De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients: A Place for Interaction? by Josefina Alberu, Maria Inés Vargas-Rojas, Luis E. Morales-Buenrostro, Jose C. Crispin, Roxana Rodríguez-Romo, Norma O. Uribe-Uribe, Gabriel Carrasco, Diana Gómez-Martín, Jorge Alcocer-Varela

“…The differences in Treg numbers observed at the late time point may reflect better immune acceptance of the graft and may be associated to long-term effects. Additional inhibitory mechanisms participating earlier in DSA development after KT deserve to be sought.…”
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Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice by Houxier Li, Nan Wang, Jiahui Wu, Shuting Tan, Yan Li, Nan Zhang, Li Yang, Aji Li, Rongting Min, Maochun Xiao, Shiyao Su, Xiang Wang, Xueyong Wang

“…Feeding mice with 1.5 g/kg and 3 g/kg of Ce-RS5 significantly reduced their body weight, positively regulated their blood lipid levels, and improved liver damage and fat accumulation. …”
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Detailed cytogenetic analysis of three duck species (the northern pintail, mallard, and common goldeneye) and karyotype evolution in the family Anatidae (Anseriformes, Aves) by V. R. Beklemisheva, K. V. Tishakova, S. A. Romanenko, D. A. Andreushkova, V. A. Yudkin, E. А. Interesova, F. Yang, M. A. Ferguson-Smith, A. S. Graphodatsky, A. A. Proskuryakova

“…The new data about the three Anatidae species add knowledge about the transformation of macro- and sex chromosomes of Anseriformes during evolution.…”
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Exploring the antioxidant and antimicrobial properties of five indigenous Kenyan plants used in traditional medicine by Virginia Gichuru, Irene Sbrocca, Michela Molinari, Teodora Chiara Tonto, Vittoria Locato, Sara Cimini, Laura De Gara

“…G. bicolor, and G. macrosiphon were found to have great potential as sources of bioactive metabolites, such as chlorophyll a (1456.29 µg/ g DW; 1104.33 µg/ g DW), chlorophyll b (712.48 µg/ g DW; 443.31 µg/ g DW), and carotenoids (369.71 µg/ g DW; 300 µg/ g DW) as well as phenols (31.78 mg GAE/g DW; 27.54 GAE/g DW), and exhibiting high antioxidant activity, according to TEAC, DPPH and FRAP assays. Additionally, L. schweinfurthii and G. macrosiphon demonstrated antimicrobial activity against the Gram-negative bacteria E. coli, as well as against Gram-positive ones, S. aureus and B. subtilis.…”
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Pan-cancer analysis of CLDN1 and its functional study in gastric cancer by Zhu Weijing, Zhang Jiaxing, Wei Yucai, Yang Shengrui, Wang Wenxuan, Li Yumin

“…It demonstrated good diagnostic potential and was associated with poor prognosis in 8 cancer types. Additionally, CLDN1 showed the highest mutation rate in lung squamous cell carcinoma. …”
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Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats by Yuka Toyoshima, Katsuyuki Nakamura, Yusuke Taguchi, Reiko Tokita, Shiho Takeuchi, Hayato Osawa, Naomi Teramoto, Hidetoshi Sugihara, Fumiaki Yoshizawa, Keitaro Yamanouchi, Shiro Minami

“…Our previous study showed that the disruption of IRS-2 impairs body growth but not glucose tolerance or insulin sensitivity in rats, which led us to hypothesize that IRS-1 plays more pivotal roles in insulin functions than IRS-2. …”
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Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

“…DW18343 triggered downstream p‐TBK1/p‐IRF3 signaling, leading to the production of multiple cytokines. Additionally, DW18343 displayed broad and long‐lasting antitumor effects in various syngeneic mouse tumor models, whether administered locally or systemically. …”
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Morale in Old Age and Its Association with Sociodemographic, Social, and Health-Related Factors in Different Age Groups by Marina Näsman, Johan Niklasson, Jan Saarela, Mikael Nygård, Birgitta Olofsson, Yngve Gustafson, Fredrica Nyqvist

