Quality of Life of Palestinian Patients on Hemodialysis: Cross-Sectional Observational Study by Hani H. Naseef, Nadin Haj Ali, Arin Arafat, Sawsan Khraishi, Abdallah Damin AbuKhalil, Ni’meh Al-Shami, Hosniyeh Ladadweh, Mohammad Alsheikh, Abdullah K. Rabba, Imad T. Asmar, Yousef Sahoury

“…There was a positive correlation between MCS and KDCS (r = 0.634, P-value <0.001), PCS and KDCS (r = 0.569, P-value <0.001), as well as MCS and PCS (r = 0.680, P-value <0.001). …”
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Vagal nerve stimulation dynamically alters anxiety-like behavior in rats by A.G. Butler, J.K. Bassi, A.A. Connelly, M.R. Melo, A.M. Allen, S.J. McDougall

“…Anxiety-like behavior was assessed using the elevated plus maze, open field test, and novelty-suppressed feeding test. Additionally, a place preference assay determined whether VNS is rewarding or aversive. …”
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An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository by Mohammed Ghazwani, Umme Hani, Riyaz Ali M. Osmani, Mohamed Rahamathulla, M. Yasmin Begum, Shadma Wahab, D. V. Gowda, Akhila Akkihebbal Ravikumar, Honnavalli Yogish kumar, Hissana Ather, Afrasim Moin

“…Combinations of PEG 1500 (10%–40%), PEG 6000 (40%–60%), and Poloxamer 407 (5%–30%) were entered as factors, and the responses evaluated were hardness, deformation time, and % drug release. In addition, the formulation was also evaluated for visual examination, weight variation, pH determination, drug content, hardness test, disintegration time, melting zone, deformation time, in vitro drug release, antifungal activity, and stability tests. …”
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Seed priming and abiotic stress tolerance in carrot: Unraveling the mechanisms of improved germination. by Marcin Nowicki, Marzena Nowakowska, Katarzyna Nowak, Wojciech Szczechura, Piotr Kaminski

“…., water, NaCl, PEG, GA3) on germination rates and seedling vigor. Additionally, we investigated the impact of inhibitors (actinomycin D-inhibitor of transcription, cycloheximide-inhibitor of translation, hydroxyurea-inhibitor of DNA synthesis, cytochalasin-inhibitor of actin polymerization) on seed germination under stress conditions. …”
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Transfer of optogenetic vectors into the brain of neonatal animals to study neuron functions during subsequent periods of development by D. A. Lanshakov, U. S. Drozd, T. A. Zapara, N. N. Dygalo

“…Thus, neonatal administration of a viral vector carrying an opto-channel gene is suitable for the study of brain neurons in rats of juvenile age, and requires additional control for gene expression during subsequent periods of development.…”
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Utility of CB-NAAT in cutaneous tuberculosis: A prospective observational study by Parul Verma, Srishti Tripathi, Swastika Suvirya, Prakriti Shukla, Amita Jain, Atin Singhai, Urmila Singh, Nishant Verma

“…Xpert MTB/RIF could identify an additional 3 cases, where all other microbiological investigations were negative. …”
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Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis by Ying Xu, Weiwei Meng, Yingqi Dai, Lin Xu, Ning Ding, Jinqing Zhang, Xuewei Zhuang

“…ATAC-seq analysis revealed that glycolysis in BC cells enhanced chromatin accessibility. Additionally, we confirmed that HDAC2 and HDAC3 act as “erasers” for H3 lysine lactylation. …”
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Habitat associations of six‐lined racerunners in longleaf pine managed with a short fire rotation for northern bobwhites by Isaiah W. Samek, Steven J. Price, Theron M. Terhune II, Darin J. McNeil

“…Although bobwhite management in these systems is mostly synonymous with longleaf pine restoration, additional conservation practices aimed at game birds (promoting fallow fields, supplemental feeding, meso‐carnivore control, cross sectional mowing, etc.) might affect the extent to which squamates benefit from habitat management. …”
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Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6 by Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer

“…Remarkably, it restored nicotinic modulation in neurons of α5SNP rats, while no such effect was observed in α5KO rats. Additionally, galantamine functioned as a positive allosteric modulator of α5*nAChRs in RS neurons, both in rat and human cortical L6, but did not affect burst spiking (BS) neurons. …”
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Predicting the infecting dengue serotype from antibody titre data using machine learning. by Bethan Cracknell Daniels, Darunee Buddhari, Taweewun Hunsawong, Sopon Iamsirithaworn, Aaron R Farmer, Derek A T Cummings, Kathryn B Anderson, Ilaria Dorigatti

“…However, in 53.4% (109/204) of the subjects, the highest titre change did not correspond to the infecting serotype, including in 34.3% (11/35) of dengue-naïve individuals (although 8/11 of these seronegative individuals were seropositive to Japanese encephalitis virus prior to their infection). …”
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Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…The objective of the current research was to explore the potential connections between immune characteristics and the development of HF, as well as to ascertain the nature of the causality between these factors.MethodsTo assess the causal association of immunological profiles with HF based on publicly available genome-wide studies, we employed a two-sample Mendelian randomization technique, utilizing the inverse variance weighted (IVW) method as our primary analytical approach. In addition, we assessed heterogeneity and cross-sectional pleiotropy through sensitivity analyses.ResultsA two-sample Mendelian randomization (MR) analysis was conducted using IVW as the primary method. …”
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Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex by Jason S. Hauptman, Joseph Antonios, Gary W. Mathern, Michael S. Levine, Carlos Cepeda

