A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of <i>Nrf2</i> Augments the Cytotoxic Effect Evoked by Tyr... by Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu, Takumi Akiyama, Norimasa Tamehiro, Norihito Shibata

“…Although B16BL6 melanoma cells showed insufficient sensitivity to the cytotoxicity assay, the siRNA-mediated knockdown of the transcription factor NRF2 (NFE2L2) repressed the expression of cytoprotective factors, thereby augmenting the cytotoxicity of all six leukoderma-inducing phenols tested in a tyrosinase-dependent manner, indicating enhanced sensitivity to <i>o</i>-quinone metabolites. Additionally, the knockdown of the NRF2-target <i>Slc7a11</i> elevated the cytotoxicity of three out of the six compounds, indicating the involvement of cystine transport in cellular protection. …”
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Effect of Deposition Temperature and Thermal Annealing on the Properties of Sputtered NiO<i>_x</i>/Si Heterojunction Photodiodes by Roumen Nedev, David Mateos-Anzaldo, Eddue Osuna-Escalante, Oscar Perez-Landeros, Mario Curiel-Alvarez, Esteban Osorio-Urquizo, Jhonathan Castillo-Saenz, Javier Lopez-Medina, Benjamin Valdez-Salas, Nicola Nedev

“…Thus, the 100 °C photodiodes might be more appropriate for applications where high responsivity is required, because of their smaller power consumption compared to the RT diodes. In addition, it was found that the increase of the deposition temperature leads to an increase of the diodes’ series resistance and the resistivity of NiO<i>_x</i>. …”
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Comparison of the conceive-design-implement-operate model and lecture-based learning in teaching the “healthcare-associated infections” course by Yu Chen, Rui Zhang, Zhenke Zhou, Min Hong, Zheng Huang, Heling Wen, Lei Peng

“…The effectiveness of these pedagogical approaches was evaluated by comparing pre-and post-training test scores, and we used the Course Experience Questionnaire (CEQ) to collect students’ feedback on the course and teaching.ResultsCompared to traditional LBL method, the CDIO model significantly improved the overall scores and practical application scores of nursing students in the HAI course, with these advantages still retained after 24 weeks. Additionally, preliminary results show that students in the CDIO model scored higher on CEQ categories such as good teaching, clear goals and standards, appropriate assessment, generic skills, and independence, but they also reported an increased workload.ConclusionOur research is the first to apply the CDIO framework to nursing education in HAI courses, enhancing nursing students’ practical application skills, particularly in the sustained retention in this area. …”
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Clinical outcomes of arthroscopic modified suture augmentation versus InternalBrace™ reconstruction in the treatment of chronic ankle instability by Zifeng Wu, Piao Xie, Shuoshuo Gu, Dahai Hu, Jinsong Hong, Xiaofei Zheng, Jieruo Li, Huige Hou

“…There were no significant differences between the two groups in the anterior drawer test results and VAS scores (P < 0.05). In addition, regarding postoperative complications, only one patient (4.2%) in the MSA group had joint laxity. …”
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Spatial analysis of teen births near the New Bedford Harbor Superfund site by Nicole V DeVille, Carolina Villanueva, Susan A Korrick, Verónica M Vieira

“…Odds ratios (OR) and 95% confidence intervals (CIs) were calculated by location across the study area. …”
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Preventive Effect of Cocoa Flavonoids via Suppression of Oxidative Stress-Induced Apoptosis in Auditory Senescent Cells by Luz del Mar Rivas-Chacón, Joaquín Yanes-Díaz, Beatriz de Lucas, Juan Ignacio Riestra-Ayora, Raquel Madrid-García, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez

