hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways by Yan Yu, Chengchun Zhu, Xiao Wang, Ying Shi, Yiping Gao, Zhiyi Yu

“…Western blotting, Ca2+ imaging and immunofluorescence assays were employed to study their antitumor mechanisms of actions.ResultsWe identified two novel hERG activators, SDUY429 and SDUY436, which effectively inhibited the proliferation and migration of MDA-MB-231 and MCF-7 cells. In addition, SDUY436 demonstrated significant anti-invasive and pro-apoptotic effects in MDA-MB-231 cells. …”
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Chronic Stress Mediates Inflammatory Cytokines Alterations and Its Role in Tumorigenesis by Liu Z, Lei M, Bai Y

“…This ongoing inflammation further enhances the activity of these transcription factors, which serve multiple roles: they act as pro-inflammatory agents in inflammatory cells, maintaining chronic inflammation; as oncogenic transcription factors in premalignant cells, promoting cancer initiation; and as pro-differentiation transcription factors in tumor-infiltrating immune cells, facilitating cancer progression. Additionally, the impact of chronic stress varies among different cancer types and individual responses to stress, highlighting the complexity of stress-related cancer mechanisms. …”
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Practices Regarding Human Papillomavirus and Cervical Cancer in A Sample of Paramedical Staff in Al- Najaf Governorate, Iraq by Alaa Mehdi Salih, Atta Ah Mousa Al –Sarray

“…Almost all paramedics work in urban areas. In addition, almost half of the participants came from medical institutions, accounting for 51.6 percent of the total, while just 2.4 percent were graduates of secondary schools. …”
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A Lightweight Mitigation Technique Against a Modified Version Number Attack in IoT Networks by Ibrahim S. Alsukayti, Mohammed Alreshoodi, Mehdi Rouissat

“…Network overhead and energy consumption were increased by more than 300% and 220%, respectively. Additionally, a reduction of over 28% and an increase of over 400% in PDR and latency, respectively, were experienced during the attack. …”
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Effect of a single rectal fecal microbiota transplantation on clinical severity and fecal microbial communities in dogs with chronic inflammatory enteropathy by Jorge Pérez‐Accino, Mazdak Salavati, Laura Glendinning, Silke Salavati Schmitz

“…Recipient microbiota composition or diversity did not change over time. Glycerol addition was associated with a difference in microbiota composition (P ≤ .001). …”
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Omics-Based Interaction Analysis Reveals Interplay of Chemical Pollutant (Ozone) and Photoradiation (UVSSR) Stressors in Skin Damage by Hong Zhang, Yiying Dong, Xue Xiao, Xiao Cui, Xuelan Gu

“…In summary, exposure to ozone in combination with UVSSR showed a joint effect on UVSSR-induced phenotypic changes in the skin; the underlying mechanism was determined by using transcriptome analysis, showing the additive impacts of ozone on UVSSR-induced skin damage, such as cellular stress and inflammatory responses. …”
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Evaluation of Antimicrobial Activity of Four Organic Acids Used in Chicks Feed to Control Salmonella typhimurium: Suggestion of Amendment in the Search Standard by Aicha El Baaboua, Mohamed El Maadoudi, Abdelhakim Bouyahya, Omar Belmehdi, Ayoub Kounnoun, Rajae Zahli, Jamal Abrini

“…The concentration of 0.04M of Na2HPO4 solution has proved, in vitro, in caecums and organs of chicks (in presence of organic acids) that strain introduced, even at low concentrations, can be recovered. The use of additives has beneficial effects in Salmonella control program. …”
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Implementation of Uterine Artery Doppler Scanning: Improving the Care of Women and Babies High Risk for Fetal Growth Restriction by Emmanuel Ekanem, Faris Karouni, Emmanuoil Katsanevakis, Habiba Kapaya

“…When numbers were compared for the two hospitals, FGR rate was higher in Lincoln 8.10% vs. 4.51% in Boston. In addition, an increased proportion of abnormal UtAD scans was observed in Lincoln (35.7%) vs. in Boston (22%) (P=0.014). …”
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Netarsudil as an Adjunctive Therapy: Efficacy and Factors Contributing to a Favorable IOP-Lowering Effect by Sandy Samuel, Hani El Helwe, Cameron E. Neeson, Nathan Hall, Ryan Sameen Meshkin, Nino Odishelidze, Rebecca Ye, Ta C. Chang, David Solá-Del Valle

“…Patients with a diagnosis of glaucoma or ocular hypertension on netarsudil and at least one other hypotensive agent for glaucoma who had at least one month of follow-up were included. Patients with additional procedures or glaucoma medication changes were excluded. …”
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Cardiopulmonary fitness in children/adolescents with chronic kidney disease and the impact of exercise training: a systematic review and meta-analysis of observational study and ra... by Fan Zhang, Yan Bai, Liuyan Huang, Yifei Zhong

