Inhibition of the anti-apoptotic protein BCL2 in EML4-ALK cell models as a second proposed therapeutic target for non-small cell lung cancer. by Richard Junior Zapata Dongo, Diletta Fontana, Luca Mologni, Juan Enrique Faya Castillo, Stefany Fiorella Infante Varillas

“…We treated these cells with ABT-199, a selective BCL2 inhibitor, and found that models with high BCL2 expression exhibited resistance, while those with lower expression showed sensitivity to BCL2 inhibition. In addition, our analysis using bioinformatics indicated that ABT-199 not only targets BCL2 but also binds to the active site of all ALK mutants, it was contrasted by in vitro ALK kinase activity inhibition by ABT-199 (5.5 μM). …”
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Third Trimester Lower Extremity Lymphorrhea by Kaori Morimoto, Luke O’Rourke

“…Lifestyle modifications were recommended, but the patient did not comply. At her 31-week office visit, the patient presented with anasarca and clear, slightly viscous fluid seeping through the atraumatic skin of her lower extremities. …”
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Combining habitat selection, behavioural states, and individual variation to predict fish spatial usage near a barrier by Rachel Mawer, Jelger Elings, Stijn P. Bruneel, Ine S. Pauwels, Eliezer Pickholtz, Renanel Pickholtz, Johan Coeck, Peter L.M. Goethals

“…Under the tested flow conditions, high spatial usage was predicted in the area directly downstream of the barrier. In addition, barbel usage was high in the area by and downstream of the fish pass entrance but not for grayling, which may indicate a need to improve pass attractiveness for grayling. …”
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Geospatial digital mapping of soil organic carbon using machine learning and geostatistical methods in different land uses by Yahya Parvizi, Shahrokh Fatehi

“…The SOC changes were simulated using multivariate analysis and machine learning methods including generalized linear model (GLM), linear additive model (LAM), cubist, random forest (RF), and support vector machine (SVM) models. …”
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What are the Thoughts of Women Whose Husbands’ Frozen Testicular Sperm Is Thawed for in vitro Fertilization on the Day of Oocyte Retrieval? A Qualitative Study by He Y, Wei Q, Chen X, Zhang C, Wang Z

“….; b. shared expectations for children help couples establish a common goal).Conclusion: It is recommended that healthcare practitioners implement strategies to enhance patient education and awareness surrounding assisted reproductive technology. Additionally, establishing and strengthening social support, reinforcing privacy protections and safety measures, promoting effective communication between partners, and managing treatment outcome expectations are crucial steps forward.Immediate Practical Implications: Women prioritize treatment efficacy, privacy preservation, and the necessity of acquiring comprehensive professional knowledge when employing their partner’s testicular sperm for in vitro fertilization. …”
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Circulating visfatin concentrations in patients with chronic obstructive pulmonary disease: systematic review and meta-analysis by Nahid Aboutaleb, Alireza Moradi, Hamzeh Mirshekari Jahangiri, Mohammad Reza Aslani, Mohammad Reza Aslani

“…Meta-regression analysis revealed a significant correlation between the pooled SMD visfatin and pooled SMD age (p < 0.01), BMI (p < 0.001), FEV1 (p < 0.001), and IL-6 (p < 0.001).ConclusionThe findings showed an insignificant decline in visfatin level among COPD patients, but additional research is necessary due to the heterogeneity in study results.Systematic review registrationPROSPERO (CRD42023450851), https://www.crd.york.ac.uk/prospero/display_record.php?…”
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Dynamic compressive characteristics of a green sandstone under coupled hydraulic-mechanical loading: Experiments and theoretical modeling by Bangbiao Wu, Geli Zhao, Ying Xu, Kaiwen Xia

“…By deducing the connection between crack length and damage evolution, the resulting law of crack expansion rate is related to the strain rate. In addition, the influence of hydraulic factors on the stress intensity factor at the crack tip is introduced. …”
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Quantitative profiling of the vaginal microbiota improves resolution of the microbiota-immune axis by Eric Armstrong, Rachel Liu, James Pollock, Sanja Huibner, Suji Udayakumar, Erastus Irungu, Pauline Ngurukiri, Peter Muthoga, Wendy Adhiambo, Sergey Yegorov, Joshua Kimani, Tara Beattie, Bryan Coburn, Rupert Kaul

“…We hypothesized that the addition of absolute abundance data would provide a more complete picture of host-microbe interactions in the female genital tract. …”
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Associations between the intake of single and multiple dietary vitamins and depression risk among populations with chronic kidney disease by Chunli Yu, Kun Liu, Weiguo Yao, Dingzhong Tang

“…Weighted multivariate logistic regression models were utilized to analyze the associations of individual dietary vitamin intakes with depression risk. Additionally, Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) regression were performed to evaluate the joint effect of the intake of the nine vitamins on depression risk.ResultsThe overall prevalence of depression was approximately 11.3% in the study participants. …”
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Neuroprotection in intrauterine herpesvirus infection by M.V. Khaitovych, R.I. Zhdanovych

