Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support by Tae Higuchi, Tomomi Ide, Takeo Fujino, Takeshi Tohyama, Yuta Nagatomi, Tomoyuki Nezu, Masataka Ikeda, Toru Hashimoto, Shouji Matsushima, Keisuke Shinohara, Masaaki Nishihara, Takeshi Iyonaga, Tomohiko Akahoshi, Tomoki Ushijima, Akira Shiose, Shintaro Kinugawa, Hiroyuki Tsutsui, Kohtaro Abe

“…ICU-AW occurred 52% of patients with CS using MCS, indicating the significance of recognizing and managing this complication for those patients. In addition, IL-15 can be a potential biomarker for the early prediction of ICU-AW.…”
Get full text

Cell-free fat extract improves embryo development and clinical outcomes in older women with previous in-vitro fertilization failure by Xiaowei Zhou, Hanfei Zhu, Jingru Duan, Lan Xia, Shen Zhao, Huihui Xu, Xian Wu, Xiaoling Wang, Bufang Xu, Yi Cao, Aijun Zhang

“…We assessed the model’s efficacy in influencing embryo development and pregnancy rates in older women with in vitro fertilization failure. In addition, we performed immunofluorescence staining, multiplex immunoassay, whole-genome amplification and DNA sequencing, time-lapse embryo monitoring, and in vitro experiments. …”
Get full text

5-deoxy-rutaecarpine protects against LPS-induced acute lung injury via inhibiting NLRP3 inflammasome-related inflammation by Jinque Luo, Jinque Luo, Xin Li, Xin Li, Li Zhang, Li Zhang, Meijing Deng, Jieyang Zhao, Jinghuan Zhang, Wenyu Tang, Qinghua Guo, Ling Wang

“…Further western blotting analysis showed 5-DR decreased the levels of NLRP3, cleaved caspase-1, and mature IL-1β in mice and J774A.1 cells exposed to LPS. Additionally, NF-κB pathway activation significantly diminished the inhibition of the NLRP3 inflammasome by 5-DR.DiscussionOur findings highlight the therapeutic potential of 5-DR as a promising candidate for treating LPS-induced ALI, offering insights into its underlying mechanism that targets NLRP3 inflammasome-mediated inflammation.…”
Get full text

A structural genomics approach to investigate Dystrophin mutations and their impact on the molecular pathways of Duchenne muscular dystrophy by Abdelbaset Mohamed Elasbali, Farah Anjum, Osama A. AlKhamees, Waleed Abu Al-Soud, Mohd Adnan, Anas Shamsi, Md. Imtaiyaz Hassan

“…Pathogenic potential was assessed using disease phenotype predictors and CADD scores, while allele frequency data from gnomAD contextualized mutation prevalence. Additionally, aggregation propensity, frustration analysis, and post-translational modification sites were analyzed for functional disruptions.ResultsOf the 184 substitutions analyzed, 50 were identified as deleterious, with 41 predicted to be pathogenic. …”
Get full text

S, Se-Codoped Dual Carbon Coating and Se Substitution in Co-Alkoxide-Derived CoS₂ Through SeS₂ Triggered Selenization for High-Performance Sodium-Ion Batterie... by Kaiqin Li, Yuqi Kang, Chengjiang Deng, Yanfeng Wang, Haocun Ba, Qi An, Xiaoyan Han, Shaozhuan Huang

“…The dual carbon–graphene matrix not only improves the electronic conductivity but also stabilizes the electrode material effectively. In addition, the Se substitution within the CoS₂ lattice further improves the electrical conductivity and promotes the Na⁺ reaction kinetics. …”
Get full text

Effect of p-InGaN Cap Layer on Low-Resistance Contact to p-GaN: Carrier Transport Mechanism and Barrier Height Characteristics by Mohit Kumar, Laurent Xu, Timothée Labau, Jérôme Biscarrat, Simona Torrengo, Matthew Charles, Christophe Lecouvey, Aurélien Olivier, Joelle Zgheib, René Escoffier, Julien Buckley

