Effect of a chemically-modified-curcumin on dental resin biodegradation by Qi Dai, Hsi-Ming Lee, Austin Giordano, Fu-Pen Chiang, Stephen G. Walker, Rafael Delgado-Ruiz, Francis Johnson, Lorne M. Golub, Ying Gu

“…Esterase enzyme inhibition assays were performed with the same test groups and activities were determined spectrophotometrically.ResultsAmong all experimental groups, CMC 2.24 significantly reduced surface roughness of dental composite (p < 0.01) and adhesive (p < 0.01) materials compared to bacteria-only group. Additionally, CMC 2.24 reduced porcine esterase activity by 46.5%, while other compounds showed minimal inhibition. …”
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Effects of systemic administration of the retinoid Isotretinoin on bone tissue: A narrative literature review by Maria Júlia Bento Martins Parreira, Bruna Trazzi Pagani, Matheus Bento Medeiros Moscatel, Daniela Vieira Buchaim, Carlos Henrique Bertoni Reis, Beatriz Flávia de Moraes Trazzi, Acácio Fuziy, Rogerio Leone Buchaim

“…To this end, articles that demonstrate effects of Isotretinoin on bone metabolism, bone mineral density, bone formation, and resorption, in addition to possible changes generated in this tissue were considered valid for inclusion in this literature review. …”
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Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival by Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, JoAnn Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou, Masha V. Poyurovsky, Jerry Edward Chipuk

“…Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. …”
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Similarity or complementarity? Understanding marital relationships in terms of sexual dimorphism in brain morphometry and gender roles by Lei Li, Xinyue Huang, Qingyu Zheng, Jinming Xiao, Xiaolong Shan, Huafu Chen, Xujun Duan

“…The actor-partner interdependence model also supports the similarity/complementarity hypothesis. Additionally, the sexual dimorphism of brain morphometry and marital satisfaction were found to share a similar transcriptional mechanism. …”
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Improvement of bonding behavior of cold-rolled stainless steel/copper composite plates via surface spinel structure treatment by Bowei Wang, Baojun You, Yuting Hu, Lun Fu, Chao Yu, Hong Xiao

“…Under the surface oxidation treatment process, the two metals were bonded at a 45% reduction rate with a shear strength of 27.35 MPa. Additionally, the shear strength of the composite plates can achieve 94.82 MPa at a 60% reduction rate. …”
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Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

“…Participants receive a single dose of autologous ex vivo-expanded Tregs and will be followed up to week 21 to collect safety and exploratory efficacy data. Additional safety monitoring will occur at 1 and 2 years post-dose. …”
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Chinese stroke association guidelines on reperfusion therapy for acute ischaemic stroke 2024 by Liping Liu, Anding Xu, Xin Wang, Yongjun Wang, Yilong Wang, Zhongrong Miao, Yuming Xu, Benyan Luo, Bin Peng, Yong Huo, Qiang Dong, Zixiao Li, Xingquan Zhao, Caiyun Wang, Hongqiu Gu, Chunjuan Wang, Zhengqi Lu, Yunyun Xiong, Shuo Wang, Lihua Wang, Linong Ji, Xiaoping Gao, Wenzhi Wang, Yi Yang, Kai Wang, Junbo Ge, Xunming Ji, Jun Pu, Tong Zhang, Bo Hu, Ning Wang, Yun Xu, Jinsheng Zeng, Gang Zhao, Zhong Chen, Aoming Jin, Xiaoyuan Niu, Jiong Shi, Shuya Li, Jianmin Zhang, Ling Yin, Dou Li, Dehong Lu, Chao Qin, Dapeng Sun, Kaifu Ke, Yanhui Du, Xiaoning Zhang, Fudong Shi, Jianxin Zhou, Lan Chu, Li Guo Li He, Shengnian Zhou, Weixin Cai, Xiaomu Wu, Zhiyi He

“…Each recommendation was graded using the CSA’s class of recommendation and level of evidence in the Guideline Development Manual of the CSA.Results This guideline, reviewed and approved by the CSA Guidelines Writing Group, outlines the criteria for patient selection for thrombolysis and thrombectomy and summarises the latest evidence on various thrombolytic drug options to support decision-making in reperfusion therapy. Additionally, the guideline includes green channel flow charts for intravenous thrombolysis and mechanical thrombectomy, designed to assist clinicians in optimising their clinical decisions.Conclusion This guideline updates the latest advancements in the field of reperfusion therapy for acute ischaemic stroke. …”
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Emission Characteristics of Volatile Organic Compounds from Typical Coal Utilization Sources: A Case Study in Shanxi of Northern China by Yang Xu, Hualong Yu, Yulong Yan, Lin Peng, Rumei Li, Cheng Wang, Zhiyong Li