“…The results showed that older age was an independent factor explaining lower level of morale. Additionally, the sociodemographic, social, and health-related variables could explain a large proportion of the variance in morale. …”
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Enrichment Mechanism of the Upper Carboniferous-Lower Permian Transitional Shale in the East Margin of the Ordos Basin, China: Evidence from Geochemical Proxies by Zhifu Wei, Yongli Wang, Gen Wang, Ting Zhang, Wei He, Xueyun Ma, Xiaoli Yu

“…For Shanxi Formation, there is a positive correlation between TOC and paleoclimate, which indicates that the enrichment of organic matter is affected by warm and humid paleoclimate and oxic environment. In addition, the paleoproductivity is lower with a positive correlation with TOC for the marine-continental transitional organic-rich shale, suggesting that it was inferior to the gathering of organic matter.…”
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Lithium and Valproate Levels Do Not Correlate with Ketamine’s Antidepressant Efficacy in Treatment-Resistant Bipolar Depression by Annie J. Xu, Mark J. Niciu, Nancy B. Lundin, David A. Luckenbaugh, Dawn F. Ionescu, Erica M. Richards, Jennifer L. Vande Voort, Elizabeth D. Ballard, Nancy E. Brutsche, Rodrigo Machado-Vieira, Carlos A. Zarate

“…Ketamine and lithium both inhibit glycogen synthase kinase 3. In addition, lithium and ketamine have synergistic antidepressant-like effects at individually subeffective doses in rodents. …”
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Stemness Maintenance Properties in Human Oral Stem Cells after Long-Term Passage by Francesca Diomede, Thangavelu Soundara Rajan, Valentina Gatta, Marco D’Aurora, Ilaria Merciaro, Marco Marchisio, Aurelio Muttini, Sergio Caputi, Placido Bramanti, Emanuela Mazzon, Oriana Trubiani

“…Neural crest-derived mesenchymal stem cells (MSCs) from human oral tissues possess immunomodulatory and regenerative properties and are emerging as a potential therapeutic tool to treat diverse diseases, such as multiple sclerosis, myocardial infarction, and connective tissue damages. In addition to cell-surface antigens, dental MSCs express embryonic stem cell markers as neural crest cells originate from the ectoderm layer. …”
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Synthesis, crystal structure, hirshfeld study, DFT analysis, molecular docking study, antimicrobial activity of β-enaminonitrile bearing 1H-pyran by Al-Anood M. Al-Dies, Fawzia F. Alblewi, Rawda M. Okasha, Mosa H. Alsehli, Rita M. A. Borik, Saleh Ihmaid, Abd El-Galil E. Amr, Hazem A. Ghabbour, Ahmed A. Elhenawy, Ahmed M. El-Agrody

“…Compound 4 exhibited favorable antimicrobial activities that were lower/resembled the reference antimicrobial agents with an IZ range of 15–31 mm. In addition, MIC, MBC, and MFC were assessed and screened for the target molecule 4, unveiling its revealing antimicrobial activities. …”
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Nursing of a patient with gout of damp-heat stagnation syndrome combined with erosive gastritis treated with auricular acupoint therapy combine with pricking and cupping therapy (耳... by ZHU Jianmei (朱建妹), CHEN Hui (陈慧), ZHANG Xiaolin (张小林), LIAO Xuefeng (廖雪锋)

“…This paper summarizes nursing measures for a patient with gout of damp-heat stagnation syndrome combined with erosive gastritis treated with auricular acupoint combine with pricking and cupping therapy. In addition to routine nursing, individualized auricular acupoint treatment including auricular bloodletting and pressing combined with pricking and cupping therapy were carried out, aiming at relieving heat and detoxification at early stage of disease, promoting blood circulation, dredging collaterals and regulating qi at midterm and invigorating spleen and warming kidney Yang and end stage of treatment. …”
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Comparative Analysis of Freeze-Dried <i>Pleurotus ostreatus</i> Mushroom Powders on Probiotic and Harmful Bacteria and Its Bioactive Compounds by Gréta Törős, Áron Béni, Ferenc Peles, Gabriella Gulyás, József Prokisch