“…The reduction in barrier height by approximately 0.42 eV in the p⁺⁺-InGaN layer enhanced hole tunneling, further lowering the contact resistivity. Additionally, polarization-induced free charges at the metal–semiconductor interface reduced band bending, thereby enhancing carrier transport. …”
Get full text

Membrane-targeted push-pull azobenzenes for the optical modulation of membrane potential by Valentina Sesti, Arianna Magni, Matteo Moschetta, Chiara Florindi, Marlene E. Pfeffer, Mattia Lorenzo DiFrancesco, Michele Guizzardi, Giulia Folpini, Luca Sala, Alessandra Gilda Ritacca, Beatrice Campanelli, Paola Moretti, Giuseppe Maria Paternò, Luca Maragliano, Matteo Tommasini, Francesco Lodola, Elisabetta Colombo, Fabio Benfenati, Chiara Bertarelli, Guglielmo Lanzani

“…The observed membrane potential modulation in in-vitro models is attributed to the variation in membrane surface charge, resulting from the light-driven modulation of the MT dipole moment within the cell membrane. Additionally, a developed mathematical model successfully captures the temporal evolution of the membrane potential upon photostimulation. …”
Get full text

The negative aspects of injury on motivation of sports and physical exercise practitioners by Hugo Enrico Souza Machado, Hugo Enrico Souza Machado, Andreza do Socorro Dantas Oliveira, Andreza do Socorro Dantas Oliveira, Eldimberg Souza da Cunha Júnior, Adriano Lopes Lemos, Eduardo Macedo Penna, Eduardo Macedo Penna, Daniel Alvarez Pires, Daniel Alvarez Pires

“…IntroductionInjury is an inherent situation in the sports and recreational environment of physical exercise practices. Additionally, injured practitioners might present different motivational drives that may impair the continuity in physical exercise. …”
Get full text

Evaluation of the intracellular lipid-lowering effect of polyphenols extract from highland barley in HepG2 cells by Yijun Yao, Zhifang Li, Bowen Qin, Xingrong Ju, Lifeng Wang

“…In vitro, the lipase assay showed an 18.4 % lipase inhibition rate when the additive contents of highland barley extract were 100 µg/mL. …”
Get full text

Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients by Jianan Zhang, Jing Li, Shi Chen, Linglin Gao, Xiaoluan Yan, Mingzhi Zhang, Jia Yu, Fenchun Wang, Hao Peng

“…Adding the interaction term of homocysteine and platelet count additionally explained 0.05% of the variance in diastolic BP (P=0.0001), and the interaction was significant (β = −0.021, P<0.001). …”
Get full text

Microneedle technology for enhanced topical treatment of skin infections by Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu, Bing Guo, Chao Lu, Chuanbin Wu, Xin Pan

“…., antibiotics, antimicrobial peptides, photosensitizers, metals, sonosensitizers, nanoenzyme, living bacteria, poly ionic liquid, and nanomoter). In addition, the nanoenzyme-based multimodal antimicrobial therapy is highlighted in addressing intractable infectious wounds. …”
Get full text

Utilization of edible poultry slaughter residues: A chicken-liver hydrolysate with glucose-lowering ability and upregulating glycogenesis in type II diabetes by Yi-Ling Lin, Yu-Pei Chen, Sheng-Yao Wang, Yi-Feng Kao, Chompunut Lumsangkul, Yi-Chen Chen

“…In db/db mice, CLH supplementation improved insulin resistance, as shown by OGTT assay, HOMA-IR value and serum glucose levels, while also reducing serum lipids and liver damage indices (p<0.05). Additionally, CLH ameliorated (p<0.05) decreased hindlimb-gastrocnemius weight, and liver lipid contents, oxidative stress (sera and liver) and inflammatory cytokines. …”
Get full text

Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Results demonstrated a significant reduction in mitochondrial superoxide anion levels without affecting mitochondrial membrane potential, indicating enhanced cellular resilience to oxidative stress. Additionally, CCRE decreased UVB-induced IL-6 expression and IKK phosphorylation, which play a crucial role in inflammaging. …”
Get full text

