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61381
Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition
Published 2025-01-01“…The release of cytochrome C from damaged mitochondria into the cytoplasm activated a Caspase cascade reaction. In addition, excessive ROS levels impaired autophagic degradation by inhibiting the fusion of autophagosomes with lysosomes. …”
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61382
Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy
Published 2025-01-01“…Finally, performing live-imaging experiments using fluorescence recovery after photobleaching and by monitoring GFP-tagged end binding protein 3 (EB3) “comets,” we observe an impairment of the plus-end polymerization speed in PCDH19-mutated cortical neurons, therefore confirming the impaired MT dynamics. In addition to altering the mitotic spindle formation, the present data unveil that PCDH19 dysfunction leads to altered cytoskeletal rearrangement, providing therapeutic targets and pharmacological options to treat this disorder.…”
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61383
Performance improvements and increased ruminal microbial interactions in Angus heifers via supplementation with native rumen bacteria during high-grain challenge
Published 2025-01-01“…The combined 35 days of microbial supplementation resulted in an improved average daily gain (ADG) of 29% (P = 0.037) and a tendency toward a 19% decrease in the feed efficiency metric, gain to feed ratio (G: F) (P = 0.055). Additionally, administration of NRM to animals on a high-grain diet, improved ruminal microbiome stability (P < 0.001), potentially encouraging the conversion of rumen lactate to propionate over time via the succinate pathway and alleviating metabolic stress.…”
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61384
RailPC: A large‐scale railway point cloud semantic segmentation dataset
Published 2024-12-01“…Abstract Semantic segmentation in the context of 3D point clouds for the railway environment holds a significant economic value, but its development is severely hindered by the lack of suitable and specific datasets. Additionally, the models trained on existing urban road point cloud datasets demonstrate poor generalisation on railway data due to a large domain gap caused by non‐overlapping special/rare categories, for example, rail track, track bed etc. …”
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61385
FGF23-related hypophosphatemia in a patient with small cell lung cancer: a case report and literature review
Published 2023-10-01“…These data suggested the overproduction of FGF23 in addition to ACTH and ADH. Because the octreotide loading test did not present a suppressive effect on ACTH or FGF23 levels, the patient was treated with phosphate supplementation, active vitamin D and metyrapone, which partially improved the serum phosphate and cortisol levels. …”
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61386
Advances in carbon dioxide capture and conversion technologies: Industrial integration for sustainable chemical production
Published 2025-01-01“…Innovative strategies, including integrated carbon capture and conversion (ICCC) and integrated carbon capture and utilization (ICCU), present promising pathways to reduce costs by combining capture and utilization processes within a single facility. Additionally, catalytic processes and biological systems, such as microalgae and microbial strains (e.g., acetogens), are paving the way for sustainable CO2 conversion into high-value products. …”
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61387
Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury
Published 2025-02-01“…UCH-L1, GFAP and pTau181 did not differ between groups, but demonstrated negative associations with days post-injury (small to medium effect sizes) suggestive of a more rapid release/clearance. …”
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61388
SSL-MBC: Self-Supervised Learning With Multibranch Consistency for Few-Shot PolSAR Image Classification
Published 2025-01-01“…Specifically, the data augmentation technique used in the pretext task involves a combination of various spatial transformations and channel transformations achieved through scattering feature extraction. In addition, the distinct scattering features of PolSAR data are considered as its unique multimodal representations. …”
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61389
Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells
Published 2025-01-01“…By employing a sequential-recording paradigm, we could disentangle those additional adaptational response changes from drug-induced modulations. …”
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61390
Addressing vaccine hesitancy in the training of healthcare professionals: Insights from the VAX-TRUST project
Published 2025-06-01“…Methods: The findings are based on a comprehensive Delphi survey conducted with a panel of 112 experts. Additionally, the study involved practical interventions carried out across seven European countries, engaging a total of 694 participants. …”
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61391
Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells
Published 2025-02-01“…In vitro experiments used HSCs to explore the antifibrotic properties of HepLPC-secretomes and their underlying molecular mechanisms. Additionally, proteomic analysis was conducted to characterize the protein composition of HepLPC-secretomes. …”
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61392
Antimicrobial Activity and Mode of Action of N-Heterocyclic Carbene Silver(I) Complexes
Published 2024-12-01“…The inhibitory properties of the four complexes were evaluated for their antimicrobial potential against a set of Gram (+) and Gram (−) bacterial strains and the fungus <i>C. albicans</i>. In addition, further investigations were made using fluorescence and scanning electron microscopy (SEM) in order to gain more insights into the mechanism of action. …”
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61393
Programmed cell death-related gene IL20RA facilitates tumor progression and remodels tumor microenvironment in thyroid cancer
Published 2025-01-01“…The function of IL20RA which could potentially provide a foundation for additional investigations into diagnostic markers and treatment targets for THCA.…”
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61394
Impact of Different Metabolic Indicators on Ventricular Repolarization Indices in Obese Children: A Case Control Study
Published 2025-02-01“…Additionally, no significant difference was revealed between obese children with and without metabolic syndrome regarding ventricular repolarization ECG parameters. …”
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61395
Global and Local Infall in the ASHES Sample (GLASHES). I. Pilot Study in G337.541
Published 2025-01-01“…Using dense gas tracers such as N _2 H ^+ ( J = 1–0) and HNC ( J = 3–2), we find signs of infall from the position–velocity diagram and more directly from the blue asymmetry profile in addition to the clump-scale velocity gradient. We estimate infall velocities from intermediate and low-mass cores to be 0.28–1.45 km s ^−1 , and infall rates to be on the order of 10 ^−4 –10 ^−3 M _⊙ yr ^−1 , both are higher than those measured in low-mass star-forming regions by more than a factor of 5 and an order of magnitude, respectively. …”
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61396
Developmental changes of skin quality from breast, back, and thigh of Pekin ducks from 1 to 6 weeks of age
Published 2025-02-01“…The results showed that the body weight, absolute skin weight, areas, and density, epidermal and dermal thickness (breast and thigh), shearing force, piercing force (back and thigh), and collagen content in Pekin ducks increased linearly and quadratically with age, reaching a plateau at 5-6 weeks of age (P < 0.05). …”
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61397
Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma
Published 2013-01-01“…Additionally, HIF-2α, TWIST, and CXCR4 mRNA expression were assessed in 30 PTCs, 10 nodular hyperplasia, and 10 normal thyroid tissue specimens using real-time RT-PCR. …”
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61398
Assisted Parkinsonism Diagnosis Using Multimodal MRI—The Role of Clinical Insights
Published 2025-01-01“…Objective To assess whether the performance of classifiers based on imaging derived biomarkers is improved with the addition of basic clinical information and to provide a practical solution to address the insecurity of classification results due to the uncertain clinical diagnosis they are based on. …”
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61399
Electrochemically-driven solid oxide tubular membrane reactor for efficient separation of oxygen and argon
Published 2025-06-01“…The resulting membrane reactor was compact, defect-free, and capable of producing Ar with a purity of 99.99 %. Additionally, under a constant total current of 0.75 A and an operating temperature of 800 °C, the membrane reactor demonstrated stable performance for over 130 hours, maintaining a Faradaic efficiency exceeding 95 %. …”
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61400
A multi‐tagged SAR ocean image dataset identifying atmospheric boundary layer structure in winter tradewind conditions
Published 2025-01-01“…This strategy extends the TenGeoP‐SARwv by identifying coexisting phenomena within a single SAR image and by the addition of mixed roll/cell states and cold pools. …”
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