Limosilactobacillus mucosae FZJTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis by Danting Dang, Bowen Li, Mengfan Ding, R. Paul Ross, Catherine Stanton, Jianxin Zhao, Bo Yang, Wei Chen

“…L. mucosae FZJTZ26M3 reduced the mice’s body weight, liver weight, and adipose tissue weight after 12 weeks of therapy. …”
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scPharm: Identifying Pharmacological Subpopulations of Single Cells for Precision Medicine in Cancers by Peng Tian, Jie Zheng, Keying Qiao, Yuxiao Fan, Yue Xu, Tao Wu, Shuting Chen, Yinuo Zhang, Bingyue Zhang, Chiara Ambrogio, Haiyun Wang

“…Its superior performance and computational efficiency are confirmed through comparative evaluations with other single‐cell prediction tools. Additionally, scPharm predicted combination drug strategies by gauging compensation or booster effects between drugs and evaluated drug toxicity in healthy cells in the tumour microenvironment. …”
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Studying flame-retardancy, smoke and toxicity of fiber-reinforced composites manufactured via modified resins and metallic coatings by Md Shafinur Murad, Abdulhammed K. Hamzat, Eylem Asmatulu, Ersin Bahçeci, Mete Bakir, Ramazan Asmatulu

“…Thermal stability, flammability, and smoke production characteristics were evaluated using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), thermomechanical analysis (TMA), UL94 vertical flame test, and standardized smoke and toxicity tests. The addition of 9,10-dihydro-9-oxo-10-phosphaphenanthrene-10-oxide (DOPO) and Cu film surface coating led to superior smoke suppression with negligible smoke production (maximum Ds of 0–4, VOF4 of 1 at 180–240 s), whereas unmodified composites showed significant smoke development (maximum Ds of 759 at 240 s, VOF4 of 1157). …”
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Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study by Jijo Francis, Honey Sebastian, Saley Daniel, Leyon Varghese, Sareena Gilvaz, Ragitha Thenkattil Sankarankutty, Siji Susan George, Pulikkottil Raphael Varghese, Suresh Kumar Raveendran

“…Since no study was reported from the Indian population, we aimed to explore theassociation of the MCP-1 -2518A/G polymorphism (rs1024611) with PCOS.Materials and Methods: In this case-control study, to analyse the distribution and association of rs1024611 with PCOS,polymerase chain reaction-fragment length polymorphism (PCR-RFLP) analysis was carried out in 202 patients whoexhibited PCOS from menarche onwards or with higher severity of symptoms and 122 age-matched controls.Results: In our study, no significant correlation was observed in rs1024611 polymorphism with PCOS patients incomparison with control. In addition to this, we found no significant difference in the genotype and allele frequenciesbetween obese and non-obese PCOS patients.Conclusion: Our finding suggests that the MCP-1 -2518 A/G polymorphism has not been associated with PCOSpredisposition.…”
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Quantifying preferential flow occurrence in dependence of land cover on the southern slopes of Mount Kilimanjaro, Tanzania by Frank Paul Shagega, Fabia Codalli, Suzanne Jacobs, Subira Eva Munishi, David Windhorst, Lutz Breuer

“…Both, very dry and very wet soil conditions were less favorable for preferential flow occurrence. …”
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LSN-GTDA: Learning Symmetrical Network via Global Thermal Diffusion Analysis for Pedestrian Trajectory Prediction in Unmanned Aerial Vehicle Scenarios by Ling Mei, Mingyu Fu, Bingjie Wang, Lvxiang Jia, Mingyu Yu, Yu Zhang, Lijun Zhang

“…Experimental results demonstrate that the LSN-GTDA method outperforms state-of-the-art approaches on benchmark datasets such as SDD and ETH-UCY, validating its effectiveness in addressing the multimodal uncertainty of pedestrian trajectory prediction.…”
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Are deprivation-specific cancer survival patterns similar according to individual-based and area-based measures? A cohort study of patients diagnosed with five malignancies in Engl... by Lucy Elliss-Brookes, Aurélien Belot, Matthew Baker, Fiona C Ingleby, Laura M Woods, Iain M Atherton

