Explainable machine learning model for predicting decline in platelet count after interventional closure in children with patent ductus arteriosus by Song-Yue Zhang, Yi-Dong Zhang, Hao Li, Qiao-Yu Wang, Qiao-Fang Ye, Xun-Min Wang, Tian-He Xia, Yue-E He, Xing Rong, Ting-Ting Wu, Rong-Zhou Wu

“…The extra tree algorithm was used for feature selection and four ML algorithms [random forest (RF), adaptive boosting, extreme gradient boosting, and logistic regression] were established. Moreover, SHapley Additive exPlanation (SHAP) to explain the importance of features and the ML models.ResultsThis study included 330 children who underwent successful transcatheter closure of PDA, of which 113 (34.2%) experienced DPC. …”
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First insight into temporal variation of digestive enzyme activities in flathead grey mullet (Mugil cephalus) during the ongrowing phase by Silvia Natale, Andrea Bertini, Enric Gisbert, Karl B. Andree, Elisa Benini, Dario Vallainc, Pier Paolo Gatta, Alessio Bonaldo, Luca Parma

“…At the end of the trial, the activity of pancreatic and intestinal enzymes were analysed at three different times: 0, 6 and 12 hours post-prandial. Additionally, the gene expression of pept1 was determined in the intestine at all considered times to provide a reference to peptide absorption. …”
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Connectome-based disentangling of epilepsy networks from insular stereoelectroencephalographic leads by Kathrin Machetanz, Eliane Weinbrenner, Thomas Volkmar Wuttke, Silke Ethofer, Randolph Helfrich, Josua Kegele, Stephan Lauxmann, Michael Alber, Sabine Rona, Marcos Tatagiba, Holger Lerche, Jürgen Honegger, Georgios Naros

“…Combining SEEG and connectomics could provide additional information about seizure propagation within the epilepsy network and might enable new treatment options in the future like deep brain stimulation.…”
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MEST Regulates the Stemness of Human Periodontal Ligament Stem Cells by Daigaku Hasegawa, Kana Hasegawa, Hiroshi Kaneko, Shinichiro Yoshida, Hiromi Mitarai, Mai Arima, Atsushi Tomokiyo, Sayuri Hamano, Hideki Sugii, Naohisa Wada, Tamotsu Kiyoshima, Hidefumi Maeda

“…On the other hand, overexpression of MEST in 2-52 cells enhanced the expression of stem cell markers and PDL-related markers and the multidifferentiation capacity. In addition, MEST-overexpressing 2-52 cells exhibited a change in morphology from a spindle shape to a stem cell-like round shape that was similar to 2-14 and 2-23 cell morphologies. …”
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IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications by Abdullah Al Mamun, Peiwu Geng, Shuanghu Wang, Chuxiao Shao, Jian Xiao

“…This review explores gut microbiota-influenced treatments for ASD, focusing on their therapeutic applications and mechanistic insights. In addition, this review discusses the interactions between gut microbiota and the immune, metabolic and neuroendocrine systems, focusing on crucial microbial metabolites including short-chain fatty acids (SCFAs) and several neurotransmitters. …”
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Electrogenic amino acid transport in the intestine of sea bream (Sparus aurata): From functional characterization to physiological effects of Lysophospholipids in aquafeeds by Rocio Robles-Arozarena, Juan Antonio Martos-Sitcha, Laura Bermúdez, Waldo Nuez-Ortín, Juan Fuentes

“…In response to sustainability concerns related to the origin of raw materials, aquaculture has emphasized the use of additives and enhancers to improve the intestinal absorption of proteins and amino acids. …”
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Sleep profile in patients with septo-optic-pituitary dysplasia: protocol for a prospective cohort study by Romina Romaniello, Sabrina Signorini, Elena Ballante, Valentina Franco, Valentina De Giorgis, Ludovica Pasca, Guido Catalano, Federica Morelli, Carlo Alberto Quaranta, Helene Vitali, Francesca Dattrino, Francesca Crema, Paola Rota, Costanza Varesio

“…Sleep quality and daytime sleepiness changes will be tracked using actigraphic assessment, standardised sleep questionnaires and a sleep EEG. Additionally, plasma and salivary melatonin profiles will be assessed for each participant.Ethics and dissemination This study has been approved by local Ethics Committee (N°0049187/23). …”
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Widely Targeted Metabolomics Analysis Reveals Key Quality-Related Metabolites in Kernels of Sweet Corn by Ruichun Yang, Yunfeng Li, Yuanyuan Zhang, Jun Huang, Junjie Liu, Zimei Lin, Qinqin Yu, Aimin Wu, Bo Wang

“…And the essential amino acids for the human body, methionine and threonine, were highly accumulated in the high-quality cultivar. …”
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Coculture with Eastern oysters is unlikely to reduce OsHV-1 impacts to farmed Pacific oysters: A modelling approach by Familusi Oluwatosin Adekunle, Gorka Bidegain, Tal Ben-Horin

“…Coculture scenarios did not provide a significant advantage for M. gigas, likely due to OsHV-1 particle saturation in the water column. …”
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Genome-wide identification of the bHLH gene family in Scutellaria baicalensis and their relationship with baicalin biosynthesis under drought stress by Yingxin Sun, Beier Wang, Lichao Zhang, Xiaohan Zheng, Peng Xu, Meng Zhang, Meiguang Han, Peng Di, Mei Han, Lin Cheng, Limin Yang

“…Transcriptomic data and qRT-PCR results demonstrated tissue-specific expression patterns for the 142 SbbHLH genes. Additionally, bHLH genes potentially involved in baicalin biosynthesis were identified under drought stress. …”
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First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study by Zeyu Zhang, Lishuang Guo, Lan Yao, Yueyue Li, Yan Hei, Qi Wang, Xiaoyi Wang, Rui Ma, Xinji Yang, Zhenhua Hu, Wei Wu