“…Our research examined polysaccharide fractions—specifically total glucans and α- and β-glucans—alongside secondary metabolites, including polyphenols and flavonoids, from freeze-dried mushroom powders. Additionally, carbon nanodots (CNDs) were also characterized. …”
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Studies on the Dual Cytotoxicity and Antioxidant Properties of Berberis vulgaris Extracts and Its Main Constituent Berberine by Lamyae El khalki, Mounir Tilaoui, Abdeslam Jaafari, Hassan Ait Mouse, Abdelmajid Zyad

“…In fact, the IC50 values are 69.65 μg/mL and 77.75 μg/mL for the ethanol and ethyl acetate extracts, respectively. In addition, several concentrations of berberine, when combined with the NO donor used at IC30, induced a synergistic cytotoxic activity at concentrations ranging from 8.40 μM to 33.60 μM, as revealed by the combination index values, using the Chou–Talalay method. …”
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Experimental study on the drag reduction performance of sodium alginate in saline solutions by Zhensong Cheng, Xin Zhang, Xiaodong Dai, Hengli Zhai, Xinwang Song, Xudong Wang, Liang Gao, Guoxin Zhang, Yuan Lu, Lei Li, Xiu Yan, Jianhua Zhang

“…Abstract Since the discovery of the turbulence drag reduction phenomenon over 70 years ago, it has been recognized that the addition of small quantities of drag-reducing agents to fluids can significantly decrease wall shear stress, thereby enhancing fluid pumpability. …”
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Assembly and analysis of the first complete mitochondrial genome sequencing of main Tea-oil Camellia cultivars Camellia drupifera (Theaceae): revealed a multi-branch mitochondrial... by Heng Liang, Huasha Qi, Jiali Chen, Yidan Wang, Moyang Liu, Xiuxiu Sun, Chunmei Wang, Tengfei Xia, Xuejie Feng, Shiling Feng, Cheng Chen, Daojun Zheng

“…Notably, repeat sequences showed a weak correlation between the abundance of simple sequence repeats (SSRs) and genome size of Camellia. Additionally, despite of the considerable variations in the sizes of Camellia mitochondrial genomes, there was little diversity in GC content and gene composition. …”
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Reducing dementia-related stigma and discrimination among community health workers in Brazil: protocol for a randomised controlled feasibility trial by Nicolas Farina, Deborah Oliveira, Sara Evans-Lacko, Cleusa P Ferri, Carolina Godoy, Fabiana A F da Mata, Elaine Mateus, Ana Carolina Arruda Franzon

“…Knowledge, attitude and intended behaviour stigma-based outcomes will be assessed at baseline and at follow-up (30 days after intervention) to both groups, with additional questions on feasibility for the experimental group at follow-up. …”
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Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant Recipients by Ajay Yadlapati, Joseph P. Lynch, Rajan Saggar, David Ross, John A. Belperio, Stephen Weigt, Abbas Ardehali, Tristan Grogan, Eric H. Yang, Jamil Aboulhosn

“…Additionally, all clinical endpoints did not show any statistical significance between the two groups. …”
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The influence of land surface temperature on Ghana’s climate variability and implications for sustainable development by Collins Oduro, Kenny Thiam Choy Lim Kam Sian, Daniel Fiifi Tawia Hagan, Hassen Babaousmail, Brian Odhiambo Ayugi, Yanjuan Wu, Tatenda Dalu, Naicheng Wu

“…Based on ground observations, our findings reveal significant correlations between land surface temperature (LST) and NST before and after the identified breakpoint year of 2001. Additionally, we observe a reduction in precipitation post-2001. …”
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