Insights into Treponema pallidum genomics from modern and ancient genomes using a novel mapping strategy by Marta Pla-Díaz, Gülfirde Akgül, Martyna Molak, Louis du Plessis, Hanna Panagiotopoulou, Karolina Doan, Wiesław Bogdanowicz, Paweł Dąbrowski, Maciej Oziembłowski, Barbara Kwiatkowska, Jacek Szczurowski, Joanna Grzelak, Natasha Arora, Kerttu Majander, Fernando González-Candelas, Verena J. Schuenemann

“…The high-coverage W86 genome introduced in this study also provided a new calibration point for Bayesian molecular clock dating, improving the reconstruction of the evolutionary history of treponemal diseases. Additionally, we identified novel recombination events, positive selection targets, and refined dating estimates for key events in the species’ history. …”
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Immersive virtual reality to assess unilateral spatial neglect in stroke patients: a preliminary study by Chloé Sauvage, Pierre Chaulet, Luana Rivas Lopez, Johanne Garbusinski, Pierre Cabaraux, Zachary Duvigneaud, Stéphane Baudry

“…Moreover, VR could provide additional information on the type of USN through the different testing modalities available. …”
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Treatment of chronic hepatitis B: options, monitoring, special cases and adverse effects by Mateusz Litwin Litwin, Agnieszka Mikosińska, Jakub Parys, Patrycja Kałuziak, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek, Marta Jajczak, Maciej Mossakowski

“…This review aims to provide an in-depth analysis of therapeutic approaches for chronic hepatitis B, considering factors such as patient age, clinical status, and liver fibrosis stage. Additionally, it emphasizes the importance of monitoring treatment efficacy and safety, while also addressing the potential adverse effects associated with antiviral therapy. …”
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Decoding the synergistic potential of herbal medicine and dietary supplements for treating postmenopausal osteoporosis by Jinfang Dou, Xuehong Hu, Junchang Liu, Jiaxian Liu, Chuyue Zhang, Yuelin Zhang, Xianjie Zhen, Siyu Tao, Jinghua Zhang, Guangjian Jiang

“…The 12-week experiment involved measurements of bone density and microstructure, histological evaluation of femoral trabeculae and bone cortex, quantification of osteoclasts in the femur, assessment of osteoclast differentiation factor expression (NFATc1 and C-Fos), and measurement of collagen I carboxyl-terminal peptide (CTX-1). Additionally, intestinal flora analysis was performed. …”
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Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels by Nathalie Idlin, Sivakumar Krishnamoorthy, Magdalena Wolczyk, Mouad Fakhri, Michal Lechowski, Natalia Stec, Jacek Milek, Pratik Kumar Mandal, Jaroslaw Cendrowski, Christos Spanos, Magdalena Dziembowska, Katarzyna Mleczko-Sanecka, Juri Rappsilber, Gracjan Michlewski

“…We show that both HuR knockout and Eltrombopag treatment modulate iron metabolism by decreasing ferritin heavy chain (FTH1) and light chain (FTL) synthesis while increasing the expression of iron-regulatory protein 2 (IRP2), a key regulator of ferritin translation. Additionally, HuR inhibition reduces the levels of glycoprotein hormones, alpha polypeptide (CGA), a marker associated with hormone-induced tumors, suggesting a potential use of Eltrombopag in treatment of cancers overexpressing CGA. …”
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Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation by Holger A. Russ, Limor Landsman, Christopher L. Moss, Roger Higdon, Renee L. Greer, Kelly Kaihara, Randy Salamon, Eugene Kolker, Matthias Hebrok

“…Two of the three factors (LGALS1 and LAMA2) increased expression of pancreatic progenitor transcript levels in a published hESC to beta cell differentiation protocol. In addition, LAMA2 partially blocks cell culture induced beta cell dedifferentiation. …”
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Molecular dynamics simulation of temperature and concentration distribution at liquid-gas interface during liquid air storage process by Zhanping You, Menghan Cheng, Changjie Ma, Yufei Xiao, Xuemin Zhao, Camila Barreneche, Xiaohui She

“…The thin and short stratification phenomenon occurs at the gas-liquid interface region. In addition, a higher heat flux leads to a higher evaporation rate and a larger oxygen concentration. …”
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Unraveling nitrogen metabolism, cold and stress adaptation in polar Bosea sp. PAMC26642 through comparative genome analysis by Anamika Khanal, Anamika Khanal, So-Ra Han, So-Ra Han, So-Ra Han, Jun Hyuck Lee, Tae-Jin Oh, Tae-Jin Oh, Tae-Jin Oh, Tae-Jin Oh