“…Given the low evidence certainty, additional high-quality trials are necessary.…”
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The Law of Fracture Evolution of Overlying Strata and Gas Emission in Goaf under the Influence of Mining by Cheng Cheng, Xiaoyu Cheng, Rui Yu, Wenping Yue, Chao Liu

“…The results showed that the development of the region with overlying strata fissures is affected by mining. In addition, the “trapezoid platform structure” is formed after fracture areas are connected. …”
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PermGuard: A Scalable Framework for Android Malware Detection Using Permission-to-Exploitation Mapping by Arvind Prasad, Shalini Chandra, Mueen Uddin, Taher Al-Shehari, Nasser A. Alsadhan, Syed Sajid Ullah

“…The dataset consists of 55,911 benign and 55,911 malware apps, providing a balanced and comprehensive foundation for analysis. Additionally, a new strategy using similarity-based selective training reduces the amount of data required for the training of an incremental learning-based model, focusing on the most relevant data to improve efficiency. …”
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Development of a Small-Working-Volume Plunger Hydraulic Pump with Improved Performance Characteristics by Alexey N. Beskopylny, Denis Medvedev, Vyacheslav Grishchenko, Evgeniy Ivliev

“…It offers production costs that are several times lower compared to existing cam-type plunger or diaphragm pumps with oil sumps and precision valve mechanisms. Additionally, it has significantly better operating characteristics and a longer service life compared to vibrating plunger pumps.…”
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ADVERSE PREGNANCY OUTCOMES IN SICKLE CELL TRAIT: A PROSPECTIVE COHORT STUDY EVALUATING CLINICAL AND HAEMATOLOGICAL PARAMETERS IN POSTPARTUM MOTHERS AND NEW-BORNS. by r. Salam Al-Kindi

“…Results – At enrolment, the first trimester, the SCT group did not manifest SCA symptoms, and there was no difference in any of the haematological parameters between the SCT and control groups. …”
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Histopathological Insights into Granulomatous Lesions: A Comprehensive Study by Archana Kumari, Irbinder K. Bali, Ayushi Chauhan, Falguni Chitkara, Deepika Wadhera

“…Histopathological examination was performed using Hematoxylin and Eosin (H&E) stain, with additional special stains like Ziehl-Neelsen and Periodic Acid-Schiff (PAS) applied where necessary. …”
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First-principles study of the matrix alloying effect of X (X = Cr, Mo, W, V, Ti, Si) on the bonding characteristics and mechanical properties of the NbC/Fe interface by Yutong Yu, Lisheng Zhong, Enci Han, Ke Shi, Kaiyuan Hu, Chengwen Zhang, Yunhua Xu, Jianhong Peng, Xu Hu

“…According to the theoretical tensile strength analysis, the addition of Mo, W, Si, and Cu will destroy the critical tensile strain at the interface. …”
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Identification and characterization of soybean phytochrome-interacting factors and their potential roles in abiotic stress by Dewei Mu, Zhaowei Shui, Haoyu Guo, Hengke Jiang, Yuhan Liu, Liqiu Luo, Yanpeng Zhang, Xinxin Zhang, Jiaxin Yu, Shulin Liao, Liang Yu, Chunyan Liu, Junbo Du

“…The soybean (Glycine max) is a significant food crop, providing essential oil and nutrients. Additionally, it is a vital industrial raw material and a lucrative cash crop. …”
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Correlation of Grade of Urothelial Cell Carcinomas and DNA Histogram Features Assessed by Flow Cytometry and Automated Image Cytometry by Marco G. W. Bol, Jan P. A. Baak, Bianca v. Diermen, E. A. M. Janssen, Susanne B. K. Buhr-Wildhagen, Kjell-Henning Kjellevold

“…To discriminate between different grades, single- and multivariate analyses was performed on DNA histogram features obtained with the MultiCycle program (using DNA index (DI) and SPF). Results: Overall measurement time of the adapted ICM method was 10.7 minutes per case (range 5.9–29.8 min.) and required little additional interactive object rejection (average 152 objects (84–298) on 3000 objects per case measured, which took 9.9 minutes on average, range 8.3–15.5 minutes). …”
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Exploring individual and organizational contributors to workplace deviant behavior by D. Daryono, R. Gunawan, U. Udin

“…Therefore, the study on workplace deviant behavior is important because it addresses both practical and theoretical concerns crucial for organizations' functioning and success. Additionally, it helps in understanding the dynamics of employee behavior, developing effective management strategies, and promoting a productive and ethical workplace environment. …”
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Morphophysiological alterations caused by insertional mutagenesis of contactin 5 (Cntn5) gene in transgenic mice by A. V. Smirnov, N. A. Feofanova, G. V. Kontsevaya, M. V. Anisimova, I. I. Kovrigin, I. A. Serova, M. P. Moshkin, L. A. Gerlinskaya, N. R. Battulin

“…Our results uncovered that homozygous mutant mice have lower body weight than controls and that it is caused by slower accumulation of fat tissue. …”
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