“…Further research could consider the separate and additional influence of area-based deprivation over individual-level characteristics (contextual effects) as well as investigate the geographic, socioeconomic and healthcare-related characteristics of areas with poor outcomes in order to inform policy intervention.…”
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Melatonin Reverses the Loss of Stemness Induced by TNF-α in Human Bone Marrow Mesenchymal Stem Cells through Upregulation of YAP Expression by Xudong Wang, Tongzhou Liang, Jincheng Qiu, Xianjian Qiu, Bo Gao, Wenjie Gao, Chengjie Lian, Taiqiu Chen, Yuanxin Zhu, Anjing Liang, Peiqiang Su, Yan Peng, Dongsheng Huang

“…Meanwhile, a detailed analysis of the molecular mechanisms showed that the melatonin receptor and YAP signaling pathway are closely related to the role that melatonin plays in negative inflammatory effects against BMMSCs. In addition, in vivo experiments showed that melatonin could reverse the damage caused by TNF-α on bone regeneration by BMMSCs in nude mice. …”
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Efficiency of Polyphenol Extraction from Artificial Honey Using C18 Cartridges and Amberlite® XAD-2 Resin: A Comparative Study by Chua Yung An, Md. Murad Hossain, Fahmida Alam, Md. Asiful Islam, Md. Ibrahim Khalil, Nadia Alam, Siew Hua Gan

“…The recoveries of vanillic acid, naringin, and rutin were excellent (>90%); however, gallic acid was not obtained when C18 cartridges were used. Additionally, the reusability of Amberlite XAD-2 resin was investigated, revealing that the mean recovery of polyphenols decreased from 43.7% (1st extraction) to 29.3% (3rd extraction). …”
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Risk factors for silicotuberculosis among miners: a scoping review by Mansour F. Saliba, Zeina Z. Karam, Moussa El Khayat, Elizabeth Koka, Dana A. Halwani, Joly Ghanawi, Layal Hneiny, Mey Jurdi, Hassan R. Dhaini, Umayya Musharrafieh, Rima R. Habib

“…Findings identified various STB risk factors including demographic factors such as age and sex, lifestyle factors including smoking and alcohol intake, clinical factors such as history of TB, grades of silicosis, and human immunodeficiency virus (HIV), in addition to occupational factors encompassing silica exposure, duration of employment, and type of work setting. …”
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Channel Mobility and Inversion Carrier Density in MFIS FEFET: Deep Insights Into Device Physics for Non-Volatile Memory Applications by Song-Hyeon Kuk, Kyul Ko, Bong Ho Kim, Joon Pyo Kim, Jae-Hoon Han, Sang-Hyeon Kim

“…This indicates that trapped carriers significantly degrade mobility and the degradation has a “history” effect, revealing that μch and Ns,inv are determined by overlapped effects of ferroelectric polarization and trapped charges. In addition, it is suggested that ferroelectric polarization induces remote phonon scattering. …”
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Relationship between prognostic nutritional index and asthma: a cross-sectional analysis by Zhimeng Jiang, Zhimeng Jiang, Xingyu Zhu, Xingyu Zhu, Huixin Jiang, Donglin Zhao, Donglin Zhao, Jianwei Tian

“…In the complete adjusted model, each additional unit of PNI was associated with a 3% reduction in the prevalence of asthma [0.97 (0.95, 0.99)]. …”
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AI-Driven Plant Health Assessment: A Comparative Analysis of Inception V3, ResNet-50 and ViT with SHAP for Accurate Disease Identification in Taro by Valeria Maeda-Gutiérrez, Juan José Oropeza-Valdez, Luis C. Reveles-Gómez, Cristian Padron-Manrique, Osbaldo Resendis-Antonio, Luis Octavio Solís-Sánchez, Hector A. Guerrero-Osuna, Carlos Alberto Olvera Olvera