“…The resultant seven additional resections were justified by histopathology and the two conservative treatments did not result in recurrence. …”
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Network-wide effects of pallidal deep brain stimulation normalised abnormal cerebellar cortical activity in the dystonic animal model by Fabiana Santana Kragelund, Konstantinos Spiliotis, Marco Heerdegen, Tina Sellmann, Henning Bathel, Anika Lüttig, Angelika Richter, Jens Starke, Rüdiger Köhling, Denise Franz

“…Pallidal DBS induced network-wide effects, normalising MFR, spike amplitudes, and connectivity measures in hamsters, thereby countervailing these electrophysiological abnormalities. Additionally, network analysis showed neural activity patterns organised into communities, with higher connectivity in both healthy and DBS groups compared to dtsz. …”
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Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a M... by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz

“…Fenofibrate treatment prevented the damage due to ischemia in MetS rats by favoring the angiotensin-(1-7)/angiotensin receptor 2 (AT2R) axis and inhibiting the angiotensin III/angiotensin IV/AT4R-IRAP signaling pathway. Additionally, fenofibrate downregulated neprilysin expression and increased bradykinin production. …”
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Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…Moreover, wogonin shows promise in treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease by promoting autophagy and reducing neuroinflammation. Additionally, it exhibits antiviral properties, offering potential benefits against CNS infections. …”
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UGCG promotes chemoresistance and breast cancer progression via NF-κB and Wnt/β-catenin pathway activation by Li Long, Lei Wang, Yiran Liang, Fangzhou Ye, Yuhan Jin, Dan Luo, Xiaoyan Li, Yajie Wang, Yaming Li, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Qifeng Yang

“…Results: UGCG expression was notably elevated in chemoresistant breast cancer tissues and cells, as identified in GEO databases and confirmed through immunohistochemistry. Additionally, findings from our cohorts indicated that higher levels of UGCG expression correlated with a lower rate of pathological complete response (pCR), suggesting it could serve as an independent predictor of chemotherapy effectiveness. …”
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Duplex qPCR for detecting and differentiating porcine epidemic diarrhea virus GI and GII subtypes by Bin Wang, Wang Han, Di Wu, Yue Jing, Li Ma, Feiyang Jiang, Shusen Ji, Lianmei Bai, Xiuju Yu, Wei Hou, Shouyu Wang, Haidong Wang

“…Leveraging this information, we developed a TaqMan probe-based quantitative real-time PCR (qPCR) assay that is uniquely tailored to detect both PEDV GI and GII subtypes.ResultsAdditionally, this qPCR can identify PEDV GI and GII subtypes with high sensitivities of 90 copies/μL and 40 copies/μL, respectively (refers to the number of copies of the DNA target per microliter of template in the reaction system), much higher than the previously reported works and especially suitable for early diagnosis and prevention. …”
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Dynamic analysis of growth characteristics, secondary metabolites accumulation, and an in-depth understanding of anthraquinones biosynthesis in Rubia cordifolia Linn. by Conglong Lian, Conglong Lian, Conglong Lian, Xiuyu Liu, Xiuyu Liu, Kaihua Guo, Kaihua Guo, Hao Yang, Hao Yang, Jingfan Yang, Jingfan Yang, Jinxu Lan, Jinxu Lan, Suiqing Chen, Suiqing Chen, Suiqing Chen, Suiqing Chen

“…We hypothesized an anthraquinone biosynthetic pathway and found 280 full-length transcripts that may be involved in anthraquinone biosynthesis in R. cordifolia. In addition, RT-qPCR was used to detect the relative expression levels of 12 candidate ungenes in the above- and underground parts of R. cordifolia. …”
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<i>Kluyveromyces lactis</i> and <i>Saccharomyces cerevisiae</i> for Fermentation of Four Different Coffee Varieties by Danilo José Machado de Abreu, Denis Henrique Silva Nadaleti, Rafaela Pereira Andrade, Tamara Leite dos Santos, Dérica Gonçalves Tavares, Cesar Elias Botelho, Mário Lúcio Vilela de Resende, Whasley Ferreira Duarte

“…<i>K. lactis</i> B10 fermentation resulted in higher chlorogenic acid only on the P2 cultivar and MGS Catucaí Pioneira (CP). In addition, 5-methyl-2-furfuryl alcohol and n-hexadecanoic acid were produced exclusively by yeast fermentation compared to spontaneous fermentation. …”
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Water scarcity: A global hindrance to sustainable development and agricultural production – A critical review of the impacts and adaptation strategies by Auindrila Biswas, Sourakanti Sarkar, Sumanta Das, Suman Dutta, Malini Roy Choudhury, Anmol Giri, Bimal Bera, Koushik Bag, Bishal Mukherjee, Koushik Banerjee, Debaditya Gupta, Debasish Paul

“…Secondly, we elaborated our discussion on water scarcity in agriculture including the impacts of water scarcity on agricultural production and its connection to climate change, population growth, and overexploitation of natural resources globally focusing on the Indian scenario. In addition, innovative water management practices and adaptation strategies to manage agricultural water use, constraints, and the need for further research are also covered. …”
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Relationship Between Motion Sickness Susceptibility and Vestibular Test Results by Ozge GEDİK TOKER, Elif KURU, Sumeyye OZDEMIR, Betul RENCBER, Ege TAKAN, Serdar ARAZ, Meliha BASOZ BEHMEN, Nilufer BAL, Fadlullah AKSOY

“…The aim of this study was to demonstrate a correlation between vestibular function tests and motion sickness. In addition, our secondary aim is to evaluate the sensitivity of the skull vibration-induced nystagmus test (SVINT) in the diagnosis of motion sickness. …”
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