Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice by Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang

“…In USP21fl/flFOXP3Cre mice, levels of IFN-gamma, IL-4, anti-soluble egg antigen (SEA) IgG and anti-soluble worm antigen preparation (SWAP) IgG increased in blood, as determined using ELISAs and multiplex fluorescent microsphere immunoassays, while the levels of IL-10, lL-17A, IL-23, IL-9, and anti-SEA IgM decreased. In addition, the levels of the USP21 protein and mRNA in the liver and spleen of KO mice decreased. …”
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Comparative monocyte and T cell responses in DENV-exposed subjects from South-East Asia and DENV-naïve residents in Taiwan by Sheng-Hsuan Wang, Yun-Erh Chuang, Sia-Seng Tan, Tzu-Chuan Ho, Oscar Guey Chuen Perng, Po-Lin Chen

“…Furthermore, the cytokine expression profiles in monocytes from both naïve individuals and previously DENV-exposed subjects were similar after DENV2 stimulation. In addition, it was observed that the function of T cells was also equivalent when monocytes were present as antigen-presenting cells for dengue antigen, NS3, in terms of cell proliferation, interferon-gamma (IFNγ) secretion, and memory response. …”
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Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction by Hernán Gonzalo Villagarcía, Vanesa Sabugo, María Cecilia Castro, Guillermo Schinella, Daniel Castrogiovanni, Eduardo Spinedi, María Laura Massa, Flavio Francini

“…Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased. …”
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Location and natural history are key to determining impact of the 2021 atmospheric heatwave on Pacific Northwest rocky intertidal communities by C. Melissa Miner, Helen D. Berry, Heath Bohlmann, Megan N. Dethier, Steven C. Fradkin, Rani Gaddam, Wendel W. Raymond, Peter T. Raimondi

“…Focal species assemblages at Olympic coast sites, where low tides occurred in the morning, were largely spared. In addition, while the heatwave was associated with substantial short-term changes in acorn barnacle, rockweed, and California mussel assemblages, lasting impacts (1 year) were only observed in the mussel assemblage at the one Salish Sea site where this species is common. …”
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Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patients by Xiaokai Fan, Daqin Feng, Donggui Wei, Anqi Li, Fangyi Wei, Shufang Deng, Muling Shen, Congzhi Qin, Yongjia Yu, Lun Liang

“…In terms of cell–cell communication within the TLS associated regions, KRT86+ CD8+ T cells, HISTIH4C+ cycling CD8+ T cells, IFNG+ CD8+ T cells, and IGKV3-20+ B cells demonstrate strong interactions with other cells. Additionally, we found that APOD+ fibroblast and CCL21+ fibroblast primarily recruit T and B cells through the CXCL12-CXCR4 ligand-receptor signaling pathway. …”
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The Application of Resolvin D1-Loaded Gelatin Methacrylate in a Rat Periodontitis Model by Zhe Xing, Jing Liu, Jiazheng Cai, Xiaofeng Jiang, Jingwen Liang, Masahito Fujio, Elin Hadler-Olsen, Jing Wang, Alpdogan Kantarci, Ying Xue

“…Compared to RvD1 alone, treatment with RvD1 complexed with GelMA significantly reduced inflammatory cell infiltration, TNF-α and RANKL expression, and osteoclast formation in periodontal tissues. Additionally, it promoted the expression of specific anti-inflammatory and regenerative markers. …”
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Taming of trinitromethyl-oxadiazole to access high density and high oxygen balance via a dual modulation strategy by Jinya Zhang, Teng Fei, Jingwei Meng, Jinxiong Cai, Lei Zhang, Siping Pang, Chunlin He

“…Notably, practical crystal morphology prediction was creatively introduced to guide the experimental crystallization conditions of 3, increasing the impact sensitivity and friction sensitivity from 1 J to 80 N (3-a) to 10 J and 240 N (3-b), respectively. Additionally, the crystal structural analyses and theoretical calculations were conducted to elucidate the reasons of differences between 3-a and 3-b in density and stability. …”
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Unveiling the molecular profile of a prostate carcinoma: implications for personalized medicine by Massimiliano Agostini, Erica Giacobbi, Francesca Servadei, Julia Bishof, Likas Funke, Giuseppe Sica, Valentina Rovella, Marco Carilli, Valerio Iacovelli, Yufang Shi, Jianquan Hou, Eleonora Candi, Gerry Melino, Giulio Cervelli, Manuel Scimeca, Alessandro Mauriello, Pierluigi Bove