“…Each cell line was divided into a control group (CTR) and an H₂O₂ group (induction of senescence by an oxygen radical). Additionally, every group of every cell line was treated with the cocoa polyphenolic extract (CPE), measuring different markers of apoptosis, viability, the activity of antioxidant enzymes, and oxidative/nitrosative stress. …”
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The Ischial Spine in Developmental Hip Dysplasia: Unraveling the Role of Acetabular Retroversion in Periacetabular Osteotomy by Gerard El-Hajj, Hicham Abdel-Nour, Rami Ayoubi, Joseph Maalouly, Fouad Jabbour, Raja Ashou, Alexandre Nehme

“…In hips with AR, the operated hips were significantly associated with the PRISS compared to the nonoperated ones (χ2 = 4.847). Additionally, the ISI was able to classify acetabular version (anteverted, neutral, and retroverted acetabula). …”
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Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13 by Cheng Tan, Hang Zhou, Qiangfei Xiong, Xian Xian, Qiyuan Liu, Zexin Zhang, Jingjing Xu, Hao Yao

“…We also explored the influence of cromolyn sodium and mast cell knockout on pulmonary fibrosis. Additionally, we explored the effect of MC-derived IL-13 on the EMT and illustrated the relationship between mast cell and pulmonary fibrosis. …”
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Bromine‐Substituted Cation Anchoring to Suppress Ion Migration in Alternating Cations Intercalation‐Type Perovskite for Stable X‐Ray Detection by Lijun Xu, Qianwen Guan, Huang Ye, Jianbo Wu, Hang Li, Yaru Geng, Chengshu Zhang, Zeng‐Kui Zhu, Zhangtong Han, Qiuxiao Yin, Junhua Luo

“…Specifically, introducing Br atom forms additional intermolecular interactions (i.e., Br···π) and enhances hydrogen bonding interactions, greatly improving the structure stability. …”
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Exploring the role of epileptic focus lateralization on facial emotion recognition in the spectrum of mesial temporal lobe epilepsy by Fabio Iannaccone, Chiara Pizzanelli, Francesca Lorenzini, Francesco Turco, Chiara Milano, Claudia Scarpitta, Luca Tommasini, Gloria Tognoni, Riccardo Morganti, Enrica Bonanni, Gabriele Siciliano

“…Conversely, left MTLE may cause less damage to FER circuits, requiring additional factors such as a history of febrile seizures and/or mesial temporal sclerosis for significant impact. …”
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Microstructure evolution and recrystallization behavior of two nickel-based single crystal superalloys by XU Fuze, LIN Yongcheng, MA Dexin, HE Daoguang, ZHAO Yunxing, LI Lyu, CHENG Bowen, DENG Yangpi

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DAShip: A Large-Scale Annotated Dataset for Ship Detection Using Distributed Acoustic Sensing Technique by Wenjin Huang, Shaoyi Chen, Yichang Wu, Ruihua Li, Tianrui Li, Yihua Huang, Xiaochun Cao, Zhaohui Li

“…However, the reliance on expert knowledge for analyzing ship passage signals hinders the development of an automated framework for ship detection, limiting the application of DAS technology in the ship detection. In addition, the scarcity of datasets for ship passage events in the DAS field hampers the adoption of deep learning technologies for enhancing ship detection. …”
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Modeling of drying kinetics and chemical analysis for optimal preservation of pitahaya, aguaymanto and pineapple fruits using a parabolic solar dehydrator in the Amazon region - Peru by Merbelita Yalta Chappa, Wildor Gosgot Angeles, Luz Quispe-Sanchez, Diana Carina Mori Servan, Homar Santillan Gomez, Manuel Oliva-Cruz, Miguel Ángel Barrena Gurbillón

“…Five mathematical models were used to determine the drying curve, with the criterion of selection the best model with the coefficient of determination (R2) and model efficiency (EF); in addition, pH and titratable acidity were evaluated during the dehydration period. …”
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Development of the novel gene chip and restriction fragment length polymorphism (RFLP) methods for rapid detection of Mycobacterium tuberculosis complex in broth culture by Wen-Hung Wang, Chun-Yu Lin, Shu-Huei Jain, Po-Liang Lu, Yen-Hsu Chen