“…To test the effectiveness of the developed neuroprotection complex (erythropoietin, early use of sensory integration techniques), 60 children with intrauterine herpesvirus infection, who were classified as high-risk for significant central nervous system disorders, were examined from birth to 1 year of age: the main group was 30 newborns who were additionally treated with a new complex of neuroprotection, and the comparison group - 30 children, whose medical support was carried out in accordance with the protocols of the Ministry of Health of Ukraine. …”
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Deaths during Sexual Activity by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…The cause of death was determined to be suffocation due to neck compression by a ligature, compounded by significant alcohol intoxication, with additional postmortem burns covering 30% of the body surface area likely occurring after death. …”
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Combined metabolomics and 16S rDNA sequence analyses of the gut microbiome reveal the action mechanism of Fructus Akebiae against hepatic fibrosis by Rong-Rong Wu, Duo-Rui Nie, Fang-Hui He, Zhi-Hang Li, Fei Xu, Fei Xu, Fei Xu

“…Analysis revealed that FAE administration reversed the carbon tetrachloride (CCl4)-induced dysbiosis by increasing the abundance of Akkermansia and reducing that of Cyanobacteria. Additionally, metabolomic analysis showed that FAE treatment reversed the CCl4-induced metabolic disorders by regulating amino and nucleotide sugar metabolism. …”
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Alendronate partially rescues the periodontal defects in OIM mouse model of osteogenesis imperfecta by Po-Jung Chen, Ke Wang, Meng-Hsuan Lin, Radhika Sharma, Zana Kalajzic, Mara O’Brien, Sumit Yadav

“…Periodontal ligament (PDL)-alveolar bone and PDL-cementum entheses’ roles under OI conditions during physiological loading and orthodontic forces remain largely unknown. In addition, bisphosphonates (e.g., alendronate) are commonly used therapeutics for the treatment of OI. …”
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Rapid landslide detection from free optical satellite imagery using a robust change detection technique by Rosa Coluzzi, Angela Perrone, Caterina Samela, Vito Imbrenda, Salvatore Manfreda, Letizia Pace, Maria Lanfredi

“…Due to the complexity of the phenomenon which might involve the displacement of massive rocks, soil, and both wet and dry vegetation from hillslopes, and the significant impact on the safety of the population and road infrastructure, the development of specific procedures for the rapid detection of landslides is extremely challenging. …”
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Disinfection of indoor air for the inactivation of SARS-CoV-2: a review of the effectiveness of UV-C technology and gaps in research by Elena Cristina Rada, Chiara Vignali, Stefano Bellazzi, Marco Carnevale Miino, Alessandro Abbà, Márta Szabó, Vincenzo Torretta, Maria Cristina Collivignarelli, Maria Cristina Collivignarelli

“…In indoor environments, a structured strategy is needed to reduce the risk of infection. In addition to maintaining proper ventilation and wearing face masks, the development of effective technologies for limiting the transmission of SARS-CoV-2 through infectious respiratory particles (IRPs) has been studied. …”
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Primary Hyperparathyroidism-Phosphaturic Mesenchymal Tumour: An Unusual Association and a Probable Syndrome by Gwendolyn Fernandes, Avanika, Gloria Khumanthem

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Nanopore adaptive sampling accurately detects nucleotide variants and improves the characterization of large‐scale rearrangement for the diagnosis of cancer predisposition by Sandy Chevrier, Corentin Richard, Marie Mille, Denis Bertrand, Romain Boidot

“…Results In our cohort, 11 samples had large‐scale rearrangements (LSR), which were all detected with ONT sequencing. In addition to perfectly detecting the locus of the LSR, we found a known MLPA amplification of exon 13 in the BRCA1 (NM_7294) gene corresponded to a duplication in tandem of both exons 12 and 13 of the reference NM_7300. …”
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Effects of a Serratus Anterior Plane Block After Video-Assisted Lung Wedge Resection: A Single-Center, Prospective, and Randomized Controlled Trial by Seokjin Lee, Tae-Yun Sung, Choon-Kyu Cho, Gyuwon Lee, Woojin Kwon

“…<i>Materials and Methods</i>: In total, 22 patients undergoing VATS lung wedge resections were randomized into two groups (SAPB and control): both received intravenous patient-controlled analgesia (PCA), and one group received additional SAPB. The primary outcome was the cumulative intravenous fentanyl consumption at 8 h postoperatively. …”
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Frontal Plane Knee Kinematics and Kinetics During Gait in Children and Youth with Achondroplasia—Correspondence with Static X-Ray Images and Relevance to Symptoms by Matthias Hösl, Antonia Thamm, Faik Kamel Afifi, Sean Nader

“…Typically, X-rays are used to assess them, but 3D gait analysis (3DGA) may additionally be used to evaluate dynamic knee function. …”
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Bioactive Properties of <i>Pentacalia vaccinioides</i> (Kunth) Cuatrec. (Asteraceae) Essential Oils: Evaluation of Antimicrobial and Antioxidant Activities by Luis G. Sequeda-Castañeda, María A. Castellanos-Gómez, Carlos L. A. Céspedes-Acuña

“…<i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i> did not show antimicrobial susceptibility to EOs. …”
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