Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus by Dongdong Lin, Cong Tang, Junbin Wang, Yun Yang, Hao Yang, Yanan Zhou, Wenhai Yu, Bai Li, Qing Huang, Haixuan Wang, Ran An, Xiaoming Liang, Yuhuan Yan, Longhai Yuan, Xuena Du, Yuxia Yuan, Yanwen Li, Shuaiyao Lu

“…We observed upregulated and downregulated metabolic status in CHIKV‐infected rhesus monkeys and mice, respectively. Additionally, we identified host factors such as S100 Calcium‐Binding Protein A8/A9 (S100A8/A9), Voltage‐Dependent Anion Channel 1/2 (VDAC1/2), Complement Component 3 (C3), Apoptosis‐Inducing Factor Mitochondria‐Associated 1 (AIFM1), Endothelial Cell‐Specific Chemotaxis Regulator (ECSCR), and Kininogen 1 (KNG1) that may contribute to CHIKV‐induced inflammation and hemorrhage. …”
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Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study by Lihua Huang, Min Xiao, Xiaoling Huang, Jun Wu, Jiao Luo, Fuxing Li, Wei Gu

“…A nomogram model was constructed based on these factors, to predict the risk of HFRS with AP, with an Area Under the Curve (AUC) of 0.90 (95% CI: 0.84–0.95). Additionally, the model calibration curve fit well according to the Hosmer-Lemeshow test (χ2=8.51, p = 0.39).Conclusion Patients with HFRS with AP exhibit higher disease severity and poorer prognosis. …”
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Liver morphometry and histopathology effects in Astyanax lacustris exposed to lambda-cyhalothrin pyrethroid insecticide by Tiago Venancio da Silva, André Luiz do Nascimento Silva, Karine Nathiele Nogueira Farias, Carla Leticia Gediel Rivero Wendt, Lucas de Oliveira Brasileiro, Edilaine Fogaça, Sabrina Fuzer Gonçalves, Brenda de Oliveira Martins, Maria Eduarda Corona Garcia, Lilian Franco-Belussi, Carlos Eurico S. Fernandes

“…These results show morphophysiological effects of LC at 10.30 µg/L in acute and chronic exposure represented by decreased glycogen storage, structural density, and volume of hepatocytes, in addition to a higher degree of histological changes.…”
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Seagrass macroinvertebrate bycatches support mosquito net trawl fishery in Madagascar by Herinirina Patricia A., Bigot Lionel, Frouin Patrick, Volandrae Huguette T.E, Randriatsara Roddy M., Behivoke Faustinato, Ranivoarivelo Lantoasinoro, Léopold Marc

“…They were sold for human consumption or animal feed, which provided additional income to fishers (USD 1–24 trip−1 and 1–72% of catch income per trip). …”
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Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway by Hongxiao Xie, Yanning Jiang, Xiumeng Zhang, Xinran Min, Jiuseng Zeng, Li Chen, Nan Zeng, Rong Liu

“…These offspring also showed diminished levels of DCX+, decreased levels of synaptic proteins, and reduced dendritic spine density and length in hippocampus. Additionally, we detected increased serum stressed hormones and decreased hippocampal glucocorticoid receptor (GR) protein level in the offspring. …”
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Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk by Hadi Feizi, Hossein Samadi Kafil, Andrey Plotnikov, Vladimir Kataev, Alexander Balkin, Ekaterina Filonchikova, Mohammad Ahangarzadeh Rezaee, Reza Ghotaslou, Mohammad Sadrkabir, Hiva Kadkhoda, Fadhil S. Kamounah, Sergei Nikitin

“…We observed that the Lachnospiraceae family depleted concomitant with acetoacetate and beta-hydroxybutyric acid (BHB) accumulations in the AP tissues. In addition, some bacterial species including Gemella morbillorum, and Morganella morganii were enriched in the AP compared to the H group. …”
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Analysis of the role of acetylation in Giardia lamblia and the giardicidal potential of garcinol by Rocío G. Patolsky, Jerónimo Laiolo, Jerónimo Laiolo, Luciano Díaz-Pérez, Gabriel Luna Pizarro, Gonzalo F. Mayol, María C. Touz, Constanza Feliziani, Andrea S. Rópolo