Impact of host climate model on contrail cirrus effective radiative forcing estimates by W. Zhang, K. Van Weverberg, K. Van Weverberg, K. Van Weverberg, C. J. Morcrette, C. J. Morcrette, W. Feng, W. Feng, K. Furtado, K. Furtado, P. R. Field, P. R. Field, C.-C. Chen, A. Gettelman, P. M. Forster, D. R. Marsh, A. Rap

“…We find that differences in background humidity between the models result in the UM-simulated contrail fractions being 2 to 3 times larger than in CAM. Additionally, the models show contrasting responses in overall global cloud fraction, with contrails increasing the total cloud fraction in the UM and decreasing it in CAM. …”
Get full text

Implementation of different strategies of the “ActTeens” intervention for adolescents: a process evaluation by Gessika Castilho dos Santos, Jadson Marcio da Silva, Renan Camargo Correa, Rodrigo de Oliveira Barbosa, Gabriel Pinzon, Maria Carolina Juvêncio Francisquini, Thais Maria de Souza Silva, Antonio Stabelini Neto

“…However, the component mHealth, when used as a single strategy, did not aid the adoption of healthy behavior. …”
Get full text

Time-resolved measurement of neutron energy isotropy in a sheared-flow-stabilized Z pinch by R.A. Ryan, P.E. Tsai, A.R. Johansen, A.E. Youmans, D.P. Higginson, J.M. Mitrani, C.S. Adams, D.A. Sutherland, B. Levitt, U. Shumlak

“…Gamma backgrounds have been measured and the impact of these contributions on the isotropy results have been studied. Additionally, a time dependent measurement of the isotropy has been resolved for the first time, indicating increases to possible deuteron beam energies at late times. …”
Get full text

Effect of comorbidity classes on survival of patients with gastrointestinal tract cancer by Linna Gao, Tian Yao, Shaohua Ge, Jiuwei Cui, Wei Li, Zengqing Guo, Hongxia Xu, Min Weng, Suyi Li, Qinghua Yao, Wen Hu, Lan Zhou, Junqiang Chen, Xianghua Wu, Qingchuan Zhao, Hongli Li, Hanping Shi, Yi Ba, He Huang, The Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) Group

“…The final model included the comorbidity classes and nine more predictors. Additionally, the performance of different simple multimorbidity measures were compared using the Bayesian information criterion (BIC), ROC curves and C-index. …”
Get full text

MORIX: Machine learning-aided framework for lethality detection and MORtality inference with eXplainable artificial intelligence in MAFLD subjects by Domenico Lofù, Paolo Sorino, Tommaso Colafiglio, Caterina Bonfiglio, Rossella Donghia, Gianluigi Giannelli, Angela Lombardi, Tommaso Di Noia, Eugenio Di Sciascio, Fedelucio Narducci

“…Experimental results identified the RF as the best model, achieving a high accuracy for both mortality risks predicted. Additionally, an eXplainable Artificial Intelligence (XAI) analysis was conducted to clarify the diagnostic logic of the RF model and to assess the impact of each feature to the prediction. …”
Get full text

Decanoic acid-enriched ketogenic diet in refractory epilepsy by Hui Jin Shin, Seonae Ryu, NaRae Lee, Eunjoo Lee, Ara Ko, Hoon-Chul Kang, Joon Soo Lee, Se Hee Kim, Heung Dong Kim, Heung Dong Kim

“…Initial treatment with classic KD was effective in two out of five patients. Upon crossover, those initially on C10-enriched KD maintained their seizure reduction, while patients initially on the classic KD showed additional seizure reduction when switched to C10-enriched KD. …”
Get full text

Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia by Liliana Sánchez-Lerma, Salim Mattar, Verónica Contreras, Jorge Miranda, Vaneza Tique, Virginia Rodríguez, Derly Rodriguez, Sonia Lopez, Andrés Rojas-Gulloso

“…Results: Of the study's total of one hundred patients, 14 % showed antibodies against hantavirus IgG, of which two were seroconverted. In addition, a risk factor OR = 8.3 (CI = 1.8–38.4) for Hantavirus was found in those patients who had contact with farm animals. …”
Get full text