“…PAMC26642, assimilatory nitrogen metabolic pathway and its associated enzymes such as nitrate reductase, NAD(P)H-nitrite reductase, ferredoxin-nitrite reductase, glutamine synthetase, glutamine synthase, and glutamate dehydrogenase were identified. In addition, carbonic anhydrase, cyanate lyase, and nitronate monooxygenase were also identified. …”
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Tangduqing Granules Attenuate Insulin Resistance and Abnormal Lipid Metabolism through the Coordinated Regulation of PPARγ and DGAT2 in Type 2 Diabetic Rats by Qinghua Zhang, Yingying Huang, Xiaojin Li, Hongyi Liu, Baichuan He, Bin Wang, Yuntao Ma, Xiang Zhou, Yaqin Liu, Shentao Wu

“…Furthermore, TDQ reversed diabetes-induced decrease in the mRNA and protein expression of PPARγ and elevation in the mRNA and protein levels of DGAT2 in the liver. In addition, we showed that interference of TDQ ameliorated palmitate-induced glucose and lipid metabolic abnormalities in HepG2 cells. …”
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Exploring South Africa's hidden marine parasite diversity: two new marine Ergasilus species (Copepoda: Cyclopoida: Ergasilidae) from the Evileye blaasop, Amblyrhynchote honckenii (... by Linda van der Spuy, Rodrigo B. Narciso, Kerry A. Hadfield, Victor Wepener, Nico J. Smit

“…The newly described species differ morphologically from each other, and their respective congeners based on the size and armature of the antenna; body segmentation; and general ornamentation throughout the entire body. …”
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Analysis of diagnostic genes and molecular mechanisms of Crohn’s disease and colon cancer based on machine learning algorithms by Jie Xiao, Junyao Liang, Tao Zhou, Man Zhou, Dexu Zhang, Hui Feng, Chusen Tang, Qian Zhou, Weiqing Yang, Xiaoqin Tan, Wanjia Zhang, Yin Xu

“…This study has identified key biomarker genes for CD and COAD: DPEP1, MMP3, and MMP13, providing additional molecular mechanism associations between the two diseases. …”
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Impact of water stress on <i>Phaeomoniella chlamydospora</i> abundance and Petri disease symptom development in young grapevines by Jared Hrycan, Pat Bowen, Thomas Forge, Miranda Hart, Jose Ramon Úrbez-Torres

“…To investigate this hypothesis, a two-year greenhouse and a four-year field experiment were conducted on young self-rooted ‘Merlot’, and ‘Merlot’ grafted onto ‘SO4’ rootstock, artificially inoculated with different spore concentrations of Pch and subjected to water stress. Additionally, the arbuscular mycorrhizal (AM) fungus Rhizophagus irregularis was inoculated in the soil in the greenhouse experiment to investigate its effects on abiotic stress mitigation and thus, disease development in water stressed and non-stressed grapevines. …”
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Single Exposure to Low-Intensity Focused Ultrasound Causes Biphasic Opening of the Blood-Brain Barrier Through Secondary Mechanisms by Tasneem A. Arsiwala, Kathryn E. Blethen, Cullen P. Wolford, Geoffrey L. Pecar, Dhruvi M. Panchal, Brooke N. Kielkowski, Peng Wang, Manish Ranjan, Jeffrey S. Carpenter, Victor Finomore, Ali Rezai, Paul R. Lockman

“…<b>Results:</b> Our findings show that LiFUS significantly increased vascular volume and glucose uptake, with reduced P-gp function in brain tissues six hours post treatment, indicating biphasic BBB disruption. Additionally, elevated levels of pro-inflammatory cytokines, including TNF-α and IL-6, were observed in both sonicated and non-sonicated regions. …”
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Effects of aminooxyacetic acid on learning and memory function and neurochemical changes in chronic alcoholism by Hongbo Jiang, Xunling Wang, Yingwei Liang, Yinghan Hou, Xinping Yue, Zhiyi Zhang, Dan Chen, Xinyi Fan, Ailin Du

“…Objective: This study aimed to investigate the effect of aminooxyacetic acid (AOAA) on cognitive function, particularly learning and memory, in a rat model of chronic alcoholism. Additionally, the study explored changes in cystathionine β-synthase (CBS), hydrogen sulfide (H₂S), and serotonin (5-HT) levels in the prefrontal cortex to understand the potential neurochemical mechanisms involved. …”
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Prevalence and characteristics of HPV vaccine hesitancy among parents of adolescent females across Saudi Arabia by Sahar Othman, Ranya Ghamri, Wala Alhamadah, Anwaar Alsatty, Dhuha Khesfaty, Ohoud Alghamdi, Ragad Arbaein, Alaa M. Baglagel, Jumana Khayyat, Bushra Almalki

