Impact of DLL3 Expression as Prognostic Factor in Extensive Stage of Small Cell Lung Cancer Treated With First‐Line Chemotherapy by Hohyung Nam, Soon‐Hee Jung, Jii Bum Lee, Jee Hyun Kong, Seungtaek Lim

“…Materials and Methods A total of 54 patients with extensive stage of SCLC (ES‐SCLC) who were treated with first‐line chemotherapy were included for our analysis. In addition, tissue specimen should be available for immuno‐histochemical staining for DLL3, and their clinico‐pathologic data, including progression‐free survival (PFS) and overall survival (OS), were obtained. …”
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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…Thirdly, given their proposed importance in membraneless organelles, we show epigenes are enriched for substantially larger intrinsically disordered regions (IDRs). Additionally, we assessed the specificity of their expression profiles and showed epigenes are more ubiquitously expressed consistent with their enrichment in pediatric syndromes with intellectual disability, multiorgan dysfunction, and developmental delay. …”
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Determination of Carrageenan in Livestock and Poultry Meat by Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry by Yanqin Sun, Xudong Zhu, Xixi Shen, Wei Wang

“…Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) has become the main method for the detection and analysis of food additives because of its good separation, high selectivity, and high sensitivity. …”
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Safety of combined drug use in patients with cardiovascular and cerebrovascular diseases: an analysis based on the spontaneous reporting database of adverse drug reactions in Hubei... by Jia Wang, Yuhang Zhao, Zherui Chen, Rui Huang

“…The strongest signal found in this study was jaundice caused by the combination of amlodipine and atorvastatin (Ω 0.025:3.08, lift: 1116.69, conviction: 1.75). Additionally, the combination of aspirin with other drugs was associated with hemorrhaging in various organs. …”
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Genetic Characteristics of the Rat Fibroblast Cell Line Rat-1 by Thomas Liehr, Stefanie Kankel, Eva Miriam Buhl, Sarah K. Schröder-Lange, Ralf Weiskirchen

“…Interestingly, the chromosomal imbalances found in Rat-1 cells resemble those found in human epithelioid sarcoma or liposarcoma. Additionally, we analyzed the transcriptome of Rat-1 cells through mRNA sequencing (mRNA-Seq) using next-generation sequencing (NGS). …”
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Exploring how PRIME-Parkinson care is implemented and whether, how and why it produces change, for who and under what conditions: a protocol for an embedded process evaluation with... by Yoav Ben-Shlomo, Sabi Redwood, Judi Kidger, Emma Tenison, Heather Brant, Emily J Henderson, Fiona Lithander, Katherine Lloyd, Safi Smith

“…The mixed-methods process evaluation will be published after the conclusion of the trial in addition to the main trial findings.Trial registration number NCT05127057.…”
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SFDA-MEF: An Unsupervised Spacecraft Feature Deformable Alignment Network for Multi-Exposure Image Fusion by Qianwen Xiong, Xiaoyuan Ren, Huanyu Yin, Libing Jiang, Canyu Wang, Zhuang Wang

“…However, traditional methods and unsupervised deep-learning methods always exhibit inherent limitations in dealing with complex overlapping regions. In addition, supervised methods are not suitable when ground truth data are scarce. …”
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Effects of Curcumin on Iron Overload in Rats by Gülüzar Özbolat, Arash Alizadeh Yegani

“….); and (iii) iron overload curcumin group that received six doses of curcumin (1000 mg/kg BW by i.p.).  In addition to six doses of iron dextran 1000 mg/kg–1 by i.p., we studied the effects of curcumin on liver function enzymes (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]); antioxidant enzymes (malondialdehyde [MDA], total oxidant status [TOS], total antioxidant status [TAS]); hematological parameters (hemoglobin [Hb], hematocrit [Hct], red blood cells [RBC], white blood cells [WBC], mean corpus volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC]); and iron parameters (serum iron profile, transferrin, total iron-binding capacity [TIBC], ferritin, and transferrin saturation [TS%]). …”
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Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder by Marina Ivanova, Ksenia Germanova, Dmitry S. Petelin, Aynur Ragimova, Grigory Kopytin, Beatrice A. Volel, Vadim V. Nikulin, Maria Herrojo Ruiz

“…First, we determined if previously reported increased learning rates in BD stem from a heightened expectation of environmental changes. Additionally, we examined if this increased expectation speeds up belief updating in decision-making, associated with modulation of rhythmic neural activity within the prefrontal, orbitofrontal, and anterior cingulate cortex (PFC, OFC, ACC). …”
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Impact of nanoparticles shapes and fuzzy volume fraction on Al2O3 – H2O nanofluid flow past an unsteady expandable surface by Adnan Saeed Butt, Naveed Yaqoob, Sameea Akbar, Gul M. Shaikh, Adeeba Farhat, Fouzia Amir, Mohamed R. Ali

“…The results indicate that temperature distribution is more pronounced in nanofluids with cylindrical nanoparticles than in those with brick-shaped nanoparticles. Additionally, a noticeable increase in fuzzy temperature is observed with higher unsteady parameters and Eckert numbers. …”
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Revisiting ‘revisiting supervised methods for effort‐aware cross‐project defect prediction’ by Fuyang Li, Peixin Yang, Jacky Wai Keung, Wenhua Hu, Haoyu Luo, Xiao Yu

