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61421
Sample Tracking Tool: A Comprehensive Approach Based on OpenArray Technology and R Scripting for Genomic Sample Monitoring
Published 2025-01-01“…Furthermore, its ability to accurately detect identical and different samples was evaluated through a simulation test conducted on an additional 100 samples. <b>Results</b>: In total, 55 probes achieved a call rate ≥90% and were subjected to the sample matching process performed by an R tool specifically developed. …”
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61422
Experience of Kenyan researchers and policy-makers with knowledge translation during COVID-19: a qualitative interview study
Published 2022-06-01“…We assessed the usefulness of these activities to identify the facilitators and barriers to KT and suggest actions that facilitate KT in similar settings.Design The study adopted a qualitative interview study design.Setting and participants Researchers at KWTRP in Kenya who were involved in KT activities during the COVID-19 pandemic (n=6) were selected to participate in key informant interviews to describe their experience. In addition, the policy-makers with whom these researchers engaged were invited to participate (n=11). …”
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61423
Optimization of CuO<sub>x</sub>/Ga<sub>2</sub>O<sub>3</sub> Heterojunction Diodes for High-Voltage Power Electronics
Published 2025-01-01“…The results indicate that increasing the diameter dimension of the CuO<sub>x</sub> layer or tuning the hole concentration to optimal values significantly enhances the breakdown voltage (V<sub>B</sub>) of single-layer HJDs by mitigating the electric field crowing effects. Additionally, a double-layer CuO<sub>x</sub> structure (p<sup>+</sup> CuO<sub>x</sub>/p<sup>−</sup> CuO<sub>x</sub>) was designed and optimized to achieve an ideal balance between the V<sub>B</sub> and specific on-resistance (R<sub>on,sp</sub>). …”
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61424
piR-26441 inhibits mitochondrial oxidative phosphorylation and tumorigenesis in ovarian cancer through m6A modification by interacting with YTHDC1
Published 2025-01-01“…The resultant TSFM loss reduced mitochondrial complex I activity and mitochondrial OXPHOS, leading to mitochondrial dysfunction in OC cells, increased reactive oxygen species levels, and thus, DNA damage and apoptosis in OC cells, thereby inhibiting OC progression. Additionally, ago-piR-26441 suppressed tumor growth and mitochondrial metabolism in the patient-derived organoid model. …”
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61425
CD7‐targeting pro‐apoptotic extracellular vesicles: A novel approach for T‐cell haematological malignancy therapy
Published 2024-12-01“…We found that αCD7/EVs efficiently targeted and were internalized by human T‐ALL Molt‐4 cells. In addition, the interaction between αCD7 and CD7 switched the EV entry pathway in Molt‐4 cells from macropinocytosis‐dependent endocytosis to clathrin‐mediated endocytosis, thereby reducing EV‐lysosome colocalization, ultimately improving CytC delivery efficiency and increasing the cytotoxicity of nascent EVs from EV‐treated Molt‐4 cells. …”
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61426
Hole-selective-molecule doping improves the layer thickness tolerance of PEDOT:PSS for efficient organic solar cells
Published 2025-01-01“…Herein, a hole-selective-molecule doping strategy is proposed to enhance the properties of PEDOT:PSS by introducing MPA2FPh-BT-BA (abbreviated as 2F) into its layer. 2F assembles at the anode to form interfacial dipoles due to its unique donor–acceptor–anchor molecular configuration, altering the anode work function and hole-selective extraction. Additionally, 2F improves the aggregation properties of PEDOT:PSS by forming hydrogen bonds with the PSS group, enhancing the conductivity characteristics. …”
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61427
Predictors of irritability in pediatric autistic populations: a scoping review
Published 2024-07-01“…To address this, we conducted a scoping review of the literature examining factors contributing to irritability in pediatric autistic populations.MethodsA literature search of Embase, MEDLINE, PubMed, PsycINFO, and Web of Science was conducted in addition to manually retrieved papers from Google Scholar. …”
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61428
Mountain sentinels in a changing world: Review and conservation implications of weather and climate effects on mountain goats (Oreamnos americanus)
Published 2025-01-01“…In many instances, climate change effects are likely to be negative and additive to existing threats (such as human disturbance, hunting, disease, predation) though benefits are expected in some cases. …”
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61429
A Coupling Method for the Stability of Reflectors and Support Structure in an ALB Optical-Mechanical System
Published 2024-12-01“…The PV value of the reflector mirror deformation under the thermal coupling reaches 32.59 nm, and the RMS value reaches 8.62 nm. Additionally, it is discovered that the maximum acceleration response of the reflector mirror under the applied 1 g acceleration excitation reaches 4.22 g when carrying out the dynamics analysis of the support structure. …”