“…Among the detected VOCs, the results identified 1-butene as the most abundant species for both the power plants (36.7%) and the residential stoves (41.7%) as well as a significant contributor at the steel plants (7.3%), and alkenes, alkanes, and aromatics composed the largest groups for the power plants (42.0%) and residential stoves (60.2%); steel plants (59.2%); and coking plants (66.1%), respectively. Additionally, the VOC profiles for power plants employing the same coal source or combustion technology exhibited strong similarities, although the BTEX ratios varied more between plants using different coal sources than those using different combustion technologies. …”
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Comprehensive comparative metabolome study of a large collection of Corsican bryophytes by Anaïs Pannequin, Anaïs Pannequin, Alain Muselli, Laurence Marcourt, Laurence Marcourt, Emerson Ferreira Queiroz, Emerson Ferreira Queiroz, Luis-Manuel Quiros-Guerrero, Luis-Manuel Quiros-Guerrero, Yoshinori Asakawa, Miwa Dounoue-Kubo, Jean-Luc Wolfender, Jean-Luc Wolfender

“…The study of bryophytes faces challenges due to their small size, and sociology, making it difficult to collect large amounts of uncontaminated samples. Additionally, their chemical specificity and the scarcity of chemical data specific to this branch further complicate their study. …”
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Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice by Zhuo Chen, Xiang Qian, Shasha Chen, Xiaoxuan Fu, Guanjun Ma, Aiqin Zhang

“…In addition, transcriptome analysis indicated that Akk combining with CDDP increased obviously the levels of IFI27l2 and IGFBP7 and was related to those pathways including the cytokine-cytokine receptor interaction, Th17 cell differentiation, FOXO, JAK-STAT, and PI3K-Akt signaling pathways. …”
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Short-term follow-up of antibiotic-loaded calcium sulfate in treating chronic periprosthetic joint infection during two-stage revision by Xiao Sun, Jun Tan, Lijuan Zhan, Mingkui Sheng, Zhongxin Tang, Lingxiao Wu, Jianzhong Xu, Haijun Ma

“…However, intergroup differences in these outcomes were not statistically significant (P > 0.05). Additionally, there was no significant difference in postoperative complication rates between the two groups.ConclusionThe use of antibiotic-loaded calcium sulfate in two-stage revision surgery for chronic knee PJI ensures sustained local antibiotic release at high concentrations, leading to rapid reduction in inflammatory markers, effective infection control, and a low complication rate. …”
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Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping by Qiuyue Zhao, Subinuer Maimaitiaili, Yan Bi, Ming Li, Xin Li, Qian Li, Xinyi Shen, Min Wu, Linqing Fu, Zhengyang Zhu, Xin Zhang, Jiu Chen, Anning Hu, Zhou Zhang, Wen Zhang, Bing Zhang

“…Then we evaluated the relationships between cognitive indicators and magnetic susceptibility value (MSV) measured by QSM of the significant brain areas, which were set as the regions of interest (ROIs). In addition, we analyzed the moderation effects of grey matter volume (GMV) of the related brain areas and several metabolic and cerebrovascular factors on the associations between MSV of ROIs and cognitive characteristics. …”
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Alterations in fecal bacteriome virome interplay and microbiota-derived dysfunction in patients with schizophrenia by Shiwan Tao, Yulu Wu, Liling Xiao, Yunqi Huang, Han Wang, Yiguo Tang, Siyi Liu, Yunjia Liu, Qianshu Ma, Yubing Yin, Minhan Dai, Min Xie, Jia Cai, Zhengyang Zhao, Qiuyue Lv, Jiashuo Zhang, Mengting Zhang, Menghan Wei, Yang Chen, Mingli Li, Qiang Wang

“…Specific gut viruses and host peripheral metabolites co-occurring with differential bacteria were identified using Multiple Co-inertia Analysis (MCIA). Additionally, we construct a latent serial mediation model (SMM) to investigate the effect of the gut virome on SCZ through the bacteriome and host metabolic profile. …”
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Relationship of Serum Uric Acid Level with Demographic Features, Risk Factors, Severity, Prognosis, Serum Levels of Vitamin D, Calcium, and Magnesium in Stroke by Payam Saadat, Alijan Ahmadi Ahangar, Mansor Babaei, Mandana Kalantar, Mohammad Ali Bayani, Hiva Barzegar, Hemmat Gholinia, Farbod Zahedi Tajrishi, Sekineh Faraji, Fatemeh Frajzadeh