“…Garcinol treatment during growth caused significant morphological changes, including plasma membrane blebbing and apoptotic-like bodies. Immunofluorescence revealed these bodies contained α-tubulin/acetylated α-tubulin and reactive oxygen species. …”
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Research progress of humanistic care in nursing teaching and teacher training (人文关怀在护理教学与师资培养中的应用研究进展) by LI Yuxin (李玉欣), LI Xiuli (李秀丽), DENG Jianhua (邓建华), LIU Sichun (刘司春), TANG Ling (唐玲)

“…The aim of nursing teaching is not only to ensure that nursing students can acquire professional knowledge and practical skills, but also to establish a correct outlook on life, values, and good medical ethics, moreover, simultaneously addressing issues such as the disconnect between theory and practice and improving the effectiveness of clinical teaching. In addition, it is required to strengthen the training of nursing teachers to achieve a high level of consistency among clinical nurses and achieve the goal of mutual learning and teaching. …”
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Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function by Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon

“…The development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel therapeutic options for infectious disease. In addition to preventing viral infection through neutralization, Abs can clear infected cells and induce immunomodulatory functions through engagement of their crystallizable fragment (Fc) with complement proteins and Fc receptors on immune cells. …”
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Telomerase and mitochondria inhibition promote apoptosis and TET2 and ANMT3a expression in triple negative breast cancer cell lines by Zeinab Mazloumi, Ali Rafat, Khadijeh Dizaji Asl, Mohammad Karimipour, Dariush Shanehbandi, Mehdi Talebi, Majid Montazer, Ali Akbar Movassaghpour, Alireza Dehnad, Raheleh Farahzadi, Hojjatollah Nozad Charoudeh

“…The expressions of DNMT3a and TET2 increased in cells. In addition, combination treatment was better than BIBR1532 and tigecycline alone. …”
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Development and validation of machine learning models for MASLD: based on multiple potential screening indicators by Hao Chen, Jingjing Zhang, Xueqin Chen, Ling Luo, Wenjiao Dong, Yongjie Wang, Jiyu Zhou, Canjin Chen, Wenhao Wang, Wenbin Zhang, Zhiyi Zhang, Yongguang Cai, Danli Kong, Yuanlin Ding

“…Subsequently, the partial dependence plot(PDP) method and SHapley Additive exPlanations (SHAP) were utilized to explain the roles of important variables in the model to filter out the optimal indicators for constructing the MASLD risk model.ResultsRanking the feature importance of the Random Forest (RF) model and eXtreme Gradient Boosting (XGBoost) model constructed using all variables found that both homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose-waist circumference (TyG-WC) were the first and second most important variables. …”
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Performance enhancement of organic single-flash cycles by eliminating the throttle valves: A comparative exergy-economic assessment by Aboulbaba Eladeb, Ali B.M. Ali, Pooya Ghodratallah, Kuwar Mausam, Rahul Thakur, Praney Madan, Lotfi Ben Said, Lioua Kolsi

“…However, its investment cost rate (Z˙tot) is 8 % higher than the MOFRC. In addition, the MOFRC, with an ηex and cel of 51.8 % and 6.87 $GJ−1, has a competitive performance compared to the ORC. …”
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Hypoxia lowers cell carbon and nitrogen content and accelerates sinking of a marine diatom Thalassiosira pseudonana by Bokun Chen, Bokun Chen, Hui Song, Hui Song, Ge Xu, Hongli Ji, Hongli Ji, Xue Yang, Xue Yang, Gang Li

“…In darkness, low O2 had no significant effect on cell C loss rate but decreased N loss rate, leading to an increase in the POC/PON ratio. In addition, hypoxia exacerbated cell mortality and sinking, suggesting that diatom-derived carbon burial may be accelerated due to marine deoxygenation in the future.…”
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High‐stability two‐dimensional perovskite LaNb2O7 for high‐performance wide‐temperature (80–780 K) UV light detection and human motion detection by Yong Zhang, Jian Yao, Lin Wang, Long Chen, Junyi Du, Pin Zhao, Qing Guo, Zhen Zhang, Lixing Kang, Xiaosheng Fang

