Polydatin enhances oxaliplatin-induced cell death by activating NOX5-ROS-mediated DNA damage and ER stress in colon cancer cells by Qi Zhao, Qi Zhao, Qi Zhao, Yan Zhang, Yan Zhang, Jieyu Liu, Peipei Chen, Annabeth Onga, Namki Cho, Ri Cui, Chenguo Zheng

“…Knocking down NOX5 attenuated the inhibition of proliferation and colony forming ability induced by PD in colon cancer cells and reversed the expression of C/EBP-homologous protein (CHOP) and activating transcription factor 4 (ATF4) proteins. In addition, combination of PD and OXA synergistically exerted anti-CRC activities by promoting DNA damage and activating ER stress signaling pathway.ConclusionThe combination of PD and OXA could be an effective treatment strategy for certain patients with CRC.…”
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Maternal dietary patterns associated with bone density in Chinese lactating women and infants at 6 months postpartum: a prospective study using data from 2018-2019 by Yalin Zhou, Xiaoyu Zhu, Ying Lü, Runlong Zhao, Hanxu Shi, Wanyun Ye, Zhang Wen, Rui Li, Hanming Huang, Yajun Xu

“…In conclusion, Factor 2 might contribute to the maintenance of eBMD in lactating women, while Factor 3 could exacerbate maternal eBMD loss. Additionally, the changes of maternal eBMD presented a positive correlation with 6-month infants’ eBMD.…”
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Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice by Robert G. Martindale, Philip C. Calder, Sarah V. Cogle, David C. Evans, Leah Gramlich, Stephen A. McClave, Manpreet S. Mundi, Maurizio Muscaritoli, Reid Nishikawa, Jayshil Patel, Lorenzo Pradelli, Martin Rosenthal, Christian Stoppe, Kelly A. Tappenden, Malissa Warren, Dan Waitzberg, Paul E. Wischmeyer, Stanislaw Klek

“…Summary: Lipids are integral to parenteral nutrition (PN) in all settings where PN is required, serving as a source of energy and essential fatty acids. In addition, lipids modulate a variety of biological functions, including inflammatory and immune responses. …”
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Chalcogenide perovskites: enticing prospects across a wide range of compositions and optoelectronic properties for stable photodetector devices by Shilpa Mariam Samuel, Sadasivan Shaji, David Avellaneda Avellaneda, Bindu Krishnan

“…Furthermore, the challenging thin film deposition, characterizations, and their application in photodetection focusing on BaZrS _3 -which is the most studied one, are ascribed. Additionally, we suggest prospects that can bring out the true potential of these materials in photodetection and photovoltaics.…”
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Planned, ongoing and completed tuberculosis treatment trials in Brazil, Russia, India, China and South Africa: a 2019 cross-sectional descriptive analysis by Tamara Kredo, Duduzile Edith Ndwandwe, Lindi Mathebula, Lovemore Mapahla, Dilyara Nurkhametova, Liliya Eugenevna Ziganshina, Mikateko Mazinu, Esme Jordan

“…We included only registered clinical trials conducted wholly in BRICS countries or with at least one recruitment centre in one of the BRICS countries that were investigating TB treatment.Results The search of the WHO-ICTRP yielded 408 trials and additional 32 trials were identified from the Russian registry. …”
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Development of a model for detection and analysis of inclusions in tomographic images of iron castings using decision trees by Dorota Wilk-Kołodziejczyk, Aleksandra Nowotny, Izabela Krzak, Adam Tchórz, Krzysztof Jaśkowiec, Marcin Małysza, Adam Bitka, Mirosław Głowacki, Marzanna Książek, Łukasz Marcjan

“…It cannot be assumed that specific types of defects will occur in the tested object (e.g. only gas porosities), which requires additional analysis of the microstructure image.…”
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Is Everyone Beating Around the Bush?: A Qualitative Study Examining the Status of Shared Decision-Making Between Veterans Affairs Providers and Surgical Patients in the ICU by M. Andrew Millis, MD, MPH, C. Ann Vitous, MA, MPH, Cara Ferguson, BS, Maedeh Marzoughi, BS, Erin Kim, BS, Sarah E. Bradley, PhD, MPH, CPH, Ashley Duby, MS, Pasithorn A. Suwanabol, MD, MS