“…A large financial burden is imposed on the families and health systems of countries in addition to the problems related to the disabilities caused by the disease for the patients. …”
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Research Note: Establishment of vector system harboring duck RNA polymerase I promoter for avian influenza virus by Yunyueng Jang, Yoon-Gi Baek, Yu-Na Lee, Ra Mi Cha, Yun-Chan Choi, Min-Ji Park, Youn-Jeong Lee, Eun-Kyoung Lee

“…In conclusion, our novel RG system harboring duck RNA pol I offers an additional tool for researching influenza viruses and may facilitate the development of vaccines for poultry.…”
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Effect of Matrine on growth performance, gut health, and gut microbiota in chickens infected with avian pathogenic Escherichia coli by Ningning Mao, Yaming Yu, Jiqin Cui, Jin He, Yang Yang, Deyun Wang

“…Results indicated that pretreatment with matrine alleviated the symptoms of APEC infection in chickens, improving survival rates and promoting weight gain. Additionally, pretreatment with matrine reduced the secretion and gene expression of IL-1β, IL-6, and TNF-α in intestinal tissues, while enhancing serum SOD, GSH, and CAT activity, as well as gene expression levels in the intestine. …”
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Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma by Xiwen Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Jianxin Chen, Linying Chen, Lianhuang Li

“…We identified eight distinct tumor-associated collagen signatures (TACS1-8) from multiphoton images of PDAC tissues and developed an optical biomarker, TACS-score, based on the TACS1-8 using ridge regression analysis. Additionally, we also extracted 142 microscopic TACS (M-TACS) from second-harmonic generation (SHG) images and constructed a new robust biomarker, M-TACS-score, using the least absolute shrinkage and selection operator (LASSO) regression analysis. …”
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Robustness and limitations of maximum entropy in plant community assembly by Jelyn Gerkema, Daniel E. Bunker, Andrew M. Cunliffe, Erika Bazzato, Michela Marignani, Tommaso Sitzia, Isabelle Aubin, Stefano Chelli, Julieta A. Rosell, Peter Poschlod, Josep Penuelas, Arildo S. Dias, Christian Rossi, Tanvir A. Shovon, Juan A. Campos, Mark C. Vanderwel, Sharif A. Mukul, Bruno E.L. Cerabolini, Thomas Sibret, Bruno Hérault, Sylvain Schmitt, Pedro Higuchi, James L. Tsakalos, Decky I. Junaedi, Yun-Peng Zhao, Vanessa Minden, Ana Carolina da Silva, Tereza Mašková, Roberto Canullo, Ning Dong, Edwin T. Pos

“…As a maximum entropy model, it does so without introducing additional bias or assumptions. Despite its increasing use, questions regarding its robustness and potential limitations remain. …”
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Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes by Congshan Jiang, Jing Xu, Wenhua Zhu, Yongsong Cai, Si Wang, Yuanxu Guo, Ke Xu, Manman Geng, Nazim Hussain, Yan Han, Fujun Zhang, Qilan Ning, Liesu Meng, Shemin Lu

“…Moreover, DICER1 deficiency could also reduce apoptosis, while DICER1 overexpression was found to decrease the proliferation and enhance apoptosis. In addition, DICER1 deficiency could lower the expression of multiple RA-related miRNAs such as miR-155. …”
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Harnessing the power of proteins in modulation of miRNAs for targeting Iron deficiency Anemia: Opinion for future implications and strategies by Ray Wagiu Basrowi, Ray Wagiu Basrowi, Ray Wagiu Basrowi, Tonny Sundjaya, Tonny Sundjaya, Dessy Pratiwi, Nurlinah Amalia, Nurlinah Amalia, Nurlinah Amalia, Yosi Yohanes Putra Tandi, Muhammad Yasir Syafa’atulloh, Garuda Nusantara Putra Utomo, Muhammad Abdir Rahman Albarok, Fahrul Nurkolis

“…These miRNA-protein interactions suggest targeted therapies such as protein-based miRNA modulators could optimize erythropoiesis, advancing IDA management. Additionally, the review emphasizes the potential of leveraging protein-miRNA interactions for precision medicine, especially in resource-limited settings where anemia’s burden is profound. …”
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