“…Importantly, it shows high responsivity (171 A W−1), extraordinary detectivity (4 × 1012 Jones), fast speed (0.3/97 ms), and long‐term stability under ambient conditions. In addition, wafer‐scale LNO film devices can be used as pixel array detectors for UV imaging, and large‐area flexible LNO film devices exhibit satisfactory photodetection performance after repeated bending tests. …”
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Exploring menstrual hygiene management practices among displaced coastal women in Kerala, India by Jessy Prabhakar, Aswin MG, Asmi Fathima Nazar, Adarsh MS, Jibin Job PJ, Nisam AP, Krishna Priya MJ, Mini GK

“…Introduction: During climate related displacement, women face additional challenges in safely managing menstrual hygiene. …”
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Ticks and Tick-Borne Pathogens in Wild Animals and Birds from Two Rehabilitation Facilities in Greece by Dimitrios Vourvidis, Georgia Tzouganatou, Sokratis Perdikaris, Evangelia Kofidou, Beatriz Martinez-Gonzalez, Mary Emmanouil, Emmanouil Papadogiannakis, Anastasia Komnenou, Emmanouil Angelakis

“…Among the pathogens detected, <i>R. aeschlimannii</i> was the most prevalent, particularly in <i>H. aegyptium</i> ticks from tortoises. Additionally, <i>R. africae</i> was identified in <i>H. aegyptium</i> from tortoises, marking the first report of this pathogen in this tick species in Greece. …”
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The youth mental health crisis: analysis and solutions by Patrick McGorry, Patrick McGorry, Hasini Gunasiri, Hasini Gunasiri, Cristina Mei, Cristina Mei, Simon Rice, Simon Rice, Caroline X. Gao, Caroline X. Gao

“…We discuss methodologies to estimate the contribution of these megatrends and outline potential barriers to implementation, along with strategies to overcome them.ConclusionThis review calls for a comprehensive global action plan, emphasizing prevention, early intervention, and improved treatment strategies. In addition to strengthening prevention, which may take time and be elusive, immediate action is needed to innovate and expand services, which are currently under-resourced and overwhelmed.…”
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Isolation and Characterization of Colistin-Resistant <i>Enterobacteriaceae</i> from Foods in Two Italian Regions in the South of Italy by Rosa Fraccalvieri, Angelica Bianco, Laura Maria Difato, Loredana Capozzi, Laura Del Sambro, Stefano Castellana, Adelia Donatiello, Luigina Serrecchia, Lorenzo Pace, Donatella Farina, Domenico Galante, Marta Caruso, Maria Tempesta, Antonio Parisi

“…Notably, seven isolates harbored <i>mcr</i> genes (<i>mcr</i>-1, <i>mcr</i>-9, and <i>mcr</i>-10). Additionally, in four of them were predicted the IncHI2 plasmids, known to facilitate the spread of colistin resistance. …”
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Towards targeted cancer therapy: Synthesis, characterization, and biological activity of a new Cu(II)-ibuprofen-2,2′-dipyridylamine metal complex by Luís P.G. Monteiro, A. Gomes, C. Silva, Ricardo F. Mendes, Filipe A. Almeida Paz, Dmitry Chernyshov, J. Rocha, F. Martel, T.M. Santos, B.J.M. Leite Ferreira

“…The coordination compound was characterised by elemental analysis, Fourier transform infrared spectroscopy, thermogravimetry, and ultraviolet–visible spectrophotometry. Additionally, the crystal structure of the copper metal complex was elucidated using single-crystal X-ray diffraction with synchrotron radiation. …”
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Anthropometric, aerobic and muscle power profile of young costa rican basketball players by Randall Gutiérrez-Vargas, José Alexis Ugalde-Ramírez, José Pino-Ortega, José Andrés Trejos-Montoya, Luis Blanco-Romero, Braulio Sánchez-Ureña, Juan Carlos Gutiérrez-Vargas, Daniel Rojas-Valverde

“…The following parameters were assessed: height, weight, body mass index, skeletal muscle mass and body fat percentage, countermovement test (CMJ) and Yo-Yo Intermittent Recovery Test Level I. …”
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