“…A few demographic variables were significantly associated with vaccine hesitancy, including lower household income and living in the southern region. In addition, lack of recommendation by their healthcare provider and inconvenience related to immunization with the vaccine were also associated with higher levels of hesitancy.ConclusionHPV vaccine hesitancy remains high among parents of adolescent females in Saudi Arabia. …”
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Dietary Nannochloropsis oculata ameliorates lead acetate induced reproductive toxicity in Barki rams: NF-κB and cytokines pathways by Doaa H. Elsayed, Sameer A. Nagadi, Heba M.A. Abdelrazek, Ahmed. S. El‑Hawy, Moharram F. El-Bassiony, Seham A. Helmy, Yasmina K. Mahmoud, Ibrahim E. Helal, Shady T. Hassan

“…Alga supplementation to lead-intoxicated rams significantly upgraded the lead induced alterations that were manifested by improvement in testicular histopathology. In conclusion, the addition of alga mitigated lead induced reproductive toxicity in rams via improving testosterone, oxidant/antioxidant status, semen criteria and reducing inflammatory cytokines.…”
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G-UNETR++: A Gradient-Enhanced Network for Accurate and Robust Liver Segmentation from Computed Tomography Images by Seungyoo Lee, Kyujin Han, Hangyeul Shin, Harin Park, Seunghyon Kim, Jeonghun Kim, Xiaopeng Yang, Jae Do Yang, Hee Chul Yu, Heecheon You

“…Two gradient-based encoders that take the second-order partial derivatives (the first two elements from the last column of the Hessian matrix of a CT scan) as inputs are proposed to learn the 3D geometric features such as the boundaries between different organs and tissues. In addition, a hybrid loss function that combines dice loss, cross-entropy loss, and Hausdorff distance loss is designed to address class imbalance and improve segmentation performance in challenging cases. …”
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A rugalmasítás határán: bérmunkaviszonyok a kertészeti ágazatban by András Vigvári, Krisztina Németh

“…Eredményeink azt mutatják, hogy a nagyüzemi kertészetek elsősorban a bérmunkaviszonyok rugalmasításán (munkaerőkölcsönzés, teljesítményalapú bérezés) keresztül igyekeznek választ adni a munkaerőhiánnyal összefüggő kihívásokra. Ezzel szemben a családi, fóliás kertészetek elsősorban apatrónus-kliens viszonyok megerősítésére alapozzák adaptációs stratégiájukat. …”
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Immunophenotypic Characterization of Human Bone Marrow Mast Cells. A Flow Cytometric Study of Normal and Pathological Bone Marrow Samples by Luis Escribano, Alberto Orfao, Jesús Villarrubia, Beatriz Díaz-Agustín, Carlos Cerveró, Agustín Rios, José L. Velasco, Juana Ciudad, José L. Navarro, Jesús F. San Miguel

“…Three patterns of antigen expression were detected: (1) markers constantly positive in all cases analyzed (CD9, CD29, CD33, CD43, CD44, CD49d, CD49e, CD51, CD71, CD117, and FcεRI), (2) antigens that were constantly negative (CD1a, CD2, CD3, CD5, CD6, CD11a, CD14, CD15, CD16, CD19, CD20, CD21, CD23, CD25, CD30, CD34, CD38, CD41a, CD42b, CD65, CD66b, HLA-DR, and CD138), and (3) markers that were positive in a variable proportion of cases – CD11b (50%), CD11c (77%), CD13 (40%), CD18 (20%), CD22 (68%), CD35 (27%), CD40 (67%), CD54 (88%) and CD61 (40%). In addition, BMMC from all cases explored were CD45+, and this antigen was expressed at an intensity similar to that of mature granulocytes.…”
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Development of VTOL-configured unmanned aquatic vehicle for underwater welding applications: An innovative design and multi-perspective computational investigations by Janani Priyadharshini Veeraperumal Senthil Nathan, Manikandan Arumugam, Mahendran Rajendran, Laxana Sourirajan, Gopinath Vinayagam, Akhila Ajith Pisharam, Sundhar Baskar, Beena Stanislaus Arputharaj, Subhav Singh, Khristina Maksudovna Vafaeva, Vijayanandh Raja

“…There is a maximum velocity of 6.119 m/s and a maximum pressure of 4940 Pa in the VTOL scenario, in addition to the least deformation of 0.126 mm, when compared to the analysis performed amidst the other materials. …”
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