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61430
Microbiological Contamination of Food Raw Materials and Ready-To-Eat Foods: Analytical Review
Published 2023-09-01“…Composite products that cannot be succumbed to additional heat treatment need new technologies that minimize microbiological contamination, e.g., intensive cooling, shock freezing, electromagnetic processing, protective food coatings, etc. …”
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61431
Newcastle Disease Virus Displaying an Ectodomain of Middle East Respiratory Syndrome Coronavirus Spike Protein Elicited Robust Humoral and Cellular Immunity in Mice
Published 2024-12-01“…The study demonstrated that modifications to the MERS-CoV spike protein were essential for its effective presentation on NDV particles. Additionally, the spike gene insert remained stable through five egg passages, confirming the vector’s stability. …”
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61432
Free convection investigation for a Casson-based Cu−H2O nanofluid in semi parabolic enclosure with corrugated cylinder
Published 2025-01-01“…An optimal range of corrugation numbers is identified for maximizing heat transfer at higher Rayleigh numbers. The addition of nanoparticles significantly improves heat transfer, with a 20 % increase in the average Nusselt number observed at Ra = 105 when the nanoparticle volume fraction increases from 0 to 0.15. …”
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61433
Clinical Practice Guidelines of the Scientific Society for the Clinical Study of Human Microbiome, of the Russian Gastroenterological Association and the Russian Society for the Pr...
Published 2023-09-01“…The disease severity is determined by clinical symptoms and laboratory findings. Additional diagnostic methods that are used according to indications and contribute to the assessment of severity include endoscopy of the colon and abdominal cavity imaging methods. …”
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61434
Understanding HIV care providers’ support for tobacco cessation among people living with HIV in Western Kenya: a formative qualitative study
Published 2024-04-01“…Providers should be trained and equipped with additional skills and resources to integrate tobacco cessation support into routine HIV care.…”
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61435
A Survey of the Knowledge, Attitudes and Practices of a Sample of Albanian Medical Students in Relation to Occupational Exposure to Biological Agents
Published 2025-01-01“…It assessed HBV vaccination status, adherence to infection control practices, knowledge of pathogen transmission, exposure incidents and attitudes towards infected patients. Three additional questions addressed air-borne transmission of tuberculosis and vaccination recommendations for healthcare workers. (3) Results: Most students (64%) reported being aware of occupational exposure risks. …”
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61436
Quantifying Baryonic Feedback on the Warm–Hot Circumgalactic Medium in CAMELS Simulations
Published 2025-01-01“…The parameters controlling the stellar feedback efficiency significantly impact AGN feedback, as seen in the suppression of black hole mass growth and delayed activation of AGN feedback to higher-mass halos with increasing stellar feedback efficiency in both simulations. Additionally, the AGN feedback efficiency parameters affect the CGM gas fraction at low halo masses in SIMBA, hinting at complex, nonlinear interactions between the AGN and supernova feedback modes. …”
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61437
Allometric models for estimating aboveground biomass and carbon stocks of the semi-arid savanna woody species, Detarium microcarpum Guill. et Perr.
Published 2025-03-01“…Three equations were tested with a diameter at the breast (dbh) alone, height (ht) as additional (dbh*ht), and diameter in combination with height (dbh2*ht) as predictors using log-transformed data with a power function. …”
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61438
Association of AFF3 Gene Polymorphism rs10865035 with Rheumatoid Arthritis: A Population-Based Case-Control Study on a Pakistani Cohort
Published 2021-01-01“…A/A + GG) (OR = 0.491 (0.667–1.215); P = 0.49), and additive model (OR = 0.826 (0.665–1.027); P = 0.08) showed insignificant distribution of the genotypes among the cases and controls. …”
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61439
Enhanced mechanical properties of Al0.43CoCrFeNi2.1 high entropy alloy fabricated through complex shear flow casting: Experiment and MD simulation
Published 2025-03-01“…Molecular dynamics (MD) simulations were used to investigate the nucleation characteristics, microstructure evolution, and dislocation evolution during solidification. Additionally, to investigate the deformation properties and mechanical behavior of the two samples, uniaxial tension was applied to the solidified samples using MD simulations. …”
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61440
Out-of-Wedlock Pregnancy Among Single Mothers in Khartoum, Sudan: Sociodemographic Characteristics, Causes, and Consequences
Published 2023-09-01“…Additionally, many mothers reported experiencing social stigma and rejection from their families due to their out-of-wedlock pregnancy. …”
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