-CPFE patients compared to healthy controls and positively correlated with RF levels.InterpretationThis study is the first to demonstrate the association of RA-CPFE with high titer of RF and the presence of autoantibodies against HBEC, suggesting a link between autoimmunity to the lung and RA-CPFE.…”
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Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors by Constantin Jotzu, Eckhard Alt, Gabriel Welte, Jie Li, Bryan T. Hennessy, Eswaran Devarajan, Srinivasalu Krishnappa, Severin Pinilla, Lilly Droll, Yao-Hua Song

“…The induction of CAFs can be abolished using a neutralizing antibody to TGFβ1 as well as by pretreatment of the hASCs with SB431542, a TGFβ1 receptor kinase inhibitor. Additionally, we found that these hASC-derived CAF-like cells exhibit functional properties of CAFs, including the ability to promote tumor cell invasion in an in vitro invasion assay, as well as increased expression of stromal-cell-derived factor 1 (SDF-1) and CCL5. …”
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Damage evolution of slab tracks with complex temperature distribution by Yang Li, Kailin Cao, Jinjie Chen, Haiyan Li, Zhihao Yang, Guocui Wang

“…These new findings are of significant theoretical importance as they emphasize the need to consider temperature distribution characteristics that have been overlooked in previous studies. Additionally, the insights from this study have practical value as they provide track engineers with a state-of-the-art recommendation for incorporating realistic temperature distribution in the evaluation of longitudinally continuous slab tracks' performance.…”
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