Efficacy of caerulomycin A in modulating macrophage polarization and cytokine response in a murine model of lipopolysaccharide-induced sepsis by Jun Zhang, Shiyue Tang

“…For in-vitro assays using the RAW264.7 macrophage cell line, the concentration of caeA that was non-toxic to cell survival was screened using the MTT assay, followed by the analyses by qRT-PCR, ELISA, Western blot and flow cytometry for M1/M2 type macrophage markers (CD86, NOS2, CD206, ARG1) and inflammatory factors (IL-1β, IL-6, TNF-α, IL-4, and IL-10) expression. In addition, the phosphorylation levels of STAT1 and STAT6 in the JAK–STAT signaling pathway were detected. …”
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Pyrolysis and Dioxin Production Characteristics of Mineralized Waste in Landfills by Jian-Ying Fu, Han-Cheng Ma, Wen-Tao Jiao, Xu Xu, Xiao-Qing Lin, Xiao-Dong Li, Ming-Xiu Zhan

“…During the pyrolysis, the PCDD/F concentration of MW is higher than that of the original MSW. After the addition of 30% biomass, the PCDD/F content increases to 16.92 ng m−3. …”
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Uncovering the molecular mechanisms of Acer fabri in adjusting to low-temperature stress through integrated physiological and transcriptomic analysis by Gongwei Chen, Dandan Zhang, Fengyuan Chen, Yixiao Zhou, Hongyu Cai, Heng Gu, Yuanzheng Yue, Lianggui Wang, Guohua Liu

“…Furthermore, it was observed that NAC (Af0033429) and MIKC (Af0004917) might have interactions with Af0048792, and MIKC (Af0004917) may additionally interact with Af0026061. These findings could enhance our understanding of the molecular mechanisms of A. fabri in response to low-temperature stress.…”
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Artificial intelligence-derived gut microbiome as a predictive biomarker for therapeutic response to immunotherapy in lung cancer: protocol for a multicentre, prospective, observat... by Ryo Toyozawa, Fumihiro Shoji, Takanori Yamashita, Fumihiko Kinoshita, Shinkichi Takamori, Takatoshi Fujishita, Kensaku Ito, Koji Yamazaki, Naoki Nakashima, Tatsuro Okamoto

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Plastome characterization and its phylogenetic implications on Lithocarpus (Fagaceae) by Lifang Yang, Shoujun Zhang, Chunya Wu, Xiaolong Jiang, Min Deng

“…Significant variability was observed in simple sequence repeats (SSRs) as well as in the boundary regions between the two single-copy regions and the inverted repeat region (SC/IR) across the plastomes. Additionally, four genes (accD, atpF, rpl32, and rps8) were found to be under positive selection. …”
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Longitudinal examination of young married women’s fertility and family planning intentions and how they relate to subsequent family planning use in Bihar and Uttar Pradesh India by Niranjan Saggurti, Lisa Calhoun, Priya Nanda, Ilene S Speizer, A J Francis Zavier, Gwyn Hainsworth

“…Additionally, intention to use FP in the next 12 months at wave 1 was significantly associated with FP use at wave 2 whereas unmet need at wave 1 was not significantly related to subsequent use. …”
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Trends, gender, and racial disparities in patients with mortality due to paroxysmal tachycardia: A nationwide analysis from 1999-2020. by Aman Goyal, Humza Saeed, Saif Yamin, Abdullah, Wania Sultan, Muhammad Khubaib Arshad, Samia Aziz Sulaiman, Mah I Kan Changez, Gauranga Mahalwar

“…Its episodic occurrence makes it difficult to identify and measure its prevalence and trends in the population. Additionally, there is limited data on disparities and trends in mortality due to paroxysmal tachycardia, which is essential for assessing current medical approaches and identifying at-risk populations.…”
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Outcomes for Dostarlimab and Real-World Treatments in Post-platinum Patients With Advanced/Recurrent Endometrial Cancer: The GARNET Trial Versus a US Electronic Health Record-Based... by Scott Goulden, Qin Shen, Robert L. Coleman, Cara Mathews, Matthias Hunger, Ankit Pahwa, Rene Schade

“…**Discussion:** Consistent with previous analyses, patients treated with dostarlimab had significantly longer OS than patients in the US real-world cohort after adjusting for the lack of randomization using stabilized IPTW. Additionally, patients had a long TTD when treated with dostarlimab, suggesting a favorable tolerability profile. …”
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Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD) by John R Hurst, Jennifer K Quint, Hana Müllerova, Liam Smeeth, Harriet Forbes, Susan Eaton, Rachael L DiSantostefano, Kourtney Davis

“…General practitioners were sent a brief questionnaire and additional evidence to support a COPD diagnosis was requested. …”
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Biochemical analysis of miR-217 and miR-532 in patients with fibromyalgia by Shymaa E. Ayoub, Azza M. Ahmed, Mostafa Y. Abdelwahed, Abeer A. Khalefa, Aeshah A. Awaji, Samer S. Zekry, Enas G. Ibrahim, Hana M. Eid, Shimaa M. Elasmer, Reham Fares