“…Providers use elements of SDM when caring for critically ill surgical patients. Additionally, this work identifies facilitators that can be leveraged and barriers that can be addressed to facilitate better communication and decision-making through SDM. …”
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Exploring the general practitioners’ perception of the inter-professional care of rheumatoid arthritis patients (GEPRA—II): a qualitative interview study by Anne-Laure Yailian, Audrey Janoly-Dumenil, Emmanuelle Vignot, Aurélie Fontana, Charline Estublier, Cyrille Confavreux, Roland Chapurlat, Claude Dussart, Humbert de Freminville

“…Regarding their perception of the community-hospital relationship, they sometimes considered it insufficient and expected more immediate interactions. Additionally, most interviewed GPs had no expectation regarding increased collaborations with community pharmacists (CPs) and several GPs were motivated to be more involved in a patient support programme. …”
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Correlation Analysis Between Multi-Drug Resistance Phenotype and Virulence Factor Expression of Clinical <i>Pseudomonas aeruginosa</i> by Wenli Xu, Runcheng Zhou, Jingwei Pan, Zhuangcong Liu, Xuyu Huang, Yueqiao Lin, Nan Li, Kecan Chen, Wenbo Sun, Yi Deng, Anping Yang, Xin Chen

“…In addition, biofilm formation was moderately associated with imipenem resistance. …”
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Single-cell sequencing uncovers the mechanistic role of DAPK1 in glioma and its diagnostic and prognostic implications by Tian-Hang Yu, Yan-Yu Ding, Yan-Yu Ding, Si-Guo Zhao, Jie-Hui Zhao, Yu Gu, Dong-Hui Chen, Fang Zhang, Wen-Ming Hong, Wen-Ming Hong

“…However, the precise role and underlying mechanisms of DAPK1 in gliomas remain inadequately understood.MethodsWe performed analyses on RNA-seq and microarray datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), in addition to single-cell RNA sequencing (scRNA-seq) data from glioma patients available in GEO. …”
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A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms by I. V. Grishchenko, A. A. Tulupov, Y. M. Rymareva, E. D. Petrovskiy, A. A. Savelov, A. M. Korostyshevskaya, Y. V. Maksimova, A. R. Shorina, E. M. Shitik, D. V. Yudkin

“…These experimental systems can serve for f inding the causes of instability and the development of therapeutic agents. In addition, a criterion was developed for the quantif ication of exogenous (CGG)n repeat instability in the transgenic cell lines’ genome.…”
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The Observed Phase Space of Mass-loss History from Massive Stars Based on Radio Observations of a Large Supernova Sample by Itai Sfaradi, Assaf Horesh, Rob Fender, Lauren Rhodes, Joe Bright, David Williams-Baldwin, Dave A. Green

“…Furthermore, we rule out mass-loss rates in the range of 2 × 10 ^−6 –10 ^−4 M _⊙ yr ^−1 for different epochs during the last 1000 yr before the explosion (assuming wind velocity of 10 km s ^−1 ) for the progenitors of ~80% of the Type II supernovae (SNe II) in our sample. In addition, we rule out the ranges of mass-loss rates suggested for red supergiants for ~50% of the progenitors of SNe II in our sample. …”
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Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE−/− mice by Xiaocui Chen, Minghui Sun, Xiang Ma, Yitong Ma, Bangdang Chen

“…Moreover, it significantly lowered serum cholesterol and triglyceride levels while increasing LDL-R level without causing hepatotoxicity in wild-type mice. Additionally, it decreased PCSK9 expression and elevated low-density lipoprotein receptor expression in Apolipoprotein E-deficient mice, leading to early changes in lipid profiles but lacking a sustained impact on circulating lipids. …”
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Blood Transfusions in Total Hip and Knee Arthroplasty: An Analysis of Outcomes by Thomas Danninger, Rehana Rasul, Jashvant Poeran, Ottokar Stundner, Madhu Mazumdar, Peter M. Fleischut, Lazaros Poultsides, Stavros G. Memtsoudis