“…False negatives in two isolates were due to a mutation in the AfeI site. Additionally, five cases showed MTBC presence when nontuberculous Mycobacterium species grew in cultures. …”
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CGDINet: A Deep Learning-Based Salient Object Detection Algorithm by Chengyu Hu, Jianxin Guo, Hanfei Xie, Qing Zhu, Baoxi Yuan, Yujie Gao, Xiangyang Ma, Jialu Chen, Juan Tian

“…CGDINet introduces the Group Consensus Aggregation Module (GCAM) embedded with the Coordinate Attention (CA) mechanism, named CAGM (Coordinate Attention-Group Consensus Aggregation Module), to enhance global feature capture capabilities and improve the processing of directional features. Additionally, the Depth Auxiliary Module (DAM) is incorporated to enhance the focus on important regions. …”
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Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission by Ryohei Mineo, Shiro Fukuda, Shigehito Suzuki, Yoshito Ito, Sachiko Tamba, Takuya Sugiyama, Yuya Fujishima, Hitoshi Nishizawa, Iichiro Shimomura, Koji Yamamoto, Yuji Matsuzawa

“…The “severe” patients were significantly older than “non-severe” patients. Additionally, no significant differences were observed in BMI, sex, or the period from onset to admission. …”
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Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment by Caroline Riedlinger, Caroline Riedlinger, Nazar Mazurak, Nazar Mazurak, Norbert Schäffeler, Andreas Stengel, Andreas Stengel, Andreas Stengel, Katrin Elisabeth Giel, Katrin Elisabeth Giel, Stephan Zipfel, Stephan Zipfel, Paul Enck, Paul Enck, Isabelle Mack, Isabelle Mack

“…In this study, we analyzed the timecourse of GI symptoms and their relation to disease-specific, demographic, anthropometric, and psychological factors in inpatients with AN.MethodsIn weekly intervals, the Gastrointestinal Symptom Rating Scale (GSRS) was completed, and body weight was measured over a mean of 9.5 weeks in inpatients with AN. …”
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NIPAL1 as a prognostic biomarker associated with pancreatic adenocarcinoma progression and immune infiltration by Youlong Zhu, Zongze Qi, Shaoqi Zu, Fangchao Yang, Yanming Wang, Lei Zhu, Xintong Li, Ruixue Li, Hong Zhu

“…Differentially expressed genes (DEGs) were identified, and Gene Set Enrichment Analysis (GSEA) was performed to elucidate potential biological mechanisms of NIPAL1 involved in PAAD development. Additionally, we analyzed the correlation between NIPAL1 expression, immune cell infiltration, and PAAD progression. …”
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A framework for quantifying the multisectoral burden of animal disease to support decision making by Sara Lysholm, Sara Lysholm, Gemma L. Chaters, Gemma L. Chaters, Carlotta Di Bari, Carlotta Di Bari, Ellen C. Hughes, Ellen C. Hughes, Ben Huntington, Ben Huntington, Jonathan Rushton, Jonathan Rushton, Lian Thomas, Lian Thomas

“…These diseases cause significant economic losses for farmers, disrupt food security and present zoonotic risks to human populations. Additionally, they contribute to antimicrobial resistance and a range of environmental issues such as greenhouse gas emissions. …”
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Influence of SARS-CoV2 Pandemic on Colorectal Cancer Diagnosis, Presentation, and Surgical Management in a Tertiary Center: A Retrospective Study by Roman Taulean, Roxana Zaharie, Dan Valean, Lia Usatiuc, Mohammad Dib, Emil Moiș, Calin Popa, Andra Ciocan, Alin Fetti, Nadim Al-Hajjar, Florin Zaharie

“…However, no significant changes in postoperative mortality or hospitalization duration were highlighted. In addition, most of the changes highlighted were reverted in the post-pandemic period. …”
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