“…According to our data, the fold changes of miR-217 and miR-532 in fibromyalgia patients were significantly lower than in controls, for miR-217 (median = 0.1359, IQR: 0.038–0.287, P < 0.001) and miR-532 [median = 0.2199, IQR: (0.114–0.421), P < 0.001]. In addition, there was a significant negative relationship between Aspartate transaminase (AST) and both miR-217 and miR-532 (r = − 0.480, P = P < 0.001 r = − 0.462, P = P < 0.001), respectively. …”
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Occurrences and characteristics of forced marriages among girls married before the age of 16 in a Northern Nigerian State by Felix O. Sanni, Olumide F. Ajani, Elizabeth A. Sanni, Zachary T. Gwa, Michael O. Dada, Yemisi B. Alabi, Donald C. Udah, Jubril A. Kareem

“…Among early married girls, 20.5% reported facing ill-treatment from their spouses, with a higher proportion (30.0%) among those coerced into marriage compared to those not coerced (17.5%). Additionally, gender-based violence from family members was notably more prevalent among girls forced into marriage (32.0%), with a significance level of P < 0.05. …”
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Abnormal insulin metabolism and decreased levels of mindfulness in type 2 diabetes mellitus by Xue Zhang, Rui Huang, Jiaxin Li, Mingyue Yang, Daowen Zhang, Cancan Liu, Kuanlu Fan

“…Early-stage diabetes patients, particularly those with lower β-cell function or higher insulin resistance levels, may require additional psychological intervention support to enhance their mindfulness and overall well-being.…”
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IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A‐Mediated NLRP3 Inflammasome by Wu Jingrui, Yang Haihui, Yan Jinjin, Fang Le

“…Furthermore, overexpression of NLRP3 partly reversed the effect of IGF2BP2 inhibition on Aβ1‐42 ‐induced hippocampal neuron injury. In addition, IGF2BP2 improved cognitive function and alleviated Aβ1‐42 neuronal injury in vivo. …”
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Sequential Serous Choroidal Detachment in Subjects Undergoing Bilateral Trabeculectomy by Maryam Yadgari, Kiana Hassanpour, Fatemeh Vafaei, Nina Firoozian, Maryam Oraee Yazdani, Zahra Khorram, Sadid Hooshmandi

“…Surgical success was defined as maintaining intraocular pressure (IOP) between 5 and 21 mmHg, requiring no additional glaucoma surgery, and exhibiting a visual acuity of at least light perception. …”
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Association between Alpha- Klotho Protein, Calcium, and Phosphate concentrations in Adult Iraqi Patients with Beta-Thalassemia Major by Ahmed J. Kadhim, Hedef D. El-Yaseen, Ali M. Jawad

“…Patients with thalassemia had decreased levels of serum calcium compared to the control group. Additionally, a strong negative association was observed between serum calcium and phosphate levels. …”
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The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro by Yakubu Jibira, Elizabeth Cudjoe, Frederick M. Tei-Maya, Benjamin Ayensu, Linda E. Amoah

“…Mangifera indica exhibited IC50 of 18.11, 20.08, and 10.23 μg/mL against the NF54, CamWT_C580Y, and FA08 parasite strains, respectively. Additive, synergistic and antagonistic interactions were observed at different combinations of A. cordifolia and M. indica extracts. …”
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Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases by Cheng-Cheng Deng, Xue-Yan Xu, Yan Zhang, Long-Can Liu, Xuan Wang, Jun-Yi Chen, Liu-Yi Yao, Ding-Heng Zhu, Bin Yang

“…However, these studies detected the gene expression of all cells in fibrotic skin diseases and did not enrich immune cells. Thus, the precise immune cell atlas in fibrotic skin diseases remains unknown. …”
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Magnetic field influence on heat transfer of NEPCM in a porous triangular cavity with a cold fin and partial heat sources: AI analysis combined with ISPH method by Munirah Aali Alotaibi, Weaam Alhejaili, Abdelraheem M. Aly, Samiyah Almalki

“…Key findings demonstrate that increasing LB by 350 % enhances temperature distribution and nanofluid velocities, reducing the heat capacity ratio Cr by approximately 20 %. The addition of cooling fins decreases peak temperatures by around 15 %. …”
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Epidemiologic Investigation of Intestinal Parasite Infection and Associated Risk Factors among Primary Schoolchildren in the Manzini and Lubombo Provinces, the Kingdom of Eswatini by Ai-Wen Yin, Yueh-Lun Lee, Sindisiwe Dlamini, Gugu Maphalala, Chien-Wei Liao, Chia-Kwung Fan

“…After consent from their parents/guardians, a total of 316 samples collected from PSC with grades 1 to 3 from four primary schools in Manzini and Lubombo were examined by the Merthiolate-Iodine-Formaldehyde (MIF) method. In addition, demographic characteristics and risk factors acquired by questionnaire surveys were included to be statistically analyzed. …”
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Archival and Newly Isolated Historical <i>Bacillus anthracis</i> Strains Populate the Deeper Phylogeny of the A.Br.075(Sterne) Clade by Markus Antwerpen, Peter Braun, Wolfgang Beyer, Dirk Aldenkortt, Michael Seidel, Gregor Grass

“…In this study, we genome-sequenced and analyzed 56 additional <i>B. anthracis</i> isolates of the A.Br.075 clade. …”
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