“…Patients requiring blood transfusion were significantly older and showed a higher comorbidity burden. In addition, these patients had significantly higher rates of major complications and a longer length of hospitalization. …”
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Research on F10.7 Index Prediction Based on Factor Decomposition and Feature Enhancement by Shuainan Yan, Yanmei Cui, Bingxian Luo, Liqin Shi, Yanxia Cai

“…These forecasts are then integrated to enhance overall prediction accuracy. We incorporate additional features such as the soft X-ray flare index (FI _SXR ), magnetic type of the active region (new_Mag), and X-ray background flux (XBF) to enhance the understanding of the underlying physical processes of solar activity. …”
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The Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry: a study protocol by Christina S. Thornton, Nicole Boechler, Vidhi Desai, Ranjani Somayaji, Swathi Purighalla, Sarah Brode, Theodore K. Marras, Ryan Cooper, Maeve Smith, Julie Jarand

“…The study's protocol received ethical approval from the lead site, the University of Calgary, with future additional approval from local ethics committees at all participating centres. …”
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DR Loss-Free Dithering-Based Digital Background Linearity Calibration for SAR-Assisted Multi-Stage ADCs With Digital Input-Interference Cancellation by Lizhen Zhang, Bo Gao, Kun-Woo Park, Kent Edrian Lozada, Raymond Mabilangan, Hyeongjin Kim, Jianhui Wu, Seung-Tak Ryu

“…We also describe a capacitor-scanning dither method to accomplish simultaneous and independent identification of multiple bit weights. In addition, a digital-domain input-interference cancellation (IIC) technique is proposed to accelerate the convergence speed of the correlation-based calibration. …”
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Cochlear Implantation in Single-Sided Deafness and Asymmetric Hearing Loss: 12 Months Follow-up Results of a European Multicenter Evaluation by Thomas Wesarg, Antje Aschendorff, Regina Baumgaertel, Julia Böttcher, Liesbeth De Coninck, Ingeborg Dhooge, Ann Dierckx, Thomas Klenzner, Philipp Schörg, Georg Sprinzl, Freya Swinnen, Nicolas Verhaert, Annelies Vermeiren, Simone Volpert, Andrzej Zarowski, Arne Ernst

“…Conclusion: The benefits shown in this study confirm and expand the existing body of evidence for the effectiveness of CI in SSD and AHL. …”
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Hypoxylon luteogranulatum (Hypoxylaceae, Xylariales), a novel species from Thailand with distinct chemical and ecological traits by Sarunyou Wongkanoun, Esteban Charria-Girón, Marjorie Cedeño-Sanchez, Boonchuai Chainuwong, Sayanh Somrithipol, Eric Kuhnert, Prasert Srikitikulchai, Natapol Pornputtapong, Frank Surup, Jennifer Luangsa-ard, Marc Stadler

“…Our molecular phylogenetic study provides substantial evidence distinguishing H. luteogranulatum clearly from H. lechatii and allied members within the Hypoxylaceae. Additionally, future studies are needed to better understand the ecological behaviour of H. luteogranulatum and identify the ecological role of the vermelhotin-like molecules within this putative interaction.…”
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Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps by Yujie Yan, Inge Seim, Yang Guo, Xupeng Chi, Zhaoshan Zhong, Dantong Wang, Mengna Li, Haining Wang, Huan Zhang, Minxiao Wang, Chaolun Li

“…Compared to its shallow-sea relatives, L. polybranchiata has a significantly higher proportion of polyunsaturated fatty acids (PUFAs) and expanded gene families involved in the biosynthesis of unsaturated fatty acids and chromatin stabilization, possibly in response to high hydrostatic pressure. Additionally, L. polybranchiata has broad digestive scope, allowing it to fully utilize the limited food resources in the deep sea to sustain a large population. …”
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