“…Recently, Ni et al. proposed an EACPDP method called EASC, which used all cross‐project modules to train a model without considering the data distribution difference between cross‐project and within‐project data. In addition, Ni et al. employed the different defect density calculation strategies when comparing EASC and baseline methods. …”
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Exercise-Intervened Circulating Extracellular Vesicles Alleviate Oxidative Stress in Cerebral Microvascular Endothelial Cells Under Hypertensive Plus Hypoxic Conditions by Smara Sigdel, Shuzhen Chen, Gideon Udoh, Jinju Wang

“…Functional studies showed that ET-cEVs can improve the compromised migration capability of mBMECs challenged by Ang II plus hypoxia. Additionally, ET-cEV treatment upregulated the expression of p-Akt/Akt in mBMECs. …”
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Tapentadol Prolonged Release for Severe Chronic Osteoarthritis Pain in the Elderly—A Subgroup Analysis of Routine Clinical Practice Data by Andreas Schwittay, Melanie Sohns, Birgit Heckes, Christian Elling

“…At the end of observation, 68% of the elderly had clinically relevant pain reductions of at least 50% (vs baseline), and 87.9% attained either their intended pain reduction target and/or an additional individual treatment target (both predefined during baseline examination). …”
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Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model by Yazhen Xie, Haifeng Xu, Zhijuan Gu

“…The expression levels of oestrogen receptor alpha (ERα) and cyclooxygenase-2 (COX-2) in uterine tissue were measured using immunohistochemical assays, and those of phosphorylated and total extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) were assessed using western blot analysis.Results Treatment with GGD significantly reduced writhing behaviour, histopathological scores, and levels of COX-2, PGE2, and PGF2α in the serum of PD rats. Additionally, GGD increased β-EP content and inhibited ERK1/2 activation and ERα expression in uterine tissues.Conclusions The results of this study suggest that GGD alleviates PD in rats by suppressing the COX-2-mediated release of PGE2 and PGF2α, modulating the ERα/ERK1/2/COX-2 pathway, and increasing β-EP content. …”
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GLOBAL SCIENCE GOVERNANCE: CASE OF INTERGOVERNMENTAL ORGANIZATIONS by M. V. Kharkevich, M. Yu. Tumanova, D. S. Korobov, S. N. Nedelko

“…The globalization of science leads to an increase in the transaction costs of scientific work due to the specifics of the institutional, linguistic, cultural, infrastructural and other conditions of this activity in individual countries, institutions, scientific fields, etc. In addition, the increase in transaction costs is also influenced by the increasing interdependence between scientists around the world. …”
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The Role of Sulfur Emission from the Petroleum Industry on Ultrafine Particle Number Concentration in Singapore by Suyi Hou, Weihan Li, Liudongqing Yang, Guorong Chen, Yilin Zhang, Mikinori Kuwata

“…Abstract Ultrafine particles, defined as particles with a diameter (dp) smaller than 100 nm, serve as an important component of cloud condensation nuclei, in addition to impacting human health. The dominant sources of ultrafine particles include traffic emissions and nucleation. …”
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Role of controlled radial expansion balloon bronchoplasty in benign subglottic and tracheal stenosis by Jeetendra Kumar Patra, Chinmaya Sundar Ray, Manoranjan Pattnaik, Subrat Kumar Behera

“…However, the remaining three patients did not achieve an optimal tracheal lumen with CRE balloon bronchoplasty and were referred for tracheal reconstruction surgery. …”
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Efficient Encoding and Decoding of Voxelized Models for Machine Learning-Based Applications by Damjan Strnad, Stefan Kohek, Borut Zalik, Libor Vasa, Andrej Nerat

“…Such on-demand expansion must be fast in order to avoid introducing substantial additional delay to the pipeline. This can be achieved by parallel decoding, which is particularly suitable for massively parallel architecture of GPUs on which the majority of machine learning is currently executed. …”
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Evaluation of Safety and Efficacy of Traction, Closed Reduction, and Subsequent Hip Fixation in Hilgenreiner Brace in Patients with Severe Forms of Hip Developmental Dysplasia by Ahmad Gharaibeh, Rastislav Sepitka, Jan Pobeha, Daniela Schreierova, Martina Habinakova, Gabriel Vasko, Marek Lacko

“…To evaluate the effectiveness and safety of traction, closed reduction, and hip fixation in Hb in patients with severe forms of hip developmental dysplasia (DDH) in follow-up. Materials and Methods. Prospective, clinical, cohort observation and retrospective matched-pair analysis. …”
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In Praise of Diversity in Participatory Heritage Planning Empowered by Artificial Intelligence: Windcatchers in Yazd by Mahda Foroughi, Tong Wang, Ana Pereira Roders

“…This model can be adapted to other key attributes in Yazd and other case studies, offering broader applications in heritage planning. Additionally, the findings underscore the potential of AI to evaluate the legislative framework’s effectiveness in enhancing public engagement.…”
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