“…The novelty of this work lies in the first-ever integration of SHapley Additive exPlanations (SHAP) with deep learning architectures to enhance model interpretability while providing a comprehensive comparison of state-of-the-art methods for this underexplored crop. …”
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Amoxicillin/Clavulanic Acid for the Treatment of Odontogenic Infections: A Randomised Study Comparing Efficacy and Tolerability versus Clindamycin by Archiel Launch Tancawan, Maria Noemi Pato, Khamiza Zainol Abidin, A. S. Mohd Asari, Tran Xuan Thong, Puja Kochhar, Chandra Muganurmath, Monique Twynholm, Keith Barker

“…The primary endpoint was percentage of subjects achieving clinical success (composite measure of pain, swelling, fever, and additional antimicrobial therapy required) at the end of treatment. …”
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SNP-array profiling data from breast cancer patients and healthy women's blood DNA samplesGEO by Rafika Indah Paramita, Sonar Soni Panigoro, Fadilah Fadilah, Septelia Inawati Wanandi, Noorwati Sutandyo

“…The DNA was obtained from stored blood samples that were collected from a total of 48 female patients diagnosed with breast cancer at Cipto Mangunkusumo National Hospital Jakarta and Dharmais National Cancer Center Hospital Jakarta. Additionally, 24 healthy women were included as control subjects. …”
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Chloroplast Vesiculation and Induced Chloroplast Vesiculation and Senescence‐Associated Gene 12 Expression During Tomato Flower Pedicel Abscission by Magda Tušek Žnidarič, Maja Zagorščak, Živa Ramšak, Katja Stare, Marko Chersicola, Maruša Pompe Novak, Aleš Kladnik, Marina Dermastia

“…Ethylene signaling appears to be involved in the regulation of these processes, as treatment with a competitive inhibitor of ethylene action, 1‐methylcyclopropene, delayed vesiculation, reduced the expression of SAG12, and increased expression of Curvature Thylakoid 1A (CURT1A). In addition, chloroplast vesiculation during abscission was associated with differential expression of photosynthesis‐related genes, particularly those involved in light reactions, underscoring the possible functional impact of the observed structural changes. …”
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ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer by Yang-Hsiang Lin, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Ming-Wei Lai, Chau-Ting Yeh

“…In the current study, online available dataset analysis uncovered that angiopoietin-like protein 3 (ANGPTL3) manifested lower expression in sorafenib-resistant liver cancer cell lines. Additionally, ANGPTL3 was downregulated in HCC tissues, with its expression positively correlated with good prognosis. …”
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Dental pulp stem cell-derived intracellular vesicles prevent orthodontic relapse by inhibiting PI3K/Akt/NF-κB-mediated osteoclast activity by Boyuan Peng, Ziwei Li, Yong Cheng, Henghua Jiang, Qingsong Ye, Guangli Han

“…Relapse distance and relapse rate were calculated to evaluate DPSC-IV’s ability to prevent relapse. Additionally, Western blot analysis were used to examine DPSC-IV’s inhibitory effect on osteoclast differentiation. …”
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A Novel Change Detection Method Based on Visual Language From High-Resolution Remote Sensing Images by Junlong Qiu, Wei Liu, Hui Zhang, Erzhu Li, Lianpeng Zhang, Xing Li

“…On the image side, we construct a side fusion network, which integrates universal features from the foundation model with domain-specific features from remote sensing through a bridging module. In addition, we introduce a change feature computation module to integrate global features, difference features, and textual information. …”
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Homoharringtonine: mechanisms, clinical applications and research progress by Wen Wang, Lan He, Lan He, Ting Lin, Ting Lin, Ting Lin, Fulan Xiang, Yibin Wu, Fangliang Zhou, Fangliang Zhou, Fangliang Zhou, Yingchun He, Yingchun He, Yingchun He

“…This article systematically reviews the pharmacological mechanisms of Homoharringtonine, focusing on its key roles in inducing apoptosis, inhibiting cell cycle progression, and reducing cell migration and invasion. Additionally, HHT exhibits multiple biological activities, including immunomodulation, antiviral effects, and anti-fibrotic properties, with recent studies also revealing its potential neuroprotective functions. …”
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