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Effects of Enteromorpha prolifera polysaccharide on intestinal health of spotted sea bass Lateolabrax maculatus by Zhongying Long, Longhui Liu, Huihui Qin, Sishun Zhou, Lumin Kong, Jianrong Ma, Hao Lin, Zhangfan Huang, Yi Lin, Zhongbao Li

“…Transcriptome results suggest that EPP may improve intestinal tissue morphology and intestinal barrier function by up-regulating tight junction protein 1 (TJP1) and zona occludens 1 (ZO-1) genes, thereby improving intestinal health. In addition, significant changes in several inflammatory factor genes were observed. …”
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Dynamic changes of extracellular vesicles during zebrafish organogenesis by Linda-Marie Mulzer, Tim Felger, Luis E. Muñoz, Gesa Engl, Heiko Reutter, Mario Schiffer, Leila Pourtalebi Jahromi, Fanni Annamária Boros, Friederike Zunke, Philipp Arnold, Alina C. Hilger

“…It was observed that the total EV number increased significantly over the first 72 hpf, but not proportionally to zfl growth in length. Additionally, sEV size also increased significantly, with a maximum diameter at 72 hpf. …”
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Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy by Fermín E. González, Alexey Chernobrovkin, Cristián Pereda, Tamara García-Salum, Andrés Tittarelli, Mercedes N. López, Flavio Salazar-Onfray, Roman A. Zubarev

“…A quantitative label-free proteome analysis of over 2800 proteins was performed, with 91 proteins that were found to be regulated by HS treatment: 18 proteins were overexpressed and 73 underexpressed. Additionally, 32 proteins were only identified in the HS-treated TRIMEL and 26 in non HS-conditioned samples. …”
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Expression Analysis of Nitrogen Metabolism-Related Genes Reveals Differences in Adaptation to Low-Nitrogen Stress between Two Different Barley Cultivars at Seedling Stage by Zhiwei Chen, Chenghong Liu, Yifei Wang, Ting He, Runhong Gao, Hongwei Xu, Guimei Guo, Yingbo Li, Longhua Zhou, Ruiju Lu, Jianhua Huang

“…The expression of HvASN1 (asparagine synthetase) was reduced in both cultivars, but it showed a lower reduction in the shoots of BI-04. In addition, gene expression and regulation differences in the shoots and roots were also compared between the barley cultivars. …”
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Uncovering the whole genome silencers of human cells via Ss-STARR-seq by Xiusheng Zhu, Lei Huang, Chao Wang, Guoli Li, Biao Deng, Dashuai Kong, Xiaoxiao Wang, Rongrong Chang, Yi Gu, Qiuhan Wen, Siyuan Kong, Yuwen Liu, Yubo Zhang

“…Additionally, the silencer did not have any significant histone markers at the genome-wide level. …”
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A systematic review of Machine Learning and Deep Learning approaches in Mexico: challenges and opportunities by José Luis Uc Castillo, Ana Elizabeth Marín Celestino, Diego Armando Martínez Cruz, José Tuxpan Vargas, José Alfredo Ramos Leal, Janete Morán Ramírez

“…It observed that Artificial Neural Networks (ANN) models were preferred, probably due to their capability to learn and model non-linear and complex relationships in addition to other popular models such as Random Forest (RF) and Support Vector Machines (SVM). …”
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Transcriptome analysis reveals effects of ethynylestradiol and bisphenol A on multiple endocrine and metabolic pathways in the pituitary and liver of female Atlantic cod (Gadus mor... by Fekadu Yadetie, Xiaokang Zhang, Anna Reboa, Gwenaëlle Samantha Chloe Noally, Mariann Eilertsen, Mitchell Stewart Fleming, Jon Vidar Helvik, Inge Jonassen, Anders Goksøyr, Odd André Karlsen