“…These results support the concept that Pten deletion results in significant changes in inhibitory inputs onto CPNs, and these alterations can be prevented with chronic rapamycin treatment. In addition, normal mice treated with rapamycin also display altered membrane and synaptic properties. …”
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Case Report: Prenatal diagnosis of novel compound heterozygous variants in WDR35 gene causing short-rib thoracic dysplasia 7 with or without polydactyly by Jianlong Zhuang, Junyu Wang, Zhengping Huang, Yu’e Chen, Chunnuan Chen

“…Both variants were thought of as pathogenic, which was further confirmed by Sanger sequencing and qPCR. In addition, two compound heterozygous variants NM_015102.5:c.[1196A&gt;G(p.E399G)];[1972C&gt;T(p.R658*)] in NPHP4 gene were also identified in the fetus, which may be partially responsible for fetal kidney hyperechogenicity and oligohydramnios.ConclusionThis is the first study reporting a novel deletion compound combined with a causative missense variant in WDR35 leading to SRTD7. …”
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GGLA-NeXtE2NET: A Dual-Branch Ensemble Network With Gated Global-Local Attention for Enhanced Brain Tumor Recognition by Adnan Saeed, Khurram Shehzad, Shahzad Sarwar Bhatti, Saim Ahmed, Ahmad Taher Azar

“…This network uses two branches to extract image features at different resolutions for fusion, thereby expanding the network receptive field. Additionally, we utilized an Enhanced Super-Resolution Generative Adversarial Network (ESRGAN) to generate images that balance MRI data and implemented multiple preprocessing techniques to tackle inherent noise in MRI images. …”
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Decomposition of skill scores for conditional verification: impact of Atlantic Multidecadal Oscillation phases on the predictability of decadal temperature forecasts by A. Richling, J. Grieger, H. W. Rust

“…Compared to the low-resolution system (preop-LR), no overall performance benefits are made in this region, but positive contributions are achieved for initialization in neutral AMO phases. Additionally, the decomposition reveals a strong imbalance among the subsets (defined by AMO phases) in terms of reference weighting, allowing for insightful interpretation and conclusions. …”
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Leveraging Social Media Data for Forest Fires Sentiment Classification: A Data-Driven Method by Warih Maharani, Hanita Daud, Noryanti Muhammad, Evizal Abdul Kadir

“…Background: The rise in forest fires over the last two years, which is due to rise in dry weather conditions and human activities, have greatly impacted an area of 1.6 million hectares, leading to significant ecological, economic, and health issues, hence the need to improve disaster response strategies. …”
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Clinical Confidence, Certification, and Connectedness: Impact of a Journal Club for Inpatient Psychiatry Faculty by David S. Im, Andrea Brelje, Christina Raghunandan, Laura Stchur, Angela Lyden, Allison Hong, Lindsay A. Bornheimer

“…Future research should examine the journal club experience and impact among a larger number of faculty and incorporate additional measures of learning outcomes.…”
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Long-Term Surgical Outcomes of Glaucoma Drainage Implants in Eyes with Preoperative Intraocular Pressure Less than 19 mmHg by Shahin Hallaj, Jae-Chiang Wong, Lauren E. Hock, Natasha Nayak Kolomeyer, Aakriti G. Shukla, Michael J. Pro, Marlene R. Moster, Jonathan S. Myers, Reza Razeghinejad, Daniel Lee

“…Clinical data of 67 eyes of 67 patients were collected from patients’ charts, and the outcomes of GDI were evaluated until 7 years. GDI failure was defined as IOP reduction of less than 20% from the baseline at two consecutive visits three months after surgery, decline to no light perception, or if additional glaucoma surgery was performed. …”
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EgoSep: Egocentric On-Screen Sound Source Separation for Real-Time Edge Computing by Donghyeok Jo, Jun-Hwa Kim, Jihoon Jeon, Chee Sun Won

“…., off-screen sounds), improving the SNR of the test data from 3.05 dB at the input to 10.01 dB at the output. Additionally, real-time feasibility is validated on the NVIDIA Jetson Nano Developer Kit, achieving a real-time factor (RTF) of 0.17, demonstrating its practicality for wearable applications. …”
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Physiological and molecular mechanisms of exogenous salicylic acid in enhancing salt tolerance in tobacco seedlings by regulating antioxidant defence system and gene expression by Xiliang Song, Jian Chen, Can Xu, Xianjie Cai, Wenjing Song, Aixia Chang, Yu Zhang, Chenggang Luo

“…The plant hormone salicylic acid (SA) has notable potential in mitigating salt toxicity, yet its mechanism in enhancing the salinity tolerance of tobacco plants is not well explored.MethodsThis study aimed to assess the potential benefits of exogenous SA application (1.0 mM) on tobacco seedlings subjected to saline soil conditions.ResultsThe foliar spray of SA partially mitigated these salt-induced effects, as evidenced by a reduction of malondialdehyde content, and improvements of leaf K+/Na+ ratios, pigment biosynthesis, and electron transport efficiency under NaCl stress. Additionally, SA increased the contents of total phenolic compound and soluble protein by 16.2% and 28.7% to alleviate NaCl-induced oxidative damage. …”
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