“…There is however incomplete understanding of xenoestrogen targets genes, their molecular mechanisms and potential effects in some of the target organs, particularly the pituitary.MethodsWe performed a comprehensive analysis of pituitary and liver transcriptome 72 h after injection of ethynylestradiol (EE2: 10, 50 or 250 nmol/kg body weight/bw) and bisphenol A (BPA: 8, 40 or 200 μmol/kg bw) in juvenile female Atlantic cod (Gadus morhua).ResultsA broad range of reproductive and metabolic pathways were affected in both organs by BPA and EE2. …”
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Lactobacillus plantarum J26 alleviates alcohol-induced oxidative liver injury by regulating the Nrf2 signaling pathway by Hongxuan Li, Shasha Cheng, Yuhong Wang, Yilin Sun, Jiaxin Zhang, Mingshuang Sun, Chaoxin Man, Yu Zhang, Yujun Jiang

“…The results showed that pre-intake of L. plantarum J26 could improve liver pathological changes, reduce lipid accumulation, increase mitochondrial ATP and mitochondrial (mtDNA) levels, and alleviate liver injury. In addition, pre-intake L. plantarum J26 can improve the level of short-chain fatty acids (SCFAs) in the intestines in mice, short chain fatty acids can be used as a signaling molecule activation of nuclear factor E2-related factor 2 (Nrf2) signaling pathway to alleviate liver oxidative stress, and maintain mitochondrial homeostasis by regulating the expression of genes related to mitochondrial dynamics and autophagy, thereby reducing cell apoptosis to alleviate alcohol-induced oxidative liver injury.…”
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Revolutionizing radiotherapy: gold nanoparticles with polyphenol coating as novel enhancers in breast cancer cells—an in vitro study by Simona Tarantino, Annalisa Bianco, Mariafrancesca Cascione, Alessandra Carlà, Lia Fiamà, Riccardo Di Corato, Livia Giotta, Paolo Pellegrino, Anna Paola Caricato, Rosaria Rinaldi, Valeria De Matteis

“…The results showed that green-synthesized AuNPs significantly enhanced the therapeutic effects of radiotherapy at lower radiation doses, indicating their potential as a valuable addition to breast cancer treatment.…”
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Influence of Process on the Formation of Main Taste Substances and Quality of Chuanhong Congou Black Tea by Jing HU, Bo DUAN, Zhiwei HE, Lei LIAO, Jiahui DU, Na LIU, Gang CHENG, Yang YE

“…Sensory evaluation combined with high-performance liquid chromatography (HPLC) and amino acid analysis were used to study the effects of withering, rolling, fermentation, and drying (first-drying and sencod-drying) on the main taste substances and their quality formation using one bud and one leaf of Sichuan group species as raw materials. …”
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Highly corrosion-resistant and photocatalytic hybrid coating on AZ31 Mg alloy via plasma electrolytic oxidation with organic-inorganic integration by Talitha Tara Thanaa, Mohammad Aadil, Alireza Askari, Arash Fattah-alhosseini, Mohammad Alkaseem, Mosab Kaseem

“…The PEO-PHEN-2IMD sample on the Mg alloy demonstrated exceptional corrosion resistance, with the lowest corrosion current density (Icorr) of 1.92 × 10-10 A/cm², a high corrosion potential (Ecorr), and the highest top layer resistance (Rtop) of 2.57 × 106 Ω·cm², indicating excellent barrier properties. Additionally, the coating achieved complete (100%) degradation of methylene blue (MB) within 30 min under visible light. …”
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Static and dynamic study of composite beams with a new interlaminar sliding field using different beam theories by Rachida Mohamed Krachaï, Noureddine Elmeiche, Ismail Mechab, Fabrice Bernard, Hichem Abbad

“…The equilibrium equations were solved analytically based on the principle of Hamilton. In addition, the numerical resolution of these equations was based on the principle of minimizing all energies using the Ritz method, while taking into account different beam theories. …”
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